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Immune cells for microbiota surveillance.

Oh J, Unutmaz D.

Science. 2019 Oct 25;366(6464):419-420. doi: 10.1126/science.aaz4014. No abstract available.


T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation.

Shimada K, Porritt RA, Markman JL, O'Rourke JG, Wakita D, Noval Rivas M, Ogawa C, Kozhaya L, Martins GA, Unutmaz D, Baloh RH, Crother TR, Chen S, Arditi M.

Immunity. 2018 Nov 20;49(5):873-885.e7. doi: 10.1016/j.immuni.2018.08.022. Epub 2018 Oct 23.


Low Peripheral T Follicular Helper Cells in Perinatally HIV-Infected Children Correlate With Advancing HIV Disease.

McCarty B, Mwamzuka M, Marshed F, Generoso M, Alvarez P, Ilmet T, Kravietz A, Ahmed A, Borkowsky W, Unutmaz D, Khaitan A.

Front Immunol. 2018 Aug 24;9:1901. doi: 10.3389/fimmu.2018.01901. eCollection 2018.


Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation.

Tastan C, Karhan E, Zhou W, Fleming E, Voigt AY, Yao X, Wang L, Horne M, Placek L, Kozhaya L, Oh J, Unutmaz D.

Mucosal Immunol. 2018 Nov;11(6):1591-1605. doi: 10.1038/s41385-018-0072-x. Epub 2018 Aug 16.


Deletion of GARP on mouse regulatory T cells is not sufficient to inhibit the growth of transplanted tumors.

Vermeersch E, Liénart S, Collignon A, Lucas S, Gallimore A, Gysemans C, Unutmaz D, Vanhoorelbeke K, De Meyer SF, Maes W, Deckmyn H.

Cell Immunol. 2018 Oct;332:129-133. doi: 10.1016/j.cellimm.2018.07.011. Epub 2018 Jul 30.


Genomic Profiling of T-Cell Neoplasms Reveals Frequent JAK1 and JAK3 Mutations With Clonal Evasion From Targeted Therapies.

Greenplate A, Wang K, Tripathi RM, Palma N, Ali SM, Stephens PJ, Miller VA, Shyr Y, Guo Y, Reddy NM, Kozhaya L, Unutmaz D, Chen X, Irish JM, Davé UP.

JCO Precis Oncol. 2018;2018. doi: 10.1200/PO.17.00019. Epub 2018 Feb 13.


Functional Interrogation of Primary Human T Cells via CRISPR Genetic Editing.

Chen X, Kozhaya L, Tastan C, Placek L, Dogan M, Horne M, Abblett R, Karhan E, Vaeth M, Feske S, Unutmaz D.

J Immunol. 2018 Sep 1;201(5):1586-1598. doi: 10.4049/jimmunol.1701616. Epub 2018 Jul 18.


ORAI1 mutations abolishing store-operated Ca2+ entry cause anhidrotic ectodermal dysplasia with immunodeficiency.

Lian J, Cuk M, Kahlfuss S, Kozhaya L, Vaeth M, Rieux-Laucat F, Picard C, Benson MJ, Jakovcevic A, Bilic K, Martinac I, Stathopulos P, Kacskovics I, Vraetz T, Speckmann C, Ehl S, Issekutz T, Unutmaz D, Feske S.

J Allergy Clin Immunol. 2018 Oct;142(4):1297-1310.e11. doi: 10.1016/j.jaci.2017.10.031. Epub 2017 Nov 16.


Serial immunological parameters in a phase II trial of exemestane and low-dose oral cyclophosphamide in advanced hormone receptor-positive breast cancer.

Kwa M, Li X, Novik Y, Oratz R, Jhaveri K, Wu J, Gu P, Meyers M, Muggia F, Speyer J, Iwano A, Bonakdar M, Kozhaya L, Tavukcuoglu E, Budan B, Raad R, Goldberg JD, Unutmaz D, Adams S.

Breast Cancer Res Treat. 2018 Feb;168(1):57-67. doi: 10.1007/s10549-017-4570-4. Epub 2017 Nov 9.


HIV-Infected Children Have Elevated Levels of PD-1+ Memory CD4 T Cells With Low Proliferative Capacity and High Inflammatory Cytokine Effector Functions.

Foldi J, Kozhaya L, McCarty B, Mwamzuka M, Marshed F, Ilmet T, Kilberg M, Kravietz A, Ahmed A, Borkowsky W, Unutmaz D, Khaitan A.

