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MHC-II neoantigens shape tumour immunity and response to immunotherapy.

Alspach E, Lussier DM, Miceli AP, Kizhvatov I, DuPage M, Luoma AM, Meng W, Lichti CF, Esaulova E, Vomund AN, Runci D, Ward JP, Gubin MM, Medrano RFV, Arthur CD, White JM, Sheehan KCF, Chen A, Wucherpfennig KW, Jacks T, Unanue ER, Artyomov MN, Schreiber RD.

Nature. 2019 Oct 23. doi: 10.1038/s41586-019-1671-8. [Epub ahead of print]


The Immunoreactive Platform of the Pancreatic Islets Influences the Development of Autoreactivity.

Unanue ER, Wan X.

Diabetes. 2019 Aug;68(8):1544-1551. doi: 10.2337/dbi18-0048.


Antigen recognition in autoimmune diabetes: a novel pathway underlying disease initiation.

Wan X, Unanue ER.

Precis Clin Med. 2018 Dec;1(3):102-110. doi: 10.1093/pcmedi/pby015. Epub 2018 Nov 23. Review.


Type I and II Interferon Receptors Differentially Regulate Type 1 Diabetes Susceptibility in Male Versus Female NOD Mice.

Carrero JA, Benshoff ND, Nalley K, Unanue ER.

Diabetes. 2018 Sep;67(9):1830-1835. doi: 10.2337/db18-0331. Epub 2018 Jul 3.


Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides.

Wan X, Zinselmeyer BH, Zakharov PN, Vomund AN, Taniguchi R, Santambrogio L, Anderson MS, Lichti CF, Unanue ER.

Nature. 2018 Aug;560(7716):107-111. doi: 10.1038/s41586-018-0341-6. Epub 2018 Jul 18.


The resident macrophages in murine pancreatic islets are constantly probing their local environment, capturing beta cell granules and blood particles.

Zinselmeyer BH, Vomund AN, Saunders BT, Johnson MW, Carrero JA, Unanue ER.

Diabetologia. 2018 Jun;61(6):1374-1383. doi: 10.1007/s00125-018-4592-4. Epub 2018 Mar 27.


Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice.

Carrero JA, McCarthy DP, Ferris ST, Wan X, Hu H, Zinselmeyer BH, Vomund AN, Unanue ER.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10418-E10427. doi: 10.1073/pnas.1713543114. Epub 2017 Nov 13.


TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.

Ulland TK, Song WM, Huang SC, Ulrich JD, Sergushichev A, Beatty WL, Loboda AA, Zhou Y, Cairns NJ, Kambal A, Loginicheva E, Gilfillan S, Cella M, Virgin HW, Unanue ER, Wang Y, Artyomov MN, Holtzman DM, Colonna M.

Cell. 2017 Aug 10;170(4):649-663.e13. doi: 10.1016/j.cell.2017.07.023.


The islet-resident macrophage is in an inflammatory state and senses microbial products in blood.

Ferris ST, Zakharov PN, Wan X, Calderon B, Artyomov MN, Unanue ER, Carrero JA.

J Exp Med. 2017 Aug 7;214(8):2369-2385. doi: 10.1084/jem.20170074. Epub 2017 Jun 19.


Unique features in the presentation of insulin epitopes in autoimmune diabetes: an update.

Wan X, Unanue ER.

Curr Opin Immunol. 2017 Jun;46:30-37. doi: 10.1016/j.coi.2017.04.001. Epub 2017 Apr 26. Review.


Listeria monocytogenes induces an interferon-enhanced activation of the integrated stress response that is detrimental for resolution of infection in mice.

Valderrama C, Clark A, Urano F, Unanue ER, Carrero JA.

Eur J Immunol. 2017 May;47(5):830-840. doi: 10.1002/eji.201646856. Epub 2017 Apr 13.


Macrophages in Endocrine Glands, with Emphasis on Pancreatic Islets.

Unanue ER.

Microbiol Spectr. 2016 Dec;4(6). doi: 10.1128/microbiolspec.MCHD-0048-2016. Review.


Macrophages and dendritic cells in islets of Langerhans in diabetic autoimmunity: a lesson on cell interactions in a mini-organ.

Carrero JA, Ferris ST, Unanue ER.

Curr Opin Immunol. 2016 Dec;43:54-59. doi: 10.1016/j.coi.2016.09.004. Epub 2016 Oct 4. Review.


The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse.

Unanue ER, Ferris ST, Carrero JA.

Immunol Rev. 2016 Jul;272(1):183-201. doi: 10.1111/imr.12430. Review.


Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites.

Wan X, Thomas JW, Unanue ER.

J Exp Med. 2016 May 30;213(6):967-78. doi: 10.1084/jem.20151869. Epub 2016 May 2.


