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Items: 15

1.

1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile.

Hunt HJ, Belanoff JK, Golding E, Gourdet B, Phillips T, Swift D, Thomas J, Unitt JF, Walters I.

Bioorg Med Chem Lett. 2015 Dec 15;25(24):5720-5. doi: 10.1016/j.bmcl.2015.10.097. Epub 2015 Oct 31.

PMID:
26546213
2.

Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates.

Forbes LV, Sjögren T, Auchère F, Jenkins DW, Thong B, Laughton D, Hemsley P, Pairaudeau G, Turner R, Eriksson H, Unitt JF, Kettle AJ.

J Biol Chem. 2013 Dec 20;288(51):36636-47. doi: 10.1074/jbc.M113.507756. Epub 2013 Nov 5.

3.

Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription.

Ashall L, Horton CA, Nelson DE, Paszek P, Harper CV, Sillitoe K, Ryan S, Spiller DG, Unitt JF, Broomhead DS, Kell DB, Rand DA, Sée V, White MR.

Science. 2009 Apr 10;324(5924):242-6. doi: 10.1126/science.1164860.

4.

Oscillations in NF-kappaB signaling control the dynamics of gene expression.

Nelson DE, Ihekwaba AE, Elliott M, Johnson JR, Gibney CA, Foreman BE, Nelson G, See V, Horton CA, Spiller DG, Edwards SW, McDowell HP, Unitt JF, Sullivan E, Grimley R, Benson N, Broomhead D, Kell DB, White MR.

Science. 2004 Oct 22;306(5696):704-8.

5.

NF-kappaB signalling is inhibited by glucocorticoid receptor and STAT6 via distinct mechanisms.

Nelson G, Wilde GJ, Spiller DG, Kennedy SM, Ray DW, Sullivan E, Unitt JF, White MR.

J Cell Sci. 2003 Jun 15;116(Pt 12):2495-503. Epub 2003 May 6.

6.

Dynamic analysis of STAT6 signalling in living cells.

Nelson G, Wilde GJ, Spiller DG, Sullivan E, Unitt JF, White MR.

FEBS Lett. 2002 Dec 4;532(1-2):188-92.

7.

Multi-parameter analysis of the kinetics of NF-kappaB signalling and transcription in single living cells.

Nelson G, Paraoan L, Spiller DG, Wilde GJ, Browne MA, Djali PK, Unitt JF, Sullivan E, Floettmann E, White MR.

J Cell Sci. 2002 Mar 15;115(Pt 6):1137-48.

8.

Novel cobalt complex inhibitors of mitochondrial calcium uptake.

Unitt JF, Boden KL, Wallace AV, Ingall AH, Coombs ME, Ince F.

Bioorg Med Chem. 1999 Sep;7(9):1891-6.

PMID:
10530937
9.

Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airway diseases. 1. Discovery and biological evaluation of some 7-(2-aminoethyl)-4-hydroxybenzothiazol-2(3H)-one analogues.

Bonnert RV, Brown RC, Chapman D, Cheshire DR, Dixon J, Ince F, Kinchin EC, Lyons AJ, Davis AM, Hallam C, Harper ST, Unitt JF, Dougall IG, Jackson DM, McKechnie K, Young A, Simpson WT.

J Med Chem. 1998 Dec 3;41(25):4915-7. No abstract available.

PMID:
9836607
10.

Intracellular [Ca2+] staircase in the isovolumic pressure--frequency relationship of Langendorff-perfused rat heart.

Field ML, Azzawi A, Unitt JF, Seymour AM, Henderson C, Radda GK.

J Mol Cell Cardiol. 1996 Jan;28(1):65-77.

PMID:
8745215
11.

The acute effects of the creatine analogue, beta-guanidinopropionic acid, on cardiac energy metabolism and function.

Unitt JF, Radda GK, Seymour AM.

Biochim Biophys Acta. 1993 Jun 10;1143(1):91-6.

PMID:
8499456
12.

Determination of free creatine and phosphocreatine concentrations in the isolated perfused rat heart by 1H- and 31P-NMR.

Unitt JF, Schrader J, Brunotte F, Radda GK, Seymour AM.

Biochim Biophys Acta. 1992 Jan 13;1133(2):115-20.

PMID:
1731953
13.

Age-dependent changes in cardiac muscle metabolism upon replacement of creatine by beta- guanidinopropionic acid.

Field ML, Unitt JF, Radda GK, Henderson C, Seymour AM.

Biochem Soc Trans. 1991 Apr;19(2):208S. No abstract available.

PMID:
1889584
14.

Acute replacement of phosphocreatine in the isolated rat heart by perfusion with the creatine analogue beta-guanidinopropionic acid.

Unitt JF, Radda GK, Seymour AM.

Biochem Soc Trans. 1990 Aug;18(4):606-7. No abstract available.

PMID:
2276461

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