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Items: 1 to 50 of 563

1.

Non-synonymous genetic variants of flavin-containing monooxygenase 3 (FMO3) in cynomolgus macaques.

Uno Y, Shimizu M, Yoda H, Origuchi Y, Yamazaki H.

Drug Metab Pharmacokinet. 2018 Sep 7. pii: S1347-4367(18)30138-1. doi: 10.1016/j.dmpk.2018.09.001. [Epub ahead of print]

PMID:
30420260
2.

Cytochrome P450 1A1, 2C9, 2C19, and 3A4 polymorphisms account for inter-individual variability of toxicological drug metabolism in cynomolgus macaques.

Uno Y, Uehara S, Murayama N, Yamazaki H.

Chem Res Toxicol. 2018 Nov 9. doi: 10.1021/acs.chemrestox.8b00257. [Epub ahead of print]

PMID:
30412386
3.

Molecular and Functional Characterization of N-Acetyltransferases NAT1 and NAT2 in Cynomolgus Macaque.

Uno Y, Murayama N, Yamazaki H.

Chem Res Toxicol. 2018 Oct 25. doi: 10.1021/acs.chemrestox.8b00236. [Epub ahead of print]

PMID:
30358977
4.

Survey of Drug Oxidation Activities in Liver and Intestine Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model.

Uehara S, Oshio T, Nakanishi K, Tomioka E, Suzuki M, Inoue T, Uno Y, Sasaki E, Yamazaki H.

Curr Drug Metab. 2018 Oct 3. doi: 10.2174/1389200219666181003143312. [Epub ahead of print]

PMID:
30280664
5.

Expression and metabolic activity of flavin-containing monooxygenase 1 in cynomolgus macaque kidney.

Uno Y, Shimizu M, Yoda H, Yamazaki H.

J Med Primatol. 2018 Sep 25. doi: 10.1111/jmp.12385. [Epub ahead of print]

PMID:
30252147
6.

Functionally relevant genetic variants of glutathione S-transferase GSTM5 in cynomolgus and rhesus macaques.

Uno Y, Murayama N, Tamura K, Yamazaki H.

Xenobiotica. 2018 Sep 14:1-23. doi: 10.1080/00498254.2018.1524187. [Epub ahead of print]

PMID:
30216105
7.

Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights.

Kushima I, Aleksic B, Nakatochi M, Shimamura T, Okada T, Uno Y, Morikawa M, Ishizuka K, Shiino T, Kimura H, Arioka Y, Yoshimi A, Takasaki Y, Yu Y, Nakamura Y, Yamamoto M, Iidaka T, Iritani S, Inada T, Ogawa N, Shishido E, Torii Y, Kawano N, Omura Y, Yoshikawa T, Uchiyama T, Yamamoto T, Ikeda M, Hashimoto R, Yamamori H, Yasuda Y, Someya T, Watanabe Y, Egawa J, Nunokawa A, Itokawa M, Arai M, Miyashita M, Kobori A, Suzuki M, Takahashi T, Usami M, Kodaira M, Watanabe K, Sasaki T, Kuwabara H, Tochigi M, Nishimura F, Yamasue H, Eriguchi Y, Benner S, Kojima M, Yassin W, Munesue T, Yokoyama S, Kimura R, Funabiki Y, Kosaka H, Ishitobi M, Ohmori T, Numata S, Yoshikawa T, Toyota T, Yamakawa K, Suzuki T, Inoue Y, Nakaoka K, Goto YI, Inagaki M, Hashimoto N, Kusumi I, Son S, Murai T, Ikegame T, Okada N, Kasai K, Kunimoto S, Mori D, Iwata N, Ozaki N.

Cell Rep. 2018 Sep 11;24(11):2838-2856. doi: 10.1016/j.celrep.2018.08.022.

8.

Detection of betacyanin in red-tube spinach (Spinacia oleracea) and its biofortification by strategic hydroponics.

Watanabe S, Ohtani Y, Aoki W, Uno Y, Sukekiyo Y, Kubokawa S, Ueda M.

PLoS One. 2018 Sep 7;13(9):e0203656. doi: 10.1371/journal.pone.0203656. eCollection 2018.

