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Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics.

Yee SW, Do TP, Huang SM, Krauss RM, Kusuhara H, Sugiyama Y, Unadkat JD, Giacomini KM.

Clin Pharmacol Ther. 2019 Nov 27. doi: 10.1002/cpt.1691. [Epub ahead of print] No abstract available.


Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.

Zhang D, Hop CECA, Patilea-Vrana G, Gampa G, Seneviratne HK, Unadkat JD, Kenny JR, Nagapudi K, Di L, Zhou L, Zak M, Wright MR, Bumpus NN, Zang R, Liu X, Lai Y, Khojasteh SC.

Drug Metab Dispos. 2019 Oct;47(10):1122-1135. doi: 10.1124/dmd.119.086744. Epub 2019 Jul 2.


Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper.

Prasad B, Achour B, Artursson P, Hop CECA, Lai Y, Smith PC, Barber J, Wisniewski JR, Spellman D, Uchida Y, Zientek MA, Unadkat JD, Rostami-Hodjegan A.

Clin Pharmacol Ther. 2019 Sep;106(3):525-543. doi: 10.1002/cpt.1537. Epub 2019 Jul 26.


Positron Emission Tomography Imaging of [11 C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A.

Billington S, Shoner S, Lee S, Clark-Snustad K, Pennington M, Lewis D, Muzi M, Rene S, Lee J, Nguyen TB, Kumar V, Ishida K, Chen L, Chu X, Lai Y, Salphati L, Hop CECA, Xiao G, Liao M, Unadkat JD.

Clin Pharmacol Ther. 2019 Nov;106(5):1056-1066. doi: 10.1002/cpt.1506. Epub 2019 Jul 22.


A marijuana-drug interaction primer: Precipitants, pharmacology, and pharmacokinetics.

Cox EJ, Maharao N, Patilea-Vrana G, Unadkat JD, Rettie AE, McCune JS, Paine MF.

Pharmacol Ther. 2019 Sep;201:25-38. doi: 10.1016/j.pharmthera.2019.05.001. Epub 2019 May 7. Review.


Quantifying Hepatic Enzyme Kinetics of (-)-∆9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC, through In Vitro Modeling.

Patilea-Vrana GI, Unadkat JD.

Drug Metab Dispos. 2019 Jul;47(7):743-752. doi: 10.1124/dmd.119.086470. Epub 2019 May 2.


Mechanisms of CYP3A Induction During Pregnancy: Studies in HepaRG Cells.

Sachar M, Kelly EJ, Unadkat JD.

AAPS J. 2019 Mar 27;21(3):45. doi: 10.1208/s12248-019-0316-z.


Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood-Brain Barrier Measured by Quantitative Targeted Proteomics.

Billington S, Salphati L, Hop CECA, Chu X, Evers R, Burdette D, Rowbottom C, Lai Y, Xiao G, Humphreys WG, Nguyen TB, Prasad B, Unadkat JD.

Clin Pharmacol Ther. 2019 Jul;106(1):228-237. doi: 10.1002/cpt.1373. Epub 2019 Mar 18.


A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation.

Kumar V, Salphati L, Hop CECA, Xiao G, Lai Y, Mathias A, Chu X, Humphreys WG, Liao M, Heyward S, Unadkat JD.

Drug Metab Dispos. 2019 Apr;47(4):350-357. doi: 10.1124/dmd.118.084988. Epub 2019 Jan 8.


Hepatic Enzymes Relevant to the Disposition of (-)-∆9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC.

Patilea-Vrana GI, Anoshchenko O, Unadkat JD.

Drug Metab Dispos. 2019 Mar;47(3):249-256. doi: 10.1124/dmd.118.085548. Epub 2018 Dec 19.


Targeted LC-MS/MS Proteomics-Based Strategy To Characterize in Vitro Models Used in Drug Metabolism and Transport Studies.

Xu M, Saxena N, Vrana M, Zhang H, Kumar V, Billington S, Khojasteh C, Heyward S, Unadkat JD, Prasad B.

Anal Chem. 2018 Oct 16;90(20):11873-11882. doi: 10.1021/acs.analchem.8b01913. Epub 2018 Sep 28.


The Importance of Incorporating OCT2 Plasma Membrane Expression and Membrane Potential in IVIVE of Metformin Renal Secretory Clearance.

Kumar V, Yin J, Billington S, Prasad B, Brown CDA, Wang J, Unadkat JD.

