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Cognitive dysfunction in diabetic rats is prevented by pyridoxamine treatment. A multidisciplinary investigation.

Kassab S, Begley P, Church SJ, Rotariu SM, Chevalier-Riffard C, Dowsey AW, Phillips AM, Zeef LAH, Grayson B, Neill JC, Cooper GJS, Unwin RD, Gardiner NJ.

Mol Metab. 2019 Aug 5. pii: S2212-8778(19)30462-4. doi: 10.1016/j.molmet.2019.08.003. [Epub ahead of print]


Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington's Disease.

Patassini S, Begley P, Xu J, Church SJ, Kureishy N, Reid SJ, Waldvogel HJ, Faull RLM, Snell RG, Unwin RD, Cooper GJS.

Metabolites. 2019 Jun 11;9(6). pii: E113. doi: 10.3390/metabo9060113.


Development and validation of a methotrexate adherence assay.

Bluett J, Riba-Garcia I, Verstappen SMM, Wendling T, Ogungbenro K, Unwin RD, Barton A.

Ann Rheum Dis. 2019 Sep;78(9):1192-1197. doi: 10.1136/annrheumdis-2019-215446. Epub 2019 Jun 5.


Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure.

Lawless M, Caldwell JL, Radcliffe EJ, Smith CER, Madders GWP, Hutchings DC, Woods LS, Church SJ, Unwin RD, Kirkwood GJ, Becker LK, Pearman CM, Taylor RF, Eisner DA, Dibb KM, Trafford AW.

Sci Rep. 2019 May 1;9(1):6801. doi: 10.1038/s41598-019-42592-1.


Regional protein expression in human Alzheimer's brain correlates with disease severity.

Xu J, Patassini S, Rustogi N, Riba-Garcia I, Hale BD, Phillips AM, Waldvogel H, Haines R, Bradbury P, Stevens A, Faull RLM, Dowsey AW, Cooper GJS, Unwin RD.

Commun Biol. 2019 Feb 4;2:43. doi: 10.1038/s42003-018-0254-9. eCollection 2019.


Mass spectrometry-based proteomics reveals the distinct nature of the skin proteomes of photoaged compared to intrinsically aged skin.

Newton VL, Riba-Garcia I, Griffiths CEM, Rawlings AV, Voegeli R, Unwin RD, Sherratt MJ, Watson REB.

Int J Cosmet Sci. 2019 Apr;41(2):118-131. doi: 10.1111/ics.12513. Epub 2019 Apr 8.


Plasma metals as potential biomarkers in dementia: a case-control study in patients with sporadic Alzheimer's disease.

Xu J, Church SJ, Patassini S, Begley P, Kellett KAB, Vardy ERLC, Unwin RD, Hooper NM, Cooper GJS.

Biometals. 2018 Apr;31(2):267-276. doi: 10.1007/s10534-018-0089-3. Epub 2018 Mar 7.


Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia.

Xu J, Church SJ, Patassini S, Begley P, Waldvogel HJ, Curtis MA, Faull RLM, Unwin RD, Cooper GJS.

Metallomics. 2017 Aug 16;9(8):1106-1119. doi: 10.1039/c7mt00074j.


Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice.

Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips AR, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJ.

Data Brief. 2016 Nov 29;10:298-303. eCollection 2017 Feb.


Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice.

Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips ARJ, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJS.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):625-631. doi: 10.1016/j.bbrc.2016.11.083. Epub 2016 Nov 16.


Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids.

Dutta A, Potier DN, Walker MJ, Gray OJ, Parker C, Holland M, Williamson AJ, Pierce A, Unwin RD, Krishnan S, Saha V, Whetton AD.

Oncotarget. 2016 Oct 25;7(43):70822-70831. doi: 10.18632/oncotarget.12224.


Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia.

Xu J, Begley P, Church SJ, Patassini S, McHarg S, Kureishy N, Hollywood KA, Waldvogel HJ, Liu H, Zhang S, Lin W, Herholz K, Turner C, Synek BJ, Curtis MA, Rivers-Auty J, Lawrence CB, Kellett KA, Hooper NM, Vardy ER, Wu D, Unwin RD, Faull RL, Dowsey AW, Cooper GJ.

