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Items: 1 to 50 of 596

1.

Cloning and tissue expression of cytochrome P450 2S1, 4V2, 7A1, 7B1, 8B1, 24A1, 26A1, 26C1, 27A1, 39A1, and 51A1 in marmosets.

Uehara S, Uno Y, Inoue T, Sasaki E, Yamazaki H.

Drug Metab Pharmacokinet. 2019 Dec 26. pii: S1347-4367(19)30240-X. doi: 10.1016/j.dmpk.2019.11.008. [Epub ahead of print]

PMID:
31980379
2.

mRNA levels of drug-metabolizing enzymes in 11 brain regions of cynomolgus macaques.

Uno Y, Yamazaki H.

Drug Metab Pharmacokinet. 2019 Dec 31. pii: S1347-4367(19)30243-5. doi: 10.1016/j.dmpk.2019.12.003. [Epub ahead of print]

PMID:
31964621
3.

Identification and characterization of a new carboxylesterase 2 isozyme, mfCES2C, in the small intestine of cynomolgus monkeys.

Ohura K, Igawa Y, Tanaka M, Matsumoto K, Kasahara A, Wada N, Kubota K, Uno Y, Imai T.

Drug Metab Dispos. 2019 Dec 13. pii: dmd.119.089011. doi: 10.1124/dmd.119.089011. [Epub ahead of print]

4.

Molecular characterization of functional UDP-glucuronosyltransferases 1A and 2B in common marmosets.

Uno Y, Uehara S, Inoue T, Kawamura S, Murayama N, Nishikawa M, Ikushiro S, Sasaki E, Yamazaki H.

Biochem Pharmacol. 2020 Feb;172:113748. doi: 10.1016/j.bcp.2019.113748. Epub 2019 Dec 10.

PMID:
31830470
5.

Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver.

Ueda T, Yokota T, Okuzaki D, Uno Y, Mashimo T, Kubota Y, Sudo T, Ishibashi T, Shingai Y, Doi Y, Ozawa T, Nakai R, Tanimura A, Ichii M, Ezoe S, Shibayama H, Oritani K, Kanakura Y.

Stem Cell Reports. 2019 Dec 10;13(6):992-1005. doi: 10.1016/j.stemcr.2019.11.002.

6.

The marmoset cytochrome P450 superfamily: Sequence/phylogenetic analyses, genomic structure, and catalytic function.

Uehara S, Uno Y, Yamazaki H.

Biochem Pharmacol. 2020 Jan;171:113721. doi: 10.1016/j.bcp.2019.113721. Epub 2019 Nov 18. Review.

PMID:
31751534
7.

Molecular characterization of cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) associated with the erythrocyte antigens in dogs.

Uno Y, Kawakami S, Ochiai K, Omi T.

Canine Genet Epidemiol. 2019 Nov 7;6:9. doi: 10.1186/s40575-019-0076-1. eCollection 2019.

8.

Expression, Function, and Prognostic Value of MAGE-D4 Protein in Esophageal Squamous Cell Carcinoma.

Uno Y, Kanda M, Sato Y, Shimizu D, Umeda S, Hattori N, Hayashi M, Tanaka C, Kobayashi D, Yamada S, Nakayama G, Motoyama S, Koike M, Kodera Y.

Anticancer Res. 2019 Nov;39(11):6015-6023. doi: 10.21873/anticanres.13807.

PMID:
31704827
9.

In vivo genotoxicity testing strategies: Report from the 7th International workshop on genotoxicity testing (IWGT).

Kirkland D, Uno Y, Luijten M, Beevers C, van Benthem J, Burlinson B, Dertinger S, Douglas GR, Hamada S, Horibata K, Lovell DP, Manjanatha M, Martus HJ, Mei N, Morita T, Ohyama W, Williams A.

Mutat Res. 2019 Nov;847:403035. doi: 10.1016/j.mrgentox.2019.03.008. Epub 2019 Apr 25.

PMID:
31699340
10.

