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Sea Anemone Toxins: A Structural Overview.

Madio B, King GF, Undheim EAB.

Mar Drugs. 2019 Jun 1;17(6). pii: E325. doi: 10.3390/md17060325. Review.


Editorial: Animal Toxins as Comprehensive Pharmacological Tools to Identify Diverse Ion Channels.

Utkin Y, Vassilevski A, Kudryavtsev D, Undheim EAB.

Front Pharmacol. 2019 Apr 24;10:423. doi: 10.3389/fphar.2019.00423. eCollection 2019. No abstract available.


Investigation of the estuarine stonefish (Synanceia horrida) venom composition.

Ziegman R, Undheim EAB, Baillie G, Jones A, Alewood PF.

J Proteomics. 2019 Jun 15;201:12-26. doi: 10.1016/j.jprot.2019.04.002. Epub 2019 Apr 4.


A process of convergent amplification and tissue-specific expression dominates the evolution of toxin and toxin-like genes in sea anemones.

Surm JM, Smith HL, Madio B, Undheim EAB, King GF, Hamilton BR, van der Burg CA, Pavasovic A, Prentis PJ.

Mol Ecol. 2019 May;28(9):2272-2289. doi: 10.1111/mec.15084. Epub 2019 May 2.


A Centipede Toxin Family Defines an Ancient Class of CSαβ Defensins.

Dash TS, Shafee T, Harvey PJ, Zhang C, Peigneur S, Deuis JR, Vetter I, Tytgat J, Anderson MA, Craik DJ, Durek T, Undheim EAB.

Structure. 2019 Feb 5;27(2):315-326.e7. doi: 10.1016/j.str.2018.10.022. Epub 2018 Dec 13.


Secreted Cysteine-Rich Repeat Proteins "SCREPs": A Novel Multi-Domain Architecture.

Maxwell M, Undheim EAB, Mobli M.

Front Pharmacol. 2018 Nov 20;9:1333. doi: 10.3389/fphar.2018.01333. eCollection 2018.


A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family.

Robinson SD, Mueller A, Clayton D, Starobova H, Hamilton BR, Payne RJ, Vetter I, King GF, Undheim EAB.

Sci Adv. 2018 Sep 12;4(9):eaau4640. doi: 10.1126/sciadv.aau4640. eCollection 2018 Sep.


Balancing sufficiency and impact in reporting standards for mass spectrometry imaging experiments.

Gustafsson OJR, Winderbaum LJ, Condina MR, Boughton BA, Hamilton BR, Undheim EAB, Becker M, Hoffmann P.

Gigascience. 2018 Oct 1;7(10). doi: 10.1093/gigascience/giy102.


PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold.

Madio B, Peigneur S, Chin YKY, Hamilton BR, Henriques ST, Smith JJ, Cristofori-Armstrong B, Dekan Z, Boughton BA, Alewood PF, Tytgat J, King GF, Undheim EAB.

Cell Mol Life Sci. 2018 Dec;75(24):4511-4524. doi: 10.1007/s00018-018-2897-6. Epub 2018 Aug 14.


Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death.

Richards KL, Milligan CJ, Richardson RJ, Jancovski N, Grunnet M, Jacobson LH, Undheim EAB, Mobli M, Chow CY, Herzig V, Csoti A, Panyi G, Reid CA, King GF, Petrou S.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8077-E8085. doi: 10.1073/pnas.1804764115. Epub 2018 Aug 3.


A complicated complex: Ion channels, voltage sensing, cell membranes and peptide inhibitors.

Zhang AH, Sharma G, Undheim EAB, Jia X, Mobli M.

Neurosci Lett. 2018 Jul 13;679:35-47. doi: 10.1016/j.neulet.2018.04.030. Epub 2018 Apr 21. Review.


The assassin bug Pristhesancus plagipennis produces two distinct venoms in separate gland lumens.

Walker AA, Mayhew ML, Jin J, Herzig V, Undheim EAB, Sombke A, Fry BG, Meritt DJ, King GF.

Nat Commun. 2018 Feb 22;9(1):755. doi: 10.1038/s41467-018-03091-5.


A Dipteran's Novel Sucker Punch: Evolution of Arthropod Atypical Venom with a Neurotoxic Component in Robber Flies (Asilidae, Diptera).

Drukewitz SH, Fuhrmann N, Undheim EAB, Blanke A, Giribaldi J, Mary R, Laconde G, Dutertre S, von Reumont BM.

Toxins (Basel). 2018 Jan 5;10(1). pii: E29. doi: 10.3390/toxins10010029.


