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Items: 1 to 50 of 85

1.

Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity.

Miyamoto Y, Kalisiak J, Korthals K, Lauwaet T, Cheung DY, Lozano R, Cobo ER, Upcroft P, Upcroft JA, Berg DE, Gillin FD, Fokin VV, Sharpless KB, Eckmann L.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17564-9. doi: 10.1073/pnas.1302664110. Epub 2013 Oct 7.

2.

Development of metronidazole-resistant lines of Blastocystis sp.

Dunn LA, Tan KS, Vanelle P, Juspin T, Crozet MD, Terme T, Upcroft P, Upcroft JA.

Parasitol Res. 2012 Jul;111(1):441-50. doi: 10.1007/s00436-012-2860-7. Epub 2012 Feb 24.

PMID:
22362365
3.

Impaired parasite attachment as fitness cost of metronidazole resistance in Giardia lamblia.

Tejman-Yarden N, Millman M, Lauwaet T, Davids BJ, Gillin FD, Dunn L, Upcroft JA, Miyamoto Y, Eckmann L.

Antimicrob Agents Chemother. 2011 Oct;55(10):4643-51. doi: 10.1128/AAC.00384-11. Epub 2011 Aug 8.

4.

Barcoding of Giardia duodenalis isolates and derived lines from an established cryobank by a mutation scanning-based approach.

Nolan MJ, Jex AR, Upcroft JA, Upcroft P, Gasser RB.

Electrophoresis. 2011 Aug;32(16):2075-90.

5.

Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia.

Leitsch D, Burgess AG, Dunn LA, Krauer KG, Tan K, Duchêne M, Upcroft P, Eckmann L, Upcroft JA.

J Antimicrob Chemother. 2011 Aug;66(8):1756-65. doi: 10.1093/jac/dkr192. Epub 2011 May 22.

6.

Chromosome sequence maps of the Giardia lamblia assemblage A isolate WB.

Upcroft JA, Krauer KG, Upcroft P.

Trends Parasitol. 2010 Oct;26(10):484-91. doi: 10.1016/j.pt.2010.07.002. Epub 2010 Aug 24. Review.

7.

Sequence map of the 2 Mb Giardia lamblia assemblage A chromosome.

Krauer KG, Burgess AG, Dunn LA, Upcroft P, Upcroft JA.

J Parasitol. 2010 Jun;96(3):660-2. doi: 10.1645/GE-2328.1.

PMID:
20557214
8.

Susceptibility in vitro of clinically metronidazole-resistant Trichomonas vaginalis to nitazoxanide, toyocamycin, and 2-fluoro-2'-deoxyadenosine.

Wright JM, Dunn LA, Kazimierczuk Z, Burgess AG, Krauer KG, Upcroft P, Upcroft JA.

Parasitol Res. 2010 Sep;107(4):847-53. doi: 10.1007/s00436-010-1938-3. Epub 2010 Jun 9.

PMID:
20532912
9.

A new-generation 5-nitroimidazole can induce highly metronidazole-resistant Giardia lamblia in vitro.

Dunn LA, Burgess AG, Krauer KG, Eckmann L, Vanelle P, Crozet MD, Gillin FD, Upcroft P, Upcroft JA.

Int J Antimicrob Agents. 2010 Jul;36(1):37-42. doi: 10.1016/j.ijantimicag.2010.03.004. Epub 2010 Apr 24.

10.

Hydrogenosomes of laboratory-induced metronidazole-resistant Trichomonas vaginalis lines are downsized while those from clinically metronidazole-resistant isolates are not.

Wright JM, Webb RI, O'Donoghue P, Upcroft P, Upcroft JA.

J Eukaryot Microbiol. 2010 Mar-Apr;57(2):171-6. doi: 10.1111/j.1550-7408.2009.00455.x. Epub 2009 Dec 10.

PMID:
20015182
11.

Treatment of metronidazole-resistant Trichomonas vaginalis.