Expression levels of microRNAs that are potential cytochrome P450 regulators in cynomolgus macaques.

Uno Y, Yamazaki H.

Xenobiotica. 2019 Nov 11:1-6. doi: 10.1080/00498254.2019.1688423. [Epub ahead of print]

PMID:
31682544
11.

The canine RAD51 mutation leads to the attenuation of interaction with PALB2.

Uemura M, Ochiai K, Morimatsu M, Michishita M, Onozawa E, Azakami D, Uno Y, Yoshikawa Y, Sasaki T, Watanabe M, Omi T.

Vet Comp Oncol. 2019 Sep 13. doi: 10.1111/vco.12542. [Epub ahead of print]

PMID:
31518051
12.

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation.

Gurumurthy CB, O'Brien AR, Quadros RM, Adams J Jr, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb KM, Eudy JD, Gan L, Gao J, Gonzales A, Guntur AR, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majewska LA, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford AW, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G.

Genome Biol. 2019 Aug 26;20(1):171. doi: 10.1186/s13059-019-1776-2.

13.

Hypothesis: Mechanism of irritable bowel syndrome in inflammatory bowel disease.

Uno Y.

Med Hypotheses. 2019 Nov;132:109324. doi: 10.1016/j.mehy.2019.109324. Epub 2019 Jul 24.

PMID:
31421429
14.

Prediction of Best-Corrected Visual Acuity With Swept-Source Optical Coherence Tomography Parameters in Keratoconus.

Esaka Y, Kojima T, Dogru M, Hasegawa A, Tamaoki A, Uno Y, Nishida T, Nakamura T, Hara S, Ichikawa K.

Cornea. 2019 Sep;38(9):1154-1160. doi: 10.1097/ICO.0000000000002043.

PMID:
31394554
15.

PD-L1-specific helper T-cells exhibit effective antitumor responses: new strategy of cancer immunotherapy targeting PD-L1 in head and neck squamous cell carcinoma.

Hirata-Nozaki Y, Ohkuri T, Ohara K, Kumai T, Nagata M, Harabuchi S, Kosaka A, Nagato T, Ishibashi K, Oikawa K, Aoki N, Ohara M, Harabuchi Y, Uno Y, Takei H, Celis E, Kobayashi H.

J Transl Med. 2019 Jun 20;17(1):207. doi: 10.1186/s12967-019-1957-5.

16.

Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease.

Balu DT, Pantazopoulos H, Huang CCY, Muszynski K, Harvey TL, Uno Y, Rorabaugh JM, Galloway CR, Botz-Zapp C, Berretta S, Weinshenker D, Coyle JT.

Neurobiol Dis. 2019 Oct;130:104511. doi: 10.1016/j.nbd.2019.104511. Epub 2019 Jun 15.

PMID:
31212068
17.

Influence of Dietary Fiber in Low FODMAP Diet for Irritable Bowel Syndrome.

Uno Y.

Am J Gastroenterol. 2019 Sep;114(9):1553-1554. doi: 10.14309/ajg.0000000000000298. No abstract available.

PMID:
31205130
18.

Prevention of gastric cancer by Helicobacter pylori eradication: A review from Japan.

Uno Y.

Cancer Med. 2019 Jul;8(8):3992-4000. doi: 10.1002/cam4.2277. Epub 2019 May 23. Review.

19.

Genetic diversity of cytochrome P450 2A with different metabolic activities in domestic cats.

Sugiyama S, Uno Y, Amano T, Kitazawa T, Teraoka H.

J Vet Med Sci. 2019 Jul 11;81(7):983-985. doi: 10.1292/jvms.19-0107. Epub 2019 May 21.

20.

Genetic diversity of cytochrome P450 1A2 with different metabolic activities in domestic cats.

Sugiyama S, Uno Y, Amano T, Kitazawa T, Teraoka H.

J Vet Med Sci. 2019 Jul 11;81(7):980-982. doi: 10.1292/jvms.19-0106. Epub 2019 May 21.

21.

Molecular and functional characterization of cytosolic sulfotransferases in cynomolgus macaque.