Venomics of Remipede Crustaceans Reveals Novel Peptide Diversity and Illuminates the Venom's Biological Role.

von Reumont BM, Undheim EAB, Jauss RT, Jenner RA.

Toxins (Basel). 2017 Jul 26;9(8). pii: E234. doi: 10.3390/toxins9080234.


Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery.

Robinson SD, Undheim EAB, Ueberheide B, King GF.

Expert Rev Proteomics. 2017 Oct;14(10):931-939. doi: 10.1080/14789450.2017.1377613. Epub 2017 Sep 13. Review.


Revisiting venom of the sea anemone Stichodactyla haddoni: Omics techniques reveal the complete toxin arsenal of a well-studied sea anemone genus.

Madio B, Undheim EAB, King GF.

J Proteomics. 2017 Aug 23;166:83-92. doi: 10.1016/j.jprot.2017.07.007. Epub 2017 Jul 21.


Modulation of Ion Channels by Cysteine-Rich Peptides: From Sequence to Structure.

Mobli M, Undheim EAB, Rash LD.

Adv Pharmacol. 2017;79:199-223. doi: 10.1016/bs.apha.2017.03.001. Epub 2017 Apr 24.


Comparative analyses of glycerotoxin expression unveil a novel structural organization of the bloodworm venom system.

Richter S, Helm C, Meunier FA, Hering L, Campbell LI, Drukewitz SH, Undheim EA, Jenner RA, Schiavo G, Bleidorn C.

BMC Evol Biol. 2017 Mar 4;17(1):64. doi: 10.1186/s12862-017-0904-4.


Melt With This Kiss: Paralyzing and Liquefying Venom of The Assassin Bug Pristhesancus plagipennis (Hemiptera: Reduviidae).

Walker AA, Madio B, Jin J, Undheim EA, Fry BG, King GF.

Mol Cell Proteomics. 2017 Apr;16(4):552-566. doi: 10.1074/mcp.M116.063321. Epub 2017 Jan 27.


Centipede venoms as a source of drug leads.

Undheim EA, Jenner RA, King GF.

Expert Opin Drug Discov. 2016 Dec;11(12):1139-1149. Epub 2016 Sep 19. Review.


Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain.

Osteen JD, Herzig V, Gilchrist J, Emrick JJ, Zhang C, Wang X, Castro J, Garcia-Caraballo S, Grundy L, Rychkov GY, Weyer AD, Dekan Z, Undheim EA, Alewood P, Stucky CL, Brierley SM, Basbaum AI, Bosmans F, King GF, Julius D.

Nature. 2016 Jun 23;534(7608):494-9. doi: 10.1038/nature17976. Epub 2016 Jun 6.


Toxin structures as evolutionary tools: Using conserved 3D folds to study the evolution of rapidly evolving peptides.

Undheim EA, Mobli M, King GF.

Bioessays. 2016 Jun;38(6):539-48. doi: 10.1002/bies.201500165. Epub 2016 May 11. Review.


Structure-Activity Relationship of Chlorotoxin-Like Peptides.

Ali SA, Alam M, Abbasi A, Undheim EA, Fry BG, Kalbacher H, Voelter W.

Toxins (Basel). 2016 Feb 2;8(2):36. doi: 10.3390/toxins8020036.


Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.

Chow CY, Cristofori-Armstrong B, Undheim EA, King GF, Rash LD.

Toxins (Basel). 2015 Jun 30;7(7):2494-513. doi: 10.3390/toxins7072494.


Weaponization of a Hormone: Convergent Recruitment of Hyperglycemic Hormone into the Venom of Arthropod Predators.

Undheim EA, Grimm LL, Low CF, Morgenstern D, Herzig V, Zobel-Thropp P, Pineda SS, Habib R, Dziemborowicz S, Fry BG, Nicholson GM, Binford GJ, Mobli M, King GF.

Structure. 2015 Jul 7;23(7):1283-92. doi: 10.1016/j.str.2015.05.003. Epub 2015 Jun 11.


Production and packaging of a biological arsenal: evolution of centipede venoms under morphological constraint.

Undheim EA, Hamilton BR, Kurniawan ND, Bowlay G, Cribb BW, Merritt DJ, Fry BG, King GF, Venter DJ.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4026-31. doi: 10.1073/pnas.1424068112. Epub 2015 Mar 16.


Centipede venom: recent discoveries and current state of knowledge.

Undheim EA, Fry BG, King GF.

Toxins (Basel). 2015 Feb 25;7(3):679-704. doi: 10.3390/toxins7030679. Review.


