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Items: 1 to 50 of 115

1.

Molecular Mechanisms Associated with ROR1-Mediated Drug Resistance: Crosstalk with Hippo-YAP/TAZ and BMI-1 Pathways.

Karvonen H, Barker H, Kaleva L, Niininen W, Ungureanu D.

Cells. 2019 Aug 2;8(8). pii: E812. doi: 10.3390/cells8080812. Review.

2.

Transanal Total Mesorectal Excision - A Case Report.

Tudor Ș, Minciună C, Lăcătuş M, Gavrilă D, Manciu S, Ungureanu D, Cordun M, Vasilescu C.

Chirurgia (Bucur). 2019 Mar-Apr;114(2):278-283. doi: 10.21614/chirurgia.114.2.278.

3.

Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting.

Karvonen H, Perttilä R, Niininen W, Hautanen V, Barker H, Murumägi A, Heckman CA, Ungureanu D.

Oncogene. 2019 Apr;38(17):3288-3300. doi: 10.1038/s41388-018-0670-9. Epub 2019 Jan 10.

PMID:
30631148
4.

Expression Analysis of Platinum Sensitive and Resistant Epithelial Ovarian Cancer Patient Samples Reveals New Candidates for Targeted Therapies.

Veskimäe K, Scaravilli M, Niininen W, Karvonen H, Jaatinen S, Nykter M, Visakorpi T, Mäenpää J, Ungureanu D, Staff S.

Transl Oncol. 2018 Oct;11(5):1160-1170. doi: 10.1016/j.tranon.2018.07.010. Epub 2018 Jul 26.

5.

Targeting Wnt signaling pseudokinases in hematological cancers.

Karvonen H, Perttilä R, Niininen W, Barker H, Ungureanu D.

Eur J Haematol. 2018 Oct;101(4):457-465. doi: 10.1111/ejh.13137. Epub 2018 Sep 5. Review.

PMID:
29989208
6.

Crosstalk between ROR1 and BCR pathways defines novel treatment strategies in mantle cell lymphoma.

Karvonen H, Chiron D, Niininen W, Ek S, Jerkeman M, Moradi E, Nykter M, Heckman CA, Kallioniemi O, Murumägi A, Ungureanu D.

Blood Adv. 2017 Nov 9;1(24):2257-2268. doi: 10.1182/bloodadvances.2017010215. eCollection 2017 Nov 14.

7.

Interaction between ROR1 and MuSK activation complex in myogenic cells.

Karvonen H, Summala K, Niininen W, Barker HR, Ungureanu D.

FEBS Lett. 2018 Feb;592(3):434-445. doi: 10.1002/1873-3468.12966. Epub 2018 Jan 14.

8.

Perioperative Patient Blood Management Programme. Multidisciplinary recommendations from the Patient Blood Management Initiative Group.

Filipescu D, Bănăţeanu R, Beuran M, Burcoş T, Corneci D, Cristian D, Diculescu M, Dobrotă A, Droc G, Isacoff D, Goşa D, Grinţescu I, Lupu A, Mirea L, Posea C, Stanca O, Ştefan M, Tomescu D, Tudor C, Ungureanu D, Mircescu G.

Rom J Anaesth Intensive Care. 2017 Oct;24(2):139-157. doi: 10.21454/rjaic.7518.242.fil.

9.

Liver Resections in a High-Volume Center: Form Standard Procedures to Extreme Surgery and Ultrasound-guided Resections.

Botea F, Ionescu M, Braşoveanu V, Hrehoreţ D, Alexandrescu S, Grigorie M, Stanciulea O, Nicolaescu D, Tomescu D, Droc G, Ungureanu D, Fota R, Croitoru A, Gheorghe L, Gheorghe C, Lupescu I, Grasu M, Boroş M, Dumitru R, Toma M, Herlea V, Popescu I.

Chirurgia (Bucur). 2017 May-Jun;112(3):259-277. doi: 10.21614/chirurgia.112.3.259.

10.

The Romanian National Program for Liver Transplantation - 852 Procedures in 815 Patients over 17 Years (2000-2017): A Continuous Evolution to Success.

Popescu I, Ionescu M, Braşoveanu V, Hrehoreţ D, Copca N, Lupaşcu C, Botea F, Dorobanţu B, Alexandrescu S, Grigorie M, Matei E, Zamfir R, Lungu V, Tomescu D, Droc G, Ungureanu D, Fota R, Manga G, Popescu M, Popa L, Gheorghe L, Iacob S, Pietrăreanu C, Mihailă M, Mic L, Constantinescu S, Gheorghe C, Cotruta B, Lupescu I, Grasu M, Boroş M, Dumitru R, Toma M, Paslaru L, Vlad L, Constantinescu I, Dima I, Herlea V, Becheanu G, Pecheanu C, Sasalovici D.