J Infect Dis. 2017 Sep 15;216(6):641-650. doi: 10.1093/infdis/jix341.


The role of platelet and endothelial GARP in thrombosis and hemostasis.

Vermeersch E, Denorme F, Maes W, De Meyer SF, Vanhoorelbeke K, Edwards J, Shevach EM, Unutmaz D, Fujii H, Deckmyn H, Tersteeg C.

PLoS One. 2017 Mar 9;12(3):e0173329. doi: 10.1371/journal.pone.0173329. eCollection 2017.


Time of Initiating Enzyme Replacement Therapy Affects Immune Abnormalities and Disease Severity in Patients with Gaucher Disease.

Limgala RP, Ioanou C, Plassmeyer M, Ryherd M, Kozhaya L, Austin L, Abidoglu C, Unutmaz D, Alpan O, Goker-Alpan O.

PLoS One. 2016 Dec 12;11(12):e0168135. doi: 10.1371/journal.pone.0168135. eCollection 2016.


HIV-Infected Children Have Lower Frequencies of CD8+ Mucosal-Associated Invariant T (MAIT) Cells that Correlate with Innate, Th17 and Th22 Cell Subsets.

Khaitan A, Kilberg M, Kravietz A, Ilmet T, Tastan C, Mwamzuka M, Marshed F, Liu M, Ahmed A, Borkowsky W, Unutmaz D.

PLoS One. 2016 Aug 25;11(8):e0161786. doi: 10.1371/journal.pone.0161786. eCollection 2016.


Bioprinting towards Physiologically Relevant Tissue Models for Pharmaceutics.

Peng W, Unutmaz D, Ozbolat IT.

Trends Biotechnol. 2016 Sep;34(9):722-732. doi: 10.1016/j.tibtech.2016.05.013. Epub 2016 Jun 10. Review.


Store-Operated Ca(2+) Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity.

Vaeth M, Eckstein M, Shaw PJ, Kozhaya L, Yang J, Berberich-Siebelt F, Clancy R, Unutmaz D, Feske S.

Immunity. 2016 Jun 21;44(6):1350-64. doi: 10.1016/j.immuni.2016.04.013. Epub 2016 May 31.


FOXP3+Helios+ Regulatory T Cells, Immune Activation, and Advancing Disease in HIV-Infected Children.

Khaitan A, Kravietz A, Mwamzuka M, Marshed F, Ilmet T, Said S, Ahmed A, Borkowsky W, Unutmaz D.

J Acquir Immune Defic Syndr. 2016 Aug 15;72(5):474-84. doi: 10.1097/QAI.0000000000001000.


Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell Function.

Kaufmann U, Shaw PJ, Kozhaya L, Subramanian R, Gaida K, Unutmaz D, McBride HJ, Feske S.

J Immunol. 2016 Jan 15;196(2):573-85. doi: 10.4049/jimmunol.1501406. Epub 2015 Dec 16.


Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells.

Vaeth M, Zee I, Concepcion AR, Maus M, Shaw P, Portal-Celhay C, Zahra A, Kozhaya L, Weidinger C, Philips J, Unutmaz D, Feske S.

J Immunol. 2015 Aug 1;195(3):1202-17. doi: 10.4049/jimmunol.1403013. Epub 2015 Jun 24.


Inhibition of HIV infection by caerin 1 antimicrobial peptides.

VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.

Peptides. 2015 Sep;71:296-303. doi: 10.1016/j.peptides.2015.05.004. Epub 2015 May 27.


Elimination of HIV-1-Infected Primary T Cell Reservoirs in an In Vitro Model of Latency.

Rawlings SA, Alonzo F 3rd, Kozhaya L, Torres VJ, Unutmaz D.

PLoS One. 2015 May 19;10(5):e0126917. doi: 10.1371/journal.pone.0126917. eCollection 2015.


STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection.

Desvignes L, Weidinger C, Shaw P, Vaeth M, Ribierre T, Liu M, Fergus T, Kozhaya L, McVoy L, Unutmaz D, Ernst JD, Feske S.

J Clin Invest. 2015 Jun;125(6):2347-62. doi: 10.1172/JCI80273. Epub 2015 May 4.


Clinical trial evidence of the antitumor activity of topical imiquimod for breast cancer skin metastases.

Adams S, Novik Y, Oratz R, Axelrod D, Speyer J, Tiersten A, Goldberg JD, Bhardwaj N, Unutmaz D, Demaria S, Formenti S.

