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The real impact of full hydroplaning on driving safety.

Spitzhüttl F, Goizet F, Unger T, Biesse F.

Accid Anal Prev. 2020 Feb 11;138:105458. doi: 10.1016/j.aap.2020.105458. [Epub ahead of print]


Rapid characterization of secreted recombinant proteins by native mass spectrometry.

Ben-Nissan G, Vimer S, Warszawski S, Katz A, Yona M, Unger T, Peleg Y, Morgenstern D, Cohen-Dvashi H, Diskin R, Fleishman SJ, Sharon M.

Commun Biol. 2018 Dec 3;1(1):213. doi: 10.1038/s42003-018-0231-3.


Effect of temperature on biogas yield increase and formation of refractory COD during thermal hydrolysis of waste activated sludge.

Toutian V, Barjenbruch M, Unger T, Loderer C, Remy C.

Water Res. 2020 Mar 15;171:115383. doi: 10.1016/j.watres.2019.115383. Epub 2019 Dec 11.


Two closed ATP- and ADP-dependent conformations in yeast Hsp90 chaperone detected by Mn(II) EPR spectroscopic techniques.

Giannoulis A, Feintuch A, Barak Y, Mazal H, Albeck S, Unger T, Yang F, Su XC, Goldfarb D.

Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):395-404. doi: 10.1073/pnas.1916030116. Epub 2019 Dec 20.


Phase 2 study of the Exportin 1 inhibitor selinexor in patients with recurrent gynecological malignancies.

Vergote IB, Lund B, Peen U, Umajuridze Z, Mau-Sorensen M, Kranich A, Van Nieuwenhuysen E, Haslund C, Nottrup T, Han SN, Concin N, Unger TJ, Chai Y, Au N, Rashal T, Joshi A, Crochiere M, Landesman Y, Shah J, Shacham S, Kauffman M, Mirza MR.

Gynecol Oncol. 2020 Feb;156(2):308-314. doi: 10.1016/j.ygyno.2019.11.012. Epub 2019 Dec 9.


Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases.

Cárdenas PD, Sonawane PD, Heinig U, Jozwiak A, Panda S, Abebie B, Kazachkova Y, Pliner M, Unger T, Wolf D, Ofner I, Vilaprinyo E, Meir S, Davydov O, Gal-On A, Burdman S, Giri A, Zamir D, Scherf T, Szymanski J, Rogachev I, Aharoni A.

Nat Commun. 2019 Nov 14;10(1):5169. doi: 10.1038/s41467-019-13211-4.


Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.

Warszawski S, Borenstein Katz A, Lipsh R, Khmelnitsky L, Ben Nissan G, Javitt G, Dym O, Unger T, Knop O, Albeck S, Diskin R, Fass D, Sharon M, Fleishman SJ.

PLoS Comput Biol. 2019 Aug 23;15(8):e1007207. doi: 10.1371/journal.pcbi.1007207. eCollection 2019 Aug.


The role of receptor MAS in microglia-driven retinal vascular development.

Foulquier S, Caolo V, Swennen G, Milanova I, Reinhold S, Recarti C, Alenina N, Bader M, Steckelings UM, Vanmierlo T, Post MJ, Jones EA, van Oostenbrugge RJ, Unger T.

Angiogenesis. 2019 Nov;22(4):481-489. doi: 10.1007/s10456-019-09671-3. Epub 2019 Jun 20.


Flexible regions govern promiscuous binding of IL-24 to receptors IL-20R1 and IL-22R1.

Zahradník J, Kolářová L, Peleg Y, Kolenko P, Svidenská S, Charnavets T, Unger T, Sussman JL, Schneider B.

FEBS J. 2019 Oct;286(19):3858-3873. doi: 10.1111/febs.14945. Epub 2019 Jun 12.


Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila.

Meltzer H, Marom E, Alyagor I, Mayseless O, Berkun V, Segal-Gilboa N, Unger T, Luginbuhl D, Schuldiner O.

Nat Commun. 2019 May 8;10(1):2113. doi: 10.1038/s41467-019-10140-0.


Tracking Conformational Changes in Calmodulin in vitro, in Cell Extract, and in Cells by Electron Paramagnetic Resonance Distance Measurements.

