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Design, synthesis, and evaluation of isoquinoline ureas as TRPV1 antagonists.

Gujarati NA, Undem BJ, Korlipara VL.

Med Chem. 2019 Jun 26. doi: 10.2174/1573406415666190626130453. [Epub ahead of print]


Allergen-induced histaminergic and non-histaminergic activation of itch C-fiber nerve terminals in mouse skin.

Jurcakova D, Ru F, Undem BJ.

Neuroscience. 2019 Jul 1;410:55-58. doi: 10.1016/j.neuroscience.2019.04.039. Epub 2019 Apr 29.


Effects of ginger constituent 6-shogaol on gastroesophageal vagal afferent C-fibers.

Huang Y, Patil MJ, Yu M, Liptak P, Undem BJ, Dong X, Wang G, Yu S.

Neurogastroenterol Motil. 2019 Jun;31(6):e13585. doi: 10.1111/nmo.13585. Epub 2019 Apr 4.


Phenotypic distinctions between the nodose and jugular TRPV1-positive vagal sensory neurons in the cynomolgus monkey.

Kollarik M, Ru F, Undem BJ.

Neuroreport. 2019 May 22;30(8):533-537. doi: 10.1097/WNR.0000000000001231.


Targeting C-fibers for peripheral acting anti-tussive drugs.

Patil MJ, Sun H, Ru F, Meeker S, Undem BJ.

Pulm Pharmacol Ther. 2019 Jun;56:15-19. doi: 10.1016/j.pupt.2019.03.002. Epub 2019 Mar 11. Review.


Sphingosine-1-phosphate activates mouse vagal airway afferent C-fibres via S1PR3 receptors.

Patil MJ, Meeker S, Bautista D, Dong X, Undem BJ.

J Physiol. 2019 Apr;597(7):2007-2019. doi: 10.1113/JP277521. Epub 2019 Feb 21.


KCNQ/M-channels regulate mouse vagal bronchopulmonary C-fiber excitability and cough sensitivity.

Sun H, Lin AH, Ru F, Patil MJ, Meeker S, Lee LY, Undem BJ.

JCI Insight. 2019 Mar 7;4(5). pii: 124467. doi: 10.1172/jci.insight.124467. eCollection 2019 Mar 7.


Voltage-Gated Sodium Channels Regulating Action Potential Generation in Itch-, Nociceptive-, and Low-Threshold Mechanosensitive Cutaneous C-Fibers.

Jurcakova D, Ru F, Kollarik M, Sun H, Krajewski J, Undem BJ.

Mol Pharmacol. 2018 Sep;94(3):1047-1056. doi: 10.1124/mol.118.112839. Epub 2018 Jun 25.


Sphingosine-1-phosphate selectively activates vagal afferent C-fiber subtype in guinea pig esophagus.

Yu X, Patil MJ, Yu M, Liu Y, Wang J, Undem BJ, Yu S.

Neurogastroenterol Motil. 2018 Sep;30(9):e13359. doi: 10.1111/nmo.13359. Epub 2018 Apr 19.


Different role of TTX-sensitive voltage-gated sodium channel (NaV 1) subtypes in action potential initiation and conduction in vagal airway nociceptors.

Kollarik M, Sun H, Herbstsomer RA, Ru F, Kocmalova M, Meeker SN, Undem BJ.

J Physiol. 2018 Apr 15;596(8):1419-1432. doi: 10.1113/JP275698.


Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness.

Han L, Limjunyawong N, Ru F, Li Z, Hall OJ, Steele H, Zhu Y, Wilson J, Mitzner W, Kollarik M, Undem BJ, Canning BJ, Dong X.

Nat Neurosci. 2018 Mar;21(3):324-328. doi: 10.1038/s41593-018-0074-8. Epub 2018 Feb 5.


Blocking voltage-gated sodium channels as a strategy to suppress pathological cough.

Sun H, Kollarik M, Undem BJ.