Spider venomics: implications for drug discovery.

Pineda SS, Undheim EA, Rupasinghe DB, Ikonomopoulou MP, King GF.

Future Med Chem. 2014 Oct;6(15):1699-714. doi: 10.4155/fmc.14.103. Review.


Clawing through evolution: toxin diversification and convergence in the ancient lineage Chilopoda (centipedes).

Undheim EA, Jones A, Clauser KR, Holland JW, Pineda SS, King GF, Fry BG.

Mol Biol Evol. 2014 Aug;31(8):2124-48. doi: 10.1093/molbev/msu162. Epub 2014 May 20.


Multifunctional warheads: diversification of the toxin arsenal of centipedes via novel multidomain transcripts.

Undheim EA, Sunagar K, Hamilton BR, Jones A, Venter DJ, Fry BG, King GF.

J Proteomics. 2014 May 6;102:1-10. doi: 10.1016/j.jprot.2014.02.024. Epub 2014 Mar 3.


Diversification of a single ancestral gene into a successful toxin superfamily in highly venomous Australian funnel-web spiders.

Pineda SS, Sollod BL, Wilson D, Darling A, Sunagar K, Undheim EA, Kely L, Antunes A, Fry BG, King GF.

BMC Genomics. 2014 Mar 5;15:177. doi: 10.1186/1471-2164-15-177.


Intraspecific venom variation in the medically significant Southern Pacific Rattlesnake (Crotalus oreganus helleri): biodiscovery, clinical and evolutionary implications.

Sunagar K, Undheim EA, Scheib H, Gren EC, Cochran C, Person CE, Koludarov I, Kelln W, Hayes WK, King GF, Antunes A, Fry BG.

J Proteomics. 2014 Mar 17;99:68-83. doi: 10.1016/j.jprot.2014.01.013. Epub 2014 Jan 24.


Vintage venoms: proteomic and pharmacological stability of snake venoms stored for up to eight decades.

Jesupret C, Baumann K, Jackson TN, Ali SA, Yang DC, Greisman L, Kern L, Steuten J, Jouiaei M, Casewell NR, Undheim EA, Koludarov I, Debono J, Low DH, Rossi S, Panagides N, Winter K, Ignjatovic V, Summerhayes R, Jones A, Nouwens A, Dunstan N, Hodgson WC, Winkel KD, Monagle P, Fry BG.

J Proteomics. 2014 Jun 13;105:285-94. doi: 10.1016/j.jprot.2014.01.004. Epub 2014 Jan 14.


Venom down under: dynamic evolution of Australian elapid snake toxins.

Jackson TN, Sunagar K, Undheim EA, Koludarov I, Chan AH, Sanders K, Ali SA, Hendrikx I, Dunstan N, Fry BG.

Toxins (Basel). 2013 Dec 18;5(12):2621-55. doi: 10.3390/toxins5122621.


A proteomics and transcriptomics investigation of the venom from the barychelid spider Trittame loki (brush-foot trapdoor).

Undheim EA, Sunagar K, Herzig V, Kely L, Low DH, Jackson TN, Jones A, Kurniawan N, King GF, Ali SA, Antunes A, Ruder T, Fry BG.

Toxins (Basel). 2013 Dec 13;5(12):2488-503. doi: 10.3390/toxins5122488.


Evolution stings: the origin and diversification of scorpion toxin peptide scaffolds.

Sunagar K, Undheim EA, Chan AH, Koludarov I, Muñoz-Gómez SA, Antunes A, Fry BG.

Toxins (Basel). 2013 Dec 13;5(12):2456-87. doi: 10.3390/toxins5122456.


Molecular evolution of vertebrate neurotrophins: co-option of the highly conserved nerve growth factor gene into the advanced snake venom arsenalf.

Sunagar K, Fry BG, Jackson TN, Casewell NR, Undheim EA, Vidal N, Ali SA, King GF, Vasudevan K, Vasconcelos V, Antunes A.

PLoS One. 2013 Nov 29;8(11):e81827. doi: 10.1371/journal.pone.0081827. eCollection 2013.


Three-fingered RAVERs: Rapid Accumulation of Variations in Exposed Residues of snake venom toxins.

Sunagar K, Jackson TN, Undheim EA, Ali SA, Antunes A, Fry BG.

Toxins (Basel). 2013 Nov 18;5(11):2172-208. doi: 10.3390/toxins5112172.


Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.

Yang S, Xiao Y, Kang D, Liu J, Li Y, Undheim EA, Klint JK, Rong M, Lai R, King GF.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17534-9. doi: 10.1073/pnas.1306285110. Epub 2013 Sep 30.


