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Treatable traits can be identified in a severe asthma registry and predict future exacerbations.

McDonald VM, Hiles SA, Godbout K, Harvey ES, Marks GB, Hew M, Peters M, Bardin PG, Reynolds PN, Upham JW, Baraket M, Bhikoo Z, Bowden J, Brockway B, Chung LP, Cochrane B, Foxley G, Garrett J, Jayaram L, Jenkins C, Katelaris C, Katsoulotos G, Koh MS, Kritikos V, Lambert M, Langton D, Lara Rivero A, Middleton PG, Nanguzgambo A, Radhakrishna N, Reddel H, Rimmer J, Southcott AM, Sutherland M, Thien F, Wark PAB, Yang IA, Yap E, Gibson PG.

Respirology. 2018 Sep 19. doi: 10.1111/resp.13389. [Epub ahead of print]


A Charter to Improve Patient Care in Severe Asthma.

Menzies-Gow A, Canonica GW, Winders TA, Correia de Sousa J, Upham JW, Fink-Wagner AH.

Adv Ther. 2018 Oct;35(10):1485-1496. doi: 10.1007/s12325-018-0777-y. Epub 2018 Sep 4.


Interleukin 33 Selectively Augments Rhinovirus-Induced Type 2 Immune Responses in Asthmatic but not Healthy People.

Jurak LM, Xi Y, Landgraf M, Carroll ML, Murray L, Upham JW.

Front Immunol. 2018 Aug 16;9:1895. doi: 10.3389/fimmu.2018.01895. eCollection 2018.


The Bronchial Epithelial Secretory IgA System in Asthma.

Upham JW.

Am J Respir Crit Care Med. 2018 Jul 30. doi: 10.1164/rccm.201806-1042LE. [Epub ahead of print] No abstract available.


PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production.

Werder RB, Lynch JP, Simpson JC, Zhang V, Hodge NH, Poh M, Forbes-Blom E, Kulis C, Smythe ML, Upham JW, Spann K, Everard ML, Phipps S.

Sci Transl Med. 2018 May 9;10(440). pii: eaao0052. doi: 10.1126/scitranslmed.aao0052.


Working while unwell: Workplace impairment in people with severe asthma.

Hiles SA, Harvey ES, McDonald VM, Peters M, Bardin P, Reynolds PN, Upham JW, Baraket M, Bhikoo Z, Bowden J, Brockway B, Chung LP, Cochrane B, Foxley G, Garrett J, Hew M, Jayaram L, Jenkins C, Katelaris C, Katsoulotos G, Koh MS, Kritikos V, Lambert M, Langton D, Lara Rivero A, Marks GB, Middleton PG, Nanguzgambo A, Radhakrishna N, Reddel H, Rimmer J, Southcott AM, Sutherland M, Thien F, Wark PAB, Yang IA, Yap E, Gibson PG.

Clin Exp Allergy. 2018 Jun;48(6):650-662. doi: 10.1111/cea.13153. Epub 2018 May 17.


Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis.

Chen AC, Tran HB, Xi Y, Yerkovich ST, Baines KJ, Pizzutto SJ, Carroll M, Robertson AAB, Cooper MA, Schroder K, Simpson JL, Gibson PG, Hodge G, Masters IB, Buntain HM, Petsky HL, Prime SJ, Chang AB, Hodge S, Upham JW.

ERJ Open Res. 2018 Mar 23;4(1). pii: 00130-2017. doi: 10.1183/23120541.00130-2017. eCollection 2018 Jan.


Airway cells from protracted bacterial bronchitis and bronchiectasis share similar gene expression profiles.

Chen AC, Pena OM, Nel HJ, Yerkovich ST, Chang AB, Baines KJ, Gibson PG, Petsky HL, Pizzutto SJ, Hodge S, Masters IB, Buntain HL, Upham JW.

