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Items: 6


Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells.

Chen HJ, Poran A, Unni AM, Huang SX, Elemento O, Snoeck HW, Varmus H.

J Exp Med. 2019 Feb 8. pii: jem.20181155. doi: 10.1084/jem.20181155. [Epub ahead of print]


Integrative Genomic Analyses Identifies GGA2 as a Cooperative Driver of EGFR-Mediated Lung Tumorigenesis.

O'Farrell H, Harbourne B, Kurlawala Z, Inoue Y, Nagelberg AL, Martinez VD, Lu D, Oh MH, Coe BP, Thu KL, Somwar R, Lam S, Lam WL, Unni AM, Beverly L, Lockwood WW.

J Thorac Oncol. 2018 Dec 19. pii: S1556-0864(18)33513-5. doi: 10.1016/j.jtho.2018.12.004. [Epub ahead of print]


Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells.

Unni AM, Harbourne B, Oh MH, Wild S, Ferrarone JR, Lockwood WW, Varmus H.

Elife. 2018 Nov 26;7. pii: e33718. doi: 10.7554/eLife.33718.


How Cancer Genomics Drives Cancer Biology: Does Synthetic Lethality Explain Mutually Exclusive Oncogenic Mutations?

Varmus H, Unni AM, Lockwood WW.

Cold Spring Harb Symp Quant Biol. 2016;81:247-255. doi: 10.1101/sqb.2016.81.030866. Epub 2017 Jan 25. Review.


Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma.

Unni AM, Lockwood WW, Zejnullahu K, Lee-Lin SQ, Varmus H.

Elife. 2015 Jun 5;4:e06907. doi: 10.7554/eLife.06907.


Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance.

Unni AM, Bondar T, Medzhitov R.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1686-91. doi: 10.1073/pnas.0701675105. Epub 2008 Jan 25.

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