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Items: 11


In vitro-In vivo extrapolation of key transporter activity at the blood-brain barrier.

Trapa PE, Troutman MD, Lau TY, Wager TT, Maurer TS, Patel NC, West MA, Umland JP, Carlo AA, Feng B, Liras JL.

Drug Metab Dispos. 2019 Jan 25. pii: dmd.118.083279. doi: 10.1124/dmd.118.083279. [Epub ahead of print]


Impact of recovery on fraction unbound using equilibrium dialysis.

Di L, Umland JP, Trapa PE, Maurer TS.

J Pharm Sci. 2012 Mar;101(3):1327-35. doi: 10.1002/jps.23013. Epub 2011 Dec 9.


Development of a new permeability assay using low-efflux MDCKII cells.

Di L, Whitney-Pickett C, Umland JP, Zhang H, Zhang X, Gebhard DF, Lai Y, Federico JJ 3rd, Davidson RE, Smith R, Reyner EL, Lee C, Feng B, Rotter C, Varma MV, Kempshall S, Fenner K, El-Kattan AF, Liston TE, Troutman MD.

J Pharm Sci. 2011 Nov;100(11):4974-85. doi: 10.1002/jps.22674. Epub 2011 Jul 15.


Species independence in brain tissue binding using brain homogenates.

Di L, Umland JP, Chang G, Huang Y, Lin Z, Scott DO, Troutman MD, Liston TE.

Drug Metab Dispos. 2011 Jul;39(7):1270-7. doi: 10.1124/dmd.111.038778. Epub 2011 Apr 7.


Strategic use of plasma and microsome binding to exploit in vitro clearance in early drug discovery.

Chang G, Steyn SJ, Umland JP, Scott DO.

ACS Med Chem Lett. 2010 Feb 3;1(2):50-3. doi: 10.1021/ml900012h. eCollection 2010 May 13.


A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function.

Chambers RJ, Abrams K, Castleberry TA, Cheng JB, Fisher DA, Kamath AV, Marfat A, Nettleton DO, Pillar JD, Salter ED, Sheils AL, Shirley JT, Turner CR, Umland JP, Lam KT.

Bioorg Med Chem Lett. 2006 Feb;16(3):718-21. Epub 2005 Nov 2.


Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase.

Trebino CE, Stock JL, Gibbons CP, Naiman BM, Wachtmann TS, Umland JP, Pandher K, Lapointe JM, Saha S, Roach ML, Carter D, Thomas NA, Durtschi BA, McNeish JD, Hambor JE, Jakobsson PJ, Carty TJ, Perez JR, Audoly LP.

Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9044-9. Epub 2003 Jun 30.


Characterization of chemokine CCR3 agonist-mediated eosinophil recruitment in the Brown-Norway rat.

Kudlacz EM, Whitney CA, Andresen CJ, Umland JP, Cheng JB.

Br J Pharmacol. 1999 Oct;128(3):788-94.


7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as novel inhibitors of human eosinophil phosphodiesterase.

Duplantier AJ, Andresen CJ, Cheng JB, Cohan VL, Decker C, DiCapua FM, Kraus KG, Johnson KL, Turner CR, UmLand JP, Watson JW, Wester RT, Williams AS, Williams JA.

J Med Chem. 1998 Jun 18;41(13):2268-77.


Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret.

Duplantier AJ, Biggers MS, Chambers RJ, Cheng JB, Cooper K, Damon DB, Eggler JF, Kraus KG, Marfat A, Masamune H, Pillar JS, Shirley JT, Umland JP, Watson JW.

J Med Chem. 1996 Jan 5;39(1):120-5.


GM-CSF rapidly primes mice for enhanced cytokine production in response to LPS and TNF.

Brissette WH, Baker DA, Stam EJ, Umland JP, Griffiths RJ.

Cytokine. 1995 Apr;7(3):291-5.


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