Pediatr Pulmonol. 2018 May;53(5):575-582. doi: 10.1002/ppul.23984. Epub 2018 Mar 24.


Sputum cytology during late-phase responses to inhalation challenge with different allergens.

Revez JA, Killian KJ, O'Byrne PM, Boulet LP, Upham JW, Gauvreau GM, Ferreira MAR.

Allergy. 2018 Jul;73(7):1470-1478. doi: 10.1111/all.13415. Epub 2018 Feb 6.


Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a-mediated T reg expansion.

Lynch JP, Werder RB, Loh Z, Sikder MAA, Curren B, Zhang V, Rogers MJ, Lane K, Simpson J, Mazzone SB, Spann K, Hayball J, Diener K, Everard ML, Blyth CC, Forstner C, Dennis PG, Murtaza N, Morrison M, Ó Cuív P, Zhang P, Haque A, Hill GR, Sly PD, Upham JW, Phipps S.

J Exp Med. 2018 Feb 5;215(2):537-557. doi: 10.1084/jem.20170298. Epub 2017 Dec 22.


Cytokine responses to two common respiratory pathogens in children are dependent on interleukin-1β.

Chen AC, Xi Y, Carroll M, Petsky HL, Gardiner SJ, Pizzutto SJ, Yerkovich ST, Baines KJ, Gibson PG, Hodge S, Masters IB, Buntain HM, Chang AB, Upham JW.

ERJ Open Res. 2017 Oct 2;3(4). pii: 00025-2017. doi: 10.1183/23120541.00025-2017. eCollection 2017 Oct.


Critical Role of Plasmacytoid Dendritic Cells in Regulating Gene Expression and Innate Immune Responses to Human Rhinovirus-16.

Xi Y, Troy NM, Anderson D, Pena OM, Lynch JP, Phipps S, Bosco A, Upham JW.

Front Immunol. 2017 Oct 25;8:1351. doi: 10.3389/fimmu.2017.01351. eCollection 2017.


Presence of atopy increases the risk of asthma relapse.

Teoh L, Mackay IM, Van Asperen PP, Acworth JP, Hurwitz M, Upham JW, Siew WH, Wang CYT, Sloots TP, Neeman T, Chang AB.

Arch Dis Child. 2018 Apr;103(4):346-351. doi: 10.1136/archdischild-2017-312982. Epub 2017 Oct 11.


Chronic IL-33 expression predisposes to virus-induced asthma exacerbations by increasing type 2 inflammation and dampening antiviral immunity.

Werder RB, Zhang V, Lynch JP, Snape N, Upham JW, Spann K, Phipps S.

J Allergy Clin Immunol. 2018 May;141(5):1607-1619.e9. doi: 10.1016/j.jaci.2017.07.051. Epub 2017 Sep 22.


Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial.

Gibson PG, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Marks GB, Baraket M, Powell H, Taylor SL, Leong LEX, Rogers GB, Simpson JL.

Lancet. 2017 Aug 12;390(10095):659-668. doi: 10.1016/S0140-6736(17)31281-3. Epub 2017 Jul 4.


Bronchiectasis in Children: Current Concepts in Immunology and Microbiology.

Pizzutto SJ, Hare KM, Upham JW.

Front Pediatr. 2017 May 29;5:123. doi: 10.3389/fped.2017.00123. eCollection 2017. Review.


Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology.

Taylor SL, Leong LEX, Choo JM, Wesselingh S, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Baraket M, Marks GB, Gibson PG, Simpson JL, Rogers GB.

J Allergy Clin Immunol. 2018 Jan;141(1):94-103.e15. doi: 10.1016/j.jaci.2017.03.044. Epub 2017 May 4.



Wurzel DF, Marchant JM, Yerkovich ST, Upham JW, Chang AB.

Chest. 2017 Apr;151(4):940-941. doi: 10.1016/j.chest.2016.12.030. No abstract available.


Can biomarkers help us hit targets in difficult-to-treat asthma?

