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Items: 29


IL-10 Has Differential Effects on the Innate and Adaptive Immune Systems of Septic Patients.

Mazer M, Unsinger J, Drewry A, Walton A, Osborne D, Blood T, Hotchkiss R, Remy KE.

J Immunol. 2019 Sep 9. pii: ji1900637. doi: 10.4049/jimmunol.1900637. [Epub ahead of print]


Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial.

Francois B, Jeannet R, Daix T, Walton AH, Shotwell MS, Unsinger J, Monneret G, Rimmelé T, Blood T, Morre M, Gregoire A, Mayo GA, Blood J, Durum SK, Sherwood ER, Hotchkiss RS.

JCI Insight. 2018 Mar 8;3(5). pii: 98960. doi: 10.1172/jci.insight.98960.


Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia.

Shindo Y, Fuchs AG, Davis CG, Eitas T, Unsinger J, Burnham CD, Green JM, Morre M, Bochicchio GV, Hotchkiss RS.

J Leukoc Biol. 2017 Feb;101(2):543-554. doi: 10.1189/jlb.4A1215-581R. Epub 2016 Sep 14.


Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression.

Shindo Y, Unsinger J, Burnham CA, Green JM, Hotchkiss RS.

Shock. 2015 Apr;43(4):334-43. doi: 10.1097/SHK.0000000000000317.


The new normal: immunomodulatory agents against sepsis immune suppression.

Hutchins NA, Unsinger J, Hotchkiss RS, Ayala A.

Trends Mol Med. 2014 Apr;20(4):224-33. doi: 10.1016/j.molmed.2014.01.002. Epub 2014 Jan 30. Review.


Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis.

Chang KC, Burnham CA, Compton SM, Rasche DP, Mazuski RJ, McDonough JS, Unsinger J, Korman AJ, Green JM, Hotchkiss RS.

Crit Care. 2013 May 11;17(3):R85. doi: 10.1186/cc12711.


Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis.

Unsinger J, Burnham CA, McDonough J, Morre M, Prakash PS, Caldwell CC, Dunne WM Jr, Hotchkiss RS.

J Infect Dis. 2012 Aug 15;206(4):606-16. doi: 10.1093/infdis/jis383. Epub 2012 Jun 12.


Dose-dependent effect of anti-CTLA-4 on survival in sepsis.

Inoue S, Bo L, Bian J, Unsinger J, Chang K, Hotchkiss RS.

Shock. 2011 Jul;36(1):38-44. doi: 10.1097/SHK.0b013e3182168cce.


Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis.

Kasten KR, Prakash PS, Unsinger J, Goetzman HS, England LG, Cave CM, Seitz AP, Mazuski CN, Zhou TT, Morre M, Hotchkiss RS, Hildeman DA, Caldwell CC.

Infect Immun. 2010 Nov;78(11):4714-22. doi: 10.1128/IAI.00456-10. Epub 2010 Sep 7.


Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis.

Brahmamdam P, Inoue S, Unsinger J, Chang KC, McDunn JE, Hotchkiss RS.

J Leukoc Biol. 2010 Aug;88(2):233-40. doi: 10.1189/jlb.0110037. Epub 2010 May 18.


Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism.

Unsinger J, Kazama H, McDonough JS, Griffith TS, Hotchkiss RS, Ferguson TA.

J Immunol. 2010 Jun 15;184(12):6766-72. doi: 10.4049/jimmunol.0904054. Epub 2010 May 12.


IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.

Unsinger J, McGlynn M, Kasten KR, Hoekzema AS, Watanabe E, Muenzer JT, McDonough JS, Tschoep J, Ferguson TA, McDunn JE, Morre M, Hildeman DA, Caldwell CC, Hotchkiss RS.

J Immunol. 2010 Apr 1;184(7):3768-79. doi: 10.4049/jimmunol.0903151. Epub 2010 Mar 3.


IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis.

Inoue S, Unsinger J, Davis CG, Muenzer JT, Ferguson TA, Chang K, Osborne DF, Clark AT, Coopersmith CM, McDunn JE, Hotchkiss RS.