Pulm Pharmacol Ther. 2017 Dec;47:38-41. doi: 10.1016/j.pupt.2017.05.010. Epub 2017 May 15. Review.


Mechanisms of pruritogen-induced activation of itch nerves in isolated mouse skin.

Ru F, Sun H, Jurcakova D, Herbstsomer RA, Meixong J, Dong X, Undem BJ.

J Physiol. 2017 Jun 1;595(11):3651-3666. doi: 10.1113/JP273795. Epub 2017 Mar 19.


Control of Neurotransmission by NaV1.7 in Human, Guinea Pig, and Mouse Airway Parasympathetic Nerves.

Kocmalova M, Kollarik M, Canning BJ, Ru F, Adam Herbstsomer R, Meeker S, Fonquerna S, Aparici M, Miralpeix M, Chi XX, Li B, Wilenkin B, McDermott J, Nisenbaum E, Krajewski JL, Undem BJ.

J Pharmacol Exp Ther. 2017 Apr;361(1):172-180. doi: 10.1124/jpet.116.238469. Epub 2017 Jan 30.


Vagal Afferent Innervation of the Airways in Health and Disease.

Mazzone SB, Undem BJ.

Physiol Rev. 2016 Jul;96(3):975-1024. doi: 10.1152/physrev.00039.2015. Review.


Parainfluenza 3-Induced Cough Hypersensitivity in the Guinea Pig Airways.

Zaccone EJ, Lieu T, Muroi Y, Potenzieri C, Undem BE, Gao P, Han L, Canning BJ, Undem BJ.

PLoS One. 2016 May 23;11(5):e0155526. doi: 10.1371/journal.pone.0155526. eCollection 2016.


Airway Vagal Neuroplasticity Associated with Respiratory Viral Infections.

Zaccone EJ, Undem BJ.

Lung. 2016 Feb;194(1):25-9. doi: 10.1007/s00408-015-9832-5. Epub 2015 Dec 17. Review.


Neural dysfunction following respiratory viral infection as a cause of chronic cough hypersensitivity.

Undem BJ, Zaccone E, McGarvey L, Mazzone SB.

Pulm Pharmacol Ther. 2015 Aug;33:52-6. doi: 10.1016/j.pupt.2015.06.006. Epub 2015 Jun 30. Review.


P2X3 receptors and sensitization of autonomic reflexes.

Ford AP, Undem BJ, Birder LA, Grundy D, Pijacka W, Paton JF.

Auton Neurosci. 2015 Sep;191:16-24. doi: 10.1016/j.autneu.2015.04.005. Epub 2015 Apr 25. Review.


Vagotomy reverses established allergen-induced airway hyperreactivity to methacholine in the mouse.

McAlexander MA, Gavett SH, Kollarik M, Undem BJ.

Respir Physiol Neurobiol. 2015 Jul;212-214:20-4. doi: 10.1016/j.resp.2015.03.007. Epub 2015 Apr 1.


TRPM8 function and expression in vagal sensory neurons and afferent nerves innervating guinea pig esophagus.

Yu X, Hu Y, Ru F, Kollarik M, Undem BJ, Yu S.

Am J Physiol Gastrointest Liver Physiol. 2015 Mar 15;308(6):G489-96. doi: 10.1152/ajpgi.00336.2014. Epub 2015 Jan 15.


Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions.

McNeil BD, Pundir P, Meeker S, Han L, Undem BJ, Kulka M, Dong X.

Nature. 2015 Mar 12;519(7542):237-41. doi: 10.1038/nature14022. Epub 2014 Dec 17.


Increased acid responsiveness in vagal sensory neurons in a guinea pig model of eosinophilic esophagitis.

Hu Y, Liu Z, Yu X, Pasricha PJ, Undem BJ, Yu S.

Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15;307(2):G149-57. doi: 10.1152/ajpgi.00097.2014. Epub 2014 May 29.


Transient receptor potential vanilloid 4 activation constricts the human bronchus via the release of cysteinyl leukotrienes.

McAlexander MA, Luttmann MA, Hunsberger GE, Undem BJ.