Dalaloyan A, Martorana A, Barak Y, Gataulin D, Reuveny E, Howe A, Elbaum M, Albeck S, Unger T, Frydman V, Abdelkader EH, Otting G, Goldfarb D.

Chemphyschem. 2019 Jul 16;20(14):1860-1868. doi: 10.1002/cphc.201900341. Epub 2019 Jun 26.


May Measurement Month 2017: Results of 39 national blood pressure screening programmes.

Poulter NR, Borghi C, Castillo RR, Charchar FJ, Ramirez AJ, Schlaich MP, Schutte AE, Stergiou G, Unger T, Wainford RD, Beaney T.

Eur Heart J Suppl. 2019 Apr;21(Suppl D):D1-D4. doi: 10.1093/eurheartj/suz055. Epub 2019 Apr 24.


Author Correction: Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity.

Chung CY, Berson A, Kennerdell JR, Sartoris A, Unger T, Porta S, Kim HJ, Smith ER, Shilatifard A, Van Deerlin V, Lee VM, Chen-Plotkin A, Bonini NM.

Nat Commun. 2019 Jan 29;10(1):555. doi: 10.1038/s41467-019-08562-x.


Rapid characterization of secreted recombinant proteins by native mass spectrometry.

Ben-Nissan G, Vimer S, Warszawski S, Katz A, Yona M, Unger T, Peleg Y, Morgenstern D, Cohen-Dvashi H, Diskin R, Fleishman SJ, Sharon M.

Commun Biol. 2018 Dec 3;1:213. doi: 10.1038/s42003-018-0231-3. eCollection 2018.


Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor.

Shraga A, Olshvang E, Davidzohn N, Khoshkenar P, Germain N, Shurrush K, Carvalho S, Avram L, Albeck S, Unger T, Lefker B, Subramanyam C, Hudkins RL, Mitchell A, Shulman Z, Kinoshita T, London N.

Cell Chem Biol. 2019 Jan 17;26(1):98-108.e5. doi: 10.1016/j.chembiol.2018.10.011. Epub 2018 Nov 15.


Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity.

Chung CY, Berson A, Kennerdell JR, Sartoris A, Unger T, Porta S, Kim HJ, Smith ER, Shilatifard A, Van Deerlin V, Lee VM, Chen-Plotkin A, Bonini NM.

Nat Commun. 2018 Oct 23;9(1):4406. doi: 10.1038/s41467-018-06543-0. Erratum in: Nat Commun. 2019 Jan 29;10(1):555.


Selinexor plus low-dose bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma.

Bahlis NJ, Sutherland H, White D, Sebag M, Lentzsch S, Kotb R, Venner CP, Gasparetto C, Del Col A, Neri P, Reece D, Kauffman M, Shacham S, Unger TJ, Jeha J, Saint-Martin JR, Shah J, Chen C.

Blood. 2018 Dec 13;132(24):2546-2554. doi: 10.1182/blood-2018-06-858852. Epub 2018 Oct 23.


Hypertension-induced cognitive impairment: insights from prolonged angiotensin II infusion in mice.

Foulquier S, Namsolleck P, Van Hagen BT, Milanova I, Post MJ, Blankesteijn WM, Rutten BP, Prickaerts J, Van Oostenbrugge RJ, Unger T.

Hypertens Res. 2018 Oct;41(10):817-827. doi: 10.1038/s41440-018-0090-9. Epub 2018 Aug 17.


Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents.

Kashyap T, Argueta C, Unger T, Klebanov B, Debler S, Senapedis W, Crochiere ML, Lee MS, Kauffman M, Shacham S, Landesman Y.

Oncotarget. 2018 Jul 20;9(56):30773-30786. doi: 10.18632/oncotarget.25637. eCollection 2018 Jul 20.


AT2R (Angiotensin AT2 Receptor) Agonist, Compound 21, Prevents Abdominal Aortic Aneurysm Progression in the Rat.

Lange C, Sommerfeld M, Namsolleck P, Kintscher U, Unger T, Kaschina E.

Hypertension. 2018 Sep;72(3):e20-e29. doi: 10.1161/HYPERTENSIONAHA.118.11168.


Selinexor synergizes with dexamethasone to repress mTORC1 signaling and induce multiple myeloma cell death.