Fricker M, Heaney LG, Upham JW.

Respirology. 2017 Apr;22(3):430-442. doi: 10.1111/resp.13014. Epub 2017 Mar 1. Review.


RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma.

Arikkatt J, Ullah MA, Short KR, Zhang V, Gan WJ, Loh Z, Werder RB, Simpson J, Sly PD, Mazzone SB, Spann KM, Ferreira MA, Upham JW, Sukkar MB, Phipps S.

Elife. 2017 Jan 18;6. pii: e21199. doi: 10.7554/eLife.21199.


Severe asthma: Current management, targeted therapies and future directions-A roundtable report.

McDonald VM, Maltby S, Reddel HK, King GG, Wark PA, Smith L, Upham JW, James AL, Marks GB, Gibson PG.

Respirology. 2017 Jan;22(1):53-60. doi: 10.1111/resp.12957. Epub 2016 Nov 30. Review.


Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma.

Navarro S, Pickering DA, Ferreira IB, Jones L, Ryan S, Troy S, Leech A, Hotez PJ, Zhan B, Laha T, Prentice R, Sparwasser T, Croese J, Engwerda CR, Upham JW, Julia V, Giacomin PR, Loukas A.

Sci Transl Med. 2016 Oct 26;8(362):362ra143.


Real-life effectiveness of omalizumab in severe allergic asthma above the recommended dosing range criteria.

Hew M, Gillman A, Sutherland M, Wark P, Bowden J, Guo M, Reddel HK, Jenkins C, Marks GB, Thien F, Rimmer J, Katsoulotos GP, Cook M, Yang I, Katelaris C, Bowler S, Langton D, Wright C, Bint M, Yozghatlian V, Burgess S, Sivakumaran P, Yan KY, Kritikos V, Peters M, Baraket M, Aminazad A, Robinson P, Jaffe A, Powell H, Upham JW, McDonald VM, Gibson PG.

Clin Exp Allergy. 2016 Nov;46(11):1407-1415. doi: 10.1111/cea.12774. Epub 2016 Jul 22.


Dendritic Cells in Human Lung Disease: Recent Advances.

Upham JW, Xi Y.

Chest. 2017 Mar;151(3):668-673. doi: 10.1016/j.chest.2016.09.030. Epub 2016 Oct 8. Review.


Protracted Bacterial Bronchitis in Children: Natural History and Risk Factors for Bronchiectasis.

Wurzel DF, Marchant JM, Yerkovich ST, Upham JW, Petsky HL, Smith-Vaughan H, Masters B, Buntain H, Chang AB.

Chest. 2016 Nov;150(5):1101-1108. doi: 10.1016/j.chest.2016.06.030. Epub 2016 Aug 24.


Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening antiviral immunity.

Lynch JP, Werder RB, Simpson J, Loh Z, Zhang V, Haque A, Spann K, Sly PD, Mazzone SB, Upham JW, Phipps S.

J Allergy Clin Immunol. 2016 Nov;138(5):1326-1337. doi: 10.1016/j.jaci.2016.02.039. Epub 2016 Apr 25.


Periostin levels and eosinophilic inflammation in poorly-controlled asthma.

Simpson JL, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Jia G, Holweg CT, Gibson PG.

BMC Pulm Med. 2016 Apr 30;16(1):67. doi: 10.1186/s12890-016-0230-4.


Sex hormones and systemic inflammation are modulators of the obese-asthma phenotype.

Scott HA, Gibson PG, Garg ML, Upham JW, Wood LG.

Allergy. 2016 Jul;71(7):1037-47. doi: 10.1111/all.12891. Epub 2016 Apr 6.


Vitamin D in Asthma. Is the Golden Bullet Losing Its Luster?

Upham JW, Sly PD.

Am J Respir Crit Care Med. 2016 Mar 15;193(6):598-600. doi: 10.1164/rccm.201511-2213ED. No abstract available.


