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Items: 1 to 50 of 564

1.

Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin.

Wang L, Li M, Lin Y, Du S, Liu Z, Ju J, Suzuki H, Sawada M, Umezawa K.

J Antibiot (Tokyo). 2020 Mar 24. doi: 10.1038/s41429-020-0302-9. [Epub ahead of print]

PMID:
32210361
2.

Inhibition of matrix metalloproteinase expression and cellular invasion by NF-κB inhibitors of microbial origin.

Umezawa K, Lin Y.

Biochim Biophys Acta Proteins Proteom. 2020 Jun;1868(6):140412. doi: 10.1016/j.bbapap.2020.140412. Epub 2020 Mar 14. Review.

PMID:
32179183
3.

Hyperstable De Novo Protein with a Dimeric Bisecting Topology.

Kimura N, Mochizuki K, Umezawa K, Hecht MH, Arai R.

ACS Synth Biol. 2020 Feb 21;9(2):254-259. doi: 10.1021/acssynbio.9b00501. Epub 2020 Jan 27.

PMID:
31951376
4.

Eosinophilic Pneumonia Associated With Natalizumab In A Patient With Multiple Sclerosis: A Case Report And Literature Review.

Yasuda Y, Nagano T, Tachihara M, Chihara N, Umezawa K, Katsurada N, Yamamoto M, Sekiguchi K, Kobayashi K, Nishimura Y.

Ther Clin Risk Manag. 2019 Nov 1;15:1283-1289. doi: 10.2147/TCRM.S225832. eCollection 2019.

5.

The differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation.

Fu H, Alabdullah M, Großmann J, Spieler F, Abdosh R, Lutz V, Kalies K, Knöpp K, Rieckmann M, Koch S, Noutsias M, Pilowski C, Dutzmann J, Sedding D, Hüttelmaier S, Umezawa K, Werdan K, Loppnow H.

Cell Death Dis. 2019 Nov 21;10(12):880. doi: 10.1038/s41419-019-2109-9.

6.

Distinct cell proliferation, myogenic differentiation, and gene expression in skeletal muscle myoblasts of layer and broiler chickens.

Nihashi Y, Umezawa K, Shinji S, Hamaguchi Y, Kobayashi H, Kono T, Ono T, Kagami H, Takaya T.

Sci Rep. 2019 Nov 11;9(1):16527. doi: 10.1038/s41598-019-52946-4.

7.

Fumarate accumulation involved in renal diabetic fibrosis in Goto-Kakizaki rats.

Miura Y, Hayakawa A, Kikuchi S, Tsumoto H, Umezawa K, Chiba Y, Soejima Y, Sawabe M, Fukui K, Akimoto Y, Endo T.

Arch Biochem Biophys. 2019 Dec 15;678:108167. doi: 10.1016/j.abb.2019.108167. Epub 2019 Nov 5.

PMID:
31704098
8.

Comparison of oral microbiome profiles in stimulated and unstimulated saliva, tongue, and mouth-rinsed water.

Jo R, Nishimoto Y, Umezawa K, Yama K, Aita Y, Ichiba Y, Murakami S, Kakizawa Y, Kumagai T, Yamada T, Fukuda S.

Sci Rep. 2019 Nov 6;9(1):16124. doi: 10.1038/s41598-019-52445-6.

9.

Ohnuki et al. Reply.

Ohnuki J, Sato T, Sasaki T, Umezawa K, Takano M.

Phys Rev Lett. 2019 Jul 26;123(4):049602. doi: 10.1103/PhysRevLett.123.049602. No abstract available.

PMID:
31491245
10.

Berberine and palmatine inhibit the growth of human rhabdomyosarcoma cells.

Shinji S, Nakamura S, Nihashi Y, Umezawa K, Takaya T.

Biosci Biotechnol Biochem. 2020 Jan;84(1):63-75. doi: 10.1080/09168451.2019.1659714. Epub 2019 Aug 29.

PMID:
31462179
11.

Targeting NF-κB-mediated inflammatory pathways in cisplatin-resistant NSCLC.

Ryan SL, Beard S, Barr MP, Umezawa K, Heavey S, Godwin P, Gray SG, Cormican D, Finn SP, Gately KA, Davies AM, Thompson EW, Richard DJ, O'Byrne KJ, Adams MN, Baird AM.

