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Items: 42

1.

Selective depletion of metastatic stem cells as therapy for human colorectal cancer.

Céspedes MV, Unzueta U, Aviñó A, Gallardo A, Álamo P, Sala R, Sánchez-Chardi A, Casanova I, Mangues MA, Lopez-Pousa A, Eritja R, Villaverde A, Vázquez E, Mangues R.

EMBO Mol Med. 2018 Oct;10(10). pii: e8772. doi: 10.15252/emmm.201708772.

2.

Conformational Conversion during Controlled Oligomerization into Nonamylogenic Protein Nanoparticles.

Sánchez JM, Sánchez-García L, Pesarrodona M, Serna N, Sánchez-Chardi A, Unzueta U, Mangues R, Vázquez E, Villaverde A.

Biomacromolecules. 2018 Sep 10;19(9):3788-3797. doi: 10.1021/acs.biomac.8b00924. Epub 2018 Aug 13.

PMID:
30052033
3.

Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin.

Díaz R, Pallarès V, Cano-Garrido O, Serna N, Sánchez-García L, Falgàs A, Pesarrodona M, Unzueta U, Sánchez-Chardi A, Sánchez JM, Casanova I, Vázquez E, Mangues R, Villaverde A.

Small. 2018 Jun;14(26):e1800665. doi: 10.1002/smll.201800665. Epub 2018 May 29.

PMID:
29845742
4.

Switching cell penetrating and CXCR4-binding activities of nanoscale-organized arginine-rich peptides.

Favaro MTP, Serna N, Sánchez-García L, Cubarsi R, Roldán M, Sánchez-Chardi A, Unzueta U, Mangues R, Ferrer-Miralles N, Azzoni AR, Vázquez E, Villaverde A.

Nanomedicine. 2018 Aug;14(6):1777-1786. doi: 10.1016/j.nano.2018.05.002. Epub 2018 May 16.

PMID:
29777875
5.

Release of targeted protein nanoparticles from functional bacterial amyloids: A death star-like approach.

Unzueta U, Cespedes MV, Sala R, Alamo P, Sánchez-Chardi A, Pesarrodona M, Sánchez-García L, Cano-Garrido O, Villaverde A, Vázquez E, Mangues R, Seras-Franzoso J.

J Control Release. 2018 Jun 10;279:29-39. doi: 10.1016/j.jconrel.2018.04.004. Epub 2018 Apr 8.

PMID:
29641987
6.

Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs.

Sánchez-García L, Serna N, Álamo P, Sala R, Céspedes MV, Roldan M, Sánchez-Chardi A, Unzueta U, Casanova I, Mangues R, Vázquez E, Villaverde A.

J Control Release. 2018 Mar 28;274:81-92. doi: 10.1016/j.jconrel.2018.01.031. Epub 2018 Jan 31.

PMID:
29408658
7.

Protein nanoparticles are nontoxic, tuneable cell stressors.

de Pinho Favaro MT, Sánchez-García L, Sánchez-Chardi A, Roldán M, Unzueta U, Serna N, Cano-Garrido O, Azzoni AR, Ferrer-Miralles N, Villaverde A, Vázquez E.

Nanomedicine (Lond). 2018 Feb;13(3):255-268. doi: 10.2217/nnm-2017-0294. Epub 2018 Jan 17.

PMID:
29338574
8.

Protein-Based Therapeutic Killing for Cancer Therapies.

Serna N, Sánchez-García L, Unzueta U, Díaz R, Vázquez E, Mangues R, Villaverde A.

Trends Biotechnol. 2018 Mar;36(3):318-335. doi: 10.1016/j.tibtech.2017.11.007. Epub 2017 Dec 12. Review.

PMID:
29246477
9.

Intracellular trafficking of a dynein-based nanoparticle designed for gene delivery.

Favaro MTP, Unzueta U, de Cabo M, Villaverde A, Ferrer-Miralles N, Azzoni AR.

Eur J Pharm Sci. 2018 Jan 15;112:71-78. doi: 10.1016/j.ejps.2017.11.002. Epub 2017 Nov 4.

PMID:
29113920
10.

Engineering multifunctional protein nanoparticles by in vitro disassembling and reassembling of heterologous building blocks.

Unzueta U, Serna N, Sánchez-García L, Roldán M, Sánchez-Chardi A, Mangues R, Villaverde A, Vázquez E.

Nanotechnology. 2017 Dec 15;28(50):505102. doi: 10.1088/1361-6528/aa963e.

PMID:
29072576
11.

Protein-only, antimicrobial peptide-containing recombinant nanoparticles with inherent built-in antibacterial activity.

Serna N, Sánchez-García L, Sánchez-Chardi A, Unzueta U, Roldán M, Mangues R, Vázquez E, Villaverde A.