Antigen presentation events during the initiation of autoimmune diabetes in the NOD mouse.

Ferris ST, Carrero JA, Unanue ER.

J Autoimmun. 2016 Jul;71:19-25. doi: 10.1016/j.jaut.2016.03.007. Epub 2016 Mar 24. Review.


Variations in MHC Class II Antigen Processing and Presentation in Health and Disease.

Unanue ER, Turk V, Neefjes J.

Annu Rev Immunol. 2016 May 20;34:265-97. doi: 10.1146/annurev-immunol-041015-055420. Epub 2016 Feb 22. Review.


The Secrets of the Class II MHC Peptidome Start To Be Revealed.

Unanue ER.

J Immunol. 2016 Feb 1;196(3):939-40. doi: 10.4049/jimmunol.1502571. No abstract available.


The pancreas anatomy conditions the origin and properties of resident macrophages.

Calderon B, Carrero JA, Ferris ST, Sojka DK, Moore L, Epelman S, Murphy KM, Yokoyama WM, Randolph GJ, Unanue ER.

J Exp Med. 2015 Sep 21;212(10):1497-512. doi: 10.1084/jem.20150496. Epub 2015 Sep 7.


Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells.

Vomund AN, Zinselmeyer BH, Hughes J, Calderon B, Valderrama C, Ferris ST, Wan X, Kanekura K, Carrero JA, Urano F, Unanue ER.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):E5496-502. doi: 10.1073/pnas.1515954112. Epub 2015 Aug 31.


Herman N. Eisen, M.D. (1918-2014): Scholar, Gentleman, and AAI President (1968-1969).

Chakraborty AK, Unanue ER.

J Immunol. 2015 Mar 15;194(6):2451-2. doi: 10.4049/jimmunol.1590003. No abstract available.


Herman Eisen (1918-2014).

Chakraborty AK, Unanue ER.

Immunity. 2014 Dec 18;41(6):869-70. No abstract available.


A minor subset of Batf3-dependent antigen-presenting cells in islets of Langerhans is essential for the development of autoimmune diabetes.

Ferris ST, Carrero JA, Mohan JF, Calderon B, Murphy KM, Unanue ER.

Immunity. 2014 Oct 16;41(4):657-69. doi: 10.1016/j.immuni.2014.09.012.


Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model.

Rowland SL, Riggs JM, Gilfillan S, Bugatti M, Vermi W, Kolbeck R, Unanue ER, Sanjuan MA, Colonna M.

J Exp Med. 2014 Sep 22;211(10):1977-91. doi: 10.1084/jem.20132620. Epub 2014 Sep 1.


ZnT8-reactive T cells are weakly pathogenic in NOD mice but can participate in diabetes under inflammatory conditions.

Nayak DK, Calderon B, Vomund AN, Unanue ER.

Diabetes. 2014 Oct;63(10):3438-48. doi: 10.2337/db13-1882. Epub 2014 May 8.


Antigen processing.

Reis e Sousa C, Unanue ER.

Curr Opin Immunol. 2014 Feb;26:138-9. doi: 10.1016/j.coi.2013.12.003. Epub 2013 Dec 22. No abstract available.


Ita Askonas and her influence in the field of antigen presentation.

Unanue ER, McMichael AJ.

Curr Opin Immunol. 2014 Feb;26:111-4. doi: 10.1016/j.coi.2013.11.004. Epub 2013 Dec 7.


The central role of antigen presentation in islets of Langerhans in autoimmune diabetes.

Calderon B, Carrero JA, Unanue ER.

Curr Opin Immunol. 2014 Feb;26:32-40. doi: 10.1016/j.coi.2013.10.011. Epub 2013 Nov 16. Review.


Antigen presentation in the autoimmune diabetes of the NOD mouse.

Unanue ER.

Annu Rev Immunol. 2014;32:579-608. doi: 10.1146/annurev-immunol-032712-095941. Epub 2014 Feb 5. Review.


Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation.

Epelman S, Lavine KJ, Beaudin AE, Sojka DK, Carrero JA, Calderon B, Brija T, Gautier EL, Ivanov S, Satpathy AT, Schilling JD, Schwendener R, Sergin I, Razani B, Forsberg EC, Yokoyama WM, Unanue ER, Colonna M, Randolph GJ, Mann DL.

Immunity. 2014 Jan 16;40(1):91-104. doi: 10.1016/j.immuni.2013.11.019.


Endoplasmic reticulum: an interface between the immune system and metabolism.

Unanue ER, Urano F.

Diabetes. 2014 Jan;63(1):48-9. doi: 10.2337/db13-1478. No abstract available.


Pathogenic CD4⁺ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes.

Mohan JF, Calderon B, Anderson MS, Unanue ER.