Goldman LM, Upcroft JA, Workowski K, Rapkin A.

Sex Health. 2009 Dec;6(4):345-7. doi: 10.1071/SH09064.

PMID:
19917205
12.

Metronidazole resistance in Trichomonas vaginalis from highland women in Papua New Guinea.

Upcroft JA, Dunn LA, Wal T, Tabrizi S, Delgadillo-Correa MG, Johnson PJ, Garland S, Siba P, Upcroft P.

Sex Health. 2009 Dec;6(4):334-8. doi: 10.1071/SH09011.

PMID:
19917203
13.

Sequence map of the 3-Mb Giardia duodenalis assemblage A chromosome.

Upcroft JA, Krauer KG, Burgess AG, Dunn LA, Chen N, Upcroft P.

Chromosome Res. 2009;17(8):1001-14. doi: 10.1007/s10577-009-9084-4. Epub 2009 Oct 16.

PMID:
19842052
14.

Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia.

Valdez CA, Tripp JC, Miyamoto Y, Kalisiak J, Hruz P, Andersen YS, Brown SE, Kangas K, Arzu LV, Davids BJ, Gillin FD, Upcroft JA, Upcroft P, Fokin VV, Smith DK, Sharpless KB, Eckmann L.

J Med Chem. 2009 Jul 9;52(13):4038-53. doi: 10.1021/jm900356n.

15.

A novel method to increase the viability of Trichomonas vaginalis in urine.

Shafir SC, Sorvillo FJ, Upcroft JA, Upcroft P.

Sex Transm Dis. 2007 Jul;34(7):485-7.

PMID:
17589330
16.

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis.

Carlton JM, Hirt RP, Silva JC, Delcher AL, Schatz M, Zhao Q, Wortman JR, Bidwell SL, Alsmark UC, Besteiro S, Sicheritz-Ponten T, Noel CJ, Dacks JB, Foster PG, Simillion C, Van de Peer Y, Miranda-Saavedra D, Barton GJ, Westrop GD, Müller S, Dessi D, Fiori PL, Ren Q, Paulsen I, Zhang H, Bastida-Corcuera FD, Simoes-Barbosa A, Brown MT, Hayes RD, Mukherjee M, Okumura CY, Schneider R, Smith AJ, Vanacova S, Villalvazo M, Haas BJ, Pertea M, Feldblyum TV, Utterback TR, Shu CL, Osoegawa K, de Jong PJ, Hrdy I, Horvathova L, Zubacova Z, Dolezal P, Malik SB, Logsdon JM Jr, Henze K, Gupta A, Wang CC, Dunne RL, Upcroft JA, Upcroft P, White O, Salzberg SL, Tang P, Chiu CH, Lee YS, Embley TM, Coombs GH, Mottram JC, Tachezy J, Fraser-Liggett CM, Johnson PJ.

Science. 2007 Jan 12;315(5809):207-12.

17.

The activity of protease inhibitors against Giardia duodenalis and metronidazole-resistant Trichomonas vaginalis.

Dunn LA, Andrews KT, McCarthy JS, Wright JM, Skinner-Adams TS, Upcroft P, Upcroft JA.

Int J Antimicrob Agents. 2007 Jan;29(1):98-102. Epub 2006 Nov 29.

PMID:
17137752
18.

Clinical significance of the redefinition of the agent of amoebiasis.

Lucas R, Upcroft JA.

Rev Latinoam Microbiol. 2001 Oct-Dec;43(4):183-7. Review.

PMID:
17061507
19.

Virulent Avian Giardia duodenalis Pathogenic for Mice.

Upcroft JA, McDonnell PA, Upcroft P.

Parasitol Today. 1998 Jul;14(7):281-4.

PMID:
17040784
20.

Future therapeutic alternatives for combating anaerobic protozoa.

Upcroft JA, Upcroft P.

Parasitol Today. 1998 Dec;14(6):212-4. No abstract available.

PMID:
17040760
21.