J Pharmacol Exp Ther. 2014 Apr;349(1):118-25. doi: 10.1124/jpet.113.210203. Epub 2014 Feb 6.


Mechanisms underlying the neuronal-based symptoms of allergy.

Undem BJ, Taylor-Clark T.

J Allergy Clin Immunol. 2014 Jun;133(6):1521-34. doi: 10.1016/j.jaci.2013.11.027. Epub 2014 Jan 13. Review.


The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological disorders.

Ford AP, Undem BJ.

Front Cell Neurosci. 2013 Dec 19;7:267. doi: 10.3389/fncel.2013.00267. Review.


Targeting voltage gated sodium channels NaV1.7, Na V1.8, and Na V1.9 for treatment of pathological cough.

Muroi Y, Undem BJ.

Lung. 2014 Feb;192(1):15-20. doi: 10.1007/s00408-013-9533-x. Epub 2013 Nov 24. Review.


Chronic cough and pain: Janus faces in sensory neurobiology?

O'Neill J, McMahon SB, Undem BJ.

Pulm Pharmacol Ther. 2013 Oct;26(5):476-85. doi: 10.1016/j.pupt.2013.06.010. Epub 2013 Jul 4. Review.


Selective inhibition of vagal afferent nerve pathways regulating cough using Nav 1.7 shRNA silencing in guinea pig nodose ganglia.

Muroi Y, Ru F, Chou YL, Carr MJ, Undem BJ, Canning BJ.

Am J Physiol Regul Integr Comp Physiol. 2013 Jun 1;304(11):R1017-23. doi: 10.1152/ajpregu.00028.2013. Epub 2013 Apr 10.


Is nerve growth factor involved in the symptoms of rhinitis?

Undem BJ.

Ann Allergy Asthma Immunol. 2012 Sep;109(3):154. doi: 10.1016/j.anai.2012.07.011. No abstract available.


Activation of mouse bronchopulmonary C-fibres by serotonin and allergen-ovalbumin challenge.

Potenzieri C, Meeker S, Undem BJ.

J Physiol. 2012 Nov 1;590(21):5449-59. doi: 10.1113/jphysiol.2012.237115. Epub 2012 Aug 20.


Allergen-induced neuromodulation in the respiratory tract.

Weigand LA, Undem BJ.

Chem Immunol Allergy. 2012;98:142-62. doi: 10.1159/000336508. Epub 2012 Jun 26. Review.


A role for ATP in bronchoconstriction-induced activation of guinea pig vagal intrapulmonary C-fibres.

Weigand LA, Ford AP, Undem BJ.

J Physiol. 2012 Aug 15;590(16):4109-20. doi: 10.1113/jphysiol.2012.233460. Epub 2012 Jun 11.


Autonomic neural control of intrathoracic airways.

Undem BJ, Potenzieri C.

Compr Physiol. 2012 Apr;2(2):1241-67. doi: 10.1002/cphy.c110032. Review.


TRPV1 induction in airway vagal low-threshold mechanosensory neurons by allergen challenge and neurotrophic factors.

Lieu TM, Myers AC, Meeker S, Undem BJ.

Am J Physiol Lung Cell Mol Physiol. 2012 May 1;302(9):L941-8. doi: 10.1152/ajplung.00366.2011. Epub 2012 Feb 17.


Selective silencing of Na(V)1.7 decreases excitability and conduction in vagal sensory neurons.

Muroi Y, Ru F, Kollarik M, Canning BJ, Hughes SA, Walsh S, Sigg M, Carr MJ, Undem BJ.

J Physiol. 2011 Dec 1;589(Pt 23):5663-76. doi: 10.1113/jphysiol.2011.215384. Epub 2011 Oct 17.


Direct activation of guinea pig vagal afferent neurons by FMRFamide.

Lee MG, Park JY, Park YK, Undem BJ.

Neuroreport. 2011 Aug 24;22(12):609-12. doi: 10.1097/WNR.0b013e3283495a6e.


