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A chimeric EccB-MycP fusion protein is functional and a stable component of the ESX-5 type VII secretion system membrane complex.

van Winden VJC, Bunduc CM, Ummels R, Bitter W, Houben ENG.

J Mol Biol. 2020 Jan 14. pii: S0022-2836(20)30022-X. doi: 10.1016/j.jmb.2019.12.040. [Epub ahead of print]


Type VII Secretion Substrates of Pathogenic Mycobacteria Are Processed by a Surface Protease.

Burggraaf MJ, Speer A, Meijers AS, Ummels R, van der Sar AM, Korotkov KV, Bitter W, Kuijl C.

mBio. 2019 Oct 29;10(5). pii: e01951-19. doi: 10.1128/mBio.01951-19.


Protease domain and transmembrane domain of the type VII secretion mycosin protease determine system-specific functioning in mycobacteria.

van Winden VJC, Damen MPM, Ummels R, Bitter W, Houben ENG.

J Biol Chem. 2019 Mar 29;294(13):4806-4814. doi: 10.1074/jbc.RA118.007090. Epub 2019 Jan 28.


Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator.

Abdallah AM, Weerdenburg EM, Guan Q, Ummels R, Borggreve S, Adroub SA, Malas TB, Naeem R, Zhang H, Otto TD, Bitter W, Pain A.

PLoS One. 2019 Jan 23;14(1):e0211003. doi: 10.1371/journal.pone.0211003. eCollection 2019.


EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF.

Phan TH, van Leeuwen LM, Kuijl C, Ummels R, van Stempvoort G, Rubio-Canalejas A, Piersma SR, Jiménez CR, van der Sar AM, Houben ENG, Bitter W.

PLoS Pathog. 2018 Aug 13;14(8):e1007247. doi: 10.1371/journal.ppat.1007247. eCollection 2018 Aug.


RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection.

Ates LS, Sayes F, Frigui W, Ummels R, Damen MPM, Bottai D, Behr MA, van Heijst JWJ, Bitter W, Majlessi L, Brosch R.

PLoS Pathog. 2018 Jun 18;14(6):e1007139. doi: 10.1371/journal.ppat.1007139. eCollection 2018 Jun.


The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd.

Lu P, Asseri AH, Kremer M, Maaskant J, Ummels R, Lill H, Bald D.

Sci Rep. 2018 Feb 8;8(1):2625. doi: 10.1038/s41598-018-20989-8.


Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis.

Ates LS, Dippenaar A, Ummels R, Piersma SR, van der Woude AD, van der Kuij K, Le Chevalier F, Mata-Espinosa D, Barrios-Payán J, Marquina-Castillo B, Guapillo C, Jiménez CR, Pain A, Houben ENG, Warren RM, Brosch R, Hernández-Pando R, Bitter W.

Nat Microbiol. 2018 Feb;3(2):181-188. doi: 10.1038/s41564-017-0090-6. Epub 2018 Jan 15.


Cell envelope stress in mycobacteria is regulated by the novel signal transduction ATPase IniR in response to trehalose.

Boot M, van Winden VJC, Sparrius M, van de Weerd R, Speer A, Ummels R, Rustad T, Sherman DR, Bitter W.

PLoS Genet. 2017 Dec 27;13(12):e1007131. doi: 10.1371/journal.pgen.1007131. eCollection 2017 Dec.


Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis.

Beckham KS, Ciccarelli L, Bunduc CM, Mertens HD, Ummels R, Lugmayr W, Mayr J, Rettel M, Savitski MM, Svergun DI, Bitter W, Wilmanns M, Marlovits TC, Parret AH, Houben EN.

Nat Microbiol. 2017 Apr 10;2:17047. doi: 10.1038/nmicrobiol.2017.47.


Identification of a substrate domain that determines system specificity in mycobacterial type VII secretion systems.

Phan TH, Ummels R, Bitter W, Houben EN.

Sci Rep. 2017 Feb 16;7:42704. doi: 10.1038/srep42704.


Mycosins Are Required for the Stabilization of the ESX-1 and ESX-5 Type VII Secretion Membrane Complexes.

van Winden VJ, Ummels R, Piersma SR, Jiménez CR, Korotkov KV, Bitter W, Houben EN.

mBio. 2016 Oct 18;7(5). pii: e01471-16. doi: 10.1128/mBio.01471-16.


Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations.

Abdallah AM, Hill-Cawthorne GA, Otto TD, Coll F, Guerra-Assunção JA, Gao G, Naeem R, Ansari H, Malas TB, Adroub SA, Verboom T, Ummels R, Zhang H, Panigrahi AK, McNerney R, Brosch R, Clark TG, Behr MA, Bitter W, Pain A.

Sci Rep. 2015 Oct 21;5:15443. doi: 10.1038/srep15443.


Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria.

Ates LS, Ummels R, Commandeur S, van de Weerd R, Sparrius M, Weerdenburg E, Alber M, Kalscheuer R, Piersma SR, Abdallah AM, Abd El Ghany M, Abdel-Haleem AM, Pain A, Jiménez CR, Bitter W, Houben EN.

PLoS Genet. 2015 May 4;11(5):e1005190. doi: 10.1371/journal.pgen.1005190. eCollection 2015 May. Erratum in: PLoS Genet. 2015 May;11(5):e1005270. van der Weerd, Robert [corrected to van de Weerd, Robert].


Genome-wide transposon mutagenesis indicates that Mycobacterium marinum customizes its virulence mechanisms for survival and replication in different hosts.

Weerdenburg EM, Abdallah AM, Rangkuti F, Abd El Ghany M, Otto TD, Adroub SA, Molenaar D, Ummels R, Ter Veen K, van Stempvoort G, van der Sar AM, Ali S, Langridge GC, Thomson NR, Pain A, Bitter W.

Infect Immun. 2015 May;83(5):1778-88. doi: 10.1128/IAI.03050-14. Epub 2015 Feb 17.


Identification of a novel conjugative plasmid in mycobacteria that requires both type IV and type VII secretion.

Ummels R, Abdallah AM, Kuiper V, Aâjoud A, Sparrius M, Naeem R, Spaink HP, van Soolingen D, Pain A, Bitter W.

mBio. 2014 Sep 23;5(5):e01744-14. doi: 10.1128/mBio.01744-14.


Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG5 in complex with PE25-PPE41 dimer.

Korotkova N, Freire D, Phan TH, Ummels R, Creekmore CC, Evans TJ, Wilmanns M, Bitter W, Parret AH, Houben EN, Korotkov KV.

Mol Microbiol. 2014 Oct;94(2):367-82. doi: 10.1111/mmi.12770. Epub 2014 Sep 15.


Analysis of SecA2-dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector.

van der Woude AD, Stoop EJ, Stiess M, Wang S, Ummels R, van Stempvoort G, Piersma SR, Cascioferro A, Jiménez CR, Houben EN, Luirink J, Pieters J, van der Sar AM, Bitter W.

Cell Microbiol. 2014 Feb;16(2):280-95. doi: 10.1111/cmi.12221. Epub 2013 Nov 6.


Differential detergent extraction of mycobacterium marinum cell envelope proteins identifies an extensively modified threonine-rich outer membrane protein with channel activity.

van der Woude AD, Mahendran KR, Ummels R, Piersma SR, Pham TV, Jiménez CR, de Punder K, van der Wel NN, Winterhalter M, Luirink J, Bitter W, Houben EN.

J Bacteriol. 2013 May;195(9):2050-9. doi: 10.1128/JB.02236-12. Epub 2013 Mar 1.


Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minimal impact on in vitro inflammatory responses.

Afonso-Barroso A, Clark SO, Williams A, Rosa GT, Nóbrega C, Silva-Gomes S, Vale-Costa S, Ummels R, Stoker N, Movahedzadeh F, van der Ley P, Sloots A, Cot M, Appelmelk BJ, Puzo G, Nigou J, Geurtsen J, Appelberg R.

Cell Microbiol. 2013 Apr;15(4):660-74. doi: 10.1111/cmi.12065. Epub 2012 Nov 21.


Composition of the type VII secretion system membrane complex.

Houben EN, Bestebroer J, Ummels R, Wilson L, Piersma SR, Jiménez CR, Ottenhoff TH, Luirink J, Bitter W.