Lung Cancer. 2019 Sep;135:217-227. doi: 10.1016/j.lungcan.2019.07.006. Epub 2019 Jul 12.

PMID:
31446998
12.

Bicoid-Dependent Activation of the Target Gene hunchback Requires a Two-Motif Sequence Code in a Specific Basal Promoter.

Ling J, Umezawa KY, Scott T, Small S.

Mol Cell. 2019 Sep 19;75(6):1178-1187.e4. doi: 10.1016/j.molcel.2019.06.038. Epub 2019 Aug 8.

PMID:
31402096
13.

Tenosynovitis Induced by an Immune Checkpoint Inhibitor: A Case Report and Literature Review.

Murakami S, Nagano T, Nakata K, Onishi A, Umezawa K, Katsurada N, Yamamoto M, Tachihara M, Kobayashi K, Nishimura Y.

Intern Med. 2019 Oct 1;58(19):2839-2843. doi: 10.2169/internalmedicine.2556-19. Epub 2019 Jun 27. Review.

14.

Growth Inhibitory Effects of Dipotassium Glycyrrhizinate in Glioblastoma Cell Lines by Targeting MicroRNAs Through the NF-κB Signaling Pathway.

Bonafé GA, Dos Santos JS, Ziegler JV, Umezawa K, Ribeiro ML, Rocha T, Ortega MM.

Front Cell Neurosci. 2019 May 28;13:216. doi: 10.3389/fncel.2019.00216. eCollection 2019.

15.

Novel cancer therapy targeting microbiome.

Nagano T, Otoshi T, Hazama D, Kiriu T, Umezawa K, Katsurada N, Nishimura Y.

Onco Targets Ther. 2019 May 13;12:3619-3624. doi: 10.2147/OTT.S207546. eCollection 2019. Review.

16.

Crucial Role of Extracellular Vesicles in Bronchial Asthma.

Nagano T, Katsurada M, Dokuni R, Hazama D, Kiriu T, Umezawa K, Kobayashi K, Nishimura Y.

Int J Mol Sci. 2019 May 27;20(10). pii: E2589. doi: 10.3390/ijms20102589. Review.

17.

Synergistic interaction of gemcitabine and paclitaxel by modulating acetylation and polymerization of tubulin in non-small cell lung cancer cell lines.

Effendi WI, Nagano T, Tachihara M, Umezawa K, Kiriu T, Dokuni R, Katsurada M, Yamamoto M, Kobayashi K, Nishimura Y.

Cancer Manag Res. 2019 Apr 29;11:3669-3679. doi: 10.2147/CMAR.S193789. eCollection 2019.

18.

Questionnaire Survey for Bronchial Asthma in Elderly Care Facilities.

Shinke H, Kamiryo H, Umezawa K, Hori S, Nakata K, Nagano T, Hazeki N, Kobayashi K, Fukabori T, Nishimura Y.

Kobe J Med Sci. 2019 Feb 13;64(5):E174-E179.

19.

Anti-Inflammatory Effect of Dehydroxymethylepoxyquinomicin, a Nuclear factor-κB Inhibitor, on Endotoxin-Induced Uveitis in Rats In vivo and In vitro.

Ando Y, Keino H, Kudo A, Hirakata A, Okada AA, Umezawa K.

Ocul Immunol Inflamm. 2020;28(2):240-248. doi: 10.1080/09273948.2019.1568502. Epub 2019 Apr 5.

PMID:
30950670
20.

Comparison of anti-atopic dermatitis activities between DHMEQ and tacrolimus ointments in mouse model without stratum corneum.

He H, Gao X, Wang X, Li X, Jiang X, Xie Z, Ma K, Ma J, Umezawa K, Zhang Y.

Int Immunopharmacol. 2019 Jun;71:43-51. doi: 10.1016/j.intimp.2019.03.015. Epub 2019 Mar 13.

PMID:
30877873
21.

Genomes of Neutrophilic Sulfur-Oxidizing Chemolithoautotrophs Representing 9 Proteobacterial Species From 8 Genera.