Argueta C, Kashyap T, Klebanov B, Unger TJ, Guo C, Harrington S, Baloglu E, Lee M, Senapedis W, Shacham S, Landesman Y.

Oncotarget. 2018 May 22;9(39):25529-25544. doi: 10.18632/oncotarget.25368. eCollection 2018 May 22.


The oncogenic fusion protein CBFB-SMMHC downregulates CD48 to evade NK cell recognition.

Kahlon S, Shreibman D, Unger T, Ben-Yehuda D, Elias S.

Blood Cancer J. 2018 May 24;8(5):48. doi: 10.1038/s41408-018-0082-7. No abstract available.


Short-chain dehydrogenase/reductase governs steroidal specialized metabolites structural diversity and toxicity in the genus Solanum.

Sonawane PD, Heinig U, Panda S, Gilboa NS, Yona M, Kumar SP, Alkan N, Unger T, Bocobza S, Pliner M, Malitsky S, Tkachev M, Meir S, Rogachev I, Aharoni A.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5419-E5428. doi: 10.1073/pnas.1804835115. Epub 2018 May 21.


Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.

Goldenzweig A, Goldsmith M, Hill SE, Gertman O, Laurino P, Ashani Y, Dym O, Unger T, Albeck S, Prilusky J, Lieberman RL, Aharoni A, Silman I, Sussman JL, Tawfik DS, Fleishman SJ.

Mol Cell. 2018 Apr 19;70(2):380. doi: 10.1016/j.molcel.2018.03.035. No abstract available.


The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury.

Rathinasabapathy A, Horowitz A, Horton K, Kumar A, Gladson S, Unger T, Martinez D, Bedse G, West J, Raizada MK, Steckelings UM, Sumners C, Katovich MJ, Shenoy V.

Front Physiol. 2018 Mar 27;9:180. doi: 10.3389/fphys.2018.00180. eCollection 2018.


Clinical Implications of Targeting XPO1-mediated Nuclear Export in Multiple Myeloma.

Gandhi UH, Senapedis W, Baloglu E, Unger TJ, Chari A, Vogl D, Cornell RF.

Clin Lymphoma Myeloma Leuk. 2018 May;18(5):335-345. doi: 10.1016/j.clml.2018.03.003. Epub 2018 Mar 14. Review.


The angiotensin type 2 receptor in the human adrenocortical zona glomerulosa and in aldosterone-producing adenoma: low expression and no functional role.

Vanderriele PE, Caroccia B, Seccia TM, Piazza M, Lenzini L, Torresan F, Iacobone M, Unger T, Rossi GP.

Clin Sci (Lond). 2018 Mar 20;132(6):627-640. doi: 10.1042/CS20171593. Print 2018 Mar 30.


The role of PbI2 in CH3NH3PbI3 perovskite stability, solar cell parameters and device degradation.

Gujar TP, Unger T, Schönleber A, Fried M, Panzer F, van Smaalen S, Köhler A, Thelakkat M.

Phys Chem Chem Phys. 2017 Dec 20;20(1):605-614. doi: 10.1039/c7cp04749e.


Safety and efficacy of selinexor in relapsed or refractory multiple myeloma and Waldenstrom macroglobulinemia.

Chen C, Siegel D, Gutierrez M, Jacoby M, Hofmeister CC, Gabrail N, Baz R, Mau-Sorensen M, Berdeja JG, Savona M, Savoie L, Trudel S, Areethamsirikul N, Unger TJ, Rashal T, Hanke T, Kauffman M, Shacham S, Reece D.

Blood. 2018 Feb 22;131(8):855-863. doi: 10.1182/blood-2017-08-797886. Epub 2017 Dec 4.


Local energetic frustration affects the dependence of green fluorescent protein folding on the chaperonin GroEL.

Bandyopadhyay B, Goldenzweig A, Unger T, Adato O, Fleishman SJ, Unger R, Horovitz A.

J Biol Chem. 2017 Dec 15;292(50):20583-20591. doi: 10.1074/jbc.M117.808576. Epub 2017 Oct 24.


A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression.

