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Items: 18


Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development.

Tostar U, Malm CJ, Meis-Kindblom JM, Kindblom LG, Toftgård R, Undén AB.

J Pathol. 2006 Jan;208(1):17-25.


Role for ELOVL3 and fatty acid chain length in development of hair and skin function.

Westerberg R, Tvrdik P, Undén AB, Månsson JE, Norlén L, Jakobsson A, Holleran WH, Elias PM, Asadi A, Flodby P, Toftgård R, Capecchi MR, Jacobsson A.

J Biol Chem. 2004 Feb 13;279(7):5621-9. Epub 2003 Oct 27.


Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1.

Bigelow RL, Chari NS, Unden AB, Spurgers KB, Lee S, Roop DR, Toftgard R, McDonnell TJ.

J Biol Chem. 2004 Jan 9;279(2):1197-205. Epub 2003 Oct 10.


Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis.

Niemann C, Unden AB, Lyle S, Zouboulis ChC, Toftgård R, Watt FM.

Proc Natl Acad Sci U S A. 2003 Sep 30;100 Suppl 1:11873-80. Epub 2003 Aug 13.


Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein.

Kogerman P, Krause D, Rahnama F, Kogerman L, Undén AB, Zaphiropoulos PG, Toftgård R.

Oncogene. 2002 Sep 5;21(39):6007-16.


PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer.

Ling G, Ahmadian A, Persson A, Undén AB, Afink G, Williams C, Uhlén M, Toftgård R, Lundeberg J, Pontén F.

Oncogene. 2001 Nov 22;20(53):7770-8.


Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1.

Nilsson M, Undèn AB, Krause D, Malmqwist U, Raza K, Zaphiropoulos PG, Toftgård R.

Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3438-43.


Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1.

Kogerman P, Grimm T, Kogerman L, Krause D, Undén AB, Sandstedt B, Toftgård R, Zaphiropoulos PG.

Nat Cell Biol. 1999 Sep;1(5):312-9.


PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas.

Zaphiropoulos PG, Undén AB, Rahnama F, Hollingsworth RE, Toftgård R.

Cancer Res. 1999 Feb 15;59(4):787-92.


Mutation analysis of the human homologue of Drosophila patched and the xeroderma pigmentosum complementation group A genes in squamous cell carcinomas of the skin.

Eklund LK, Lindström E, Undén AB, Lundh-Rozell B, Ståhle-Bäckdahl M, Zaphiropoulos PG, Toftgård R, Söderkvist P.

Mol Carcinog. 1998 Feb;21(2):87-92.


Trichoepitheliomas contain somatic mutations in the overexpressed PTCH gene: support for a gatekeeper mechanism in skin tumorigenesis.

Vorechovský I, Undén AB, Sandstedt B, Toftgård R, Ståhle-Bäckdahl M.

Cancer Res. 1997 Nov 1;57(21):4677-81.


Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma.

Undén AB, Zaphiropoulos PG, Bruce K, Toftgård R, Ståhle-Bäckdahl M.

Cancer Res. 1997 Jun 15;57(12):2336-40.


Fine mapping of the locus for nevoid basal cell carcinoma syndrome on chromosome 9q.

Undén AB, Ståhle-Bäckdahl M, Holmberg E, Larsson C, Toftgård R.

Acta Derm Venereol. 1997 Jan;77(1):4-9.


Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PTCH inactivation.

Unden AB, Holmberg E, Lundh-Rozell B, Stähle-Bäckdahl M, Zaphiropoulos PG, Toftgård R, Vorechovsky I.

Cancer Res. 1996 Oct 15;56(20):4562-5.


The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas.

Gailani MR, Ståhle-Bäckdahl M, Leffell DJ, Glynn M, Zaphiropoulos PG, Pressman C, Undén AB, Dean M, Brash DE, Bale AE, Toftgård R.

Nat Genet. 1996 Sep;14(1):78-81.


Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.

Hahn H, Wicking C, Zaphiropoulous PG, Gailani MR, Shanley S, Chidambaram A, Vorechovsky I, Holmberg E, Unden AB, Gillies S, Negus K, Smyth I, Pressman C, Leffell DJ, Gerrard B, Goldstein AM, Dean M, Toftgard R, Chenevix-Trench G, Wainwright B, Bale AE.

Cell. 1996 Jun 14;85(6):841-51.

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