Sci Rep. 2016 Jun 9;6:27524. doi: 10.1038/srep27524.


Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain.

Patassini S, Begley P, Xu J, Church SJ, Reid SJ, Kim EH, Curtis MA, Dragunow M, Waldvogel HJ, Snell RG, Unwin RD, Faull RL, Cooper GJ.

Biochim Biophys Acta. 2016 Sep;1862(9):1650-62. doi: 10.1016/j.bbadis.2016.06.002. Epub 2016 Jun 4.


Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder.

Xu J, Begley P, Church SJ, Patassini S, Hollywood KA, Jüllig M, Curtis MA, Waldvogel HJ, Faull RL, Unwin RD, Cooper GJ.

Biochim Biophys Acta. 2016 Jun;1862(6):1084-92. doi: 10.1016/j.bbadis.2016.03.001. Epub 2016 Mar 5.


Effects of Obesity on Perivascular Adipose Tissue Vasorelaxant Function: Nitric Oxide, Inflammation and Elevated Systemic Blood Pressure.

Aghamohammadzadeh R, Unwin RD, Greenstein AS, Heagerty AM.

J Vasc Res. 2015;52(5):299-305. doi: 10.1159/000443885. Epub 2016 Feb 25.


Identification of elevated urea as a severe, ubiquitous metabolic defect in the brain of patients with Huntington's disease.

Patassini S, Begley P, Reid SJ, Xu J, Church SJ, Curtis M, Dragunow M, Waldvogel HJ, Unwin RD, Snell RG, Faull RL, Cooper GJ.

Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):161-6. doi: 10.1016/j.bbrc.2015.10.140. Epub 2015 Oct 30.


Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy.

Freeman OJ, Unwin RD, Dowsey AW, Begley P, Ali S, Hollywood KA, Rustogi N, Petersen RS, Dunn WB, Cooper GJ, Gardiner NJ.

Diabetes. 2016 Jan;65(1):228-38. doi: 10.2337/db15-0835. Epub 2015 Oct 15.


Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease.

Church SJ, Begley P, Kureishy N, McHarg S, Bishop PN, Bechtold DA, Unwin RD, Cooper GJ.

Biochem Biophys Res Commun. 2015 May 8;460(3):549-54. doi: 10.1016/j.bbrc.2015.03.067. Epub 2015 Mar 20.


A HPLC-SRM-MS based method for the detection and quantification of methotrexate in urine at doses used in clinical practice for patients with rheumatological disease: a potential measure of adherence.

Bluett J, Riba-Garcia I, Hollywood K, Verstappen SM, Barton A, Unwin RD.

Analyst. 2015 Mar 21;140(6):1981-7. doi: 10.1039/c4an02321h.


Streaming visualisation of quantitative mass spectrometry data based on a novel raw signal decomposition method.

Zhang Y, Bhamber R, Riba-Garcia I, Liao H, Unwin RD, Dowsey AW.

Proteomics. 2015 Apr;15(8):1419-27. doi: 10.1002/pmic.201400428. Epub 2015 Mar 9.


The application of targeted mass spectrometry-based strategies to the detection and localization of post-translational modifications.

Chicooree N, Unwin RD, Griffiths JR.

Mass Spectrom Rev. 2015 Nov-Dec;34(6):595-626. doi: 10.1002/mas.21421. Epub 2014 Apr 15. Review.


A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility.

Williamson AJ, Pierce A, Jaworska E, Zhou C, Aspinall-O'Dea M, Lancashire L, Unwin RD, Abraham SA, Walker MJ, Cadecco S, Spooncer E, Holyoake TL, Whetton AD.

Mol Cell Proteomics. 2013 Nov;12(11):3319-29. doi: 10.1074/mcp.M112.024604. Epub 2013 Sep 1.


A label-free selected reaction monitoring workflow identifies a subset of pregnancy specific glycoproteins as potential predictive markers of early-onset pre-eclampsia.

Blankley RT, Fisher C, Westwood M, North R, Baker PN, Walker MJ, Williamson A, Whetton AD, Lin W, McCowan L, Roberts CT, Cooper GJ, Unwin RD, Myers JE.

