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Corpora amylacea in prostatectomy tissue and associations with molecular, histological, and lifestyle factors.

DuPre NC, Flavin R, Sfanos KS, Unger RH, To S, Gazeeva E, Fiorentino M, De Marzo AM, Rider JR, Mucci LA; Transdisciplinary Prostate Cancer Partnership(ToPCaP).

Prostate. 2018 Jul 15. doi: 10.1002/pros.23692. [Epub ahead of print]


Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice.

Sharma AX, Quittner-Strom EB, Lee Y, Johnson JA, Martin SA, Yu X, Li J, Lu J, Cai Z, Chen S, Wang MY, Zhang Y, Pearson MJ, Dorn AC, McDonald JG, Gordillo R, Yan H, Thai D, Wang ZV, Unger RH, Holland WL.

Cell Rep. 2018 Feb 13;22(7):1760-1773. doi: 10.1016/j.celrep.2018.01.065.


Dapagliflozin suppresses glucagon signaling in rodent models of diabetes.

Wang MY, Yu X, Lee Y, McCorkle SK, Chen S, Li J, Wang ZV, Davidson JA, Scherer PE, Holland WL, Unger RH, Roth MG.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6611-6616. doi: 10.1073/pnas.1705845114. Epub 2017 Jun 5.


Hypoglycemic Effect of Combined Ghrelin and Glucagon Receptor Blockade.

Mani BK, Uchida A, Lee Y, Osborne-Lawrence S, Charron MJ, Unger RH, Berglund ED, Zigman JM.

Diabetes. 2017 Jul;66(7):1847-1857. doi: 10.2337/db16-1303. Epub 2017 May 9.


Insulin and Glucagon: Partners for Life.

Holst JJ, Holland W, Gromada J, Lee Y, Unger RH, Yan H, Sloop KW, Kieffer TJ, Damond N, Herrera PL.

Endocrinology. 2017 Apr 1;158(4):696-701. doi: 10.1210/en.2016-1748. Review.


Glucagon antagonism in islet cell proliferation.

Dean ED, Unger RH, Holland WL.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3006-3008. doi: 10.1073/pnas.1700468114. Epub 2017 Mar 10. No abstract available.


Perineural Invasion and Risk of Lethal Prostate Cancer.

Zareba P, Flavin R, Isikbay M, Rider JR, Gerke TA, Finn S, Pettersson A, Giunchi F, Unger RH, Tinianow AM, Andersson SO, Andrén O, Fall K, Fiorentino M, Mucci LA; Transdisciplinary Prostate Cancer Partnership (ToPCaP).

Cancer Epidemiol Biomarkers Prev. 2017 May;26(5):719-726. doi: 10.1158/1055-9965.EPI-16-0237. Epub 2017 Jan 6.


Sniffing out significant "Pee values": genome wide association study of asparagus anosmia.

Markt SC, Nuttall E, Turman C, Sinnott J, Rimm EB, Ecsedy E, Unger RH, Fall K, Finn S, Jensen MK, Rider JR, Kraft P, Mucci LA.

BMJ. 2016 Dec 13;355:i6071. doi: 10.1136/bmj.i6071.


Clinical Trials, Triumphs, and Tribulations of Glucagon Receptor Antagonists.

Pearson MJ, Unger RH, Holland WL.

Diabetes Care. 2016 Jul;39(7):1075-7. doi: 10.2337/dci15-0033. No abstract available.


Glucagon is the key factor in the development of diabetes.

Lee YH, Wang MY, Yu XX, Unger RH.

Diabetologia. 2016 Jul;59(7):1372-1375. doi: 10.1007/s00125-016-3965-9. Epub 2016 Apr 26. Review.


MitoNEET-Parkin Effects in Pancreatic α- and β-Cells, Cellular Survival, and Intrainsular Cross Talk.

Kusminski CM, Chen S, Ye R, Sun K, Wang QA, Spurgin SB, Sanders PE, Brozinick JT, Geldenhuys WJ, Li WH, Unger RH, Scherer PE.

