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Items: 36

1.

Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs.

Hay DW, Giardina GA, Griswold DE, Underwood DC, Kotzer CJ, Bush B, Potts W, Sandhu P, Lundberg D, Foley JJ, Schmidt DB, Martin LD, Kilian D, Legos JJ, Barone FC, Luttmann MA, Grugni M, Raveglia LF, Sarau HM.

J Pharmacol Exp Ther. 2002 Jan;300(1):314-23.

PMID:
11752131
2.

Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models.

Ames RS, Lee D, Foley JJ, Jurewicz AJ, Tornetta MA, Bautsch W, Settmacher B, Klos A, Erhard KF, Cousins RD, Sulpizio AC, Hieble JP, McCafferty G, Ward KW, Adams JL, Bondinell WE, Underwood DC, Osborn RR, Badger AM, Sarau HM.

J Immunol. 2001 May 15;166(10):6341-8.

3.

SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung.

Underwood DC, Osborn RR, Bochnowicz S, Webb EF, Rieman DJ, Lee JC, Romanic AM, Adams JL, Hay DW, Griswold DE.

Am J Physiol Lung Cell Mol Physiol. 2000 Nov;279(5):L895-902.

4.

Differences in time-related cardiopulmonary responses to hypoxia in three rat strains.

Bochnowicz S, Osborn RR, Luttmann MA, Louden C, Hart T, Hay DW, Underwood DC.

Clin Exp Hypertens. 2000 Jul;22(5):471-92.

PMID:
10937839
5.

Inhibition of p38 MAP kinase as a therapeutic strategy.

Lee JC, Kumar S, Griswold DE, Underwood DC, Votta BJ, Adams JL.

Immunopharmacology. 2000 May;47(2-3):185-201. Review.

PMID:
10878289
6.

New phosphodiesterase inhibitors as therapeutics for the treatment of chronic lung disease.

Barnette MS, Underwood DC.

Curr Opin Pulm Med. 2000 Mar;6(2):164-9. Review.

PMID:
10741778
7.

SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence.

Underwood DC, Osborn RR, Kotzer CJ, Adams JL, Lee JC, Webb EF, Carpenter DC, Bochnowicz S, Thomas HC, Hay DW, Griswold DE.

J Pharmacol Exp Ther. 2000 Apr;293(1):281-8.

PMID:
10734180
8.

The antitussive activity of delta-opioid receptor stimulation in guinea pigs.

Kotzer CJ, Hay DW, Dondio G, Giardina G, Petrillo P, Underwood DC.

J Pharmacol Exp Ther. 2000 Feb;292(2):803-9.

PMID:
10640321
9.

In vitro and in vivo pharmacological characterization of SB 201993, an eicosanoid-like LTB4 receptor antagonist with anti-inflammatory activity.

Sarau HM, Foley JJ, Schmidt DB, Martin LD, Webb EF, Tzimas MN, Breton JJ, Chabot-Fletcher M, Underwood DC, Hay DW, Kingsbury WD, Chambers PA, Pendrak I, Jakas DR, Sathe GM, Van Horn S, Daines RA, Griswold DE.

Prostaglandins Leukot Essent Fatty Acids. 1999 Jul;61(1):55-64.

PMID:
10477044
10.

Ariflo (SB 207499), a second generation phosphodiesterase 4 inhibitor for the treatment of asthma and COPD: from concept to clinic.

Torphy TJ, Barnette MS, Underwood DC, Griswold DE, Christensen SB, Murdoch RD, Nieman RB, Compton CH.

Pulm Pharmacol Ther. 1999;12(2):131-5. Review. No abstract available.

PMID:
10373396
11.

cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy.

Anderson KM, Berrebi-Bertrand I, Kirkpatrick RB, McQueney MS, Underwood DC, Rouanet S, Chabot-Fletcher M.

J Mol Cell Cardiol. 1999 Apr;31(4):705-19.

PMID:
10329199
12.

Effect of SB 217242 on hypoxia-induced cardiopulmonary changes in the high altitude-sensitive rat.

Underwood DC, Bochnowicz S, Osborn RR, Luttmann MA, Louden CS, Hart TK, Elliott JD, Hay DW.

Pulm Pharmacol Ther. 1999;12(1):13-26.

PMID:
10208832
13.

Antiasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig.

Underwood DC, Bochnowicz S, Osborn RR, Kotzer CJ, Luttmann MA, Hay DW, Gorycki PD, Christensen SB, Torphy TJ.

J Pharmacol Exp Ther. 1998 Dec;287(3):988-95.

PMID:
9864284
14.

Food restriction-mediated adrenal influences on antigen-induced bronchoconstriction and airway eosinophil influx in the guinea pig.

Underwood DC, Matthews JK, Osborn RR, Hay DW.

Int Arch Allergy Immunol. 1998 Sep;117(1):52-9.

PMID:
9751848
15.

Chronic hypoxia-induced cardiopulmonary changes in three rat strains: inhibition by the endothelin receptor antagonist SB 217242.

Underwood DC, Bochnowicz S, Osborn RR, Louden CS, Hart TK, Ohlstein EH, Hay DW.

J Cardiovasc Pharmacol. 1998;31 Suppl 1:S453-5.

PMID:
9595510
16.

1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma.

Christensen SB, Guider A, Forster CJ, Gleason JG, Bender PE, Karpinski JM, DeWolf WE Jr, Barnette MS, Underwood DC, Griswold DE, Cieslinski LB, Burman M, Bochnowicz S, Osborn RR, Manning CD, Grous M, Hillegas LM, Bartus JO, Ryan MD, Eggleston DS, Haltiwanger RC, Torphy TJ.