Gallagher MD, Posavi M, Huang P, Unger TL, Berlyand Y, Gruenewald AL, Chesi A, Manduchi E, Wells AD, Grant SFA, Blobel GA, Brown CD, Chen-Plotkin AS.

Am J Hum Genet. 2017 Nov 2;101(5):643-663. doi: 10.1016/j.ajhg.2017.09.004. Epub 2017 Oct 19.


Protein recognition by a pattern-generating fluorescent molecular probe.

Pode Z, Peri-Naor R, Georgeson JM, Ilani T, Kiss V, Unger T, Markus B, Barr HM, Motiei L, Margulies D.

Nat Nanotechnol. 2017 Dec;12(12):1161-1168. doi: 10.1038/nnano.2017.175. Epub 2017 Oct 16. Review.


Principles for computational design of binding antibodies.

Baran D, Pszolla MG, Lapidoth GD, Norn C, Dym O, Unger T, Albeck S, Tyka MD, Fleishman SJ.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):10900-10905. doi: 10.1073/pnas.1707171114. Epub 2017 Sep 25.


Structural studies demonstrating a bacteriophage-like replication cycle of the eukaryote-infecting Paramecium bursaria chlorella virus-1.

Milrot E, Shimoni E, Dadosh T, Rechav K, Unger T, Van Etten JL, Minsky A.

PLoS Pathog. 2017 Aug 29;13(8):e1006562. doi: 10.1371/journal.ppat.1006562. eCollection 2017 Aug.


Excited state dynamics and conformations of a Cu(ii)-phthalocyanine-perylenebisimide dyad.

Wilma K, Unger T, Tuncel Kostakoğlu S, Hollfelder M, Hunger C, Lang A, Gürek AG, Thelakkat M, Köhler J, Köhler A, Gekle S, Hildner R.

Phys Chem Chem Phys. 2017 Aug 23;19(33):22169-22176. doi: 10.1039/c7cp04026a.


AT2 receptors in cardiovascular and renal diseases.

Kaschina E, Namsolleck P, Unger T.

Pharmacol Res. 2017 Nov;125(Pt A):39-47. doi: 10.1016/j.phrs.2017.07.008. Epub 2017 Jul 8. Review.


AT1-receptor blockade attenuates outward aortic remodeling associated with diet-induced obesity in mice.

Krueger F, Kappert K, Foryst-Ludwig A, Kramer F, Clemenz M, Grzesiak A, Sommerfeld M, Paul Frese J, Greiner A, Kintscher U, Unger T, Kaschina E.

Clin Sci (Lond). 2017 Jul 13;131(15):1989-2005. doi: 10.1042/CS20170131. Print 2017 Aug 1.


Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis.

Machlus KR, Wu SK, Vijey P, Soussou TS, Liu ZJ, Shacham E, Unger TJ, Kashyap T, Klebanov B, Sola-Visner M, Crochiere M, Italiano JE Jr, Landesman Y.

Blood. 2017 Aug 31;130(9):1132-1143. doi: 10.1182/blood-2016-11-752840. Epub 2017 Jun 19.


Corrigendum: Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism.

Sonawane PD, Pollier J, Panda S, Szymanski J, Massalha H, Yona M, Unger T, Malitsky S, Arendt P, Pauwels L, Almekias-Siegl E, Rogachev I, Meir S, Cárdenas PD, Masri A, Petrikov M, Schaller H, Schaffer AA, Kamble A, Giri AP, Goossens A, Aharoni A.

Nat Plants. 2017 Jun 12;3:17101. doi: 10.1038/nplants.2017.101.


Harnessing the Profinity eXact™ System for Expression and Purification of Heterologous Proteins in E. coli.

Peleg Y, Prabahar V, Bednarczyk D, Unger T.

Methods Mol Biol. 2017;1586:33-43. doi: 10.1007/978-1-4939-6887-9_3.


Selective inhibition of nuclear export with selinexor in patients with non-Hodgkin lymphoma.

Kuruvilla J, Savona M, Baz R, Mau-Sorensen PM, Gabrail N, Garzon R, Stone R, Wang M, Savoie L, Martin P, Flinn I, Jacoby M, Unger TJ, Saint-Martin JR, Rashal T, Friedlander S, Carlson R, Kauffman M, Shacham S, Gutierrez M.