Diabetes. 2016 Jun;65(6):1534-55. doi: 10.2337/db15-1323. Epub 2016 Feb 19.


Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.

Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, McIntosh C, Nuttall E, Brandt I, Penney KL, Hartman M, Kraft P, Parmigiani G, Christensen K, Koskenvuo M, Holm NV, Heikkilä K, Pukkala E, Skytthe A, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) Collaboration.

JAMA. 2016 Jan 5;315(1):68-76. doi: 10.1001/jama.2015.17703. Erratum in: JAMA. 2016 Feb 23;315(8):822.


Glucagon therapeutics: Dawn of a new era for diabetes care.

Davidson JA, Holland WL, Roth MG, Wang MY, Lee Y, Yu X, McCorkle SK, Scherer PE, Unger RH.

Diabetes Metab Res Rev. 2016 Oct;32(7):660-665. doi: 10.1002/dmrr.2773. Epub 2016 Feb 7. Review.


An AlphaScreen Assay for the Discovery of Synthetic Chemical Inhibitors of Glucagon Production.

Evans MR, Wei S, Posner BA, Unger RH, Roth MG.

J Biomol Screen. 2016 Apr;21(4):325-32. doi: 10.1177/1087057115622201. Epub 2015 Dec 16.


ABO blood group alleles and prostate cancer risk: Results from the breast and prostate cancer cohort consortium (BPC3).

Markt SC, Shui IM, Unger RH, Urun Y, Berg CD, Black A, Brennan P, Bueno-de-Mesquita HB, Gapstur SM, Giovannucci E, Haiman C, Henderson B, Hoover RN, Hunter DJ, Key TJ, Khaw KT, Canzian F, Larranga N, Le Marchand L, Ma J, Naccarati A, Siddiq A, Stampfer MJ, Stattin P, Stevens VL, Stram DO, Tjønneland A, Travis RC, Trichopoulos D, Ziegler RG, Lindstrom S, Kraft P, Mucci LA, Choueiri TK, Wilson KM.

Prostate. 2015 Nov;75(15):1677-81. doi: 10.1002/pros.23035. Epub 2015 Aug 13.


Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway.

Wang MY, Yan H, Shi Z, Evans MR, Yu X, Lee Y, Chen S, Williams A, Philippe J, Roth MG, Unger RH.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2503-8. doi: 10.1073/pnas.1424934112. Epub 2015 Feb 9. Erratum in: Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4158. Dosage error in article text.


A new biology of diabetes revealed by leptin.

Unger RH, Roth MG.

Cell Metab. 2015 Jan 6;21(1):15-20. doi: 10.1016/j.cmet.2014.10.011. Epub 2014 Nov 20. Review. Erratum in: Cell Metab. 2015 Apr 7;21(4):647.


Alveolar-capillary adaptation to chronic hypoxia in the fatty lung.

Yilmaz C, Ravikumar P, Gyawali D, Iyer R, Unger RH, Hsia CC.

Acta Physiol (Oxf). 2015 Apr;213(4):933-46. doi: 10.1111/apha.12419. Epub 2014 Nov 25.


Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells.

Lee Y, Berglund ED, Yu X, Wang MY, Evans MR, Scherer PE, Holland WL, Charron MJ, Roth MG, Unger RH.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13217-22. doi: 10.1073/pnas.1409638111. Epub 2014 Aug 25.


Noninvasive assessment of alveolar microvascular recruitment in conscious non-sedated rats.

Yilmaz C, Dane DM, Ravikumar P, Unger RH, Hsia CC.

Respir Physiol Neurobiol. 2014 Jan 1;190:105-12. doi: 10.1016/j.resp.2013.09.010. Epub 2013 Oct 4.


Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine.

Unger RH, Scherer PE, Holland WL.

Mol Biol Cell. 2013 Oct;24(19):3011-5. doi: 10.1091/mbc.E12-10-0774.


