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Genomic analysis and antimicrobial resistance of Neisseria gonorrhoeae isolates from Vietnam in 2011 and 2015-16.

Lan PT, Golparian D, Ringlander J, Van Hung L, Van Thuong N, Unemo M.

J Antimicrob Chemother. 2020 Feb 18. pii: dkaa040. doi: 10.1093/jac/dkaa040. [Epub ahead of print]


Validation of an Aptima-format Finnish new variant of Chlamydia trachomatis (FI-nvCT) surveillance assay, 2019.

Weinbaum B, Williams A, Hadad R, Vinluan B, Puolakkainen M, Unemo M, Getman D.

Euro Surveill. 2020 Feb;25(5). doi: 10.2807/1560-7917.ES.2020.25.5.2000038.


Bacterial vaginosis-associated vaginal microbiota is an age-independent risk factor for Chlamydia trachomatis, Mycoplasma genitalium and Trichomonas vaginalis infections in low-risk women, St. Petersburg, Russia.

Shipitsyna E, Khusnutdinova T, Budilovskaya O, Krysanova A, Shalepo K, Savicheva A, Unemo M.

Eur J Clin Microbiol Infect Dis. 2020 Feb 8. doi: 10.1007/s10096-020-03831-w. [Epub ahead of print]


Antimicrobial resistance in Neisseria gonorrhoeae isolates from foreign-born population in the European Gonococcal Antimicrobial Surveillance Programme.

Hernando Rovirola C, Spiteri G, Sabidó M, Montoliu A, Gonzalez V, Casabona J, Cole MJ, Noori T, Unemo M.

Sex Transm Infect. 2020 Feb 4. pii: sextrans-2018-053912. doi: 10.1136/sextrans-2018-053912. [Epub ahead of print]


Genomic evolution of Neisseria gonorrhoeae since the preantibiotic era (1928-2013): antimicrobial use/misuse selects for resistance and drives evolution.

Golparian D, Harris SR, Sánchez-Busó L, Hoffmann S, Shafer WM, Bentley SD, Jensen JS, Unemo M.

BMC Genomics. 2020 Feb 3;21(1):116. doi: 10.1186/s12864-020-6511-6.


Antimicrobial resistance in Mycoplasma genitalium sampled from the British general population.

Pitt R, Unemo M, Sonnenberg P, Alexander S, Beddows S, Cole MJ, Clifton S, Mercer CH, Johnson AM, Ison CA, Field N.

Sex Transm Infect. 2020 Jan 10. pii: sextrans-2019-054129. doi: 10.1136/sextrans-2019-054129. [Epub ahead of print]


Adherence to the 2012 European gonorrhoea guideline in the WHO European Region according to the 2018-19 International Union against Sexually Transmitted Infections European Collaborative Clinical Group gonorrhoea survey.

Unemo M, Clarke E, Boiko I, Patel C, Patel R; ECCG Core Group.

Int J STD AIDS. 2020 Jan;31(1):69-76. doi: 10.1177/0956462419879278. Epub 2019 Dec 16. No abstract available.


The European gonococcal antimicrobial surveillance programme (Euro-GASP) appropriately reflects the antimicrobial resistance situation for Neisseria gonorrhoeae in the European Union/European Economic Area.

Cole MJ, Quinten C, Jacobsson S, Day M, Amato-Gauci AJ, Woodford N, Spiteri G, Unemo M; Euro-GASP network.

BMC Infect Dis. 2019 Dec 10;19(1):1040. doi: 10.1186/s12879-019-4631-x.


The first wide-scale drug repurposing screen using the Prestwick Chemical Library (1200 bioactive molecules) against Neisseria gonorrhoeae identifies high in vitro activity of auranofin and many additional drugs.

Foerster S, Gustafsson TN, Brochado AR, Desilvestro V, Typas A, Unemo M.

APMIS. 2019 Dec 7. doi: 10.1111/apm.13014. [Epub ahead of print]


The 2018-19 International Union against Sexually Transmitted Infections European Collaborative Clinical Group report on the diagnosis and treatment of gonorrhoea in Europe.

