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Items: 1 to 50 of 333

1.

A Case of Drug-Induced Proximal Tubular Dysfunction.

Hall AM, Unwin RJ.

Clin J Am Soc Nephrol. 2019 Jun 10. pii: CJN.01430219. doi: 10.2215/CJN.01430219. [Epub ahead of print] No abstract available.

PMID:
31182554
2.

Development and validation of a methotrexate adherence assay.

Bluett J, Riba-Garcia I, Verstappen SMM, Wendling T, Ogungbenro K, Unwin RD, Barton A.

Ann Rheum Dis. 2019 Jun 5. pii: annrheumdis-2019-215446. doi: 10.1136/annrheumdis-2019-215446. [Epub ahead of print]

3.

Mild cognitive impairment and kidney disease: clinical aspects.

Viggiano D, Wagner CA, Blankestijn PJ, Bruchfeld A, Fliser D, Fouque D, Frische S, Gesualdo L, Gutiérrez E, Goumenos D, Hoorn EJ, Eckardt KU, Knauß S, König M, Malyszko J, Massy Z, Nitsch D, Pesce F, Rychlík I, Soler MJ, Spasovski G, Stevens KI, Trepiccione F, Wanner C, Wiecek A, Zoccali C, Unwin R, Capasso G.

Nephrol Dial Transplant. 2019 Apr 9. pii: gfz051. doi: 10.1093/ndt/gfz051. [Epub ahead of print] No abstract available.

PMID:
31071220
4.

Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure.

Lawless M, Caldwell JL, Radcliffe EJ, Smith CER, Madders GWP, Hutchings DC, Woods LS, Church SJ, Unwin RD, Kirkwood GJ, Becker LK, Pearman CM, Taylor RF, Eisner DA, Dibb KM, Trafford AW.

Sci Rep. 2019 May 1;9(1):6801. doi: 10.1038/s41598-019-42592-1.

5.

A preliminary survey of practice patterns across several European kidney stone centers and a call for action in developing shared practice.

Ferraro PM, Arrabal-Polo MÁ, Capasso G, Croppi E, Cupisti A, Ernandez T, Fuster DG, Galan JA, Grases F, Hoorn EJ, Knauf F, Letavernier E, Mohebbi N, Moochhala S, Petkova K, Pozdzik A, Sayer J, Seitz C, Strazzullo P, Trinchieri A, Vezzoli G, Vitale C, Vogt L, Unwin RJ, Bonny O, Gambaro G.

Urolithiasis. 2019 Jun;47(3):219-224. doi: 10.1007/s00240-019-01119-z. Epub 2019 Mar 8.

PMID:
30848320
6.

Regional protein expression in human Alzheimer's brain correlates with disease severity.

Xu J, Patassini S, Rustogi N, Riba-Garcia I, Hale BD, Phillips AM, Waldvogel H, Haines R, Bradbury P, Stevens A, Faull RLM, Dowsey AW, Cooper GJS, Unwin RD.

Commun Biol. 2019 Feb 4;2:43. doi: 10.1038/s42003-018-0254-9. eCollection 2019.

7.

Inherited proximal tubular disorders and nephrolithiasis.

Oliveira B, Unwin R, Walsh SB.

Urolithiasis. 2019 Feb;47(1):35-42. doi: 10.1007/s00240-018-01103-z. Epub 2019 Jan 23. Review.

PMID:
30673801
8.

Mass spectrometry-based proteomics reveals the distinct nature of the skin proteomes of photoaged compared to intrinsically aged skin.

Newton VL, Riba-Garcia I, Griffiths CEM, Rawlings AV, Voegeli R, Unwin RD, Sherratt MJ, Watson REB.

Int J Cosmet Sci. 2019 Apr;41(2):118-131. doi: 10.1111/ics.12513. Epub 2019 Apr 8.

PMID:
30661253
9.

Physiological regulation of phosphate by vitamin D, parathyroid hormone (PTH) and phosphate (Pi).