Identification of STOML2 as a putative novel asthma risk gene associated with IL6R.

Revez JA, Matheson MC, Hui J, Baltic S; Australian Asthma Genetics Consortium (AAGC) collaborators, James A, Upham JW, Dharmage S, Thompson PJ, Martin NG, Hopper JL, Ferreira MA.

Allergy. 2016 Jul;71(7):1020-30. doi: 10.1111/all.12869. Epub 2016 Mar 24.


Is Alveolar Macrophage Phagocytic Dysfunction in Children With Protracted Bacterial Bronchitis a Forerunner to Bronchiectasis?

Hodge S, Upham JW, Pizzutto S, Petsky HL, Yerkovich S, Baines KJ, Gibson P, Simpson JL, Buntain H, Chen ACH, Hodge G, Chang AB.

Chest. 2016 Feb;149(2):508-515. doi: 10.1016/j.chest.2015.10.066.


Reduced Antiviral Interferon Production in Poorly Controlled Asthma Is Associated With Neutrophilic Inflammation and High-Dose Inhaled Corticosteroids.

Simpson JL, Carroll M, Yang IA, Reynolds PN, Hodge S, James AL, Gibson PG, Upham JW.

Chest. 2016 Mar;149(3):704-13. doi: 10.1016/j.chest.2015.12.018. Epub 2015 Dec 24.


Inhaled non-steroid anti-inflammatories for children and adults with bronchiectasis.

Pizzutto SJ, Upham JW, Yerkovich ST, Chang AB.

Cochrane Database Syst Rev. 2016 Jan 27;(1):CD007525. doi: 10.1002/14651858.CD007525.pub3. Review.


Rhinovirus stimulated IFN-α production: how important are plasmacytoid DCs, monocytes and endosomal pH?

Xi Y, Finlayson A, White OJ, Carroll ML, Upham JW.

Clin Transl Immunology. 2015 Oct 30;4(10):e46. doi: 10.1038/cti.2015.27. eCollection 2015 Oct.


Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma.

Simpson JL, Daly J, Baines KJ, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Hugenholtz P, Willner D, Gibson PG.

Eur Respir J. 2016 Mar;47(3):792-800. doi: 10.1183/13993003.00405-2015. Epub 2015 Dec 2.


Protracted bacterial bronchitis: The last decade and the road ahead.

Chang AB, Upham JW, Masters IB, Redding GR, Gibson PG, Marchant JM, Grimwood K.

Pediatr Pulmonol. 2016 Mar;51(3):225-42. doi: 10.1002/ppul.23351. Epub 2015 Dec 4. Review.


PBB: definition, mechanisms, and treatment.

Chang AB, Grimwood K, Gibson PG, Upham JW.

Lancet Respir Med. 2015 Oct;3(10):743-4. doi: 10.1016/S2213-2600(15)00243-X. Epub 2015 Aug 19. No abstract available.


Increased Peripheral Blood Pro-Inflammatory/Cytotoxic Lymphocytes in Children with Bronchiectasis.

Hodge G, Upham JW, Chang AB, Baines KJ, Yerkovich ST, Pizzutto SJ, Hodge S.

PLoS One. 2015 Aug 10;10(8):e0133695. doi: 10.1371/journal.pone.0133695. eCollection 2015.


High Pulmonary Levels of IL-6 and IL-1β in Children with Chronic Suppurative Lung Disease Are Associated with Low Systemic IFN-γ Production in Response to Non-Typeable Haemophilus influenzae.

Pizzutto SJ, Upham JW, Yerkovich ST, Chang AB.

PLoS One. 2015 Jun 12;10(6):e0129517. doi: 10.1371/journal.pone.0129517. eCollection 2015.


Acute exercise is associated with reduced exhaled nitric oxide in physically inactive adults with asthma.