Chirurgia (Bucur). 2017 May-Jun;112(3):229-243. doi: 10.21614/chirurgia.112.3.229.

11.

Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders.

Puleo DE, Kucera K, Hammarén HM, Ungureanu D, Newton AS, Silvennoinen O, Jorgensen WL, Schlessinger J.

ACS Med Chem Lett. 2017 May 17;8(6):618-621. doi: 10.1021/acsmedchemlett.7b00153. eCollection 2017 Jun 8.

12.

Targeting ROR1 identifies new treatment strategies in hematological cancers.

Karvonen H, Niininen W, Murumägi A, Ungureanu D.

Biochem Soc Trans. 2017 Apr 15;45(2):457-464. doi: 10.1042/BST20160272. Review.

PMID:
28408486
14.

First report of cytokine removal using CytoSorb® in severe noninfectious inflammatory syndrome after liver transplantation.

Tomescu DR, Olimpia Dima S, Ungureanu D, Popescu M, Tulbure D, Popescu I.

Int J Artif Organs. 2016 May 16;39(3):136-40. doi: 10.5301/ijao.5000489. Epub 2016 Apr 14.

PMID:
27079418
15.

The impact of donor liver graft quality on postoperative outcome in liver transplant recipients. A single centre experience.

Tomescu D, Popescu M, Jipa L, Fota R, Ungureanu D, Zamfir R, Orban C, Dima SO, Popescu I.

Rom J Anaesth Intensive Care. 2016 Apr;23(1):19-26. doi: 10.21454/rjaic.7518.231.gft.

16.

Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).

Min X, Ungureanu D, Maxwell S, Hammarén H, Thibault S, Hillert EK, Ayres M, Greenfield B, Eksterowicz J, Gabel C, Walker N, Silvennoinen O, Wang Z.

J Biol Chem. 2015 Nov 6;290(45):27261-70. doi: 10.1074/jbc.M115.672048. Epub 2015 Sep 10.

17.

Retromolar trigone--oropharynx junction maligns tumor surgery: transmandibular versus oral approach.

Cobzeanu BM, Popescu E, Costan VV, Ungureanu D, Cobzeanu MD.

Rev Med Chir Soc Med Nat Iasi. 2015 Jan-Mar;119(1):119-26.

PMID:
25970954
18.

ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation.

Hammarén HM, Ungureanu D, Grisouard J, Skoda RC, Hubbard SR, Silvennoinen O.

Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4642-7. doi: 10.1073/pnas.1423201112. Epub 2015 Mar 30.

19.

Measuring fatigue as a symptom in COPD: From descriptors and questionnaires to the importance of the problem.

Antoniu SA, Ungureanu D.

Chron Respir Dis. 2015 Aug;12(3):179-88. doi: 10.1177/1479972315575716. Epub 2015 Mar 6. Review.

PMID:
25749347
20.

What's new in ethics of cardio-pulmonary resuscitation research: too little time and too many rules?

Petriş AO, Cimpoeşu DC, Ungureanu D.

Intensive Care Med. 2015 Jan;41(1):120-2. doi: 10.1007/s00134-014-3557-4. Epub 2014 Nov 22. No abstract available.

PMID:
25416644
21.

Insulin resistance and adipokine levels correlate with early atherosclerosis - a study in prediabetic patients.

Mihai BM, Petriş AO, Ungureanu DA, Lăcătuşu CM.

Open Med (Wars). 2014 Sep 26;10(1):14-24. doi: 10.1515/med-2015-0003. eCollection 2015.

22.

The JH2 domain and SH2-JH2 linker regulate JAK2 activity: A detailed kinetic analysis of wild type and V617F mutant kinase domains.

Sanz Sanz A, Niranjan Y, Hammarén H, Ungureanu D, Ruijtenbeek R, Touw IP, Silvennoinen O, Hilhorst R.

Biochim Biophys Acta. 2014 Oct;1844(10):1835-41. doi: 10.1016/j.bbapap.2014.07.003. Epub 2014 Aug 7.

PMID:
25107665
23.

Vitamin D status in patients admitted in a clinic of endocrinology.

Găleanu C, Florescu A, Ungureanu MC, Grozavu I, Loghin A, Ungureanu D.

Rev Med Chir Soc Med Nat Iasi. 2014 Apr-Jun;118(2):327-32.

PMID:
25076695
24.

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase.

Shan Y, Gnanasambandan K, Ungureanu D, Kim ET, Hammarén H, Yamashita K, Silvennoinen O, Shaw DE, Hubbard SR.