Clarke E, Patel C, Patel R, Unemo M; European Collaborative Clinical Group (ECCG).

Int J STD AIDS. 2020 Jan;31(1):77-81. doi: 10.1177/0956462419879270. Epub 2019 Dec 2. No abstract available.



Unemo M, Seifert HS, Hook EW 3rd, Hawkes S, Ndowa F, Dillon JR.

Nat Rev Dis Primers. 2019 Nov 21;5(1):79. doi: 10.1038/s41572-019-0128-6. Review.


In vitro antimicrobial combination testing of and evolution of resistance to the first-in-class spiropyrimidinetrione zoliflodacin combined with six therapeutically relevant antimicrobials for Neisseria gonorrhoeae.

Foerster S, Drusano G, Golparian D, Neely M, Piddock LJV, Alirol E, Unemo M.

J Antimicrob Chemother. 2019 Dec 1;74(12):3521-3529. doi: 10.1093/jac/dkz376.


C4BP-IgM protein as a therapeutic approach to treat Neisseria gonorrhoeae infections.

Bettoni S, Shaughnessy J, Maziarz K, Ermert D, Gulati S, Zheng B, Mörgelin M, Jacobsson S, Riesbeck K, Unemo M, Ram S, Blom AM.

JCI Insight. 2019 Dec 5;4(23). pii: 131886. doi: 10.1172/jci.insight.131886.


The 'Finnish new variant of Chlamydia trachomatis' escaping detection in the Aptima Combo 2 assay is widespread across Norway, June to August 2019.

Johansen TB, Kløvstad H, Rykkvin R, Herrfurth-Erichsen EB, Sorthe J, Njølstad G, Ebbesen MH, Nygaard RM, Sandmoen EK, Thilesen C, Onken A, Liljedal I, Hadad R, Unemo M.

Euro Surveill. 2019 Oct;24(42). doi: 10.2807/1560-7917.ES.2019.24.42.1900592.


Genetic variation regulates the activation and specificity of Restriction-Modification systems in Neisseria gonorrhoeae.

Sánchez-Busó L, Golparian D, Parkhill J, Unemo M, Harris SR.

Sci Rep. 2019 Oct 11;9(1):14685. doi: 10.1038/s41598-019-51102-2.


Antimicrobial resistance (AMR) and molecular characterization of Neisseria gonorrhoeae in Ghana, 2012-2015.

Attram N, Agbodzi B, Dela H, Behene E, Nyarko EO, Kyei NNA, Larbi JA, Lawson BWL, Addo KK, Newman MJ, Duplessis CA, Adams N, Unemo M, Letizia AG.

PLoS One. 2019 Oct 10;14(10):e0223598. doi: 10.1371/journal.pone.0223598. eCollection 2019.


Rise and fall of the new variant of Chlamydia trachomatis in Sweden: mathematical modelling study.

Smid JH, Althaus CL, Low N, Unemo M, Herrmann B.

Sex Transm Infect. 2019 Oct 5. pii: sextrans-2019-054057. doi: 10.1136/sextrans-2019-054057. [Epub ahead of print]


High in vitro susceptibility to the first-in-class spiropyrimidinetrione zoliflodacin among consecutive clinical Neisseria gonorrhoeae isolates from Thailand (2018) and South Africa (2015-2017).

Jacobsson S, Kularatne R, Kittiyaowamarn R, Maseko V, Paopang P, Sangprasert P, Sirivongrangson P, Piddock L, Wi T, Alirol E, Unemo M.

Antimicrob Agents Chemother. 2019 Sep 23. pii: AAC.01479-19. doi: 10.1128/AAC.01479-19. [Epub ahead of print]


Diagnosing sexually transmitted infections in resource-constrained settings: challenges and ways forward.

Wi TE, Ndowa FJ, Ferreyra C, Kelly-Cirino C, Taylor MM, Toskin I, Kiarie J, Santesso N, Unemo M.