Acta Biomater. 2017 Sep 15;60:256-263. doi: 10.1016/j.actbio.2017.07.027. Epub 2017 Jul 19.

PMID:
28735028
12.

Intrinsic functional and architectonic heterogeneity of tumor-targeted protein nanoparticles.

Pesarrodona M, Crosas E, Cubarsi R, Sánchez-Chardi A, Saccardo P, Unzueta U, Rueda F, Sanchez-García L, Serna N, Mangues R, Ferrer-Miralles N, Vázquez E, Villaverde A.

Nanoscale. 2017 May 18;9(19):6427-6435. doi: 10.1039/c6nr09182b.

PMID:
28463351
13.

The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles.

Sánchez-García L, Serna N, Mattanovich M, Cazzanelli P, Sánchez-Chardi A, Conchillo-Solé O, Cortés F, Daura X, Unzueta U, Mangues R, Villaverde A, Vázquez E.

Chem Commun (Camb). 2017 Apr 20;53(33):4565-4568. doi: 10.1039/c6cc09900a.

PMID:
28322369
14.

Engineering tumor cell targeting in nanoscale amyloidal materials.

Unzueta U, Seras-Franzoso J, Céspedes MV, Saccardo P, Cortés F, Rueda F, Garcia-Fruitós E, Ferrer-Miralles N, Mangues R, Vázquez E, Villaverde A.

Nanotechnology. 2017 Jan 6;28(1):015102. Epub 2016 Nov 28.

PMID:
27893441
15.

Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs.

Céspedes MV, Fernández Y, Unzueta U, Mendoza R, Seras-Franzoso J, Sánchez-Chardi A, Álamo P, Toledo-Rubio V, Ferrer-Miralles N, Vázquez E, Schwartz S, Abasolo I, Corchero JL, Mangues R, Villaverde A.

Sci Rep. 2016 Oct 24;6:35765. doi: 10.1038/srep35765.

16.

Functional inclusion bodies produced in the yeast Pichia pastoris.

Rueda F, Gasser B, Sánchez-Chardi A, Roldán M, Villegas S, Puxbaum V, Ferrer-Miralles N, Unzueta U, Vázquez E, Garcia-Fruitós E, Mattanovich D, Villaverde A.

Microb Cell Fact. 2016 Oct 1;15(1):166.

17.

CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis.

Cano-Garrido O, Céspedes MV, Unzueta U, Saccardo P, Roldán M, Sánchez-Chardi A, Cubarsi R, Vázquez E, Mangues R, García-Fruitós E, Villaverde A.

Nanomedicine (Lond). 2016 Sep;11(18):2387-98. doi: 10.2217/nnm-2016-0200. Epub 2016 Aug 16.

18.

Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4+ colorectal cancer models.

Céspedes MV, Unzueta U, Álamo P, Gallardo A, Sala R, Casanova I, Pavón MA, Mangues MA, Trías M, López-Pousa A, Villaverde A, Vázquez E, Mangues R.

Nanomedicine. 2016 Oct;12(7):1987-1996. doi: 10.1016/j.nano.2016.04.003. Epub 2016 Apr 13.

PMID:
27085904
19.

Conformational and functional variants of CD44-targeted protein nanoparticles bio-produced in bacteria.

Pesarrodona M, Fernández Y, Foradada L, Sánchez-Chardi A, Conchillo-Solé O, Unzueta U, Xu Z, Roldán M, Villegas S, Ferrer-Miralles N, Schwartz S Jr, Rinas U, Daura X, Abasolo I, Vázquez E, Villaverde A.

Biofabrication. 2016 Apr 14;8(2):025001. doi: 10.1088/1758-5090/8/2/025001.

PMID:
27078873
20.

Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli.

Rueda F, Céspedes MV, Sánchez-Chardi A, Seras-Franzoso J, Pesarrodona M, Ferrer-Miralles N, Vázquez E, Rinas U, Unzueta U, Mamat U, Mangues R, García-Fruitós E, Villaverde A.

Microb Cell Fact. 2016 Apr 8;15:59. doi: 10.1186/s12934-016-0457-z.

21.

Rational engineering of single-chain polypeptides into protein-only, BBB-targeted nanoparticles.

Serna N, Céspedes MV, Saccardo P, Xu Z, Unzueta U, Álamo P, Pesarrodona M, Sánchez-Chardi A, Roldán M, Mangues R, Vázquez E, Villaverde A, Ferrer-Miralles N.

Nanomedicine. 2016 Jul;12(5):1241-51. doi: 10.1016/j.nano.2016.01.004. Epub 2016 Mar 4.

PMID:
26949165
22.

Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials.

Rueda F, Céspedes MV, Conchillo-Solé O, Sánchez-Chardi A, Seras-Franzoso J, Cubarsi R, Gallardo A, Pesarrodona M, Ferrer-Miralles N, Daura X, Vázquez E, García-Fruitós E, Mangues R, Unzueta U, Villaverde A.