Mol Cell Proteomics. 2013 Nov;12(11):3148-59. doi: 10.1074/mcp.M112.026872. Epub 2013 Jul 29.


Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability.

White DJ, Unwin RD, Bindels E, Pierce A, Teng HY, Muter J, Greystoke B, Somerville TD, Griffiths J, Lovell S, Somervaille TC, Delwel R, Whetton AD, Meyer S.

PLoS One. 2013 Jun 12;8(6):e66510. doi: 10.1371/journal.pone.0066510. Print 2013.


Application of the MIDAS approach for analysis of lysine acetylation sites.

Evans CA, Griffiths JR, Unwin RD, Whetton AD, Corfe BM.

Methods Mol Biol. 2013;981:25-36. doi: 10.1007/978-1-62703-305-3_3.


Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera.

Keenan TD, Clark SJ, Unwin RD, Ridge LA, Day AJ, Bishop PN.

Invest Ophthalmol Vis Sci. 2012 Nov 7;53(12):7528-38. doi: 10.1167/iovs.12-10797.


An assessment of peptide enrichment methods employing mTRAQ quantification approaches.

Potier DN, Griffiths JR, Unwin RD, Walker MJ, Carrick E, Willamson AJ, Whetton AD.

Anal Chem. 2012 Jul 3;84(13):5604-10. doi: 10.1021/ac300584y. Epub 2012 Jun 19.


Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation.

Pierce A, Williamson A, Jaworska E, Griffiths JR, Taylor S, Walker M, Aspinall-O'Dea M, Spooncer E, Unwin RD, Poolman T, Ray D, Whetton AD.

PLoS One. 2012;7(6):e38928. doi: 10.1371/journal.pone.0038928. Epub 2012 Jun 22. Erratum in: PLoS One. 2013;8(6). doi:10.1371/annotation/df82a4c0-2909-43a0-8a7f-5bd2ce9ca0bd. O'Dea, Mark Aspinall [corrected to Aspinall-O'Dea, Mark].


Statistical considerations of optimal study design for human plasma proteomics and biomarker discovery.

Zhou C, Simpson KL, Lancashire LJ, Walker MJ, Dawson MJ, Unwin RD, Rembielak A, Price P, West C, Dive C, Whetton AD.

J Proteome Res. 2012 Apr 6;11(4):2103-13. doi: 10.1021/pr200636x. Epub 2012 Mar 12.


Simultaneous analysis of relative protein expression levels across multiple samples using iTRAQ isobaric tags with 2D nano LC-MS/MS.

Unwin RD, Griffiths JR, Whetton AD.

Nat Protoc. 2010 Sep;5(9):1574-82. doi: 10.1038/nprot.2010.123. Epub 2010 Aug 26.


Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways.

Dobbin E, Graham C, Freeburn RW, Unwin RD, Griffiths JR, Pierce A, Whetton AD, Wheadon H.

Stem Cell Res. 2010 Nov;5(3):226-43. doi: 10.1016/j.scr.2010.08.001. Epub 2010 Aug 26.


Quantification of proteins by iTRAQ.

Unwin RD.

Methods Mol Biol. 2010;658:205-15. doi: 10.1007/978-1-60761-780-8_12.


Assessment of downstream effectors of BCR/ABL protein tyrosine kinase using combined proteomic approaches.

Lee CF, Griffiths S, Rodríguez-Suárez E, Pierce A, Unwin RD, Jaworska E, Evans CA, J Gaskell S, Whetton AD.

Proteomics. 2010 Sep;10(18):3321-42. doi: 10.1002/pmic.201000176.


Ribosome-associated nucleophosmin 1: increased expression and shuttling activity distinguishes prognostic subtypes in chronic lymphocytic leukaemia.

Rees-Unwin KS, Faragher R, Unwin RD, Adams J, Brown PJ, Buckle AM, Pettitt A, Hutchinson CV, Johnson SM, Pulford K, Banham AH, Whetton AD, Lucas G, Mason DY, Burthem J.

Br J Haematol. 2010 Feb;148(4):534-43. doi: 10.1111/j.1365-2141.2009.07979.x. Epub 2009 Nov 23.


Systems-level dynamic analyses of fate change in murine embryonic stem cells.