Genotyping Trichomonas vaginalis.

Upcroft JA, Delgadillo-Correa MG, Dunne RL, Sturm AW, Johnson PJ, Upcroft P.

Int J Parasitol. 2006 Jun;36(7):821-8. Epub 2006 Mar 20.

PMID:
16698025
22.

5-Nitroimidazole drugs effective against metronidazole-resistant Trichomonas vaginalis and Giardia duodenalis.

Upcroft JA, Dunn LA, Wright JM, Benakli K, Upcroft P, Vanelle P.

Antimicrob Agents Chemother. 2006 Jan;50(1):344-7.

23.

Rearranged subtelomeric rRNA genes in Giardia duodenalis.

Upcroft JA, Abedinia M, Upcroft P.

Eukaryot Cell. 2005 Feb;4(2):484-6.

24.

Efficacy of antigiardial drugs.

Wright JM, Dunn LA, Upcroft P, Upcroft JA.

Expert Opin Drug Saf. 2003 Nov;2(6):529-41. Review.

PMID:
14585063
25.

Drug resistance in the sexually transmitted protozoan Trichomonas vaginalis.

Dunne RL, Dunn LA, Upcroft P, O'Donoghue PJ, Upcroft JA.

Cell Res. 2003 Aug;13(4):239-49. Review.

26.

Giardia duodenalis trophozoites isolated from a parrot (Cacatua galerita) colonize the small intestinal tracts of domestic kittens and lambs.

McDonnell PA, Scott KG, Teoh DA, Olson ME, Upcroft JA, Upcroft P, Buret AG.

Vet Parasitol. 2003 Jan 20;111(1):31-46.

PMID:
12523977
27.

Synthesis, antiprotozoal and antibacterial activity of nitro- and halogeno-substituted benzimidazole derivatives.

Kazimierczuk Z, Upcroft JA, Upcroft P, Górska A, Starościak B, Laudy A.

Acta Biochim Pol. 2002;49(1):185-95.

28.

Parenteral and mucosal delivery of a novel multi-epitope M protein-based group A streptococcal vaccine construct: investigation of immunogenicity in mice.

Dunn LA, McMillan DJ, Batzloff M, Zeng W, Jackson DC, Upcroft JA, Upcroft P, Olive C.

Vaccine. 2002 Jun 21;20(21-22):2635-40.

PMID:
12034087
29.

A rapid-cooling method for cryopreserving Entamoeba histolytica.

Samarawickrema NA, Upcroft JA, Thammapalerd N, Upcroft P.

Ann Trop Med Parasitol. 2001 Dec;95(8):853-5. No abstract available.

PMID:
11784440
30.

Orally administered Giardia duodenalis extracts enhance an antigen-specific antibody response.

Dunn LA, Upcroft JA, Fowler EV, Matthews BS, Upcroft P.

Infect Immun. 2001 Oct;69(10):6503-10.

31.

Drug susceptibility testing of anaerobic protozoa.

Upcroft JA, Upcroft P.

Antimicrob Agents Chemother. 2001 Jun;45(6):1810-4.

32.

Drug targets and mechanisms of resistance in the anaerobic protozoa.

Upcroft P, Upcroft JA.

Clin Microbiol Rev. 2001 Jan;14(1):150-64. Review.

33.

Ferredoxin involvement in metronidazole resistance of Giardia duodenalis.

Liu SM, Brown DM, O'Donoghue P, Upcroft P, Upcroft JA.

Mol Biochem Parasitol. 2000 Apr 30;108(1):137-40. No abstract available.

PMID:
10802327
34.

Organization and structure of the Giardia genome.

Upcroft P, Upcroft JA.

Protist. 1999 Mar;150(1):17-23. Review. No abstract available.

PMID:
10724515
35.

Immune and pathophysiological responses to different strains of Giardia duodenalis in neonatal mice.

Williamson AL, O'Donoghue PJ, Upcroft JA, Upcroft P.

