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Items: 1 to 50 of 52

1.

Antibodies to Protein but Not Glycolipid Structures Are Important for Host Defense against Mycoplasma pneumoniae.

Meyer Sauteur PM, de Bruijn ACJM, Graça C, Tio-Gillen AP, Estevão SC, Hoogenboezem T, Hendriks RW, Berger C, Jacobs BC, van Rossum AMC, Huizinga R, Unger WWJ.

Infect Immun. 2019 Jan 24;87(2). pii: e00663-18. doi: 10.1128/IAI.00663-18. Print 2019 Feb.

PMID:
30396892
2.

The Art and Science of Diagnosing Mycoplasma pneumoniae Infection.

Meyer Sauteur PM, Unger WWJ, van Rossum AMC, Berger C.

Pediatr Infect Dis J. 2018 Nov;37(11):1192-1195. doi: 10.1097/INF.0000000000002171. No abstract available.

PMID:
30169485
3.

Vertical Transmission of Mycoplasma pneumoniae Infection.

Huber BM, Meyer Sauteur PM, Unger WWJ, Hasters P, Eugster MR, Brandt S, Bloemberg GV, Natalucci G, Berger C.

Neonatology. 2018;114(4):332-336. doi: 10.1159/000490610. Epub 2018 Aug 8.

PMID:
30089291
4.

Intrathecal antibody responses to GalC in Guillain-Barré syndrome triggered by Mycoplasma pneumoniae.

Meyer Sauteur PM, Huizinga R, Tio-Gillen AP, Drenthen J, Unger WWJ, Jacobs E, van Rossum AMC, Jacobs BC.

J Neuroimmunol. 2018 Jan 15;314:13-16. doi: 10.1016/j.jneuroim.2017.11.011. Epub 2017 Nov 16.

PMID:
29301655
5.

Notch signaling is impaired during inflammation in a Lunatic Fringe-dependent manner.

Derada Troletti C, Lopes Pinheiro MA, Charabati M, Gowing E, van Het Hof B, van der Pol SMA, Geerts D, Prat A, Fontijn RD, Unger WW, de Vries HE.

Brain Behav Immun. 2018 Mar;69:48-56. doi: 10.1016/j.bbi.2017.12.016. Epub 2017 Dec 28.

PMID:
29289661
6.

Siglec-1 inhibits RSV-induced interferon gamma production by adult T cells in contrast to newborn T cells.

Jans J, Unger WWJ, Vissers M, Ahout IML, Schreurs I, Wickenhagen A, de Groot R, de Jonge MI, Ferwerda G.

Eur J Immunol. 2018 Apr;48(4):621-631. doi: 10.1002/eji.201747161. Epub 2018 Jan 18.

7.

Antibody responses to GalC in severe and complicated childhood Guillain-Barré syndrome.

Meyer Sauteur PM, Huizinga R, Tio-Gillen AP, de Wit MY, Unger WWJ, Berger C, van Rossum AMC, Jacobs BC.

J Peripher Nerv Syst. 2018 Mar;23(1):67-69. doi: 10.1111/jns.12243. No abstract available.

8.

The Role of B Cells in Carriage and Clearance of Mycoplasma pneumoniae From the Respiratory Tract of Mice.

Meyer Sauteur PM, de Groot RCA, Estevão SC, Hoogenboezem T, de Bruijn ACJM, Sluijter M, de Bruijn MJW, De Kleer IM, van Haperen R, van den Brand JMA, Bogaert D, Fraaij PLA, Vink C, Hendriks RW, Samsom JN, Unger WWJ, van Rossum AMC.

J Infect Dis. 2018 Jan 4;217(2):298-309. doi: 10.1093/infdis/jix559.

PMID:
29099932
9.

Things that could be Mycoplasma pneumoniae.

de Groot RCA, Meyer Sauteur PM, Unger WWJ, van Rossum AMC.

J Infect. 2017 Jun;74 Suppl 1:S95-S100. doi: 10.1016/S0163-4453(17)30198-6. Review.

PMID:
28646969
10.

Multi-center evaluation of one commercial and 12 in-house real-time PCR assays for detection of Mycoplasma pneumoniae.