Proteomic comparison of Hypnale hypnale (hump-nosed pit-viper) and Calloselasma rhodostoma (Malayan pit-viper) venoms.

Ali SA, Baumann K, Jackson TN, Wood K, Mason S, Undheim EA, Nouwens A, Koludarov I, Hendrikx I, Jones A, Fry BG.

J Proteomics. 2013 Oct 8;91:338-43. doi: 10.1016/j.jprot.2013.07.020. Epub 2013 Aug 2.


Functional characterization on invertebrate and vertebrate tissues of tachykinin peptides from octopus venoms.

Ruder T, Ali SA, Ormerod K, Brust A, Roymanchadi ML, Ventura S, Undheim EA, Jackson TN, Mercier AJ, King GF, Alewood PF, Fry BG.

Peptides. 2013 Sep;47:71-6. doi: 10.1016/j.peptides.2013.07.002. Epub 2013 Jul 11.


Dracula's children: molecular evolution of vampire bat venom.

Low DH, Sunagar K, Undheim EA, Ali SA, Alagon AC, Ruder T, Jackson TN, Pineda Gonzalez S, King GF, Jones A, Antunes A, Fry BG.

J Proteomics. 2013 Aug 26;89:95-111. doi: 10.1016/j.jprot.2013.05.034. Epub 2013 Jun 5.


Venom proteomic characterization and relative antivenom neutralization of two medically important Pakistani elapid snakes (Bungarus sindanus and Naja naja).

Ali SA, Yang DC, Jackson TN, Undheim EA, Koludarov I, Wood K, Jones A, Hodgson WC, McCarthy S, Ruder T, Fry BG.

J Proteomics. 2013 Aug 26;89:15-23. doi: 10.1016/j.jprot.2013.05.015. Epub 2013 May 25.


Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli.

Klint JK, Senff S, Saez NJ, Seshadri R, Lau HY, Bende NS, Undheim EA, Rash LD, Mobli M, King GF.

PLoS One. 2013 May 7;8(5):e63865. doi: 10.1371/journal.pone.0063865. Print 2013.


Squeezers and leaf-cutters: differential diversification and degeneration of the venom system in toxicoferan reptiles.

Fry BG, Undheim EA, Ali SA, Jackson TN, Debono J, Scheib H, Ruder T, Morgenstern D, Cadwallader L, Whitehead D, Nabuurs R, van der Weerd L, Vidal N, Roelants K, Hendrikx I, Gonzalez SP, Koludarov I, Jones A, King GF, Antunes A, Sunagar K.

Mol Cell Proteomics. 2013 Jul;12(7):1881-99. doi: 10.1074/mcp.M112.023143. Epub 2013 Apr 1.


Molecular phylogeny and evolution of the proteins encoded by coleoid (cuttlefish, octopus, and squid) posterior venom glands.

Ruder T, Sunagar K, Undheim EA, Ali SA, Wai TC, Low DH, Jackson TN, King GF, Antunes A, Fry BG.

J Mol Evol. 2013 Apr;76(4):192-204. doi: 10.1007/s00239-013-9552-5. Epub 2013 Mar 2.


Differential evolution and neofunctionalization of snake venom metalloprotease domains.

Brust A, Sunagar K, Undheim EA, Vetter I, Yang DC, Casewell NR, Jackson TN, Koludarov I, Alewood PF, Hodgson WC, Lewis RJ, King GF, Antunes A, Hendrikx I, Fry BG.

Mol Cell Proteomics. 2013 Mar;12(3):651-63. doi: 10.1074/mcp.M112.023135. Epub 2012 Dec 12. Erratum in: Mol Cell Proteomics. 2013 May;12(5):1488. Yang, Dary C [corrected to Yang, Daryl C].


Structural and molecular diversification of the Anguimorpha lizard mandibular venom gland system in the arboreal species Abronia graminea.

Koludarov I, Sunagar K, Undheim EA, Jackson TN, Ruder T, Whitehead D, Saucedo AC, Mora GR, Alagon AC, King G, Antunes A, Fry BG.

J Mol Evol. 2012 Dec;75(5-6):168-83. doi: 10.1007/s00239-012-9529-9. Epub 2012 Nov 17.


On the venom system of centipedes (Chilopoda), a neglected group of venomous animals.

Undheim EA, King GF.

Toxicon. 2011 Mar 15;57(4):512-24. doi: 10.1016/j.toxicon.2011.01.004. Epub 2011 Jan 19. Review.


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