Targeting peripheral afferent nerve terminals for cough and dyspnea.

Muroi Y, Undem BJ.

Curr Opin Pharmacol. 2011 Jun;11(3):254-64. doi: 10.1016/j.coph.2011.05.006. Epub 2011 Jun 24. Review.


Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch.

Patel KN, Liu Q, Meeker S, Undem BJ, Dong X.

PLoS One. 2011;6(5):e20559. doi: 10.1371/journal.pone.0020559. Epub 2011 May 31.


Basic mechanisms of itch.

Potenzieri C, Undem BJ.

Clin Exp Allergy. 2012 Jan;42(1):8-19. doi: 10.1111/j.1365-2222.2011.03791.x. Epub 2011 Jun 6. Review.


Sensing pulmonary oxidative stress by lung vagal afferents.

Taylor-Clark TE, Undem BJ.

Respir Physiol Neurobiol. 2011 Sep 30;178(3):406-13. doi: 10.1016/j.resp.2011.05.003. Epub 2011 May 10. Review.


Neuroplasticity in vagal afferent neurons involved in cough.

Lieu T, Undem BJ.

Pulm Pharmacol Ther. 2011 Jun;24(3):276-9. doi: 10.1016/j.pupt.2011.02.003. Epub 2011 Mar 2.


Neurotrophin and GDNF family ligand receptor expression in vagal sensory nerve subtypes innervating the adult guinea pig respiratory tract.

Lieu T, Kollarik M, Myers AC, Undem BJ.

Am J Physiol Lung Cell Mol Physiol. 2011 May;300(5):L790-8. doi: 10.1152/ajplung.00449.2010. Epub 2011 Feb 18.


Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs.

Nassenstein C, Taylor-Clark TE, Myers AC, Ru F, Nandigama R, Bettner W, Undem BJ.

J Physiol. 2010 Dec 1;588(Pt 23):4769-83. doi: 10.1113/jphysiol.2010.195339. Epub 2010 Oct 11.


Transgene expression and effective gene silencing in vagal afferent neurons in vivo using recombinant adeno-associated virus vectors.

Kollarik M, Carr MJ, Ru F, Ring CJ, Hart VJ, Murdock P, Myers AC, Muroi Y, Undem BJ.

J Physiol. 2010 Nov 1;588(Pt 21):4303-15. doi: 10.1113/jphysiol.2010.192971. Epub 2010 Aug 24.


Thrombin and trypsin directly activate vagal C-fibres in mouse lung via protease-activated receptor-1.

Kwong K, Nassenstein C, de Garavilla L, Meeker S, Undem BJ.

J Physiol. 2010 Apr 1;588(Pt 7):1171-7. doi: 10.1113/jphysiol.2009.181669. Epub 2010 Feb 8.


Targeting primary afferent nerves for novel antitussive therapy.

Undem BJ, Carr MJ.

Chest. 2010 Jan;137(1):177-84. doi: 10.1378/chest.09-1960. Review.


Vagal control of mucociliary clearance in murine lungs: a study in a chronic preparation.

Bhashyam AR, Mogayzel PJ Jr, Cleary JC, Undem BJ, Kollarik M, Fox J, Laube BL.

Auton Neurosci. 2010 Apr 19;154(1-2):74-8. doi: 10.1016/j.autneu.2009.12.002. Epub 2010 Jan 3.


Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels.

Taylor-Clark TE, Undem BJ.

J Physiol. 2010 Feb 1;588(Pt 3):423-33. doi: 10.1113/jphysiol.2009.183301. Epub 2009 Dec 14.


Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.

Liu Q, Tang Z, Surdenikova L, Kim S, Patel KN, Kim A, Ru F, Guan Y, Weng HJ, Geng Y, Undem BJ, Kollarik M, Chen ZF, Anderson DJ, Dong X.

Cell. 2009 Dec 24;139(7):1353-65. doi: 10.1016/j.cell.2009.11.034. Epub 2009 Dec 10.

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