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Optimization of DNA extraction from human urinary samples for mycobiome community profiling.

Ackerman AL, Anger JT, Khalique MU, Ackerman JE, Tang J, Kim J, Underhill DM, Freeman MR; NIH Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP).

PLoS One. 2019 Apr 25;14(4):e0210306. doi: 10.1371/journal.pone.0210306. eCollection 2019.


Malassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models.

Limon JJ, Tang J, Li D, Wolf AJ, Michelsen KS, Funari V, Gargus M, Nguyen C, Sharma P, Maymi VI, Iliev ID, Skalski JH, Brown J, Landers C, Borneman J, Braun J, Targan SR, McGovern DPB, Underhill DM.

Cell Host Microbe. 2019 Mar 13;25(3):377-388.e6. doi: 10.1016/j.chom.2019.01.007. Epub 2019 Mar 5.


Mucosal immune responses to fungi and the implications for inflammatory bowel disease.

Limon JJ, Kershaw KM, Underhill DM.

Curr Opin Gastroenterol. 2018 Nov;34(6):398-403. doi: 10.1097/MOG.0000000000000483.


Expansion of commensal fungus Wallemia mellicola in the gastrointestinal mycobiota enhances the severity of allergic airway disease in mice.

Skalski JH, Limon JJ, Sharma P, Gargus MD, Nguyen C, Tang J, Coelho AL, Hogaboam CM, Crother TR, Underhill DM.

PLoS Pathog. 2018 Sep 20;14(9):e1007260. doi: 10.1371/journal.ppat.1007260. eCollection 2018 Sep.


Cryptococcal meningitis in a daily cannabis smoker without evidence of immunodeficiency.

Shapiro BB MD, MPH, Hedrick R, Vanle BC, Becker CA, Nguyen C, Underhill DM, Morgan MA, Kopple JD, Danovitch I, IsHak WW.

BMJ Case Rep. 2018 Jan 26;2018. pii: bcr-2017-221435. doi: 10.1136/bcr-2017-221435.


Peptidoglycan recognition by the innate immune system.

Wolf AJ, Underhill DM.

Nat Rev Immunol. 2018 Apr;18(4):243-254. doi: 10.1038/nri.2017.136. Epub 2018 Jan 2. Review.


Host-microbe interactions: commensal fungi in the gut.

Paterson MJ, Oh S, Underhill DM.

Curr Opin Microbiol. 2017 Dec;40:131-137. doi: 10.1016/j.mib.2017.11.012. Epub 2017 Nov 22. Review.


O-Acetylation of Peptidoglycan Limits Helper T Cell Priming and Permits Staphylococcus aureus Reinfection.

Sanchez M, Kolar SL, Müller S, Reyes CN, Wolf AJ, Ogawa C, Singhania R, De Carvalho DD, Arditi M, Underhill DM, Martins GA, Liu GY.

Cell Host Microbe. 2017 Oct 11;22(4):543-551.e4. doi: 10.1016/j.chom.2017.08.008. Epub 2017 Sep 21.


Commensal Fungi in Health and Disease.

Limon JJ, Skalski JH, Underhill DM.

Cell Host Microbe. 2017 Aug 9;22(2):156-165. doi: 10.1016/j.chom.2017.07.002. Review.


Direct Antimicrobial Activity of IFN-β.

Kaplan A, Lee MW, Wolf AJ, Limon JJ, Becker CA, Ding M, Murali R, Lee EY, Liu GY, Wong GCL, Underhill DM.

J Immunol. 2017 May 15;198(10):4036-4045. doi: 10.4049/jimmunol.1601226. Epub 2017 Apr 14.


The mycobiome of the human urinary tract: potential roles for fungi in urology.

Ackerman AL, Underhill DM.

Ann Transl Med. 2017 Jan;5(2):31. doi: 10.21037/atm.2016.12.69. Review.


Myeloid ATG16L1 Facilitates Host-Bacteria Interactions in Maintaining Intestinal Homeostasis.