Jacquillet G, Unwin RJ.

Pflugers Arch. 2019 Jan;471(1):83-98. doi: 10.1007/s00424-018-2231-z. Epub 2018 Nov 5. Review.

10.

The renal and blood pressure response to low sodium diet in P2X4 receptor knockout mice.

Craigie E, Menzies RI, Larsen CK, Jacquillet G, Carrel M, Wildman SS, Loffing J, Leipziger J, Shirley DG, Bailey MA, Unwin RJ.

Physiol Rep. 2018 Oct;6(20):e13899. doi: 10.14814/phy2.13899.

11.

Publisher Correction: Tubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney disease.

van Raaij S, van Swelm R, Bouman K, Cliteur M, van den Heuvel MC, Pertijs J, Patel D, Bass P, van Goor H, Unwin R, Srai SK, Swinkels D.

Sci Rep. 2018 Sep 3;8(1):13390. doi: 10.1038/s41598-018-31457-8.

12.

EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association.

Paredes R, Schneider M, Stevens A, White DJ, K Williamson AJ, Muter J, Pearson S, Kelly JR, Connors K, Wiseman DH, Chadwick JA, Löffler H, Teng HY, Lovell S, Unwin R, van de Vrugt HJ, Smith H, Kustikova O, Schambach A, P Somervaille TC, Pierce A, Whetton AD, Meyer S.

Nucleic Acids Res. 2018 Sep 19;46(16):8663. doi: 10.1093/nar/gky711. No abstract available.

13.

Acute saccharin infusion has no effect on renal glucose handling in normal rats in vivo.

Jacquillet G, Debnam ES, Unwin RJ, Marks J.

Physiol Rep. 2018 Jul;6(14):e13804. doi: 10.14814/phy2.13804.

14.

Liquorice, Liddle, Bartter or Gitelman-how to differentiate?

Mumford E, Unwin RJ, Walsh SB.

Nephrol Dial Transplant. 2019 Jan 1;34(1):38-39. doi: 10.1093/ndt/gfy199.

PMID:
29982819
15.

EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association.

Paredes R, Schneider M, Stevens A, White DJ, Williamson AJK, Muter J, Pearson S, Kelly JR, Connors K, Wiseman DH, Chadwick JA, Löffler H, Teng HY, Lovell S, Unwin R, van de Vrugt HJ, Smith H, Kustikova O, Schambach A, Somervaille TCP, Pierce A, Whetton AD, Meyer S.

Nucleic Acids Res. 2018 Sep 6;46(15):7662-7674. doi: 10.1093/nar/gky536. Erratum in: Nucleic Acids Res. 2018 Sep 19;46(16):8663.

16.

Tubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney disease.

van Raaij S, van Swelm R, Bouman K, Cliteur M, van den Heuvel MC, Pertijs J, Patel D, Bass P, van Goor H, Unwin R, Srai SK, Swinkels D.

Sci Rep. 2018 Jun 19;8(1):9353. doi: 10.1038/s41598-018-27107-8. Erratum in: Sci Rep. 2018 Sep 3;8(1):13390.

17.

Glycine Amidinotransferase (GATM), Renal Fanconi Syndrome, and Kidney Failure.

Reichold M, Klootwijk ED, Reinders J, Otto EA, Milani M, Broeker C, Laing C, Wiesner J, Devi S, Zhou W, Schmitt R, Tegtmeier I, Sterner C, Doellerer H, Renner K, Oefner PJ, Dettmer K, Simbuerger JM, Witzgall R, Stanescu HC, Dumitriu S, Iancu D, Patel V, Mozere M, Tekman M, Jaureguiberry G, Issler N, Kesselheim A, Walsh SB, Gale DP, Howie AJ, Martins JR, Hall AM, Kasgharian M, O'Brien K, Ferreira CR, Atwal PS, Jain M, Hammers A, Charles-Edwards G, Choe CU, Isbrandt D, Cebrian-Serrano A, Davies B, Sandford RN, Pugh C, Konecki DS, Povey S, Bockenhauer D, Lichter-Konecki U, Gahl WA, Unwin RJ, Warth R, Kleta R.