Dumke R, Benitez AJ, Chalker V, Gullsby K, Henrich B, Hidalgo-Grass C, Hoogenboezem T, Kese D, Loens K, Maaskant J, Michael-Gayego A, Moses AE, Nir-Paz R, Pas SD, Pereyre S, Petersen RF, Rosenblatt M, van Rossum AMC, Uldum SA, Unger WWJ, Ursi D, Winchell JM, Bebear C; ESCMID Study Group for Mycoplasma Infections.

Diagn Microbiol Infect Dis. 2017 Jun;88(2):111-114. doi: 10.1016/j.diagmicrobio.2017.03.004. Epub 2017 Mar 8.

PMID:
28318608
11.

Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration.

Lopes Pinheiro MA, Kamermans A, Garcia-Vallejo JJ, van Het Hof B, Wierts L, O'Toole T, Boeve D, Verstege M, van der Pol SM, van Kooyk Y, de Vries HE, Unger WW.

Elife. 2016 Jun 23;5. pii: e13149. doi: 10.7554/eLife.13149.

12.

Infection with and Carriage of Mycoplasma pneumoniae in Children.

Meyer Sauteur PM, Unger WW, Nadal D, Berger C, Vink C, van Rossum AM.

Front Microbiol. 2016 Mar 23;7:329. doi: 10.3389/fmicb.2016.00329. eCollection 2016. Review.

13.

Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells.

Streng-Ouwehand I, Ho NI, Litjens M, Kalay H, Boks MA, Cornelissen LA, Kaur Singh S, Saeland E, Garcia-Vallejo JJ, Ossendorp FA, Unger WW, van Kooyk Y.

Elife. 2016 Mar 21;5. pii: e11765. doi: 10.7554/eLife.11765.

14.

Microbes and asthma: Opportunities for intervention.

Smits HH, Hiemstra PS, Prazeres da Costa C, Ege M, Edwards M, Garn H, Howarth PH, Jartti T, de Jong EC, Maizels RM, Marsland BJ, McSorley HJ, Müller A, Pfefferle PI, Savelkoul H, Schwarze J, Unger WW, von Mutius E, Yazdanbakhsh M, Taube C.

J Allergy Clin Immunol. 2016 Mar;137(3):690-7. doi: 10.1016/j.jaci.2016.01.004. Review.

PMID:
26947981
15.

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells.

Perdicchio M, Ilarregui JM, Verstege MI, Cornelissen LA, Schetters ST, Engels S, Ambrosini M, Kalay H, Veninga H, den Haan JM, van Berkel LA, Samsom JN, Crocker PR, Sparwasser T, Berod L, Garcia-Vallejo JJ, van Kooyk Y, Unger WW.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3329-34. doi: 10.1073/pnas.1507706113. Epub 2016 Mar 3.

16.

Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells.

Perdicchio M, Cornelissen LA, Streng-Ouwehand I, Engels S, Verstege MI, Boon L, Geerts D, van Kooyk Y, Unger WW.

Oncotarget. 2016 Feb 23;7(8):8771-82. doi: 10.18632/oncotarget.6822.

17.

Langerin-mediated internalization of a modified peptide routes antigens to early endosomes and enhances cross-presentation by human Langerhans cells.

Fehres CM, Duinkerken S, Bruijns SC, Kalay H, van Vliet SJ, Ambrosini M, de Gruijl TD, Unger WW, Garcia-Vallejo JJ, van Kooyk Y.

Cell Mol Immunol. 2017 Apr;14(4):360-370. doi: 10.1038/cmi.2015.87. Epub 2015 Oct 12.

18.

Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression.

Unger WW, Mayer CT, Engels S, Hesse C, Perdicchio M, Puttur F, Streng-Ouwehand I, Litjens M, Kalay H, Berod L, Sparwasser T, van Kooyk Y.

Oncoimmunology. 2014 Oct 31;4(8):e970462. eCollection 2015 Aug.

19.

Controlled release of a model vaccine by nanoporous ceramic microneedle arrays.