Zhang H, Zheng L, McGovern DP, Hamill AM, Ichikawa R, Kanazawa Y, Luu J, Kumagai K, Cilluffo M, Fukata M, Targan SR, Underhill DM, Zhang X, Shih DQ.

J Immunol. 2017 Mar 1;198(5):2133-2146. doi: 10.4049/jimmunol.1601293. Epub 2017 Jan 27.


Immunity to Commensal Fungi: Detente and Disease.

Wheeler ML, Limon JJ, Underhill DM.

Annu Rev Pathol. 2017 Jan 24;12:359-385. doi: 10.1146/annurev-pathol-052016-100342. Epub 2016 Dec 21. Review.


Autocrine Type I IFN Signaling in Dendritic Cells Stimulated with Fungal β-Glucans or Lipopolysaccharide Promotes CD8 T Cell Activation.

Hassanzadeh-Kiabi N, Yáñez A, Dang I, Martins GA, Underhill DM, Goodridge HS.

J Immunol. 2017 Jan 1;198(1):375-382. Epub 2016 Nov 21.


Inflammatory properties of antibiotic-treated bacteria.

Wolf AJ, Liu GY, Underhill DM.

J Leukoc Biol. 2017 Jan;101(1):127-134. doi: 10.1189/jlb.4MR0316-153RR. Epub 2016 Aug 30. Review.


Élie Metchnikoff (1845-1916): celebrating 100 years of cellular immunology and beyond.

Underhill DM, Gordon S, Imhof BA, Núñez G, Bousso P.

Nat Rev Immunol. 2016 Oct;16(10):651-6. doi: 10.1038/nri.2016.89. Epub 2016 Aug 1. Review.


Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan.

Wolf AJ, Reyes CN, Liang W, Becker C, Shimada K, Wheeler ML, Cho HC, Popescu NI, Coggeshall KM, Arditi M, Underhill DM.

Cell. 2016 Jul 28;166(3):624-636. doi: 10.1016/j.cell.2016.05.076. Epub 2016 Jun 30.


Immunological Consequences of Intestinal Fungal Dysbiosis.

Wheeler ML, Limon JJ, Bar AS, Leal CA, Gargus M, Tang J, Brown J, Funari VA, Wang HL, Crother TR, Arditi M, Underhill DM, Iliev ID.

Cell Host Microbe. 2016 Jun 8;19(6):865-73. doi: 10.1016/j.chom.2016.05.003. Epub 2016 May 26.


C9orf72 is required for proper macrophage and microglial function in mice.

O'Rourke JG, Bogdanik L, Yáñez A, Lall D, Wolf AJ, Muhammad AK, Ho R, Carmona S, Vit JP, Zarrow J, Kim KJ, Bell S, Harms MB, Miller TM, Dangler CA, Underhill DM, Goodridge HS, Lutz CM, Baloh RH.

Science. 2016 Mar 18;351(6279):1324-9. doi: 10.1126/science.aaf1064.


Group B Streptococcus Evades Host Immunity by Degrading Hyaluronan.

Kolar SL, Kyme P, Tseng CW, Soliman A, Kaplan A, Liang J, Nizet V, Jiang D, Murali R, Arditi M, Underhill DM, Liu GY.

Cell Host Microbe. 2015 Dec 9;18(6):694-704. doi: 10.1016/j.chom.2015.11.001.


Immune Interactions with Pathogenic and Commensal Fungi: A Two-Way Street.

Underhill DM, Pearlman E.

Immunity. 2015 Nov 17;43(5):845-58. doi: 10.1016/j.immuni.2015.10.023. Review.


Poorly Cross-Linked Peptidoglycan in MRSA Due to mecA Induction Activates the Inflammasome and Exacerbates Immunopathology.

Müller S, Wolf AJ, Iliev ID, Berg BL, Underhill DM, Liu GY.

Cell Host Microbe. 2015 Nov 11;18(5):604-12. doi: 10.1016/j.chom.2015.10.011.