Drug Metab Dispos. 2018 Oct;46(10):1441-1445. doi: 10.1124/dmd.118.082313. Epub 2018 Aug 9.


Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance.

Zamek-Gliszczynski MJ, Taub ME, Chothe PP, Chu X, Giacomini KM, Kim RB, Ray AS, Stocker SL, Unadkat JD, Wittwer MB, Xia C, Yee SW, Zhang L, Zhang Y; International Transporter Consortium.

Clin Pharmacol Ther. 2018 Nov;104(5):890-899. doi: 10.1002/cpt.1112. Epub 2018 Aug 8. Review.


Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches.

Guo Y, Chu X, Parrott NJ, Brouwer KLR, Hsu V, Nagar S, Matsson P, Sharma P, Snoeys J, Sugiyama Y, Tatosian D, Unadkat JD, Huang SM, Galetin A; International Transporter Consortium.

Clin Pharmacol Ther. 2018 Nov;104(5):865-889. doi: 10.1002/cpt.1183. Epub 2018 Sep 12.


Transport Kinetics, Selective Inhibition, and Successful Prediction of In Vivo Inhibition of Rat Hepatic Organic Anion Transporting Polypeptides.

Ishida K, Ullah M, Tóth B, Juhasz V, Unadkat JD.

Drug Metab Dispos. 2018 Sep;46(9):1251-1258. doi: 10.1124/dmd.118.080770. Epub 2018 Jun 11.


Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product-Drug Interactions: A NaPDI Center Recommended Approach.

Johnson EJ, González-Peréz V, Tian DD, Lin YS, Unadkat JD, Rettie AE, Shen DD, McCune JS, Paine MF.

Drug Metab Dispos. 2018 Jul;46(7):1046-1052. doi: 10.1124/dmd.118.081273. Epub 2018 May 7.


Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.

Zou L, Stecula A, Gupta A, Prasad B, Chien HC, Yee SW, Wang L, Unadkat JD, Stahl SH, Fenner KS, Giacomini KM.

Mol Pharmacol. 2018 Jul;94(1):689-699. doi: 10.1124/mol.117.111153. Epub 2018 May 2.


Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study.

Prasad B, Bhatt DK, Johnson K, Chapa R, Chu X, Salphati L, Xiao G, Lee C, Hop CECA, Mathias A, Lai Y, Liao M, Humphreys WG, Kumer SC, Unadkat JD.

Drug Metab Dispos. 2018 Jul;46(7):943-952. doi: 10.1124/dmd.118.080523. Epub 2018 Apr 25.


Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics.

Billington S, Ray AS, Salphati L, Xiao G, Chu X, Humphreys WG, Liao M, Lee CA, Mathias A, Hop CECA, Rowbottom C, Evers R, Lai Y, Kelly EJ, Prasad B, Unadkat JD.

Drug Metab Dispos. 2018 Feb;46(2):189-196. doi: 10.1124/dmd.117.077289. Epub 2017 Nov 14.


Successful Prediction of In Vivo Hepatobiliary Clearances and Hepatic Concentrations of Rosuvastatin Using Sandwich-Cultured Rat Hepatocytes, Transporter-Expressing Cell Lines, and Quantitative Proteomics.

Ishida K, Ullah M, Tóth B, Juhasz V, Unadkat JD.

Drug Metab Dispos. 2018 Jan;46(1):66-74. doi: 10.1124/dmd.117.076539. Epub 2017 Oct 30.


Optimization and Application of a Biotinylation Method for Quantification of Plasma Membrane Expression of Transporters in Cells.

Kumar V, Nguyen TB, Tóth B, Juhasz V, Unadkat JD.

AAPS J. 2017 Sep;19(5):1377-1386. doi: 10.1208/s12248-017-0121-5. Epub 2017 Jul 24.


Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses.

Zhang Z, Imperial MZ, Patilea-Vrana GI, Wedagedera J, Gaohua L, Unadkat JD.

Drug Metab Dispos. 2017 Aug;45(8):920-938. doi: 10.1124/dmd.117.075192. Epub 2017 Jun 6.


Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model II: Verification of the model for passive placental permeability drugs.

Zhang Z, Unadkat JD.

Drug Metab Dispos. 2017 Aug;45(8):939-946. doi: 10.1124/dmd.116.073957. Epub 2017 Jan 3.


Placental ABC Transporters: Biological Impact and Pharmaceutical Significance.