J Am Soc Nephrol. 2018 Jul;29(7):1849-1858. doi: 10.1681/ASN.2017111179. Epub 2018 Apr 13.

PMID:
29654216
18.

Plasma metals as potential biomarkers in dementia: a case-control study in patients with sporadic Alzheimer's disease.

Xu J, Church SJ, Patassini S, Begley P, Kellett KAB, Vardy ERLC, Unwin RD, Hooper NM, Cooper GJS.

Biometals. 2018 Apr;31(2):267-276. doi: 10.1007/s10534-018-0089-3. Epub 2018 Mar 7.

19.

P2X7 receptor antagonism ameliorates renal dysfunction in a rat model of sepsis.

Arulkumaran N, Sixma ML, Pollen S, Ceravola E, Jentho E, Prendecki M, Bass PS, Tam FWK, Unwin RJ, Singer M.

Physiol Rep. 2018 Mar;6(5). doi: 10.14814/phy2.13622.

20.

Renal Tubular Cell Mitochondrial Dysfunction Occurs Despite Preserved Renal Oxygen Delivery in Experimental Septic Acute Kidney Injury.

Arulkumaran N, Pollen S, Greco E, Courtneidge H, Hall AM, Duchen MR, Tam FWK, Unwin RJ, Singer M.

Crit Care Med. 2018 Apr;46(4):e318-e325. doi: 10.1097/CCM.0000000000002937.

21.

Changes in urinary risk profile after short-term low sodium and low calcium diet in recurrent Swiss kidney stone formers.

Seeger H, Kaelin A, Ferraro PM, Weber D, Jaeger P, Ambuehl P, Robertson WG, Unwin R, Wagner CA, Mohebbi N.

BMC Nephrol. 2017 Dec 4;18(1):349. doi: 10.1186/s12882-017-0755-7.

22.

A more tubulocentric view of diabetic kidney disease.

Zeni L, Norden AGW, Cancarini G, Unwin RJ.

J Nephrol. 2017 Dec;30(6):701-717. doi: 10.1007/s40620-017-0423-9. Epub 2017 Aug 24. Review.

23.

Fainting Fanconi syndrome clarified by proxy: a case report.

Walsh SB, Unwin R, Kleta R, Van't Hoff W, Bass P, Hussain K, Ellard S, Bockenhauer D.

BMC Nephrol. 2017 Jul 11;18(1):230. doi: 10.1186/s12882-017-0649-8.

24.

Label Free Detection of Sensitive Mid-Infrared Biomarkers of Glomerulonephritis in Urine Using Fourier Transform Infrared Spectroscopy.

Yu MC, Rich P, Foreman L, Smith J, Yu MS, Tanna A, Dibbur V, Unwin R, Tam FWK.

Sci Rep. 2017 Jul 4;7(1):4601. doi: 10.1038/s41598-017-04774-7.

25.

Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia.

Xu J, Church SJ, Patassini S, Begley P, Waldvogel HJ, Curtis MA, Faull RLM, Unwin RD, Cooper GJS.

Metallomics. 2017 Aug 16;9(8):1106-1119. doi: 10.1039/c7mt00074j.

PMID:
28654115
26.

Hyperglycemia-induced Renal P2X7 Receptor Activation Enhances Diabetes-related Injury.

Menzies RI, Booth JWR, Mullins JJ, Bailey MA, Tam FWK, Norman JT, Unwin RJ.

EBioMedicine. 2017 May;19:73-83. doi: 10.1016/j.ebiom.2017.04.011. Epub 2017 Apr 20.

27.

Sequential Analysis of a Panel of Biomarkers and Pathologic Findings in a Resuscitated Rat Model of Sepsis and Recovery.