Boks MA, Unger WW, Engels S, Ambrosini M, Kooyk Yv, Luttge R.

Int J Pharm. 2015 Aug 1;491(1-2):375-83. doi: 10.1016/j.ijpharm.2015.06.025. Epub 2015 Jun 23.

PMID:
26116016
20.

In situ Delivery of Antigen to DC-SIGN(+)CD14(+) Dermal Dendritic Cells Results in Enhanced CD8(+) T-Cell Responses.

Fehres CM, van Beelen AJ, Bruijns SCM, Ambrosini M, Kalay H, Bloois LV, Unger WWJ, Garcia-Vallejo JJ, Storm G, de Gruijl TD, Kooyk YV.

J Invest Dermatol. 2015 Sep;135(9):2228-2236. doi: 10.1038/jid.2015.152. Epub 2015 Apr 14.

21.

Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation.

Baptista AP, Roozendaal R, Reijmers RM, Koning JJ, Unger WW, Greuter M, Keuning ED, Molenaar R, Goverse G, Sneeboer MM, den Haan JM, Boes M, Mebius RE.

Elife. 2014 Nov 19;3. doi: 10.7554/eLife.04433.

22.

CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG.

García-Vallejo JJ, Ilarregui JM, Kalay H, Chamorro S, Koning N, Unger WW, Ambrosini M, Montserrat V, Fernandes RJ, Bruijns SC, van Weering JR, Paauw NJ, O'Toole T, van Horssen J, van der Valk P, Nazmi K, Bolscher JG, Bajramovic J, Dijkstra CD, 't Hart BA, van Kooyk Y.

J Exp Med. 2014 Jun 30;211(7):1465-83. doi: 10.1084/jem.20122192. Epub 2014 Jun 16.

23.

Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8+ T-cell cross-priming.

Fehres CM, Bruijns SC, van Beelen AJ, Kalay H, Ambrosini M, Hooijberg E, Unger WW, de Gruijl TD, van Kooyk Y.

Eur J Immunol. 2014 Aug;44(8):2415-24. doi: 10.1002/eji.201344094. Epub 2014 Jun 24.

24.

Understanding the biology of antigen cross-presentation for the design of vaccines against cancer.

Fehres CM, Unger WW, Garcia-Vallejo JJ, van Kooyk Y.

Front Immunol. 2014 Apr 8;5:149. doi: 10.3389/fimmu.2014.00149. eCollection 2014. Review.

25.

Skin-resident antigen-presenting cells: instruction manual for vaccine development.

Fehres CM, Garcia-Vallejo JJ, Unger WW, van Kooyk Y.

Front Immunol. 2013 Jun 20;4:157. doi: 10.3389/fimmu.2013.00157. eCollection 2013.

26.

In vivo targeting of human DC-SIGN drastically enhances CD8⁺ T-cell-mediated protective immunity.

Hesse C, Ginter W, Förg T, Mayer CT, Baru AM, Arnold-Schrauf C, Unger WW, Kalay H, van Kooyk Y, Berod L, Sparwasser T.

Eur J Immunol. 2013 Oct;43(10):2543-53. doi: 10.1002/eji.201343429. Epub 2013 Jul 22.

27.

Glycan-based DC-SIGN targeting to enhance antigen cross-presentation in anticancer vaccines.

García-Vallejo JJ, Unger WW, Kalay H, van Kooyk Y.

Oncoimmunology. 2013 Feb 1;2(2):e23040.

28.

Notch controls generation and function of human effector CD8+ T cells.

Kuijk LM, Verstege MI, Rekers NV, Bruijns SC, Hooijberg E, Roep BO, de Gruijl TD, van Kooyk Y, Unger WW.

Blood. 2013 Apr 4;121(14):2638-46. doi: 10.1182/blood-2012-07-442962. Epub 2013 Feb 4.

29.

Glycan-based DC-SIGN targeting vaccines to enhance antigen cross-presentation.

van Kooyk Y, Unger WW, Fehres CM, Kalay H, García-Vallejo JJ.

Mol Immunol. 2013 Sep;55(2):143-5. doi: 10.1016/j.molimm.2012.10.031. Epub 2012 Nov 14. Review.