J Immunol. 2010 Feb 1;184(3):1401-9. doi: 10.4049/jimmunol.0902307. Epub 2009 Dec 21.


Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice.

Unsinger J, McDonough JS, Shultz LD, Ferguson TA, Hotchkiss RS.

J Leukoc Biol. 2009 Aug;86(2):219-27. doi: 10.1189/jlb.1008615. Epub 2009 Apr 15.


Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury.

Unsinger J, Kazama H, McDonough JS, Hotchkiss RS, Ferguson TA.

J Leukoc Biol. 2009 Mar;85(3):382-90. doi: 10.1189/jlb.0808491. Epub 2008 Dec 30.


Targeted delivery of siRNA to cell death proteins in sepsis.

Brahmamdam P, Watanabe E, Unsinger J, Chang KC, Schierding W, Hoekzema AS, Zhou TT, McDonough JS, Holemon H, Heidel JD, Coopersmith CM, McDunn JE, Hotchkiss RS.

Shock. 2009 Aug;32(2):131-9. doi: 10.1097/SHK.0b013e318194bcee.


Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages.

Peck-Palmer OM, Unsinger J, Chang KC, McDonough JS, Perlman H, McDunn JE, Hotchkiss RS.

Shock. 2009 Apr;31(4):359-66. doi: 10.1097/SHK.0b013e31818ba2a2.


Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival.

Peck-Palmer OM, Unsinger J, Chang KC, Davis CG, McDunn JE, Hotchkiss RS.

J Leukoc Biol. 2008 Apr;83(4):1009-18. doi: 10.1189/jlb.0807528. Epub 2008 Jan 22.


Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis.

Schwulst SJ, Muenzer JT, Peck-Palmer OM, Chang KC, Davis CG, McDonough JS, Osborne DF, Walton AH, Unsinger J, McDunn JE, Hotchkiss RS.

Shock. 2008 Aug;30(2):127-34. doi: 10.1097/shk.0b013e318162cf17.


Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis.

Chang KC, Unsinger J, Davis CG, Schwulst SJ, Muenzer JT, Strasser A, Hotchkiss RS.

FASEB J. 2007 Mar;21(3):708-19. Epub 2007 Feb 16.


Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis.

Muenzer JT, Davis CG, Dunne BS, Unsinger J, Dunne WM, Hotchkiss RS.

Shock. 2006 Dec;26(6):565-70.


The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis.

Unsinger J, Herndon JM, Davis CG, Muenzer JT, Hotchkiss RS, Ferguson TA.

J Immunol. 2006 Dec 1;177(11):7968-73.


In vivo correction of complement regulatory protein deficiency with an inhibitor targeting the red blood cell membrane.

Spitzer D, Unsinger J, Mao D, Wu X, Molina H, Atkinson JP.

J Immunol. 2005 Dec 1;175(11):7763-70.


G-CSF induced progenitor mobilization in mice with PIGA- blood cells.

Han B, Unsinger J, Liu F, Link DC, Bessler M.

Hematol J. 2004;5(4):347-52.


Stable and strictly controlled expression of LTR-flanked autoregulated expression cassettes upon adenoviral transfer.

Unsinger J, Lindenmaier W, May T, Hauser H, Wirth D.

Biochem Biophys Res Commun. 2004 Jul 2;319(3):879-87.


ScFv-mediated in vivo targeting of DAF to erythrocytes inhibits lysis by complement.

Spitzer D, Unsinger J, Bessler M, Atkinson JP.

Mol Immunol. 2004 Feb;40(13):911-9.


Retroviral vectors for the transduction of autoregulated, bidirectional expression cassettes.

Unsinger J, Kröger A, Hauser H, Wirth D.

Mol Ther. 2001 Nov;4(5):484-9.


Polyvalent DNA vaccines with bidirectional promoters.

Kwissa M, Unsinger J, Schirmbeck R, Hauser H, Reimann J.

J Mol Med (Berl). 2000;78(9):495-506.


New approaches towards ex vivo and in vivo gene therapy.

Hauser H, Spitzer D, Verhoeyen E, Unsinger J, Wirth D.

Cells Tissues Organs. 2000;167(2-3):75-80. Review.


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