9.

Genetic Variants of Glutathione S-Transferase GSTT1 and GSTT2 in Cynomolgus Macaques: Identification of GSTT Substrates and Functionally Relevant Alleles.

Uno Y, Murayama N, Kato M, Tanaka S, Ohkoshi T, Yamazaki H.

Chem Res Toxicol. 2018 Oct 15;31(10):1086-1091. doi: 10.1021/acs.chemrestox.8b00198. Epub 2018 Sep 13.

PMID:
30169019
10.

Functional characterization of insect-specific RabX6 of Bombyx mori.

Uno T, Ozakiya Y, Furutani M, Sakamoto K, Uno Y, Kajiwara H, Kanamaru K, Mizoguchi A.

Histochem Cell Biol. 2018 Aug 21. doi: 10.1007/s00418-018-1710-9. [Epub ahead of print]

PMID:
30132061
11.

Expression, Functional Characterization, and Preliminary Crystallization of the Cochaperone Prefoldin from the Thermophilic Fungus Chaetomium thermophilum.

Morita K, Yamamoto YY, Hori A, Obata T, Uno Y, Shinohara K, Noguchi K, Noi K, Ogura T, Ishii K, Kato K, Kikumoto M, Arranz R, Valpuesta JM, Yohda M.

Int J Mol Sci. 2018 Aug 19;19(8). pii: E2452. doi: 10.3390/ijms19082452.

12.

Metabolism of steroids by cytochrome P450 2C9 variants.

Uno T, Nakano R, Kitagawa R, Okada M, Kanamaru K, Takenaka S, Uno Y, Imaishi H.

Biopharm Drug Dispos. 2018 Sep;39(8):371-377. doi: 10.1002/bdd.2153.

PMID:
30098040
13.

Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial.

Yamasue H, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Owada K, Yassin W, Kushima I, Benner S, Ogawa N, Eriguchi Y, Kawano N, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H.

Mol Psychiatry. 2018 Jun 29. doi: 10.1038/s41380-018-0097-2. [Epub ahead of print]

PMID:
29955161
14.

Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques.

Uno Y, Takahira R, Murayama N, Ishii Y, Ikenaka Y, Ishizuka M, Yamazaki H, Ikushiro S.

Biochem Pharmacol. 2018 Sep;155:172-181. doi: 10.1016/j.bcp.2018.06.027. Epub 2018 Jun 23.

PMID:
29944869
15.

The cholesterol, fatty acid and triglyceride synthesis pathways regulated by site 1 protease (S1P) are required for efficient replication of severe fever with thrombocytopenia syndrome virus.

Urata S, Uno Y, Kurosaki Y, Yasuda J.

Biochem Biophys Res Commun. 2018 Sep 5;503(2):631-636. doi: 10.1016/j.bbrc.2018.06.053. Epub 2018 Jun 14.

PMID:
29906459
16.

Limited expression of functional cytochrome p450 2c subtypes in the liver and small intestine of domestic cats.

Ono Y, Sugiyama S, Matsushita M, Kitazawa T, Amano T, Uno Y, Ikushiro S, Teraoka H.

Xenobiotica. 2018 Jul 13:1-9. doi: 10.1080/00498254.2018.1483543. [Epub ahead of print]

PMID:
29848168
17.

"Latent Gastric Cancer" after Eradicating Helicobacter pylori.

Uno Y.

Gut Liver. 2018 May 15;12(3):367-368. doi: 10.5009/gnl17463. No abstract available.

18.

CLICK: one-step generation of conditional knockout mice.

Miyasaka Y, Uno Y, Yoshimi K, Kunihiro Y, Yoshimura T, Tanaka T, Ishikubo H, Hiraoka Y, Takemoto N, Tanaka T, Ooguchi Y, Skehel P, Aida T, Takeda J, Mashimo T.

BMC Genomics. 2018 May 2;19(1):318. doi: 10.1186/s12864-018-4713-y.

19.

[Effective Techniques to Reduce Radiation Exposure to Medical Staff during Assist of X-ray Computed Tomography Examination].

Miyajima R, Fujibuchi T, Miyachi Y, Tateishi S, Uno Y, Amakawa K, Ohura H, Orita S.