Adv Mater. 2015 Dec 16;27(47):7816-22. doi: 10.1002/adma.201503676. Epub 2015 Oct 28.

PMID:
26509451
23.

Towards protein-based viral mimetics for cancer therapies.

Unzueta U, Céspedes MV, Vázquez E, Ferrer-Miralles N, Mangues R, Villaverde A.

Trends Biotechnol. 2015 May;33(5):253-8. doi: 10.1016/j.tibtech.2015.02.007. Epub 2015 Mar 22.

PMID:
25805413
24.

BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS.

Peluffo H, Unzueta U, Negro-Demontel ML, Xu Z, Váquez E, Ferrer-Miralles N, Villaverde A.

Biotechnol Adv. 2015 Mar-Apr;33(2):277-87. doi: 10.1016/j.biotechadv.2015.02.004. Epub 2015 Feb 16. Review.

PMID:
25698504
25.

Strategies for the production of difficult-to-express full-length eukaryotic proteins using microbial cell factories: production of human alpha-galactosidase A.

Unzueta U, Vázquez F, Accardi G, Mendoza R, Toledo-Rubio V, Giuliani M, Sannino F, Parrilli E, Abasolo I, Schwartz S Jr, Tutino ML, Villaverde A, Corchero JL, Ferrer-Miralles N.

Appl Microbiol Biotechnol. 2015 Jul;99(14):5863-74. doi: 10.1007/s00253-014-6328-9. Epub 2015 Jan 24.

PMID:
25616525
26.

Dialysis: a characterization method of aggregation tendency.

Pesarrodona M, Unzueta U, Vázquez E.

Methods Mol Biol. 2015;1258:321-30. doi: 10.1007/978-1-4939-2205-5_18. Review.

PMID:
25447873
27.

Intracellular targeting of CD44+ cells with self-assembling, protein only nanoparticles.

Pesarrodona M, Ferrer-Miralles N, Unzueta U, Gener P, Tatkiewicz W, Abasolo I, Ratera I, Veciana J, Schwartz S Jr, Villaverde A, Vazquez E.

Int J Pharm. 2014 Oct 1;473(1-2):286-95. doi: 10.1016/j.ijpharm.2014.07.016. Epub 2014 Jul 11.

PMID:
25019161
28.

In vivo architectonic stability of fully de novo designed protein-only nanoparticles.

Céspedes MV, Unzueta U, Tatkiewicz W, Sánchez-Chardi A, Conchillo-Solé O, Álamo P, Xu Z, Casanova I, Corchero JL, Pesarrodona M, Cedano J, Daura X, Ratera I, Veciana J, Ferrer-Miralles N, Vazquez E, Villaverde A, Mangues R.

ACS Nano. 2014 May 27;8(5):4166-76. doi: 10.1021/nn4055732. Epub 2014 Apr 14.

PMID:
24708510
29.

Sheltering DNA in self-organizing, protein-only nano-shells as artificial viruses for gene delivery.

Unzueta U, Saccardo P, Domingo-Espín J, Cedano J, Conchillo-Solé O, García-Fruitós E, Céspedes MV, Corchero JL, Daura X, Mangues R, Ferrer-Miralles N, Villaverde A, Vázquez E.

Nanomedicine. 2014 Apr;10(3):535-41. doi: 10.1016/j.nano.2013.11.006. Epub 2013 Nov 21.

PMID:
24269989
30.

Improved performance of protein-based recombinant gene therapy vehicles by tuning downstream procedures.

Unzueta U, Saccardo P, Ferrer-Miralles N, García-Fruitós E, Vazquez E, Villaverde A, Cortés F, Mangues R.

Biotechnol Prog. 2013 Nov-Dec;29(6):1458-63. doi: 10.1002/btpr.1798. Epub 2013 Sep 16.

PMID:
23956238
31.

Multifunctional nanovesicle-bioactive conjugates prepared by a one-step scalable method using CO2-expanded solvents.

Cabrera I, Elizondo E, Esteban O, Corchero JL, Melgarejo M, Pulido D, Córdoba A, Moreno E, Unzueta U, Vazquez E, Abasolo I, Schwartz S Jr, Villaverde A, Albericio F, Royo M, García-Parajo MF, Ventosa N, Veciana J.

Nano Lett. 2013 Aug 14;13(8):3766-74. doi: 10.1021/nl4017072. Epub 2013 Jul 15.

PMID:
23829208
32.

Topographically targeted osteogenesis of mesenchymal stem cells stimulated by inclusion bodies attached to polycaprolactone surfaces.

Seras-Franzoso J, Tsimbouri PM, Burgess KV, Unzueta U, Garcia-Fruitos E, Vazquez E, Villaverde A, Dalby MJ.