Uno Y, Murayama N, Yamazaki H.

Biochem Pharmacol. 2019 Aug;166:153-162. doi: 10.1016/j.bcp.2019.05.018. Epub 2019 May 14.

PMID:
31100221
22.

Quantitative facial expression analysis revealed the efficacy and time course of oxytocin in autism.

Owada K, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Yassin W, Kushima I, Benner S, Ogawa N, Kawano N, Eriguchi Y, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H, Yamasue H.

Brain. 2019 Jul 1;142(7):2127-2136. doi: 10.1093/brain/awz126.

PMID:
31096266
23.

ASO Author Reflections: Increased Expression of DNAJC12 is Associated with Aggressive Phenotype of Gastric Cancer.

Uno Y, Kanda M.

Ann Surg Oncol. 2019 Dec;26(Suppl 3):592-593. doi: 10.1245/s10434-019-07404-w. Epub 2019 Apr 24. No abstract available.

PMID:
31020503
24.

Risk of Probiotics: Functional Gastrointestinal Symptoms in Patients With Inflammatory Bowel Disease.

Uno Y.

Clin Gastroenterol Hepatol. 2019 Oct;17(11):2382-2383. doi: 10.1016/j.cgh.2019.04.031. Epub 2019 Apr 17. No abstract available.

PMID:
31004756
25.

[A New-born Case of Total Conus Defect and Single Coronary Artery with Situs Inversus Totalis Suspected Kartagener Syndrome].

Uno Y, Shinohara G, Nakao M, Morita K.

Kyobu Geka. 2019 Mar;72(3):199-203. Japanese.

PMID:
30923296
26.

Molecular cytogenetic characterization of repetitive sequences comprising centromeric heterochromatin in three Anseriformes species.

Uno Y, Nishida C, Hata A, Ishishita S, Matsuda Y.

PLoS One. 2019 Mar 26;14(3):e0214028. doi: 10.1371/journal.pone.0214028. eCollection 2019.

27.

Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques.

Uno Y, Takahira R, Murayama N, Onozeki S, Kawamura S, Uehara S, Ikenaka Y, Ishizuka M, Ikushiro S, Yamazaki H.

Biochem Pharmacol. 2019 May;163:335-344. doi: 10.1016/j.bcp.2019.03.002. Epub 2019 Mar 2.

PMID:
30836059
28.

Genetic diversity of cytochrome P450 3A with different metabolic activity in domestic cats.

Sugiyama S, Uno Y, Amano T, Kitazawa T, Teraoka H.

J Vet Med Sci. 2019 Apr 16;81(4):598-600. doi: 10.1292/jvms.18-0692. Epub 2019 Mar 4.

29.

Glutamate hypothesis in schizophrenia.

Uno Y, Coyle JT.

Psychiatry Clin Neurosci. 2019 May;73(5):204-215. doi: 10.1111/pcn.12823. Epub 2019 Mar 6. Review.

PMID:
30666759
30.

Functional characterization for polymorphic organic anion transporting polypeptides (OATP/SLCO1B1, 1B3, 2B1) of monkeys recombinantly expressed with various OATP probes.

Takahashi T, Uno Y, Yamazaki H, Kume T.

Biopharm Drug Dispos. 2019 Feb;40(2):62-69. doi: 10.1002/bdd.2171. Epub 2019 Feb 10.

PMID:
30652318
31.

Increased Expression of DNAJC12 is Associated with Aggressive Phenotype of Gastric Cancer.

Uno Y, Kanda M, Miwa T, Umeda S, Tanaka H, Tanaka C, Kobayashi D, Suenaga M, Hattori N, Hayashi M, Yamada S, Nakayama G, Fujiwara M, Kodera Y.

Ann Surg Oncol. 2019 Mar;26(3):836-844. doi: 10.1245/s10434-018-07149-y. Epub 2019 Jan 7.

PMID:
30617870
33.

Non-synonymous genetic variants of flavin-containing monooxygenase 3 (FMO3) in cynomolgus macaques.