Blood. 2017 Jun 15;129(24):3175-3183. doi: 10.1182/blood-2016-11-750174. Epub 2017 May 3.


Evidence for Heterodimerization and Functional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS.

Leonhardt J, Villela DC, Teichmann A, Münter LM, Mayer MC, Mardahl M, Kirsch S, Namsolleck P, Lucht K, Benz V, Alenina N, Daniell N, Horiuchi M, Iwai M, Multhaup G, Schülein R, Bader M, Santos RA, Unger T, Steckelings UM.

Hypertension. 2017 Jun;69(6):1128-1135. doi: 10.1161/HYPERTENSIONAHA.116.08814. Epub 2017 May 1.


Coordination of Meristem Doming and the Floral Transition by Late Termination, a Kelch Repeat Protein.

Tal L, Friedlander G, Gilboa NS, Unger T, Gilad S, Eshed Y.

Plant Cell. 2017 Apr;29(4):681-696. doi: 10.1105/tpc.17.00030. Epub 2017 Apr 7.


[Management of different cardiovascular risk factors with a combination tablet (polypill)].

Bramlage P, März W, Westermann D, Weisser B, Wirtz JH, Zeymer U, Baumgart P, van Mark G, Laufs U, Krämer BK, Unger T.

Herz. 2018 May;43(3):246-257. doi: 10.1007/s00059-017-4554-5. Epub 2017 Mar 24. Review. German.


A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia.

Garzon R, Savona M, Baz R, Andreeff M, Gabrail N, Gutierrez M, Savoie L, Mau-Sorensen PM, Wagner-Johnston N, Yee K, Unger TJ, Saint-Martin JR, Carlson R, Rashal T, Kashyap T, Klebanov B, Shacham S, Kauffman M, Stone R.

Blood. 2017 Jun 15;129(24):3165-3174. doi: 10.1182/blood-2016-11-750158. Epub 2017 Mar 23.


Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism.

Sonawane PD, Pollier J, Panda S, Szymanski J, Massalha H, Yona M, Unger T, Malitsky S, Arendt P, Pauwels L, Almekias-Siegl E, Rogachev I, Meir S, Cárdenas PD, Masri A, Petrikov M, Schaller H, Schaffer AA, Kamble A, Giri AP, Goossens A, Aharoni A.

Nat Plants. 2016 Dec 22;3:16205. doi: 10.1038/nplants.2016.205. Erratum in: Nat Plants. 2017 Jun 12;3:17101.


The angiotensin type 2 receptor and the kidney.

Peluso AA, Santos RA, Unger T, Steckelings UM.

Curr Opin Nephrol Hypertens. 2017 Jan;26(1):36-42. Review.


Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death.

Kashyap T, Argueta C, Aboukameel A, Unger TJ, Klebanov B, Mohammad RM, Muqbil I, Azmi AS, Drolen C, Senapedis W, Lee M, Kauffman M, Shacham S, Landesman Y.

Oncotarget. 2016 Nov 29;7(48):78883-78895. doi: 10.18632/oncotarget.12428.


Emission Enhancement and Intermittency in Polycrystalline Organolead Halide Perovskite Films.

Li C, Zhong Y, Luna CA, Unger T, Deichsel K, Gräser A, Köhler J, Köhler A, Hildner R, Huettner S.

Molecules. 2016 Aug 18;21(8). pii: E1081. doi: 10.3390/molecules21081081.


Phase IB Study of Selinexor, a First-in-Class Inhibitor of Nuclear Export, in Patients With Advanced Refractory Bone or Soft Tissue Sarcoma.

Gounder MM, Zer A, Tap WD, Salah S, Dickson MA, Gupta AA, Keohan ML, Loong HH, D'Angelo SP, Baker S, Condy M, Nyquist-Schultz K, Tanner L, Erinjeri JP, Jasmine FH, Friedlander S, Carlson R, Unger TJ, Saint-Martin JR, Rashal T, Ellis J, Kauffman M, Shacham S, Schwartz GK, Abdul Razak AR.

J Clin Oncol. 2016 Sep 10;34(26):3166-74. doi: 10.1200/JCO.2016.67.6346. Epub 2016 Jul 25. Erratum in: J Clin Oncol. 2017 Mar;35(7):812.

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