J Int AIDS Soc. 2019 Aug;22 Suppl 6:e25343. doi: 10.1002/jia2.25343. Review.


World Health Organization Global Gonococcal Antimicrobial Surveillance Program (WHO GASP): review of new data and evidence to inform international collaborative actions and research efforts.

Unemo M, Lahra MM, Cole M, Galarza P, Ndowa F, Martin I, Dillon JR, Ramon-Pardo P, Bolan G, Wi T.

Sex Health. 2019 Aug 23. doi: 10.1071/SH19023. [Epub ahead of print]


Gentamicin 240 mg plus azithromycin 2 g vs. ceftriaxone 500 mg plus azithromycin 2 g for treatment of rectal and pharyngeal gonorrhoea: a randomized controlled trial.

Rob F, Klubalová B, Nyčová E, Hercogová J, Unemo M.

Clin Microbiol Infect. 2020 Feb;26(2):207-212. doi: 10.1016/j.cmi.2019.08.004. Epub 2019 Aug 14.


Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016.

Rowley J, Vander Hoorn S, Korenromp E, Low N, Unemo M, Abu-Raddad LJ, Chico RM, Smolak A, Newman L, Gottlieb S, Thwin SS, Broutet N, Taylor MM.

Bull World Health Organ. 2019 Aug 1;97(8):548-562P. doi: 10.2471/BLT.18.228486. Epub 2019 Jun 6.


The Finnish New Variant of Chlamydia trachomatis with a Single Nucleotide Polymorphism in the 23S rRNA Target Escapes Detection by the Aptima Combo 2 Test.

Hokynar K, Rantakokko-Jalava K, Hakanen A, Havana M, Mannonen L, Jokela P, Kurkela S, Lappalainen M, Unemo M, Puolakkainen M.

Microorganisms. 2019 Jul 31;7(8). pii: E227. doi: 10.3390/microorganisms7080227.


The impact of antimicrobials on gonococcal evolution.

Sánchez-Busó L, Golparian D, Corander J, Grad YH, Ohnishi M, Flemming R, Parkhill J, Bentley SD, Unemo M, Harris SR.

Nat Microbiol. 2019 Nov;4(11):1941-1950. doi: 10.1038/s41564-019-0501-y. Epub 2019 Jul 29.


Finnish new variant of Chlamydia trachomatis escaping detection in the Aptima Combo 2 assay also present in Örebro County, Sweden, May 2019.

Unemo M, Hansen M, Hadad R, Lindroth Y, Fredlund H, Puolakkainen M, Sundqvist M.

Euro Surveill. 2019 Jun;24(26). doi: 10.2807/1560-7917.ES.2019.24.26.1900370.


2019 European guideline on the management of lymphogranuloma venereum.

de Vries HJC, de Barbeyrac B, de Vrieze NHN, Viset JD, White JA, Vall-Mayans M, Unemo M.

J Eur Acad Dermatol Venereol. 2019 Oct;33(10):1821-1828. doi: 10.1111/jdv.15729. Epub 2019 Jun 26.


Letter to the editor: Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019.

Unemo M, Getman D, Hadad R, Cole M, Thomson N, Puolakkainen M, Spiteri G.

Euro Surveill. 2019 Jun;24(24). doi: 10.2807/1560-7917.ES.2019.24.24.1900354. No abstract available.


Now Is the Time to Implement Whole Genome Sequencing in the Global Antimicrobial Resistance Surveillance for Neisseria gonorrhoeae?

Golparian D, Unemo M.

EClinicalMedicine. 2019 Feb 18;7:11-12. doi: 10.1016/j.eclinm.2019.02.002. eCollection 2019 Jan. No abstract available.


Prediction of Minimum Inhibitory Concentrations of Antimicrobials for Neisseria gonorrhoeae Using Whole-Genome Sequencing.

Eyre DW, Golparian D, Unemo M.

Methods Mol Biol. 2019;1997:59-76. doi: 10.1007/978-1-4939-9496-0_4.


Antimicrobial Resistance in Neisseria gonorrhoeae and Treatment of Gonorrhea.