CD4(+) T-cell survival in the GI tract requires dectin-1 during fungal infection.

Drummond RA, Dambuza IM, Vautier S, Taylor JA, Reid DM, Bain CC, Underhill DM, Masopust D, Kaplan DH, Brown GD.

Mucosal Immunol. 2016 Mar;9(2):492-502. doi: 10.1038/mi.2015.79. Epub 2015 Sep 9.


Characterization of Bacterial and Fungal Microbiome in Children with Hirschsprung Disease with and without a History of Enterocolitis: A Multicenter Study.

Frykman PK, Nordenskjöld A, Kawaguchi A, Hui TT, Granström AL, Cheng Z, Tang J, Underhill DM, Iliev I, Funari VA, Wester T; HAEC Collaborative Research Group (HCRG).

PLoS One. 2015 Apr 24;10(4):e0124172. doi: 10.1371/journal.pone.0124172. eCollection 2015.


Mycobiome: Approaches to analysis of intestinal fungi.

Tang J, Iliev ID, Brown J, Underhill DM, Funari VA.

J Immunol Methods. 2015 Jun;421:112-121. doi: 10.1016/j.jim.2015.04.004. Epub 2015 Apr 17.


Time to cast a larger net.

Wheeler ML, Underhill DM.

Nat Immunol. 2014 Nov;15(11):1000-1. doi: 10.1038/ni.3013. No abstract available.


The mycobiota: interactions between commensal fungi and the host immune system.

Underhill DM, Iliev ID.

Nat Rev Immunol. 2014 Jun;14(6):405-16. doi: 10.1038/nri3684. Review.


Cutting edge: FYCO1 recruitment to dectin-1 phagosomes is accelerated by light chain 3 protein and regulates phagosome maturation and reactive oxygen production.

Ma J, Becker C, Reyes C, Underhill DM.

J Immunol. 2014 Feb 15;192(4):1356-60. doi: 10.4049/jimmunol.1302835. Epub 2014 Jan 17.


Striking a balance: fungal commensalism versus pathogenesis.

Iliev ID, Underhill DM.

Curr Opin Microbiol. 2013 Jun;16(3):366-73. doi: 10.1016/j.mib.2013.05.004. Epub 2013 Jun 4. Review.


β-Glucan signaling connects phagocytosis to autophagy.

Ma J, Underhill DM.

Glycobiology. 2013 Sep;23(9):1047-51. doi: 10.1093/glycob/cwt046. Epub 2013 Jun 6. Review.


Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce.

Yáñez A, Hassanzadeh-Kiabi N, Ng MY, Megías J, Subramanian A, Liu GY, Underhill DM, Gil ML, Goodridge HS.

Eur J Immunol. 2013 Aug;43(8):2114-25. doi: 10.1002/eji.201343403. Epub 2013 Jun 7.


Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence.

Nakayama M, Kurokawa K, Nakamura K, Lee BL, Sekimizu K, Kubagawa H, Hiramatsu K, Yagita H, Okumura K, Takai T, Underhill DM, Aderem A, Ogasawara K.

J Immunol. 2012 Dec 15;189(12):5903-11. doi: 10.4049/jimmunol.1201940. Epub 2012 Nov 14.


Failure to induce IFN-β production during Staphylococcus aureus infection contributes to pathogenicity.

Kaplan A, Ma J, Kyme P, Wolf AJ, Becker CA, Tseng CW, Liu GY, Underhill DM.

J Immunol. 2012 Nov 1;189(9):4537-45. doi: 10.4049/jimmunol.1201111. Epub 2012 Sep 24.


Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens.

Ma J, Becker C, Lowell CA, Underhill DM.

J Biol Chem. 2012 Oct 5;287(41):34149-56. doi: 10.1074/jbc.M112.382812. Epub 2012 Aug 17.


Information processing during phagocytosis.

Underhill DM, Goodridge HS.