Mol Microbiol. 2012 Oct;86(2):472-84. doi: 10.1111/j.1365-2958.2012.08206.x. Epub 2012 Aug 27.


Specific chaperones for the type VII protein secretion pathway.

Daleke MH, van der Woude AD, Parret AH, Ummels R, de Groot AM, Watson D, Piersma SR, Jiménez CR, Luirink J, Bitter W, Houben EN.

J Biol Chem. 2012 Sep 14;287(38):31939-47. doi: 10.1074/jbc.M112.397596. Epub 2012 Jul 29.


General secretion signal for the mycobacterial type VII secretion pathway.

Daleke MH, Ummels R, Bawono P, Heringa J, Vandenbroucke-Grauls CM, Luirink J, Bitter W.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11342-7. doi: 10.1073/pnas.1119453109. Epub 2012 Jun 25.


SecB-like chaperone controls a toxin-antitoxin stress-responsive system in Mycobacterium tuberculosis.

Bordes P, Cirinesi AM, Ummels R, Sala A, Sakr S, Bitter W, Genevaux P.

Proc Natl Acad Sci U S A. 2011 May 17;108(20):8438-43. doi: 10.1073/pnas.1101189108. Epub 2011 May 2.


Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) protein domains target LipY lipases of pathogenic mycobacteria to the cell surface via the ESX-5 pathway.

Daleke MH, Cascioferro A, de Punder K, Ummels R, Abdallah AM, van der Wel N, Peters PJ, Luirink J, Manganelli R, Bitter W.

J Biol Chem. 2011 May 27;286(21):19024-34. doi: 10.1074/jbc.M110.204966. Epub 2011 Apr 6.


Mycobacterium marinum MMAR_2380, a predicted transmembrane acyltransferase, is essential for the presence of the mannose cap on lipoarabinomannan.

Driessen NN, Stoop EJ, Ummels R, Gurcha SS, Mishra AK, Larrouy-Maumus G, Nigou J, Gilleron M, Puzo G, Maaskant JJ, Sparrius M, Besra GS, Bitter W, Vandenbroucke-Grauls CM, Appelmelk BJ.

Microbiology. 2010 Nov;156(Pt 11):3492-502. doi: 10.1099/mic.0.037507-0. Epub 2010 Aug 5.


Identification of mycobacterial alpha-glucan as a novel ligand for DC-SIGN: involvement of mycobacterial capsular polysaccharides in host immune modulation.

Geurtsen J, Chedammi S, Mesters J, Cot M, Driessen NN, Sambou T, Kakutani R, Ummels R, Maaskant J, Takata H, Baba O, Terashima T, Bovin N, Vandenbroucke-Grauls CM, Nigou J, Puzo G, Lemassu A, Daffé M, Appelmelk BJ.

J Immunol. 2009 Oct 15;183(8):5221-31. doi: 10.4049/jimmunol.0900768. Epub 2009 Sep 25.


Role of phosphatidylinositol mannosides in the interaction between mycobacteria and DC-SIGN.

Driessen NN, Ummels R, Maaskant JJ, Gurcha SS, Besra GS, Ainge GD, Larsen DS, Painter GF, Vandenbroucke-Grauls CM, Geurtsen J, Appelmelk BJ.

Infect Immun. 2009 Oct;77(10):4538-47. doi: 10.1128/IAI.01256-08. Epub 2009 Aug 3.


The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction.

Appelmelk BJ, den Dunnen J, Driessen NN, Ummels R, Pak M, Nigou J, Larrouy-Maumus G, Gurcha SS, Movahedzadeh F, Geurtsen J, Brown EJ, Eysink Smeets MM, Besra GS, Willemsen PT, Lowary TL, van Kooyk Y, Maaskant JJ, Stoker NG, van der Ley P, Puzo G, Vandenbroucke-Grauls CM, Wieland CW, van der Poll T, Geijtenbeek TB, van der Sar AM, Bitter W.

Cell Microbiol. 2008 Apr;10(4):930-44. Epub 2007 Dec 5.


Lowest-order corrections to the RPA polarizability and GW self-energy of a semiconducting wire.

de Groot HJ, Ummels RT, Bobbert PA, Haeringen Wv.

Phys Rev B Condens Matter. 1996 Jul 15;54(4):2374-2380. No abstract available.


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