Female hair restoration.

Unger RH.

Facial Plast Surg Clin North Am. 2013 Aug;21(3):407-17. doi: 10.1016/j.fsc.2013.05.011. Review.


Role of fibroblast growth factor 21 in biology of glucagon.

Berglund ED, Unger RH.

Diabetes. 2013 May;62(5):1376. doi: 10.2337/db12-1840. No abstract available.


Dissecting the actions of widely used diabetes drugs.

Unger RH, Berglund ED, Habener JF, Cherrington AD.

Nat Med. 2013 Mar;19(3):272-3. doi: 10.1038/nm.3123. No abstract available.


Estimating the number of lifetime follicular units: a survey and comments of experienced hair transplant surgeons.

Unger WP, Unger RH, Wesley CK.

Dermatol Surg. 2013 May;39(5):755-60. doi: 10.1111/dsu.12108. Epub 2013 Jan 7.


The influence of peri-incisional triamcinolone acetonide injection on wound edge apposition.

Wesley CK, Teo LH, Xu T, Unger RH, Unger WP.

J Dermatolog Treat. 2014 Aug;25(4):345-9. doi: 10.3109/09546634.2012.755253. Epub 2013 Feb 3.


Iatrogenic hyperinsulinemia in type 1 diabetes: its effect on atherogenic risk markers.

Wang MY, Yu X, Lee Y, McCorkle SK, Clark GO, Strowig S, Unger RH, Raskin P.

J Diabetes Complications. 2013 Jan-Feb;27(1):70-4. doi: 10.1016/j.jdiacomp.2012.08.008. Epub 2012 Oct 15.


Pancreatic steatosis and its relationship to β-cell dysfunction in humans: racial and ethnic variations.

Szczepaniak LS, Victor RG, Mathur R, Nelson MD, Szczepaniak EW, Tyer N, Chen I, Unger RH, Bergman RN, Lingvay I.

Diabetes Care. 2012 Nov;35(11):2377-83. doi: 10.2337/dc12-0701. Epub 2012 Sep 11.


Metabolic manifestations of insulin deficiency do not occur without glucagon action.

Lee Y, Berglund ED, Wang MY, Fu X, Yu X, Charron MJ, Burgess SC, Unger RH.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14972-6. doi: 10.1073/pnas.1205983109. Epub 2012 Aug 13.


Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover.

Unger RH, Cherrington AD.

J Clin Invest. 2012 Jan;122(1):4-12. doi: 10.1172/JCI60016. Epub 2012 Jan 3. Review.


Factors influencing postoperative hyperesthesia in hair restoration surgery.

Wesley CK, Unger RH, Rosenberg M, Unger MA, Unger WP.

J Cosmet Dermatol. 2011 Dec;10(4):301-6. doi: 10.1111/j.1473-2165.2011.00582.x.


Glucagon responses of isolated α cells to glucose, insulin, somatostatin, and leptin.

Chen L, Philippe J, Unger RH.

Endocr Pract. 2011 Sep-Oct;17(5):819-25. doi: 10.4158/EP11101.OR.


Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice.

Lee Y, Wang MY, Du XQ, Charron MJ, Unger RH.

Diabetes. 2011 Feb;60(2):391-7. doi: 10.2337/db10-0426.


Paracrinology of islets and the paracrinopathy of diabetes.

Unger RH, Orci L.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16009-12. doi: 10.1073/pnas.1006639107. Epub 2010 Aug 26.


Fatty diabetic lung: functional impairment in a model of metabolic syndrome.

Yilmaz C, Ravikumar P, Bellotto DJ, Unger RH, Hsia CC.

J Appl Physiol (1985). 2010 Dec;109(6):1913-9. doi: 10.1152/japplphysiol.00549.2010. Epub 2010 Aug 26.


Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats.

Kruger AJ, Yang C, Lipson KL, Pino SC, Leif JH, Hogan CM, Whalen BJ, Guberski DL, Lee Y, Unger RH, Greiner DL, Rossini AA, Bortell R.