Unemo M, Golparian D, Eyre DW.

Methods Mol Biol. 2019;1997:37-58. doi: 10.1007/978-1-4939-9496-0_3.


In vitro activity of the ketolide cethromycin in multidrug-resistant clinical Neisseria gonorrhoeae isolates and international reference strains.

Jacobsson S, Alirol E, Unemo M.

J Chemother. 2019 Sep;31(5):246-251. doi: 10.1080/1120009X.2019.1615724. Epub 2019 May 20.


Clonal expansion and spread of the ceftriaxone-resistant Neisseria gonorrhoeae strain FC428, identified in Japan in 2015, and closely related isolates.

Lee K, Nakayama SI, Osawa K, Yoshida H, Arakawa S, Furubayashi KI, Kameoka H, Shimuta K, Kawahata T, Unemo M, Ohnishi M.

J Antimicrob Chemother. 2019 Jul 1;74(7):1812-1819. doi: 10.1093/jac/dkz129.


Population-level antimicrobial consumption is associated with decreased antimicrobial susceptibility in Neisseria gonorrhoeae in 24 European countries: an ecological analysis.

Kenyon C, Buyze J, Spiteri G, Cole MJ, Unemo M.

J Infect Dis. 2019 Apr 8. pii: jiz153. doi: 10.1093/infdis/jiz153. [Epub ahead of print]


Ten years of external quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in Europe elucidate high reliability of data.

Cole MJ, Quaye N, Jacobsson S, Day M, Fagan E, Ison C, Pitt R, Seaton S, Woodford N, Stary A, Pleininger S, Crucitti T, Hunjak B, Maikanti P, Hoffmann S, Viktorova J, Buder S, Kohl P, Tzelepi E, Siatravani E, Balla E, Hauksdóttir GS, Rose L, Stefanelli P, Carannante A, Pakarna G, Mifsud F, Cassar RZ, Linde I, Bergheim T, Steinbakk M, Mlynarczyk-Bonikowska B, Borrego MJ, Shepherd J, Pavlik P, Jeverica S, Vazquez J, Abad R, Weiss S, Spiteri G, Unemo M.

BMC Infect Dis. 2019 Mar 25;19(1):281. doi: 10.1186/s12879-019-3900-z.


Antimicrobial susceptibility of Neisseria gonorrhoeae isolates and treatment of gonorrhoea patients in Ternopil and Dnipropetrovsk regions of Ukraine, 2013-2018.

Boiko I, Golparian D, Krynytska I, Bezkorovaina H, Frankenberg A, Onuchyna M, Jacobsson S, Unemo M.

APMIS. 2019 Jul;127(7):503-509. doi: 10.1111/apm.12948. Epub 2019 May 21.


Collecting and exploiting data to understand a nation's sexual health needs: Implications for the British National Surveys of Sexual Attitudes and Lifestyles (Natsal).

Mercer CH, Clifton S, Prior G, Aldridge RW, Bonell C, Copas AJ, Field N, Gibbs J, Macdowall W, Mitchell KR, Tanton C, Thomson N, Unemo M, Sonnenberg P.

Sex Transm Infect. 2019 May;95(3):159-161. doi: 10.1136/sextrans-2018-053571. Epub 2019 Mar 19. No abstract available. Erratum in: Sex Transm Infect. 2019 May 28;:.


The resurgence of syphilis in high-income countries in the 2000s: a focus on Europe.

Spiteri G, Unemo M, Mårdh O, Amato-Gauci AJ.

Epidemiol Infect. 2019 Jan;147:e143. doi: 10.1017/S0950268819000281.


Genome-based epidemiology and antimicrobial resistance determinants of Neisseria gonorrhoeae isolates with decreased susceptibility and resistance to extended-spectrum cephalosporins in Argentina in 2011-16.

Gianecini RA, Golparian D, Zittermann S, Litvik A, Gonzalez S, Oviedo C, Melano RG, Unemo M, Galarza P; Gonococcal Antimicrobial Susceptibility Surveillance Programme-Argentina (GASSP-AR) Working Group .