Scott HA, Latham JR, Callister R, Pretto JJ, Baines K, Saltos N, Upham JW, Wood LG.

Ann Allergy Asthma Immunol. 2015 Jun;114(6):470-9. doi: 10.1016/j.anai.2015.04.002. Epub 2015 Apr 29.


Toward making inroads in reducing the disparity of lung health in Australian indigenous and new zealand māori children.

Chang AB, Marsh RL, Upham JW, Hoffman LR, Smith-Vaughan H, Holt D, Toombs M, Byrnes C, Yerkovich ST, Torzillo PJ, O'Grady KA, Grimwood K.

Front Pediatr. 2015 Feb 13;3:9. doi: 10.3389/fped.2015.00009. eCollection 2015. Review. No abstract available.


Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1β.

Gao P, Gibson PG, Baines KJ, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Zhang J, Simpson JL.

Respir Res. 2015 Jan 24;16:5. doi: 10.1186/s12931-014-0163-5.


An immunodiagnostic assay for quantitation of specific IgE to the major pollen allergen component, Pas n 1, of the subtropical Bahia grass.

Timbrell VL, Riebelt L, Simmonds C, Solley G, Smith WB, Mclean-Tooke A, van Nunen S, Smith PK, Upham JW, Langguth D, Davies JM.

Int Arch Allergy Immunol. 2014;165(4):219-28. doi: 10.1159/000369341. Epub 2015 Jan 23.


IgE+ B cells are scarce, but allergen-specific B cells with a memory phenotype circulate in patients with allergic rhinitis.

Wong KJ, Timbrell V, Xi Y, Upham JW, Collins AM, Davies JM.

Allergy. 2015 Apr;70(4):420-8. doi: 10.1111/all.12563. Epub 2015 Feb 2.


Improving immunity to Haemophilus influenzae in children with chronic suppurative lung disease.

Pizzutto SJ, Yerkovich ST, Upham JW, Hales BJ, Thomas WR, Chang AB.

Vaccine. 2015 Jan 3;33(2):321-6. doi: 10.1016/j.vaccine.2014.11.024. Epub 2014 Nov 22.


Influenza epidemiology, vaccine coverage and vaccine effectiveness in sentinel Australian hospitals in 2013: the Influenza Complications Alert Network.

Cheng AC, Dwyer DE, Holmes M, Irving LB, Brown SG, Waterer GW, Korman TM, Hunter C, Hewagama S, Friedman ND, Wark PA, Simpson G, Upham JW, Bowler SD, Senenayake SN, Kotsimbos TC, Kelly PM.

Commun Dis Intell Q Rep. 2014 Jun 30;38(2):E143-9.


Asthma is associated with multiple alterations in anti-viral innate signalling pathways.

Pritchard AL, White OJ, Burel JG, Carroll ML, Phipps S, Upham JW.

PLoS One. 2014 Sep 9;9(9):e106501. doi: 10.1371/journal.pone.0106501. eCollection 2014.


Children with chronic suppurative lung disease have a reduced capacity to synthesize interferon-gamma in vitro in response to non-typeable Haemophilus influenzae.

Pizzutto SJ, Yerkovich ST, Upham JW, Hales BJ, Thomas WR, Chang AB.

PLoS One. 2014 Aug 11;9(8):e104236. doi: 10.1371/journal.pone.0104236. eCollection 2014.


Mediators of neutrophil function in children with protracted bacterial bronchitis.

Baines KJ, Upham JW, Yerkovich ST, Chang AB, Marchant JM, Carroll M, Simpson JL, Gibson PG.

Chest. 2014 Oct;146(4):1013-1020. doi: 10.1378/chest.14-0131.


Full blood count parameters for the detection of asthma inflammatory phenotypes.

Zhang XY, Simpson JL, Powell H, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Lin JT, Gibson PG.

Clin Exp Allergy. 2014 Sep;44(9):1137-45. doi: 10.1111/cea.12345.


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