Nat Struct Mol Biol. 2014 Jul;21(7):579-84. doi: 10.1038/nsmb.2849. Epub 2014 Jun 11.

25.

Immune therapies for malignant mesothelioma.

Antoniu SA, Dimofte G, Ungureanu D.

Expert Rev Anticancer Ther. 2014 Aug;14(8):965-73. doi: 10.1586/14737140.2014.919859. Epub 2014 May 16. Review.

PMID:
24833011
26.

Rad51 overexpression and resistance to genotoxic agents. A study in the fission yeast Schizosaccharomyces pombe.

Stanescu RS, Bordeianu G, Stoica B, Ungureanu D, Rusu M, Petrescu-Danila E.

Rev Med Chir Soc Med Nat Iasi. 2014 Jan-Mar;118(1):133-40.

PMID:
24741789
27.

Early dynamics of leptin plasma level in surgical critically ill patients. a prospective comparative study.

Grigoraş I, Branisteanu DD, Ungureanu D, Rusu D, Ristescu I.

Chirurgia (Bucur). 2014 Jan-Feb;109(1):66-72.

28.

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.

Varghese LN, Ungureanu D, Liau NP, Young SN, Laktyushin A, Hammaren H, Lucet IS, Nicola NA, Silvennoinen O, Babon JJ, Murphy JM.

Biochem J. 2014 Mar 1;458(2):395-405. doi: 10.1042/BJ20131516.

29.

Rad52 protein function study by fluorescence tagging.

Bordeianu G, Petrescu-Danila E, Ungureanu D, Stoica B, Stanescu R, Cernomaz A, Rusu M.

Rev Med Chir Soc Med Nat Iasi. 2013 Apr-Jun;117(2):444-9.

PMID:
24340529
30.

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.

Murphy JM, Zhang Q, Young SN, Reese ML, Bailey FP, Eyers PA, Ungureanu D, Hammaren H, Silvennoinen O, Varghese LN, Chen K, Tripaydonis A, Jura N, Fukuda K, Qin J, Nimchuk Z, Mudgett MB, Elowe S, Gee CL, Liu L, Daly RJ, Manning G, Babon JJ, Lucet IS.

Biochem J. 2014 Jan 15;457(2):323-34. doi: 10.1042/BJ20131174.

31.

Cardiac troponin T and NT-proBNP as biomarkers of early myocardial damage in amitriptyline-induced cardiovascular toxicity in rats.

Sorodoc V, Sorodoc L, Ungureanu D, Sava A, Jaba IM.

Int J Toxicol. 2013 Sep-Oct;32(5):351-7. doi: 10.1177/1091581813503888. Epub 2013 Sep 20.

PMID:
24055824
32.

Analysis of steady-state Förster resonance energy transfer data by avoiding pitfalls: interaction of JAK2 tyrosine kinase with N-methylanthraniloyl nucleotides.

Niranjan Y, Ungureanu D, Hammarén H, Sanz-Sanz A, Westphal AH, Borst JW, Silvennoinen O, Hilhorst R.

Anal Biochem. 2013 Nov 15;442(2):213-22. doi: 10.1016/j.ab.2013.07.020. Epub 2013 Jul 23.

PMID:
23891636
33.

New insights into the structure and function of the pseudokinase domain in JAK2.

Silvennoinen O, Ungureanu D, Niranjan Y, Hammaren H, Bandaranayake R, Hubbard SR.

Biochem Soc Trans. 2013 Aug;41(4):1002-7. doi: 10.1042/BST20130005. Review.

PMID:
23863170
34.

Non-alcoholic fatty liver disease is associated with cardiovascular risk factors of metabolic syndrome.

Hurjui DM, Niţă O, Graur LI, Mihalache L, Popescu DS, Huţanaşu IC, Ungureanu D, Graur M.

Rev Med Chir Soc Med Nat Iasi. 2012 Jul-Sep;116(3):692-9.

PMID:
23272512
35.

Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1.

Grönholm J, Vanhatupa S, Ungureanu D, Väliaho J, Laitinen T, Valjakka J, Silvennoinen O.

BMC Biochem. 2012 Oct 8;13:20. doi: 10.1186/1471-2091-13-20.

36.

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.

Bandaranayake RM, Ungureanu D, Shan Y, Shaw DE, Silvennoinen O, Hubbard SR.

Nat Struct Mol Biol. 2012 Aug;19(8):754-9. doi: 10.1038/nsmb.2348. Epub 2012 Jul 22.

37.

Evaluation of serum and gingival crevicular fluid C-reactive protein and IL-6 levels in patients with periodontitis and transient ischemic attacks.