Nat Rev Immunol. 2012 Jun 15;12(7):492-502. doi: 10.1038/nri3244. Review.


Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis.

Iliev ID, Funari VA, Taylor KD, Nguyen Q, Reyes CN, Strom SP, Brown J, Becker CA, Fleshner PR, Dubinsky M, Rotter JI, Wang HL, McGovern DP, Brown GD, Underhill DM.

Science. 2012 Jun 8;336(6086):1314-7. doi: 10.1126/science.1221789. Epub 2012 Jun 6.


Mechanisms of Fc receptor and dectin-1 activation for phagocytosis.

Goodridge HS, Underhill DM, Touret N.

Traffic. 2012 Aug;13(8):1062-71. doi: 10.1111/j.1600-0854.2012.01382.x. Epub 2012 Jun 19. Review.


Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.

Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, Rentsendorj A, Vargas M, Guerrero C, Wang Y, Fitzgerald KA, Underhill DM, Town T, Arditi M.

Immunity. 2012 Mar 23;36(3):401-14. doi: 10.1016/j.immuni.2012.01.009. Epub 2012 Feb 16.


Phagosomal degradation increases TLR access to bacterial ligands and enhances macrophage sensitivity to bacteria.

Wolf AJ, Arruda A, Reyes CN, Kaplan AT, Shimada T, Shimada K, Arditi M, Liu G, Underhill DM.

J Immunol. 2011 Dec 1;187(11):6002-10. doi: 10.4049/jimmunol.1100232. Epub 2011 Oct 26.


Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'.

Goodridge HS, Reyes CN, Becker CA, Katsumoto TR, Ma J, Wolf AJ, Bose N, Chan AS, Magee AS, Danielson ME, Weiss A, Vasilakos JP, Underhill DM.

Nature. 2011 Apr 28;472(7344):471-5. doi: 10.1038/nature10071.


Adaptor protein Lnk inhibits c-Fms-mediated macrophage function.

Gueller S, Goodridge HS, Niebuhr B, Xing H, Koren-Michowitz M, Serve H, Underhill DM, Brandts CH, Koeffler HP.

J Leukoc Biol. 2010 Oct;88(4):699-706. doi: 10.1189/jlb.0309185. Epub 2010 Jun 22.


Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion.

Shimada T, Park BG, Wolf AJ, Brikos C, Goodridge HS, Becker CA, Reyes CN, Miao EA, Aderem A, Götz F, Liu GY, Underhill DM.

Cell Host Microbe. 2010 Jan 21;7(1):38-49. doi: 10.1016/j.chom.2009.12.008.


Beta-glucan recognition by the innate immune system.

Goodridge HS, Wolf AJ, Underhill DM.

Immunol Rev. 2009 Jul;230(1):38-50. doi: 10.1111/j.1600-065X.2009.00793.x. Review.


Differential use of CARD9 by dectin-1 in macrophages and dendritic cells.

Goodridge HS, Shimada T, Wolf AJ, Hsu YM, Becker CA, Lin X, Underhill DM.

J Immunol. 2009 Jan 15;182(2):1146-54.


Host-microbe interactions: fungi.

Underhill DM.

Curr Opin Microbiol. 2008 Aug;11(4):303-4. doi: 10.1016/j.mib.2008.07.001. Epub 2008 Jul 24. No abstract available.


Fungal Recognition by TLR2 and Dectin-1.

Goodridge HS, Underhill DM.

Handb Exp Pharmacol. 2008;(183):87-109. Review.


Collaboration between the innate immune receptors dectin-1, TLRs, and Nods.

Underhill DM.

Immunol Rev. 2007 Oct;219:75-87. Review.


Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine production.

Nakayama M, Underhill DM, Petersen TW, Li B, Kitamura T, Takai T, Aderem A.

J Immunol. 2007 Apr 1;178(7):4250-9.


A pair of 9s: it's in the CARDs.

Underhill DM, Shimada T.

Nat Immunol. 2007 Feb;8(2):122-4.


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