J Clin Oncol. 2014 Oct 1;32(28):3204-5. doi: 10.1200/JCO.2014.56.1282. Epub 2014 Aug 4. No abstract available.


Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors.

Mercer F, Khaitan A, Kozhaya L, Aberg JA, Unutmaz D.

J Immunol. 2014 Aug 1;193(3):1047-54. doi: 10.4049/jimmunol.1302936. Epub 2014 Jun 23.


Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids.

Ramesh R, Kozhaya L, McKevitt K, Djuretic IM, Carlson TJ, Quintero MA, McCauley JL, Abreu MT, Unutmaz D, Sundrud MS.

J Exp Med. 2014 Jan 13;211(1):89-104. doi: 10.1084/jem.20130301. Epub 2014 Jan 6.


The metalloprotease ADAM12 regulates the effector function of human Th17 cells.

Zhou AX, El Hed A, Mercer F, Kozhaya L, Unutmaz D.

PLoS One. 2013 Nov 21;8(11):e81146. doi: 10.1371/journal.pone.0081146. eCollection 2013.


Staphylococcus aureus leukotoxin ED targets the chemokine receptors CXCR1 and CXCR2 to kill leukocytes and promote infection.

Reyes-Robles T, Alonzo F 3rd, Kozhaya L, Lacy DB, Unutmaz D, Torres VJ.

Cell Host Microbe. 2013 Oct 16;14(4):453-9. doi: 10.1016/j.chom.2013.09.005.


Turkey must end violent response to protests.

Altindis E, Alpar MA, Aksay E, Beckwith J, Bökel C, Curl RF, Darnell RB, Elledge SJ, Erman B, Frahm J, Goff SP, Greengard P, Hoffmann R, Ilhan B, Kaslin J, Lipkin SM, Poulopoulou C, Raz E, Rubin MA, Salturk M, Schrock RR, Trautmann A, Unutmaz D, Weinstein H, Kizil C.

Science. 2013 Jul 19;341(6143):236. doi: 10.1126/science.341.6143.236-a. No abstract available. Erratum in: Science. 2013 Aug 30;341(6149):959.


Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation.

Edwards JP, Fujii H, Zhou AX, Creemers J, Unutmaz D, Shevach EM.

J Immunol. 2013 Jun 1;190(11):5506-15. doi: 10.4049/jimmunol.1300199. Epub 2013 May 3.


GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo.

Zhou AX, Kozhaya L, Fujii H, Unutmaz D.

J Immunol. 2013 May 15;190(10):5057-64. doi: 10.4049/jimmunol.1300065. Epub 2013 Apr 10.


Probing the effector and suppressive functions of human T cell subsets using antigen-specific engineered T cell receptors.

Wan Q, Kozhaya L, Imberg K, Mercer F, Zhong S, Krogsgaard M, Unutmaz D.

PLoS One. 2013;8(2):e56302. doi: 10.1371/journal.pone.0056302. Epub 2013 Feb 20.


CCR5 is a receptor for Staphylococcus aureus leukotoxin ED.

Alonzo F 3rd, Kozhaya L, Rawlings SA, Reyes-Robles T, DuMont AL, Myszka DG, Landau NR, Unutmaz D, Torres VJ.

Nature. 2013 Jan 3;493(7430):51-5. doi: 10.1038/nature11724. Epub 2012 Dec 12.


Topical TLR7 agonist imiquimod can induce immune-mediated rejection of skin metastases in patients with breast cancer.

Adams S, Kozhaya L, Martiniuk F, Meng TC, Chiriboga L, Liebes L, Hochman T, Shuman N, Axelrod D, Speyer J, Novik Y, Tiersten A, Goldberg JD, Formenti SC, Bhardwaj N, Unutmaz D, Demaria S.

Clin Cancer Res. 2012 Dec 15;18(24):6748-57. doi: 10.1158/1078-0432.CCR-12-1149. Epub 2012 Jul 5.


Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection.

Ambrose Z, Lee K, Ndjomou J, Xu H, Oztop I, Matous J, Takemura T, Unutmaz D, Engelman A, Hughes SH, KewalRamani VN.

J Virol. 2012 Apr;86(8):4708-14. doi: 10.1128/JVI.05887-11. Epub 2012 Feb 1.


Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+ human memory T cells.

Wan Q, Kozhaya L, ElHed A, Ramesh R, Carlson TJ, Djuretic IM, Sundrud MS, Unutmaz D.