PMID:
23158834
30.

Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.

Unger WW, Pearson T, Abreu JR, Laban S, van der Slik AR, der Kracht SM, Kester MG, Serreze DV, Shultz LD, Griffioen M, Drijfhout JW, Greiner DL, Roep BO.

PLoS One. 2012;7(11):e49213. doi: 10.1371/journal.pone.0049213. Epub 2012 Nov 14.

31.

Multivalent glycopeptide dendrimers for the targeted delivery of antigens to dendritic cells.

García-Vallejo JJ, Ambrosini M, Overbeek A, van Riel WE, Bloem K, Unger WW, Chiodo F, Bolscher JG, Nazmi K, Kalay H, van Kooyk Y.

Mol Immunol. 2013 Apr;53(4):387-97. doi: 10.1016/j.molimm.2012.09.012. Epub 2012 Oct 24.

PMID:
23103377
32.

Glycan-modified liposomes boost CD4+ and CD8+ T-cell responses by targeting DC-SIGN on dendritic cells.

Unger WW, van Beelen AJ, Bruijns SC, Joshi M, Fehres CM, van Bloois L, Verstege MI, Ambrosini M, Kalay H, Nazmi K, Bolscher JG, Hooijberg E, de Gruijl TD, Storm G, van Kooyk Y.

J Control Release. 2012 May 30;160(1):88-95. doi: 10.1016/j.jconrel.2012.02.007. Epub 2012 Feb 15.

PMID:
22366522
33.

Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers.

Unger WW, Velthuis J, Abreu JR, Laban S, Quinten E, Kester MG, Reker-Hadrup S, Bakker AH, Duinkerken G, Mulder A, Franken KL, Hilbrands R, Keymeulen B, Peakman M, Ossendorp F, Drijfhout JW, Schumacher TN, Roep BO.

J Autoimmun. 2011 Nov;37(3):151-9. doi: 10.1016/j.jaut.2011.05.012. Epub 2011 Jun 1.

PMID:
21636247
34.

Design of neo-glycoconjugates that target the mannose receptor and enhance TLR-independent cross-presentation and Th1 polarization.

Singh SK, Streng-Ouwehand I, Litjens M, Kalay H, Burgdorf S, Saeland E, Kurts C, Unger WW, van Kooyk Y.

Eur J Immunol. 2011 Apr;41(4):916-25. doi: 10.1002/eji.201040762. Epub 2011 Mar 14.

35.

DC-SIGN mediated antigen-targeting using glycan-modified liposomes: formulation considerations.

Joshi MD, Unger WW, van Beelen AJ, Bruijns SC, Litjens M, van Bloois L, Kalay H, van Kooyk Y, Storm G.

Int J Pharm. 2011 Sep 20;416(2):426-32. doi: 10.1016/j.ijpharm.2011.02.055. Epub 2011 Mar 1.

PMID:
21371544
36.

C-type Lectin Receptors for Tumor Eradication: Future Directions.

Streng-Ouwehand I, Unger WW, Van Kooyk Y.

Cancers (Basel). 2011 Aug 8;3(3):3169-88. doi: 10.3390/cancers3033169.

37.

'Dressed for success' C-type lectin receptors for the delivery of glyco-vaccines to dendritic cells.

Unger WW, van Kooyk Y.

Curr Opin Immunol. 2011 Feb;23(1):131-7. doi: 10.1016/j.coi.2010.11.011. Epub 2010 Dec 17. Review.

PMID:
21169001
38.

Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers.

Velthuis JH, Unger WW, Abreu JR, Duinkerken G, Franken K, Peakman M, Bakker AH, Reker-Hadrup S, Keymeulen B, Drijfhout JW, Schumacher TN, Roep BO.

Diabetes. 2010 Jul;59(7):1721-30. doi: 10.2337/db09-1486. Epub 2010 Mar 31.

39.

Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: differential role for PD-L1.

Unger WW, Laban S, Kleijwegt FS, van der Slik AR, Roep BO.

Eur J Immunol. 2009 Nov;39(11):3147-59. doi: 10.1002/eji.200839103.