Nihon Hoshasen Gijutsu Gakkai Zasshi. 2018;74(4):326-334. doi: 10.6009/jjrt.2018_JSRT_74.4.326. Japanese.

20.

Colonic transit time and pressure based on Bernoulli's principle.

Uno Y.

Clin Exp Gastroenterol. 2018 Apr 5;11:153-163. doi: 10.2147/CEG.S153676. eCollection 2018.

21.

Importance of cynomolgus monkeys in development of monoclonal antibody drugs.

Iwasaki K, Uno Y, Utoh M, Yamazaki H.

Drug Metab Pharmacokinet. 2018 Mar 20. pii: S1347-4367(17)30074-5. doi: 10.1016/j.dmpk.2018.02.003. [Epub ahead of print] Review.

PMID:
29655914
22.

In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants.

Nakanishi K, Uehara S, Kusama T, Inoue T, Shimura K, Kamiya Y, Murayama N, Shimizu M, Uno Y, Sasaki E, Yamazaki H.

Biochem Pharmacol. 2018 Jun;152:272-278. doi: 10.1016/j.bcp.2018.04.002. Epub 2018 Apr 5.

PMID:
29626440
23.

Development and validation of a scoring system for prediction of insulin requirement for optimal control of blood glucose during glucocorticoid treatments.

Kawashima M, Taguchi K, Kitada Y, Yamauchi M, Ikeda T, Kajita K, Murakami D, Okada H, Uno Y, Mori I, Ishizuka T, Morita H.

Diabetes Res Clin Pract. 2018 Jun;140:72-80. doi: 10.1016/j.diabres.2018.03.043. Epub 2018 Apr 3.

PMID:
29621562
24.

Molecular characterization and polymorphisms of butyrylcholinesterase in cynomolgus macaques.

Uno Y, Uehara S, Mahadhi HMD, Ohura K, Hosokawa M, Imai T.

J Med Primatol. 2018 Jun;47(3):185-191. doi: 10.1111/jmp.12342. Epub 2018 Mar 24.

PMID:
29573432
25.

Correlation between the results of in vitro and in vivo chromosomal damage tests in consideration of exposure levels of test chemicals.

Yamamura E, Aruga C, Muto S, Baba N, Uno Y.

Genes Environ. 2018 Mar 6;40:6. doi: 10.1186/s41021-018-0094-3. eCollection 2018.

26.

Polymorphisms of cytochrome P450 2B6 (CYP2B6) in cynomolgus and rhesus macaques.

Uno Y, Uehara S, Yamazaki H.

J Med Primatol. 2018 Feb 22. doi: 10.1111/jmp.12336. [Epub ahead of print]

PMID:
29468688
27.

Radiation-induced enteropathy - how a low-FODMAP diet might help.

Uno Y.

Scand J Gastroenterol. 2018 Mar;53(3):377-378. doi: 10.1080/00365521.2018.1437929. Epub 2018 Feb 12. No abstract available.

PMID:
29433349
28.

Marmoset cytochrome P450 2B6, a propofol hydroxylase expressed in liver.

Oshio T, Uehara S, Uno Y, Inoue T, Sasaki E, Yamazaki H.

Xenobiotica. 2018 Feb 21:1-5. doi: 10.1080/00498254.2018.1439204. [Epub ahead of print]

PMID:
29417863
29.

Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver.

Uno Y, Igawa Y, Tanaka M, Ohura K, Hosokawa M, Imai T.

Xenobiotica. 2018 Apr 27:1-9. doi: 10.1080/00498254.2018.1435927. [Epub ahead of print]

PMID:
29384423
30.

Integrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder.

Takata A, Miyake N, Tsurusaki Y, Fukai R, Miyatake S, Koshimizu E, Kushima I, Okada T, Morikawa M, Uno Y, Ishizuka K, Nakamura K, Tsujii M, Yoshikawa T, Toyota T, Okamoto N, Hiraki Y, Hashimoto R, Yasuda Y, Saitoh S, Ohashi K, Sakai Y, Ohga S, Hara T, Kato M, Nakamura K, Ito A, Seiwa C, Shirahata E, Osaka H, Matsumoto A, Takeshita S, Tohyama J, Saikusa T, Matsuishi T, Nakamura T, Tsuboi T, Kato T, Suzuki T, Saitsu H, Nakashima M, Mizuguchi T, Tanaka F, Mori N, Ozaki N, Matsumoto N.