Int J Parasitol. 2000 Feb;30(2):129-36.

PMID:
10704595
36.

Keto-acid oxidoreductases in the anaerobic protozoa.

Upcroft JA, Upcroft P.

J Eukaryot Microbiol. 1999 Jul-Aug;46(4):447-9. Review.

PMID:
10461388
37.

Alternative 2-keto acid oxidoreductase activities in Trichomonas vaginalis.

Brown DM, Upcroft JA, Dodd HN, Chen N, Upcroft P.

Mol Biochem Parasitol. 1999 Jan 25;98(2):203-14.

PMID:
10080389
38.

Efficacy of new 5-nitroimidazoles against metronidazole-susceptible and -resistant Giardia, Trichomonas, and Entamoeba spp.

Upcroft JA, Campbell RW, Benakli K, Upcroft P, Vanelle P.

Antimicrob Agents Chemother. 1999 Jan;43(1):73-6.

39.

Giardia infection in budgerigars.

Filippich LJ, McDonnell PA, Munoz E, Upcroft JA.

Aust Vet J. 1998 Apr;76(4):246-9.

PMID:
9612542
40.

A dynein heavy chain homologue gene in Hexamita inflata.

Chen N, Upcroft JA, Upcroft P.

Gene. 1998 Feb 16;208(1):83-7.

PMID:
9479053
41.

Anaerobic bacterial metabolism in the ancient eukaryote Giardia duodenalis.

Brown DM, Upcroft JA, Edwards MR, Upcroft P.

Int J Parasitol. 1998 Jan;28(1):149-64. Review.

PMID:
9504342
42.

Involvement of superoxide dismutase and pyruvate:ferredoxin oxidoreductase in mechanisms of metronidazole resistance in Entamoeba histolytica.

Samarawickrema NA, Brown DM, Upcroft JA, Thammapalerd N, Upcroft P.

J Antimicrob Chemother. 1997 Dec;40(6):833-40.

PMID:
9462435
43.

Nucleotide variation in the cytidine triphosphate synthetase gene of Giardia duodenalis.

Swarbrick A, Lim RL, Upcroft JA, Stewart TS.

J Eukaryot Microbiol. 1997 Nov-Dec;44(6):531-4.

PMID:
9435124
44.

Lethal Giardia from a wild-caught sulphur-crested cockatoo (Cacatua galerita) established in vitro chronically infects mice.

Upcroft JA, McDonnell PA, Gallagher AN, Chen N, Upcroft P.

Parasitology. 1997 May;114 ( Pt 5):407-12.

PMID:
9149411
45.
46.

A thioredoxin reductase-class of disulphide reductase in the protozoan parasite Giardia duodenalis.

Brown DM, Upcroft JA, Upcroft P.

Mol Biochem Parasitol. 1996 Dec 20;83(2):211-20.

PMID:
9027754
47.

A novel protein kinase gene family in Giardia duodenalis.

Chen N, Upcroft JA, Upcroft P.

Gene. 1996 Oct 24;177(1-2):191-4.

PMID:
8921866
48.

A H2O-producing NADH oxidase from the protozoan parasite Giardia duodenalis.

Brown DM, Upcroft JA, Upcroft P.

Eur J Biochem. 1996 Oct 1;241(1):155-61.

49.

Characterisation and purification of pyruvate:ferredoxin oxidoreductase from Giardia duodenalis.

Townson SM, Upcroft JA, Upcroft P.

Mol Biochem Parasitol. 1996 Aug;79(2):183-93.

PMID:
8855555
50.

Pyruvate: ferredoxin oxidoreductase from Entamoeba histolytica recognized by a monoclonal antibody.

Thammapalerd N, Kotimanusvanij D, Duchêne M, Upcroft JA, Mitchell R, Healey A, Samarawickrema N, Tharavanij S, Wiedermann G, Upcroft P.

Southeast Asian J Trop Med Public Health. 1996 Mar;27(1):63-70.

PMID:
9031403

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