J Antimicrob Chemother. 2019 Jun 1;74(6):1551-1559. doi: 10.1093/jac/dkz054.


Emergence and Spread of Cephalosporin-Resistant Neisseria gonorrhoeae with Mosaic penA Alleles, South Korea, 2012-2017.

Lee H, Suh YH, Lee S, Kim YK, Han MS, Bae HG, Unemo M, Lee K.

Emerg Infect Dis. 2019 Mar;25(3):416-424. doi: 10.3201/eid2503.181503.


In vitro activity of the novel oral antimicrobial SMT-571, with a new mechanism of action, against MDR and XDR Neisseria gonorrhoeae: future treatment option for gonorrhoea?

Jacobsson S, Mason C, Khan N, Meo P, Unemo M.

J Antimicrob Chemother. 2019 Jun 1;74(6):1591-1594. doi: 10.1093/jac/dkz060.


Quantitation of all Four Gardnerella vaginalis Clades Detects Abnormal Vaginal Microbiota Characteristic of Bacterial Vaginosis More Accurately than Putative G. vaginalis Sialidase A Gene Count.

Shipitsyna E, Krysanova A, Khayrullina G, Shalepo K, Savicheva A, Guschin A, Unemo M.

Mol Diagn Ther. 2019 Feb;23(1):139-147. doi: 10.1007/s40291-019-00382-5.


Pharmacokinetic considerations regarding the treatment of bacterial sexually transmitted infections with azithromycin: a review.

Kong FYS, Horner P, Unemo M, Hocking JS.

J Antimicrob Chemother. 2019 May 1;74(5):1157-1166. doi: 10.1093/jac/dky548.


Pharmacokinetic Data Are Predictive of In Vivo Efficacy for Cefixime and Ceftriaxone against Susceptible and Resistant Neisseria gonorrhoeae Strains in the Gonorrhea Mouse Model.

Connolly KL, Eakin AE, Gomez C, Osborn BL, Unemo M, Jerse AE.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e01644-18. doi: 10.1128/AAC.01644-18. Print 2019 Mar.


Antibiotic resistance and NG-MAST sequence types of Neisseria gonorrhoeae isolates in Poland compared to the world.

Mlynarczyk-Bonikowska B, Malejczyk M, Majewski S, Unemo M.

Postepy Dermatol Alergol. 2018 Dec;35(6):346-551. doi: 10.5114/ada.2018.79780. Epub 2018 Nov 26. Review.


Antimicrobial resistance prediction and phylogenetic analysis of Neisseria gonorrhoeae isolates using the Oxford Nanopore MinION sequencer.

Golparian D, Donà V, Sánchez-Busó L, Foerster S, Harris S, Endimiani A, Low N, Unemo M.

Sci Rep. 2018 Dec 4;8(1):17596. doi: 10.1038/s41598-018-35750-4.


Stably high azithromycin resistance and decreasing ceftriaxone susceptibility in Neisseria gonorrhoeae in 25 European countries, 2016.

Day MJ, Spiteri G, Jacobsson S, Woodford N, Amato-Gauci AJ, Cole MJ, Unemo M; Euro-GASP network.

BMC Infect Dis. 2018 Dec 3;18(1):609. doi: 10.1186/s12879-018-3528-4.


Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018.

Golparian D, Rose L, Lynam A, Mohamed A, Bercot B, Ohnishi M, Crowley B, Unemo M.

Euro Surveill. 2018 Nov;23(47). doi: 10.2807/1560-7917.ES.2018.23.47.1800617.


Establishment of a Gonococcal Antimicrobial Surveillance Programme, in Accordance With World Health Organization Standards, in Côte d'Ivoire, Western Africa, 2014-2017.

Yéo A, Kouamé-Blavo B, Kouamé CE, Ouattara A, Yao AC, Gbedé BD, Bazan F, Faye-Ketté H, Dosso M, Wi T, Unemo M.

Sex Transm Dis. 2019 Mar;46(3):179-184. doi: 10.1097/OLQ.0000000000000943.


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