Arulkumaran N, Sixma ML, Jentho E, Ceravola E, Bass PS, Kellum JA, Unwin RJ, Tam FWK, Singer M.

Crit Care Med. 2017 Aug;45(8):e821-e830. doi: 10.1097/CCM.0000000000002381.

28.

The effects of dual PPARα/γ agonism compared with ACE inhibition in the BTBRob/ob mouse model of diabetes and diabetic nephropathy.

Ericsson A, Tonelius P, Lal M, Sabirsh A, Böttcher G, William-Olsson L, Strömstedt M, Johansson C, Hyberg G, Tapani S, Jönsson-Rylander AC, Unwin R.

Physiol Rep. 2017 Mar;5(5). pii: e13186. doi: 10.14814/phy2.13186.

29.

Postprandial adjustments in renal phosphate excretion do not involve a gut-derived phosphaturic factor.

Lee GJ, Mossa-Al Hashimi L, Debnam ES, Unwin RJ, Marks J.

Exp Physiol. 2017 Apr 1;102(4):462-474. doi: 10.1113/EP086062. Epub 2017 Mar 14.

30.

Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice.

Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips AR, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJ.

Data Brief. 2016 Nov 29;10:298-303. eCollection 2017 Feb.

31.

Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition.

Dermit M, Casado P, Rajeeve V, Wilkes EH, Foxler DE, Campbell H, Critchlow S, Sharp TV, Gribben JG, Unwin R, Cutillas PR.

Oncogene. 2017 May 11;36(19):2762-2774. doi: 10.1038/onc.2016.435. Epub 2016 Dec 19.

32.

Vitamin D deficiency is prevalent among idiopathic stone formers, but does correction pose any risk?

Johri N, Jaeger P, Ferraro PM, Shavit L, Nair D, Robertson WG, Gambaro G, Unwin RJ.

Urolithiasis. 2017 Dec;45(6):535-543. doi: 10.1007/s00240-016-0954-x. Epub 2016 Dec 16.

33.

Tubular and genetic disorders associated with kidney stones.

Mohebbi N, Ferraro PM, Gambaro G, Unwin R.

Urolithiasis. 2017 Feb;45(1):127-137. doi: 10.1007/s00240-016-0945-y. Epub 2016 Nov 28. Review.

PMID:
27896392
34.

Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice.

Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips ARJ, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJS.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):625-631. doi: 10.1016/j.bbrc.2016.11.083. Epub 2016 Nov 16.

PMID:
27865831
35.

Putative tissue location and function of the SLC5 family member SGLT3.

Soták M, Marks J, Unwin RJ.

Exp Physiol. 2017 Jan 1;102(1):5-13. doi: 10.1113/EP086042. Review.

36.

Purinergic signaling in kidney disease.

Menzies RI, Tam FW, Unwin RJ, Bailey MA.

Kidney Int. 2017 Feb;91(2):315-323. doi: 10.1016/j.kint.2016.08.029. Epub 2016 Oct 22. Review.

37.

Infrared vibrational spectroscopy: a rapid and novel diagnostic and monitoring tool for cystinuria.

Oliver KV, Vilasi A, Maréchal A, Moochhala SH, Unwin RJ, Rich PR.

Sci Rep. 2016 Oct 10;6:34737. doi: 10.1038/srep34737.

38.

Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids.

Dutta A, Potier DN, Walker MJ, Gray OJ, Parker C, Holland M, Williamson AJ, Pierce A, Unwin RD, Krishnan S, Saha V, Whetton AD.

Oncotarget. 2016 Oct 25;7(43):70822-70831. doi: 10.18632/oncotarget.12224.

39.

Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia.

Xu J, Begley P, Church SJ, Patassini S, McHarg S, Kureishy N, Hollywood KA, Waldvogel HJ, Liu H, Zhang S, Lin W, Herholz K, Turner C, Synek BJ, Curtis MA, Rivers-Auty J, Lawrence CB, Kellett KA, Hooper NM, Vardy ER, Wu D, Unwin RD, Faull RL, Dowsey AW, Cooper GJ.