40.

TLR triggering on tolerogenic dendritic cells results in TLR2 up-regulation and a reduced proinflammatory immune program.

Chamorro S, García-Vallejo JJ, Unger WW, Fernandes RJ, Bruijns SC, Laban S, Roep BO, 't Hart BA, van Kooyk Y.

J Immunol. 2009 Sep 1;183(5):2984-94. doi: 10.4049/jimmunol.0801155. Epub 2009 Jul 31.

41.

Accumulation of autoreactive effector T cells and allo-specific regulatory T cells in the pancreas allograft of a type 1 diabetic recipient.

Velthuis JH, Unger WW, van der Slik AR, Duinkerken G, Engelse M, Schaapherder AF, Ringers J, van Kooten C, de Koning EJ, Roep BO.

Diabetologia. 2009 Mar;52(3):494-503. doi: 10.1007/s00125-008-1237-z. Epub 2008 Dec 23.

PMID:
19104770
42.

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.

Skowera A, Ellis RJ, Varela-Calviño R, Arif S, Huang GC, Van-Krinks C, Zaremba A, Rackham C, Allen JS, Tree TI, Zhao M, Dayan CM, Sewell AK, Unger WW, Drijfhout JW, Ossendorp F, Roep BO, Peakman M.

J Clin Invest. 2008 Oct;118(10):3390-402. doi: 10.1172/JCI35449. Erratum in: J Clin Invest. 2009 Sep;119(9):2844. Unger, Wendy [corrected to Unger, Wendy W].

43.

Identification of the immunodominant CTL epitope of EGFP in C57BL/6 mice.

Han WG, Unger WW, Wauben MH.

Gene Ther. 2008 May;15(9):700-1. doi: 10.1038/sj.gt.3303104. Epub 2008 Feb 21. No abstract available.

PMID:
18288211
44.

Differential inhibition of autoreactive memory- and alloreactive naive T cell responses by soluble cytotoxic T lymphocyte antigen 4 (sCTLA4), CTLA4Ig and LEA29Y.

Huurman VA, Unger WW, Koeleman BP, Oaks MK, Chandraker AK, Terpstra OT, Roep BO.

Clin Exp Immunol. 2007 Dec;150(3):487-93. Epub 2007 Oct 9.

45.

Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men.

Unger WW, Pinkse GG, Mulder-van der Kracht S, van der Slik AR, Kester MG, Ossendorp F, Drijfhout JW, Serreze DV, Roep BO.

Ann N Y Acad Sci. 2007 Apr;1103:192-5. Epub 2007 Mar 21.

PMID:
17376840
46.

New cohorts of naive T cells exacerbate ongoing allergy but can be suppressed by regulatory T cells.

Hauet-Broere F, Unger WW, van Berkel LA, Garssen J, Hoijer MA, Kraal G, Samsom JN.

Allergy. 2005 Dec;60(12):1530-6.

PMID:
16266386
47.

Fc gamma RIIB regulates nasal and oral tolerance: a role for dendritic cells.

Samsom JN, van Berkel LA, van Helvoort JM, Unger WW, Jansen W, Thepen T, Mebius RE, Verbeek SS, Kraal G.

J Immunol. 2005 May 1;174(9):5279-87.

48.

Early events in antigen-specific regulatory T cell induction via nasal and oral mucosa.

Samsom JN, Hauet-Broere F, Unger WW, VAN Berkel LA, Kraal G.

Ann N Y Acad Sci. 2004 Dec;1029:385-9.

PMID:
15681788
49.

Early events in peripheral regulatory T cell induction via the nasal mucosa.

Unger WW, Hauet-Broere F, Jansen W, van Berkel LA, Kraal G, Samsom JN.

J Immunol. 2003 Nov 1;171(9):4592-603.

50.

Functional CD25- and CD25+ mucosal regulatory T cells are induced in gut-draining lymphoid tissue within 48 h after oral antigen application.

Hauet-Broere F, Unger WW, Garssen J, Hoijer MA, Kraal G, Samsom JN.

Eur J Immunol. 2003 Oct;33(10):2801-10.

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