Nanomedicine (Lond). 2014 Feb;9(2):207-20. doi: 10.2217/nnm.13.43. Epub 2013 Apr 30.

PMID:
23631503
33.

A nanostructured bacterial bioscaffold for the sustained bottom-up delivery of protein drugs.

Seras-Franzoso J, Peebo K, Luis Corchero J, Tsimbouri PM, Unzueta U, Rinas U, Dalby MJ, Vazquez E, García-Fruitós E, Villaverde A.

Nanomedicine (Lond). 2013 Oct;8(10):1587-99. doi: 10.2217/nnm.12.188. Epub 2013 Feb 8.

PMID:
23394133
34.

Non-amyloidogenic peptide tags for the regulatable self-assembling of protein-only nanoparticles.

Unzueta U, Ferrer-Miralles N, Cedano J, Zikung X, Pesarrodona M, Saccardo P, García-Fruitós E, Domingo-Espín J, Kumar P, Gupta KC, Mangues R, Villaverde A, Vazquez E.

Biomaterials. 2012 Nov;33(33):8714-22. doi: 10.1016/j.biomaterials.2012.08.033. Epub 2012 Sep 3.

PMID:
22954515
35.

Intracellular CXCR4⁺ cell targeting with T22-empowered protein-only nanoparticles.

Unzueta U, Céspedes MV, Ferrer-Miralles N, Casanova I, Cedano J, Corchero JL, Domingo-Espín J, Villaverde A, Mangues R, Vázquez E.

Int J Nanomedicine. 2012;7:4533-44. doi: 10.2147/IJN.S34450. Epub 2012 Aug 15.

36.

RGD-based cell ligands for cell-targeted drug delivery act as potent trophic factors.

Domingo-Espín J, Petegnief V, de Vera N, Conchillo-Solé O, Saccardo P, Unzueta U, Vazquez E, Cedano J, Negro L, Daura X, Peluffo H, Planas AM, Villaverde A, Ferrer-Miralles N.

Nanomedicine. 2012 Nov;8(8):1263-6. doi: 10.1016/j.nano.2012.06.005. Epub 2012 Jul 25.

PMID:
22841914
37.

Engineered biological entities for drug delivery and gene therapy protein nanoparticles.

Domingo-Espín J, Unzueta U, Saccardo P, Rodríguez-Carmona E, Corchero JL, Vázquez E, Ferrer-Miralles N.

Prog Mol Biol Transl Sci. 2011;104:247-98. doi: 10.1016/B978-0-12-416020-0.00006-1. Review.

PMID:
22093221
38.

Nanoparticulate architecture of protein-based artificial viruses is supported by protein-DNA interactions.

Domingo-Espín J, Vazquez E, Ganz J, Conchillo O, García-Fruitós E, Cedano J, Unzueta U, Petegnief V, Gonzalez-Montalbán N, Planas AM, Daura X, Peluffo H, Ferrer-Miralles N, Villaverde A.

Nanomedicine (Lond). 2011 Aug;6(6):1047-61. doi: 10.2217/nnm.11.28. Epub 2011 Jun 9.

PMID:
21651444
39.

Internalization and kinetics of nuclear migration of protein-only, arginine-rich nanoparticles.

Vázquez E, Cubarsi R, Unzueta U, Roldán M, Domingo-Espín J, Ferrer-Miralles N, Villaverde A.

Biomaterials. 2010 Dec;31(35):9333-9. doi: 10.1016/j.biomaterials.2010.08.065. Epub 2010 Sep 24.

PMID:
20869766
40.

Protein aggregation and soluble aggregate formation screened by a fast microdialysis assay.

Toledo-Rubio V, Vazquez E, Platas G, Domingo-Espín J, Unzueta U, Steinkamp E, García-Fruitós E, Ferrer-Miralles N, Villaverde A.

J Biomol Screen. 2010 Apr;15(4):453-7. doi: 10.1177/1087057110363911. Epub 2010 Mar 16.

PMID:
20233904
41.

Protein nanodisk assembling and intracellular trafficking powered by an arginine-rich (R9) peptide.

Vazquez E, Roldán M, Diez-Gil C, Unzueta U, Domingo-Espín J, Cedano J, Conchillo O, Ratera I, Veciana J, Daura X, Ferrer-Miralles N, Villaverde A.

Nanomedicine (Lond). 2010 Feb;5(2):259-68. doi: 10.2217/nnm.09.98.

PMID:
20148637
42.

Rehosting of bacterial chaperones for high-quality protein production.

Martínez-Alonso M, Toledo-Rubio V, Noad R, Unzueta U, Ferrer-Miralles N, Roy P, Villaverde A.

Appl Environ Microbiol. 2009 Dec;75(24):7850-4. doi: 10.1128/AEM.01532-09. Epub 2009 Oct 9.

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