Haba D, Teslaru S, Ungureanu D, Hodorog D, Alecu C, Benghiac AG, Zetu L, Ancuţa C, Ancuţa E, Nemţoi A, Iordache C.

Rom J Morphol Embryol. 2011;52(4):1243-7.

38.

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling.

Ungureanu D, Wu J, Pekkala T, Niranjan Y, Young C, Jensen ON, Xu CF, Neubert TA, Skoda RC, Hubbard SR, Silvennoinen O.

Nat Struct Mol Biol. 2011 Aug 14;18(9):971-6. doi: 10.1038/nsmb.2099.

39.

Analysis of Jak2 catalytic function by peptide microarrays: the role of the JH2 domain and V617F mutation.

Sanz A, Ungureanu D, Pekkala T, Ruijtenbeek R, Touw IP, Hilhorst R, Silvennoinen O.

PLoS One. 2011 Apr 18;6(4):e18522. doi: 10.1371/journal.pone.0018522.

40.

[Comparative study concerning food intake in a group of people with dyslipidemias vs. a control group in the Targu Neamt area].

Gonţea M, Gavăt V, Albu A, Ungureanu D.

Rev Med Chir Soc Med Nat Iasi. 2010 Apr-Jun;114(2):531-5. Romanian.

PMID:
20700998
41.

Sumoylation of Drosophila transcription factor STAT92E.

Grönholm J, Ungureanu D, Vanhatupa S, Rämet M, Silvennoinen O.

J Innate Immun. 2010;2(6):618-24. doi: 10.1159/000318676. Epub 2010 Jul 12.

42.

Total antioxidant status in the blood serum of rats after biogenic amines administration.

Zamosteanu N, Filip C, Albu E, Ungureanu D, Cuciureanu R.

Rev Med Chir Soc Med Nat Iasi. 2009 Apr-Jun;113(2):502-4.

PMID:
21491824
43.

[Evaluation of oral injuries in experimental induced diabetes mellitus by analysis of some gingival fluid markers].

Foia L, Toma V, Ungureanu D, Zlei M, Indrei A, Forna D, Habas D, Nanescu S.

Rev Med Chir Soc Med Nat Iasi. 2008 Oct-Dec;112(4):1066-71. Romanian.

PMID:
20209788
44.

Flow cytometry-based quantification of cytokine levels in AML patients plasma and cell culture supernatants.

Dăcălescu A, Zlei M, Aanei C, Ungureanu D, Tepeluş M, Burcoveanu C, Dănăilă C.

Rev Med Chir Soc Med Nat Iasi. 2008 Jan-Mar;112(1):196-202.

PMID:
18677926
45.

[Relationship diabetes mellitus-periodontal disease: etiology and risk factors].

Foia L, Toma V, Ungureanu D, Aanei C, Costuleanu M.

Rev Med Chir Soc Med Nat Iasi. 2007 Jul-Sep;111(3):748-53. Review. Romanian.

PMID:
18293711
46.

Th1 and Th2 cytokine response in patients with pulmonary tuberculosis and health care workers occupationally exposed to M. tuberculosis.

Cozmei C, Constantinescu D, Carasevici E, Anisie E, Ungureanu D, Sorete-Arbore A, Gramadă D, Mihăescu T, Croitoru C, Popa D.

Rev Med Chir Soc Med Nat Iasi. 2007 Jul-Sep;111(3):702-9.

PMID:
18293704
47.

MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1.

Vanhatupa S, Ungureanu D, Paakkunainen M, Silvennoinen O.

Biochem J. 2008 Jan 1;409(1):179-85.

PMID:
17897103
48.

[Acute urinary retention in primary vaginal carcinoma: therapeutic approach].

Glück G, Mitulescu G, Ungureanu D, Stîngu C.

Chirurgia (Bucur). 2007 May-Jun;102(3):349-54. Romanian.

PMID:
17687867
49.

[Oxidative stress and immune response in eumenorrheic underweight patients].

Mocanu V, Mandaşescu S, Dascaliţa AM, Ungureanu D, Costan AR, Luca V, Zbranca E.

Rev Med Chir Soc Med Nat Iasi. 2006 Oct-Dec;110(4):842-6. Romanian.

PMID:
17438885
50.

[High values of soluble cytokeratin 18 in breast carcinomas may have different meanings].

Cianga P, Cianga C, Anisie E, Zlei M, Ungureanu D, Munteanu D, Chifu C, Diaconu C, Carasevici E.

Rev Med Chir Soc Med Nat Iasi. 2005 Oct-Dec;109(4):836-40. Romanian.

PMID:
16610185

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