Uno Y, Shimizu M, Yoda H, Origuchi Y, Yamazaki H.

Drug Metab Pharmacokinet. 2019 Feb;34(1):104-107. doi: 10.1016/j.dmpk.2018.09.001. Epub 2018 Sep 7.

PMID:
30420260
34.

Cytochrome P450 1A1, 2C9, 2C19, and 3A4 Polymorphisms Account for Interindividual Variability of Toxicological Drug Metabolism in Cynomolgus Macaques.

Uno Y, Uehara S, Murayama N, Yamazaki H.

Chem Res Toxicol. 2018 Dec 17;31(12):1373-1381. doi: 10.1021/acs.chemrestox.8b00257. Epub 2018 Nov 19.

PMID:
30412386
35.

Molecular and Functional Characterization of N-Acetyltransferases NAT1 and NAT2 in Cynomolgus Macaque.

Uno Y, Murayama N, Yamazaki H.

Chem Res Toxicol. 2018 Nov 19;31(11):1269-1276. doi: 10.1021/acs.chemrestox.8b00236. Epub 2018 Oct 25.

PMID:
30358977
36.

Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model.

Uehara S, Oshio T, Nakanishi K, Tomioka E, Suzuki M, Inoue T, Uno Y, Sasaki E, Yamazaki H.

Curr Drug Metab. 2019;20(2):103-113. doi: 10.2174/1389200219666181003143312. Review.

37.

Expression and metabolic activity of flavin-containing monooxygenase 1 in cynomolgus macaque kidney.

Uno Y, Shimizu M, Yoda H, Yamazaki H.

J Med Primatol. 2019 Feb;48(1):51-53. doi: 10.1111/jmp.12385. Epub 2018 Sep 25.

PMID:
30252147
38.

Functionally relevant genetic variants of glutathione S-transferase GSTM5 in cynomolgus and rhesus macaques.

Uno Y, Murayama N, Tamura K, Yamazaki H.

Xenobiotica. 2019 Aug;49(8):995-1000. doi: 10.1080/00498254.2018.1524187. Epub 2018 Dec 6.

PMID:
30216105
39.

Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights.

Kushima I, Aleksic B, Nakatochi M, Shimamura T, Okada T, Uno Y, Morikawa M, Ishizuka K, Shiino T, Kimura H, Arioka Y, Yoshimi A, Takasaki Y, Yu Y, Nakamura Y, Yamamoto M, Iidaka T, Iritani S, Inada T, Ogawa N, Shishido E, Torii Y, Kawano N, Omura Y, Yoshikawa T, Uchiyama T, Yamamoto T, Ikeda M, Hashimoto R, Yamamori H, Yasuda Y, Someya T, Watanabe Y, Egawa J, Nunokawa A, Itokawa M, Arai M, Miyashita M, Kobori A, Suzuki M, Takahashi T, Usami M, Kodaira M, Watanabe K, Sasaki T, Kuwabara H, Tochigi M, Nishimura F, Yamasue H, Eriguchi Y, Benner S, Kojima M, Yassin W, Munesue T, Yokoyama S, Kimura R, Funabiki Y, Kosaka H, Ishitobi M, Ohmori T, Numata S, Yoshikawa T, Toyota T, Yamakawa K, Suzuki T, Inoue Y, Nakaoka K, Goto YI, Inagaki M, Hashimoto N, Kusumi I, Son S, Murai T, Ikegame T, Okada N, Kasai K, Kunimoto S, Mori D, Iwata N, Ozaki N.

Cell Rep. 2018 Sep 11;24(11):2838-2856. doi: 10.1016/j.celrep.2018.08.022.

40.

Detection of betacyanin in red-tube spinach (Spinacia oleracea) and its biofortification by strategic hydroponics.

Watanabe S, Ohtani Y, Aoki W, Uno Y, Sukekiyo Y, Kubokawa S, Ueda M.

PLoS One. 2018 Sep 7;13(9):e0203656. doi: 10.1371/journal.pone.0203656. eCollection 2018.