J Med Chem. 1998 Mar 12;41(6):821-35.

PMID:
9526558
17.
18.

Hypoxia-induced pulmonary hypertension in an optimized environment for the guineapig.

Bochnowicz S, Osborn RR, Hay DW, Underwood DC.

Lab Anim. 1997 Oct;31(4):347-56.

PMID:
9350706
19.

The influence of endogenous catecholamines on the inhibitory effects of rolipram against early- and late-phase response to antigen in the guinea pig.

Underwood DC, Matthews JK, Osborn RR, Bochnowicz S, Torphy TJ.

J Pharmacol Exp Ther. 1997 Jan;280(1):210-9.

PMID:
8996198
20.
21.

Catecholamine and beta-adrenoceptor influences on airway reactivity to antigen in guinea pigs.

Underwood DC, Matthews JK, Osborn RR, Novak LB, Bochnowicz S, Meunier LD.

Int Arch Allergy Immunol. 1996 Mar;109(3):286-94.

PMID:
8620099
22.

Pharmacological characterization of SB 202235, a potent and selective 5-lipoxygenase inhibitor: effects in models of allergic asthma.

Chabot-Fletcher MC, Underwood DC, Breton JJ, Adams JL, Kagey-Sobotka A, Griswold DE, Marshall LA, Sarau HM, Winkler JD, Hay DW.

J Pharmacol Exp Ther. 1995 Jun;273(3):1147-55.

PMID:
7791085
23.

Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea pig.

Bochnowicz S, Underwood DC.

Prostaglandins Leukot Essent Fatty Acids. 1995 Jun;52(6):403-11.

PMID:
7644563
24.

Phosphodiesterase IV inhibitors as therapy for eosinophil-induced lung injury in asthma.

Torphy TJ, Barnette MS, Hay DW, Underwood DC.

Environ Health Perspect. 1994 Dec;102 Suppl 10:79-84.

25.

Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs.

Underwood DC, Kotzer CJ, Bochnowicz S, Osborn RR, Luttmann MA, Hay DW, Torphy TJ.

J Pharmacol Exp Ther. 1994 Jul;270(1):250-9.

PMID:
8035322
26.

Differential antagonism of airway contractile responses to prostaglandin (PG)D2 and 9 alpha, 11 beta-PGF2 by atropine, SK&F 88046 and SQ 29,548 in the guinea pig.

Underwood DC, Muccitelli RM, Luttmann MA, Hay DW, Torphy TJ, Wasserman MA.

J Pharmacol Exp Ther. 1994 Jan;268(1):304-10.

PMID:
8301572
27.

Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram.

Underwood DC, Osborn RR, Novak LB, Matthews JK, Newsholme SJ, Undem BJ, Hand JM, Torphy TJ.

J Pharmacol Exp Ther. 1993 Jul;266(1):306-13.

PMID:
8392555
28.

Lack of late-phase airway responses in conscious guinea pigs after a variety of antigen challenges.

Underwood DC, Osborn RR, Hand JM.

Agents Actions. 1992 Nov;37(3-4):191-4.

PMID:
1295368
29.

Analysis of bronchoconstrictor responses to platelet-activating factor in the cat.

Underwood DC, Kadowitz PJ.

J Appl Physiol (1985). 1989 Jul;67(1):377-82.

PMID:
2759966
30.

The bronchopulmonary pharmacology of SK&F 104353 in anesthetized guinea pigs: demonstration of potent and selective antagonism of responses to peptidoleukotrienes.

Torphy TJ, Newton JF, Wasserman MA, Vickery-Clark L, Osborn RR, Bailey LS, Yodis LA, Underwood DC, Hay DW.

J Pharmacol Exp Ther. 1989 May;249(2):430-7.

PMID:
2542530
31.

Inhibition of pulmonary thromboxane A2 synthase activity and airway responses by CGS 13080.

McNamara DB, Harrington JK, Bellan JA, Graybar GB, Underwood DC, Kadowitz PJ.

Mol Cell Biochem. 1989 Jan 23;85(1):29-41.

PMID:
2725478
32.

Inhibition of thromboxane responses in the airway of the cat by SQ29,548 and OKY 1581.

Kadowitz PJ, McNamara DB, Tilden SJ, Hyman AL, Underwood DC.

Adv Prostaglandin Thromboxane Leukot Res. 1989;19:535-8. No abstract available.

PMID:
2526533
33.

Silk gland-specific tRNA(Ala) genes are tightly clustered in the silkworm genome.

Underwood DC, Knickerbocker H, Gardner G, Condliffe DP, Sprague KU.

Mol Cell Biol. 1988 Dec;8(12):5504-12.

34.

Blockade of thromboxane responses in the airway of the cat by SQ 29,548.

Underwood DC, Kriseman T, McNamara DB, Hyman AL, Kadowitz PJ.

J Appl Physiol (1985). 1987 Jun;62(6):2193-200.

PMID:
2440845
35.

Effects of OKY 1581 on bronchoconstrictor responses to arachidonic acid and PGH2.

Tilden SJ, Underwood DC, Cowen KH, Wegmann MJ, Graybar GB, Hyman AL, McNamara DB, Kadowitz PJ.

J Appl Physiol (1985). 1987 May;62(5):2066-74.

PMID:
2954941
36.

Analysis of airway responses to A23187 in the cat.

Kriseman T, Underwood DC, Hyman AL, Kadowitz PJ.

J Pharmacol Exp Ther. 1986 Nov;239(2):395-9.

PMID:
3095538

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