Lu R, Markowetz F, Unwin RD, Leek JT, Airoldi EM, MacArthur BD, Lachmann A, Rozov R, Ma'ayan A, Boyer LA, Troyanskaya OG, Whetton AD, Lemischka IR.

Nature. 2009 Nov 19;462(7271):358-62. doi: 10.1038/nature08575.


Developmental fate determination and marker discovery in hematopoietic stem cell biology using proteomic fingerprinting.

Spooncer E, Brouard N, Nilsson SK, Williams B, Liu MC, Unwin RD, Blinco D, Jaworska E, Simmons PJ, Whetton AD.

Mol Cell Proteomics. 2008 Mar;7(3):573-81. Epub 2007 Dec 14.


Quantitative proteomics analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis.

Williamson AJ, Smith DL, Blinco D, Unwin RD, Pearson S, Wilson C, Miller C, Lancashire L, Lacaud G, Kouskoff V, Whetton AD.

Mol Cell Proteomics. 2008 Mar;7(3):459-72. Epub 2007 Nov 27.


Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases.

Pierce A, Unwin RD, Evans CA, Griffiths S, Carney L, Zhang L, Jaworska E, Lee CF, Blinco D, Okoniewski MJ, Miller CJ, Bitton DA, Spooncer E, Whetton AD.

Mol Cell Proteomics. 2008 May;7(5):853-63. Epub 2007 Oct 21.


The use of isobaric tag peptide labeling (iTRAQ) and mass spectrometry to examine rare, primitive hematopoietic cells from patients with chronic myeloid leukemia.

Griffiths SD, Burthem J, Unwin RD, Holyoake TL, Melo JV, Lucas GS, Whetton AD.

Mol Biotechnol. 2007 Jun;36(2):81-9.


How will haematologists use proteomics?

Unwin RD, Whetton AD.

Blood Rev. 2007 Nov;21(6):315-26. Epub 2007 Sep 24. Review.


The application of a hypothesis-driven strategy to the sensitive detection and location of acetylated lysine residues.

Griffiths JR, Unwin RD, Evans CA, Leech SH, Corfe BM, Whetton AD.

J Am Soc Mass Spectrom. 2007 Aug;18(8):1423-8. Epub 2007 May 6.


Systematic proteome and transcriptome analysis of stem cell populations.

Unwin RD, Whetton AD.

Cell Cycle. 2006 Aug;5(15):1587-91. Epub 2006 Aug 1. Review.


Relative quantification in proteomics: new approaches for biochemistry.

Unwin RD, Evans CA, Whetton AD.

Trends Biochem Sci. 2006 Aug;31(8):473-84. Epub 2006 Jul 11.


Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells.

Unwin RD, Smith DL, Blinco D, Wilson CL, Miller CJ, Evans CA, Jaworska E, Baldwin SA, Barnes K, Pierce A, Spooncer E, Whetton AD.

Blood. 2006 Jun 15;107(12):4687-94. Epub 2006 Feb 28.


Multiple reaction monitoring to identify sites of protein phosphorylation with high sensitivity.

Unwin RD, Griffiths JR, Leverentz MK, Grallert A, Hagan IM, Whetton AD.

Mol Cell Proteomics. 2005 Aug;4(8):1134-44. Epub 2005 May 27.


Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells.

Unwin RD, Pierce A, Watson RB, Sternberg DW, Whetton AD.

Mol Cell Proteomics. 2005 Jul;4(7):924-35. Epub 2005 Apr 22.


Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: identification of the Rho pathway as a target of BCR/ABL.

Unwin RD, Sternberg DW, Lu Y, Pierce A, Gilliland DG, Whetton AD.

J Biol Chem. 2005 Feb 25;280(8):6316-26. Epub 2004 Nov 29.


The potential for proteomic definition of stem cell populations.

Unwin RD, Gaskell SJ, Evans CA, Whetton AD.

Exp Hematol. 2003 Dec;31(12):1147-59. Review.


Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect.

Unwin RD, Craven RA, Harnden P, Hanrahan S, Totty N, Knowles M, Eardley I, Selby PJ, Banks RE.

Proteomics. 2003 Aug;3(8):1620-32.


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