Joshi AA, Vaidya SS, St-Pierre MV, Mikheev AM, Desino KE, Nyandege AN, Audus KL, Unadkat JD, Gerk PM.

Pharm Res. 2016 Dec;33(12):2847-2878. Epub 2016 Sep 19. Review.


Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics.

Prasad B, Johnson K, Billington S, Lee C, Chung GW, Brown CD, Kelly EJ, Himmelfarb J, Unadkat JD.

Drug Metab Dispos. 2016 Dec;44(12):1920-1924. Epub 2016 Sep 12.


Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics.

Wang L, Collins C, Kelly EJ, Chu X, Ray AS, Salphati L, Xiao G, Lee C, Lai Y, Liao M, Mathias A, Evers R, Humphreys W, Hop CE, Kumer SC, Unadkat JD.

Drug Metab Dispos. 2016 Nov;44(11):1752-1758. Epub 2016 Aug 19.


Transport vs. Metabolism: What Determines the Pharmacokinetics and Pharmacodynamics of Drugs? Insights From the Extended Clearance Model.

Patilea-Vrana G, Unadkat JD.

Clin Pharmacol Ther. 2016 Nov;100(5):413-418. doi: 10.1002/cpt.437. Epub 2016 Aug 27.


Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.

Prasad B, Gaedigk A, Vrana M, Gaedigk R, Leeder JS, Salphati L, Chu X, Xiao G, Hop C, Evers R, Gan L, Unadkat JD.

Clin Pharmacol Ther. 2016 Oct;100(4):362-70. doi: 10.1002/cpt.409. Epub 2016 Aug 13.


The role of the equilibrative nucleoside transporter 1 on tissue and fetal distribution of ribavirin in the mouse.

Endres CJ, Moss AM, Ishida K, Govindarajan R, Unadkat JD.

Biopharm Drug Dispos. 2016 Sep;37(6):336-44. doi: 10.1002/bdd.2015.


CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids.

Farooq M, Kelly EJ, Unadkat JD.

Drug Metab Dispos. 2016 May;44(5):750-7. doi: 10.1124/dmd.115.069229. Epub 2016 Mar 10. Retraction in: Drug Metab Dispos. 2018 Sep;46(9):1360.


Modulation of P-glycoprotein at the Human Blood-Brain Barrier by Quinidine or Rifampin Treatment: A Positron Emission Tomography Imaging Study.

Liu L, Collier AC, Link JM, Domino KB, Mankoff DA, Eary JF, Spiekerman CF, Hsiao P, Deo AK, Unadkat JD.

Drug Metab Dispos. 2015 Nov;43(11):1795-804. doi: 10.1124/dmd.114.058685. Epub 2015 Sep 9.


Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content.

Shirasaka Y, Chaudhry AS, McDonald M, Prasad B, Wong T, Calamia JC, Fohner A, Thornton TA, Isoherranen N, Unadkat JD, Rettie AE, Schuetz EG, Thummel KE.

Pharmacogenomics J. 2016 Aug;16(4):375-87. doi: 10.1038/tpj.2015.58. Epub 2015 Sep 1.


Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2- Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood-Brain Barrier Drug Penetration.

Liu H, Yu N, Lu S, Ito S, Zhang X, Prasad B, He E, Lu X, Li Y, Wang F, Xu H, An G, Unadkat JD, Kusuhara H, Sugiyama Y, Sahi J.

Drug Metab Dispos. 2015 Jul;43(7):1008-18. doi: 10.1124/dmd.115.064170. Epub 2015 Apr 23.


Prediction of gestational age-dependent induction of in vivo hepatic CYP3A activity based on HepaRG cells and human hepatocytes.

Zhang Z, Farooq M, Prasad B, Grepper S, Unadkat JD.

Drug Metab Dispos. 2015 Jun;43(6):836-42. doi: 10.1124/dmd.114.062984. Epub 2015 Mar 23.


The concept of fraction of drug transported (ft ) with special emphasis on BBB efflux of CNS and antiretroviral drugs.

Prasad B, Unadkat JD.

Clin Pharmacol Ther. 2015 Apr;97(4):320-3. doi: 10.1002/cpt.72. Epub 2015 Feb 13.


Interspecies variability in expression of hepatobiliary transporters across human, dog, monkey, and rat as determined by quantitative proteomics.

Wang L, Prasad B, Salphati L, Chu X, Gupta A, Hop CE, Evers R, Unadkat JD.