Cell Rep. 2018 Jan 16;22(3):734-747. doi: 10.1016/j.celrep.2017.12.074.

31.

Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility.

Yu Y, Lin Y, Takasaki Y, Wang C, Kimura H, Xing J, Ishizuka K, Toyama M, Kushima I, Mori D, Arioka Y, Uno Y, Shiino T, Nakamura Y, Okada T, Morikawa M, Ikeda M, Iwata N, Okahisa Y, Takaki M, Sakamoto S, Someya T, Egawa J, Usami M, Kodaira M, Yoshimi A, Oya-Ito T, Aleksic B, Ohno K, Ozaki N.

Transl Psychiatry. 2018 Jan 10;8(1):12. doi: 10.1038/s41398-017-0061-y.

32.

Letter: irritable bowel syndrome-how a low-FODMAP diet or yoga might help.

Uno Y.

Aliment Pharmacol Ther. 2018 Feb;47(3):444-445. doi: 10.1111/apt.14433. No abstract available.

PMID:
29314135
33.

Astrocytes in primary cultures express serine racemase, synthesize d-serine and acquire A1 reactive astrocyte features.

Li S, Uno Y, Rudolph U, Cobb J, Liu J, Anderson T, Levy D, Balu DT, Coyle JT.

Biochem Pharmacol. 2018 May;151:245-251. doi: 10.1016/j.bcp.2017.12.023. Epub 2018 Jan 3.

PMID:
29305854
34.

Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans.

Uno Y, Uehara S, Yamazaki H.

Biochem Pharmacol. 2018 Jul;153:184-195. doi: 10.1016/j.bcp.2017.12.015. Epub 2017 Dec 23. Review.

PMID:
29277691
35.

Analysis of major paralogs encoding the Fra a 1 allergen based on their organ-specificity in Fragaria × ananassa.

Ishibashi M, Nabe T, Nitta Y, Tsuruta H, Iduhara M, Uno Y.

Plant Cell Rep. 2018 Mar;37(3):411-424. doi: 10.1007/s00299-017-2237-6. Epub 2017 Nov 25.

PMID:
29177844
36.

Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies.

Murayama N, Yajima K, Hikawa M, Shimura K, Ishii Y, Takada M, Uno Y, Utoh M, Iwasaki K, Yamazaki H.

Biopharm Drug Dispos. 2018 Feb;39(2):116-121. doi: 10.1002/bdd.2115. Epub 2017 Dec 21.

PMID:
29136681
37.

FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice.

Misaka T, Murakawa T, Nishida K, Omori Y, Taneike M, Omiya S, Molenaar C, Uno Y, Yamaguchi O, Takeda J, Shah AM, Otsu K.

J Mol Cell Cardiol. 2018 Jan;114:93-104. doi: 10.1016/j.yjmcc.2017.11.004. Epub 2017 Nov 10.

38.

Possible involvement of a cell adhesion molecule, Migfilin, in brain development and pathogenesis of autism spectrum disorders.

Ishizuka K, Tabata H, Ito H, Kushima I, Noda M, Yoshimi A, Usami M, Watanabe K, Morikawa M, Uno Y, Okada T, Mori D, Aleksic B, Ozaki N, Nagata KI.

J Neurosci Res. 2018 May;96(5):789-802. doi: 10.1002/jnr.24194. Epub 2017 Nov 8.

PMID:
29114925
39.

Molecular cloning and tissue distribution of a novel marmoset ABC transporter.

Uehara S, Uno Y, Inoue T, Sasaki E, Yamazaki H.

Biopharm Drug Dispos. 2018 Jan;39(1):59-63. doi: 10.1002/bdd.2111. Epub 2017 Dec 11.

PMID:
29059459
40.

Letter: low-FODMAP diet for exercise-induced gastrointestinal syndrome.

Uno Y.