J Exp Med. 2011 Aug 29;208(9):1875-87. doi: 10.1084/jem.20102516. Epub 2011 Aug 8.


FoxP3 interacts with linker histone H1.5 to modulate gene expression and program Treg cell activity.

Mackey-Cushman SL, Gao J, Holmes DA, Nunoya JI, Wang R, Unutmaz D, Su L.

Genes Immun. 2011 Oct;12(7):559-67. doi: 10.1038/gene.2011.31. Epub 2011 Jun 9.


Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis.

Dumont AL, Nygaard TK, Watkins RL, Smith A, Kozhaya L, Kreiswirth BN, Shopsin B, Unutmaz D, Voyich JM, Torres VJ.

Mol Microbiol. 2011 Feb;79(3):814-25. doi: 10.1111/j.1365-2958.2010.07490.x. Epub 2010 Dec 13.


Revisiting immune exhaustion during HIV infection.

Khaitan A, Unutmaz D.

Curr HIV/AIDS Rep. 2011 Mar;8(1):4-11. doi: 10.1007/s11904-010-0066-0. Review.


A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells.

Manel N, Hogstad B, Wang Y, Levy DE, Unutmaz D, Littman DR.

Nature. 2010 Sep 9;467(7312):214-7. doi: 10.1038/nature09337. Erratum in: Nature. 2011 Feb 17;470(7334):424.


Th17 cells and HIV infection.

Elhed A, Unutmaz D.

Curr Opin HIV AIDS. 2010 Mar;5(2):146-50. doi: 10.1097/COH.0b013e32833647a8. Review.


Flexible use of nuclear import pathways by HIV-1.

Lee K, Ambrose Z, Martin TD, Oztop I, Mulky A, Julias JG, Vandegraaff N, Baumann JG, Wang R, Yuen W, Takemura T, Shelton K, Taniuchi I, Li Y, Sodroski J, Littman DR, Coffin JM, Hughes SH, Unutmaz D, Engelman A, KewalRamani VN.

Cell Host Microbe. 2010 Mar 18;7(3):221-33. doi: 10.1016/j.chom.2010.02.007.


Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection.

El Hed A, Khaitan A, Kozhaya L, Manel N, Daskalakis D, Borkowsky W, Valentine F, Littman DR, Unutmaz D.

J Infect Dis. 2010 Mar 15;201(6):843-54. doi: 10.1086/651021.


Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity.

Furtak V, Mulky A, Rawlings SA, Kozhaya L, Lee K, Kewalramani VN, Unutmaz D.

PLoS One. 2010 Feb 5;5(2):e9081. doi: 10.1371/journal.pone.0009081.


Expression and function of TNF and IL-1 receptors on human regulatory T cells.

Mercer F, Kozhaya L, Unutmaz D.

PLoS One. 2010 Jan 11;5(1):e8639. doi: 10.1371/journal.pone.0008639.


The gut feeling of Treg cells: IL-10 is the silver lining during colitis.

Unutmaz D, Pulendran B.

Nat Immunol. 2009 Nov;10(11):1141-3. doi: 10.1038/ni1109-1141.


Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells.

Wang R, Kozhaya L, Mercer F, Khaitan A, Fujii H, Unutmaz D.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13439-44. doi: 10.1073/pnas.0901965106. Epub 2009 Jul 28.


GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.

Tran DQ, Andersson J, Wang R, Ramsey H, Unutmaz D, Shevach EM.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13445-50. doi: 10.1073/pnas.0901944106. Epub 2009 Jul 27.


RORC2: the master of human Th17 cell programming.

Unutmaz D.

Eur J Immunol. 2009 Jun;39(6):1452-5. doi: 10.1002/eji.200939540.


Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response.

Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A.

Science. 2009 Jun 5;324(5932):1334-8. doi: 10.1126/science.1172638.


Natural killer T cells: an unconventional T-cell subset with diverse effector and regulatory functions.

Balato A, Unutmaz D, Gaspari AA.

J Invest Dermatol. 2009 Jul;129(7):1628-42. doi: 10.1038/jid.2009.30. Epub 2009 Mar 5. Review.


Differences in APOBEC3G expression in CD4+ T helper lymphocyte subtypes modulate HIV-1 infectivity.

Vetter ML, Johnson ME, Antons AK, Unutmaz D, D'Aquila RT.

PLoS Pathog. 2009 Feb;5(2):e1000292. doi: 10.1371/journal.ppat.1000292. Epub 2009 Feb 6.

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