Drug Metab Dispos. 2015 Mar;43(3):367-74. doi: 10.1124/dmd.114.061580. Epub 2014 Dec 22.


Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: addressing methodologic issues of plasma membrane isolation and expression-activity relationship.

Kumar V, Prasad B, Patilea G, Gupta A, Salphati L, Evers R, Hop CE, Unadkat JD.

Drug Metab Dispos. 2015 Feb;43(2):284-8. doi: 10.1124/dmd.114.061614. Epub 2014 Dec 8.


Identification of CYP3A7 for glyburide metabolism in human fetal livers.

Shuster DL, Risler LJ, Prasad B, Calamia JC, Voellinger JL, Kelly EJ, Unadkat JD, Hebert MF, Shen DD, Thummel KE, Mao Q.

Biochem Pharmacol. 2014 Dec 15;92(4):690-700. doi: 10.1016/j.bcp.2014.09.025. Epub 2014 Oct 22.


Role of (drug) transporters in imaging in health and disease.

Stieger B, Unadkat JD, Prasad B, Langer O, Gali H.

Drug Metab Dispos. 2014 Dec;42(12):2007-15. doi: 10.1124/dmd.114.059873. Epub 2014 Sep 23. Review.


Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport--an update.

Mao Q, Unadkat JD.

AAPS J. 2015 Jan;17(1):65-82. doi: 10.1208/s12248-014-9668-6. Epub 2014 Sep 19. Review.


Protein abundance of clinically relevant multidrug transporters along the entire length of the human intestine.

Drozdzik M, Gröer C, Penski J, Lapczuk J, Ostrowski M, Lai Y, Prasad B, Unadkat JD, Siegmund W, Oswald S.

Mol Pharm. 2014 Oct 6;11(10):3547-55. doi: 10.1021/mp500330y. Epub 2014 Sep 11.


Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo.

Kaspera R, Kirby BJ, Sahele T, Collier AC, Kharasch ED, Unadkat JD, Totah RA.

Biochem Pharmacol. 2014 Sep 1;91(1):109-18. doi: 10.1016/j.bcp.2014.06.020. Epub 2014 Jun 25.


PET imaging of Oatp-mediated hepatobiliary transport of [(11)C] rosuvastatin in the rat.

He J, Yu Y, Prasad B, Link J, Miyaoka RS, Chen X, Unadkat JD.

Mol Pharm. 2014 Aug 4;11(8):2745-54. doi: 10.1021/mp500027c. Epub 2014 Jul 8.


Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins.

Salphati L, Chu X, Chen L, Prasad B, Dallas S, Evers R, Mamaril-Fishman D, Geier EG, Kehler J, Kunta J, Mezler M, Laplanche L, Pang J, Rode A, Soars MG, Unadkat JD, van Waterschoot RA, Yabut J, Schinkel AH, Scheer N.

Drug Metab Dispos. 2014 Aug;42(8):1301-13. doi: 10.1124/dmd.114.057976. Epub 2014 May 22.


Activity of P-Glycoprotein, a β-Amyloid Transporter at the Blood-Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease.

Deo AK, Borson S, Link JM, Domino K, Eary JF, Ke B, Richards TL, Mankoff DA, Minoshima S, O'Sullivan F, Eyal S, Hsiao P, Maravilla K, Unadkat JD.

J Nucl Med. 2014 Jul;55(7):1106-11. doi: 10.2967/jnumed.113.130161. Epub 2014 May 19.


Optimized approaches for quantification of drug transporters in tissues and cells by MRM proteomics.

Prasad B, Unadkat JD.

AAPS J. 2014 Jul;16(4):634-48. doi: 10.1208/s12248-014-9602-y. Epub 2014 Apr 22. Review.


Comparison of Heavy Labeled (SIL) Peptide versus SILAC Protein Internal Standards for LC-MS/MS Quantification of Hepatic Drug Transporters.

Prasad B, Unadkat JD.

Int J Proteomics. 2014;2014:451510. doi: 10.1155/2014/451510. Epub 2014 Feb 25.


Mechanism of an unusual, but clinically significant, digoxin-bupropion drug interaction.

He J, Yu Y, Prasad B, Chen X, Unadkat JD.

Biopharm Drug Dispos. 2014 Jul;35(5):253-63. doi: 10.1002/bdd.1890. Epub 2014 Mar 3.


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