Sci Rep. 2016 Jun 9;6:27524. doi: 10.1038/srep27524.

40.

Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain.

Patassini S, Begley P, Xu J, Church SJ, Reid SJ, Kim EH, Curtis MA, Dragunow M, Waldvogel HJ, Snell RG, Unwin RD, Faull RL, Cooper GJ.

Biochim Biophys Acta. 2016 Sep;1862(9):1650-62. doi: 10.1016/j.bbadis.2016.06.002. Epub 2016 Jun 4.

41.

Supporting practice learning time for non-medical prescribing students: managers' views.

Unwin R, Redman S, Bain H, Macphee M, McElhinney E, Downer F, Paterson R.

Nurs Manag (Harrow). 2016 Jun;23(3):25-9. doi: 10.7748/nm.23.3.25.s27.

PMID:
27246432
42.

Experimental type II diabetes and related models of impaired glucose metabolism differentially regulate glucose transporters at the proximal tubule brush border membrane.

Chichger H, Cleasby ME, Srai SK, Unwin RJ, Debnam ES, Marks J.

Exp Physiol. 2016 Jun 1;101(6):731-42. doi: 10.1113/EP085670. Epub 2016 May 10.

43.

Increased renal papillary density in kidney stone formers detectable by CT scan is a potential marker of stone risk, but is unrelated to underlying hypercalciuria.

Shavit L, Girfoglio D, Kirkham A, Allen D, Ferraro PM, Moochhala S, Unwin R.

Urolithiasis. 2016 Oct;44(5):471-5. doi: 10.1007/s00240-016-0873-x. Epub 2016 Mar 29.

PMID:
27023714
44.

Persistent severe polyuria after renal transplant.

Wong T, Laing C, Ekong R, Povey S, Unwin RJ.

Clin Kidney J. 2016 Apr;9(2):180-3. doi: 10.1093/ckj/sfv100. Epub 2015 Oct 20.

45.
46.

Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder.

Xu J, Begley P, Church SJ, Patassini S, Hollywood KA, Jüllig M, Curtis MA, Waldvogel HJ, Faull RL, Unwin RD, Cooper GJ.

Biochim Biophys Acta. 2016 Jun;1862(6):1084-92. doi: 10.1016/j.bbadis.2016.03.001. Epub 2016 Mar 5.

47.

Effects of Obesity on Perivascular Adipose Tissue Vasorelaxant Function: Nitric Oxide, Inflammation and Elevated Systemic Blood Pressure.

Aghamohammadzadeh R, Unwin RD, Greenstein AS, Heagerty AM.

J Vasc Res. 2015;52(5):299-305. doi: 10.1159/000443885. Epub 2016 Feb 25.

48.

Designing disordered materials using DNA-coated colloids of bacteriophage fd and gold.

Ruff Z, Nathan SH, Unwin RR, Zupkauskas M, Joshi D, Salmond GP, Grey CP, Eiser E.

Faraday Discuss. 2016;186:473-88. doi: 10.1039/c5fd00120j.

PMID:
26864018
49.

Non-medical prescribing assessment - An evaluation of a nationally agreed multi method approach.

Paterson RE, Redman SG, Unwin R, McElhinney E, Macphee M, Downer F.

Nurse Educ Pract. 2016 Jan;16(1):280-6. doi: 10.1016/j.nepr.2015.10.008. Epub 2015 Oct 20.

PMID:
26526295
50.

Identification of elevated urea as a severe, ubiquitous metabolic defect in the brain of patients with Huntington's disease.

Patassini S, Begley P, Reid SJ, Xu J, Church SJ, Curtis M, Dragunow M, Waldvogel HJ, Unwin RD, Snell RG, Faull RL, Cooper GJ.

Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):161-6. doi: 10.1016/j.bbrc.2015.10.140. Epub 2015 Oct 30.

PMID:
26522227

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