Aliment Pharmacol Ther. 2017 Nov;46(10):1021-1022. doi: 10.1111/apt.14330. No abstract available.

PMID:
29052863
41.

Association with polymorphic marmoset cytochrome P450 2C19 of in vivo hepatic clearances of chirally separated R-omeprazole and S-warfarin using individual marmoset physiologically based pharmacokinetic models.

Kusama T, Toda A, Shimizu M, Uehara S, Inoue T, Uno Y, Utoh M, Sasaki E, Yamazaki H.

Xenobiotica. 2018 Oct;48(10):1072-1077. doi: 10.1080/00498254.2017.1393121. Epub 2017 Nov 10.

PMID:
29034770
42.

Overexpression of microRNAs from the Gtl2-Rian locus contributes to postnatal death in mice.

Kumamoto S, Takahashi N, Nomura K, Fujiwara M, Kijioka M, Uno Y, Matsuda Y, Sotomaru Y, Kono T.

Hum Mol Genet. 2017 Oct 1;26(19):3653-3662. doi: 10.1093/hmg/ddx223.

43.

A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility.

Kimura H, Fujita Y, Kawabata T, Ishizuka K, Wang C, Iwayama Y, Okahisa Y, Kushima I, Morikawa M, Uno Y, Okada T, Ikeda M, Inada T, Branko A, Mori D, Yoshikawa T, Iwata N, Nakamura H, Yamashita T, Ozaki N.

Transl Psychiatry. 2017 Aug 22;7(8):e1214. doi: 10.1038/tp.2017.170.

44.

Social support helps protect against perinatal bonding failure and depression among mothers: a prospective cohort study.

Ohara M, Okada T, Aleksic B, Morikawa M, Kubota C, Nakamura Y, Shiino T, Yamauchi A, Uno Y, Murase S, Goto S, Kanai A, Masuda T, Nakatochi M, Ando M, Ozaki N.

Sci Rep. 2017 Aug 25;7(1):9546. doi: 10.1038/s41598-017-08768-3.

45.

Expression of cytochrome P450 regulators in cynomolgus macaque.

Uno Y, Yamazaki H.

Xenobiotica. 2018 Jul;48(7):695-703. doi: 10.1080/00498254.2017.1363928. Epub 2017 Sep 11.

PMID:
28812950
46.

Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders.

Ishizuka K, Fujita Y, Kawabata T, Kimura H, Iwayama Y, Inada T, Okahisa Y, Egawa J, Usami M, Kushima I, Uno Y, Okada T, Ikeda M, Aleksic B, Mori D, Someya T, Yoshikawa T, Iwata N, Nakamura H, Yamashita T, Ozaki N.

Transl Psychiatry. 2017 Aug 1;7(8):e1184. doi: 10.1038/tp.2017.173.

47.

Progesterone hydroxylation by cytochromes P450 2C and 3A enzymes in marmoset liver microsomes.

Nakanishi K, Uehara S, Uno Y, Inoue T, Sasaki E, Yamazaki H.

Xenobiotica. 2018 Aug;48(8):757-763. doi: 10.1080/00498254.2017.1363444. Epub 2017 Aug 17.

PMID:
28762864
48.

Metabolism of 7-ethoxycoumarin, flavanone and steroids by cytochrome P450 2C9 variants.

Uno T, Nakano R, Kanamaru K, Takenaka S, Uno Y, Imaishi H.

Biopharm Drug Dispos. 2017 Nov;38(8):486-493. doi: 10.1002/bdd.2090. Epub 2017 Oct 13.

PMID:
28758225
49.

Development of genotyping method for functionally relevant variants of cytochromes P450 in cynomolgus macaques.

Uno Y, Osada N, Sakurai S, Shimozawa N, Iwata T, Ikeo K, Yamazaki H.

J Vet Pharmacol Ther. 2018 Feb;41(1):e30-e34. doi: 10.1111/jvp.12443. Epub 2017 Jul 28.

PMID:
28752932
50.

Enigma of Intestinal Gas in Irritable Bowel Syndrome.

Uno Y.

Am J Gastroenterol. 2017 Jul;112(7):1166-1167. doi: 10.1038/ajg.2017.75. No abstract available.

PMID:
28725060

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