Autoimmunity. 2011 Mar;44(2):137-48. doi: 10.3109/08916934.2010.482116. Epub 2010 Aug 9.


Technical insights from a former hair restoration surgery technician.

Unger RH, Wesley CK.

Dermatol Surg. 2010 May;36(5):679-82. doi: 10.1111/j.1524-4725.2010.01529.x. Epub 2010 Apr 1. No abstract available.


Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity.

Unger RH, Scherer PE.

Trends Endocrinol Metab. 2010 Jun;21(6):345-52. doi: 10.1016/j.tem.2010.01.009. Epub 2010 Mar 10. Review.


Leptin therapy in insulin-deficient type I diabetes.

Wang MY, Chen L, Clark GO, Lee Y, Stevens RD, Ilkayeva OR, Wenner BR, Bain JR, Charron MJ, Newgard CB, Unger RH.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4813-9. doi: 10.1073/pnas.0909422107. Epub 2010 Mar 1.


Fatty diabetic lung: altered alveolar structure and surfactant protein expression.

Foster DJ, Ravikumar P, Bellotto DJ, Unger RH, Hsia CC.

Am J Physiol Lung Cell Mol Physiol. 2010 Mar;298(3):L392-403. doi: 10.1152/ajplung.00041.2009. Epub 2010 Jan 8.


Special issue on lipotoxicity.

Vidal-Puig A, Unger RH.

Biochim Biophys Acta. 2010 Mar;1801(3):207-8. doi: 10.1016/j.bbalip.2009.12.010. Epub 2010 Jan 4. No abstract available.


Pancreatic steatosis: harbinger of type 2 diabetes in obese rodents.

Lee Y, Lingvay I, Szczepaniak LS, Ravazzola M, Orci L, Unger RH.

Int J Obes (Lond). 2010 Feb;34(2):396-400. doi: 10.1038/ijo.2009.245. Epub 2009 Dec 15.


Lipid homeostasis, lipotoxicity and the metabolic syndrome.

Unger RH, Clark GO, Scherer PE, Orci L.

Biochim Biophys Acta. 2010 Mar;1801(3):209-14. doi: 10.1016/j.bbalip.2009.10.006. Epub 2009 Nov 27. Review.


Noninvasive quantification of pancreatic fat in humans.

Lingvay I, Esser V, Legendre JL, Price AL, Wertz KM, Adams-Huet B, Zhang S, Unger RH, Szczepaniak LS.

J Clin Endocrinol Metab. 2009 Oct;94(10):4070-6. doi: 10.1210/jc.2009-0584. Epub 2009 Sep 22.


Diabetes and apoptosis: lipotoxicity.

Kusminski CM, Shetty S, Orci L, Unger RH, Scherer PE.

Apoptosis. 2009 Dec;14(12):1484-95. doi: 10.1007/s10495-009-0352-8. Review.


Making insulin-deficient type 1 diabetic rodents thrive without insulin.

Yu X, Park BH, Wang MY, Wang ZV, Unger RH.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14070-5. doi: 10.1073/pnas.0806993105. Epub 2008 Sep 8.


Noninvasive tracking of gene expression by reporter transgene imaging.

Unger RH.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12641-2. doi: 10.1073/pnas.0806875105. No abstract available.


Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome.

Wang MY, Grayburn P, Chen S, Ravazzola M, Orci L, Unger RH.

Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6139-44. doi: 10.1073/pnas.0801981105. Epub 2008 Apr 14.


How obesity causes diabetes in Zucker diabetic fatty rats.

Unger RH.

Trends Endocrinol Metab. 1997 Sep;8(7):276-82.


Reinventing type 2 diabetes: pathogenesis, treatment, and prevention.

Unger RH.

JAMA. 2008 Mar 12;299(10):1185-7. doi: 10.1001/jama.299.10.1185. No abstract available.


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