41.

Genetic Variants of Glutathione S-Transferase GSTT1 and GSTT2 in Cynomolgus Macaques: Identification of GSTT Substrates and Functionally Relevant Alleles.

Uno Y, Murayama N, Kato M, Tanaka S, Ohkoshi T, Yamazaki H.

Chem Res Toxicol. 2018 Oct 15;31(10):1086-1091. doi: 10.1021/acs.chemrestox.8b00198. Epub 2018 Sep 13.

PMID:
30169019
42.

Functional characterization of insect-specific RabX6 of Bombyx mori.

Uno T, Ozakiya Y, Furutani M, Sakamoto K, Uno Y, Kajiwara H, Kanamaru K, Mizoguchi A.

Histochem Cell Biol. 2019 Feb;151(2):187-198. doi: 10.1007/s00418-018-1710-9. Epub 2018 Aug 21.

PMID:
30132061
43.

Expression, Functional Characterization, and Preliminary Crystallization of the Cochaperone Prefoldin from the Thermophilic Fungus Chaetomium thermophilum.

Morita K, Yamamoto YY, Hori A, Obata T, Uno Y, Shinohara K, Noguchi K, Noi K, Ogura T, Ishii K, Kato K, Kikumoto M, Arranz R, Valpuesta JM, Yohda M.

Int J Mol Sci. 2018 Aug 19;19(8). pii: E2452. doi: 10.3390/ijms19082452.

44.

Metabolism of steroids by cytochrome P450 2C9 variants.

Uno T, Nakano R, Kitagawa R, Okada M, Kanamaru K, Takenaka S, Uno Y, Imaishi H.

Biopharm Drug Dispos. 2018 Sep;39(8):371-377. doi: 10.1002/bdd.2153.

PMID:
30098040
45.

Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial.

Yamasue H, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Owada K, Yassin W, Kushima I, Benner S, Ogawa N, Eriguchi Y, Kawano N, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H.

Mol Psychiatry. 2018 Jun 29. doi: 10.1038/s41380-018-0097-2. [Epub ahead of print]

PMID:
29955161
46.

Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques.

Uno Y, Takahira R, Murayama N, Ishii Y, Ikenaka Y, Ishizuka M, Yamazaki H, Ikushiro S.

Biochem Pharmacol. 2018 Sep;155:172-181. doi: 10.1016/j.bcp.2018.06.027. Epub 2018 Jun 23.

PMID:
29944869
47.

The cholesterol, fatty acid and triglyceride synthesis pathways regulated by site 1 protease (S1P) are required for efficient replication of severe fever with thrombocytopenia syndrome virus.

Urata S, Uno Y, Kurosaki Y, Yasuda J.

Biochem Biophys Res Commun. 2018 Sep 5;503(2):631-636. doi: 10.1016/j.bbrc.2018.06.053. Epub 2018 Jun 14.

PMID:
29906459
48.

Limited expression of functional cytochrome p450 2c subtypes in the liver and small intestine of domestic cats.

Ono Y, Sugiyama S, Matsushita M, Kitazawa T, Amano T, Uno Y, Ikushiro S, Teraoka H.

Xenobiotica. 2019 Jun;49(6):627-635. doi: 10.1080/00498254.2018.1483543. Epub 2018 Jul 13.

PMID:
29848168
49.

"Latent Gastric Cancer" after Eradicating Helicobacter pylori.

Uno Y.

Gut Liver. 2018 May 15;12(3):367-368. doi: 10.5009/gnl17463. No abstract available.

50.

CLICK: one-step generation of conditional knockout mice.

Miyasaka Y, Uno Y, Yoshimi K, Kunihiro Y, Yoshimura T, Tanaka T, Ishikubo H, Hiraoka Y, Takemoto N, Tanaka T, Ooguchi Y, Skehel P, Aida T, Takeda J, Mashimo T.

BMC Genomics. 2018 May 2;19(1):318. doi: 10.1186/s12864-018-4713-y.

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