J Exp Med. 2013 Oct 21;210(11):2403-14. doi: 10.1084/jem.20130582. Epub 2013 Oct 14.


Identifying the initiating events of anti-Listeria responses using mice with conditional loss of IFN-γ receptor subunit 1 (IFNGR1).

Lee SH, Carrero JA, Uppaluri R, White JM, Archambault JM, Lai KS, Chan SR, Sheehan KC, Unanue ER, Schreiber RD.

J Immunol. 2013 Oct 15;191(8):4223-34. doi: 10.4049/jimmunol.1300910. Epub 2013 Sep 18.


Perspectives on anti-CD47 antibody treatment for experimental cancer.

Unanue ER.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10886-7. doi: 10.1073/pnas.1308463110. Epub 2013 Jun 19. No abstract available.


Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse.

Carrero JA, Calderon B, Towfic F, Artyomov MN, Unanue ER.

PLoS One. 2013;8(3):e59701. doi: 10.1371/journal.pone.0059701. Epub 2013 Mar 26. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/f277b29e-361b-4e56-b55b-612ebaca0432.


Neutrophils control the magnitude and spread of the immune response in a thromboxane A2-mediated process.

Yang CW, Unanue ER.

J Exp Med. 2013 Feb 11;210(2):375-87. doi: 10.1084/jem.20122183. Epub 2013 Jan 21.


The ever surprising field of antigen presentation.

Neefjes J, Unanue ER.

Mol Immunol. 2013 Sep;55(2):105. doi: 10.1016/j.molimm.2012.11.003. Epub 2013 Jan 6. No abstract available.


A novel pathway of presentation by class II-MHC molecules involving peptides or denatured proteins important in autoimmunity.

Mohan JF, Unanue ER.

Mol Immunol. 2013 Sep;55(2):166-8. doi: 10.1016/j.molimm.2012.10.024. Epub 2012 Nov 27. Review.


Unconventional recognition of peptides by T cells and the implications for autoimmunity.

Mohan JF, Unanue ER.

Nat Rev Immunol. 2012 Oct;12(10):721-8. doi: 10.1038/nri3294. Epub 2012 Sep 7. Review.


Listeriolysin o is strongly immunogenic independently of its cytotoxic activity.

Carrero JA, Vivanco-Cid H, Unanue ER.

PLoS One. 2012;7(3):e32310. doi: 10.1371/journal.pone.0032310. Epub 2012 Mar 5.


Mechanisms and immunological effects of apoptosis caused by Listeria monocytogenes.

Carrero JA, Unanue ER.

Adv Immunol. 2012;113:157-74. doi: 10.1016/B978-0-12-394590-7.00001-4. Review.


Studies with Listeria monocytogenes lead the way.

Unanue ER, Carrero JA.

Adv Immunol. 2012;113:1-5. doi: 10.1016/B978-0-12-394590-7.00009-9. No abstract available.


Antigen presentation events in autoimmune diabetes.

Calderon B, Unanue ER.

Curr Opin Immunol. 2012 Feb;24(1):119-28. doi: 10.1016/j.coi.2011.11.005. Epub 2011 Dec 15. Review.


Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells.

Ireland JM, Unanue ER.

J Exp Med. 2011 Dec 19;208(13):2625-32. doi: 10.1084/jem.20110640. Epub 2011 Dec 12.


Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization.

Edelson BT, Bradstreet TR, KC W, Hildner K, Herzog JW, Sim J, Russell JH, Murphy TL, Unanue ER, Murphy KM.

PLoS One. 2011;6(10):e25660. doi: 10.1371/journal.pone.0025660. Epub 2011 Oct 17.


Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion.

Mohan JF, Petzold SJ, Unanue ER.

J Exp Med. 2011 Nov 21;208(12):2375-83. doi: 10.1084/jem.20111502. Epub 2011 Nov 7.


CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes.

Edelson BT, Bradstreet TR, Hildner K, Carrero JA, Frederick KE, KC W, Belizaire R, Aoshi T, Schreiber RD, Miller MJ, Murphy TL, Unanue ER, Murphy KM.

Immunity. 2011 Aug 26;35(2):236-48. doi: 10.1016/j.immuni.2011.06.012.


Presentation of type B peptide-MHC complexes from hen egg white lysozyme by TLR ligands and type I IFNs independent of H2-DM regulation.

Strong BS, Unanue ER.

J Immunol. 2011 Sep 1;187(5):2193-201. doi: 10.4049/jimmunol.1100152. Epub 2011 Jul 25.


RNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in mice.

McCartney SA, Vermi W, Lonardi S, Rossini C, Otero K, Calderon B, Gilfillan S, Diamond MS, Unanue ER, Colonna M.

J Clin Invest. 2011 Apr;121(4):1497-507. doi: 10.1172/JCI44005. Epub 2011 Mar 14.

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