Watanabe T, Kojima H, Umezawa K, Hori C, Takasuka TE, Kato Y, Fukui M.

Front Microbiol. 2019 Feb 25;10:316. doi: 10.3389/fmicb.2019.00316. eCollection 2019.

22.

Genomic Characteristics of Desulfonema ishimotonii Tokyo 01T Implying Horizontal Gene Transfer Among Phylogenetically Dispersed Filamentous Gliding Bacteria.

Watanabe M, Kojima H, Umezawa K, Fukui M.

Front Microbiol. 2019 Feb 19;10:227. doi: 10.3389/fmicb.2019.00227. eCollection 2019.

23.

JAK/STAT3 and NF-κB Signaling Pathways Regulate Cancer Stem-Cell Properties in Anaplastic Thyroid Cancer Cells.

Shiraiwa K, Matsuse M, Nakazawa Y, Ogi T, Suzuki K, Saenko V, Xu S, Umezawa K, Yamashita S, Tsukamoto K, Mitsutake N.

Thyroid. 2019 May;29(5):674-682. doi: 10.1089/thy.2018.0212. Epub 2019 Mar 15.

PMID:
30784360
24.

Dehydroxymethylepoxyquinomicin suppresses atopic dermatitis-like lesions in a stratum corneum-removed murine model through NF-κB inhibition.

Jiang X, He H, Xie Z, Wen H, Li X, Li X, Ma J, Umezawa K, Zhang Y.

Immunopharmacol Immunotoxicol. 2019 Feb;41(1):32-39. doi: 10.1080/08923973.2018.1510962. Epub 2019 Feb 6.

PMID:
30724631
25.

Conophylline inhibits high fat diet-induced non-alcoholic fatty liver disease in mice.

Ohashi T, Nakade Y, Ibusuki M, Kitano R, Yamauchi T, Kimoto S, Inoue T, Kobayashi Y, Sumida Y, Ito K, Nakao H, Umezawa K, Yoneda M.

PLoS One. 2019 Jan 28;14(1):e0210068. doi: 10.1371/journal.pone.0210068. eCollection 2019.

26.

Phospholipase Cε plays a crucial role in neutrophilic inflammation accompanying acute lung injury through augmentation of CXC chemokine production from alveolar epithelial cells.

Umezawa K, Nagano T, Kobayashi K, Dokuni R, Katsurada M, Yamamoto M, Yoshikawa Y, Kataoka T, Nishimura Y.

Respir Res. 2019 Jan 11;20(1):9. doi: 10.1186/s12931-019-0975-4.

27.

Fungal PQQ-dependent dehydrogenases and their potential in biocatalysis.

Takeda K, Umezawa K, Várnai A, Eijsink VG, Igarashi K, Yoshida M, Nakamura N.

Curr Opin Chem Biol. 2019 Apr;49:113-121. doi: 10.1016/j.cbpa.2018.12.001. Epub 2018 Dec 20. Review.

PMID:
30580186
28.

Isolation of ketomycin from Actinomycetes as an inhibitor of 2D and 3D cancer cell invasion.

Lin Y, Chen Y, Ukaji T, Okada S, Umezawa K.

J Antibiot (Tokyo). 2019 Mar;72(3):148-154. doi: 10.1038/s41429-018-0129-9. Epub 2018 Dec 3.

PMID:
30510246
29.

Hydrophobic Surface Enhances Electrostatic Interaction in Water.

Sato T, Sasaki T, Ohnuki J, Umezawa K, Takano M.

Phys Rev Lett. 2018 Nov 16;121(20):206002. doi: 10.1103/PhysRevLett.121.206002.

PMID:
30500220
30.

Genomics and Development of Lentinus tigrinus: A White-Rot Wood-Decaying Mushroom with Dimorphic Fruiting Bodies.

Wu B, Xu Z, Knudson A, Carlson A, Chen N, Kovaka S, LaButti K, Lipzen A, Pennachio C, Riley R, Schakwitz W, Umezawa K, Ohm RA, Grigoriev IV, Nagy LG, Gibbons J, Hibbett D.

Genome Biol Evol. 2018 Dec 1;10(12):3250-3261. doi: 10.1093/gbe/evy246.

31.

The plant alkaloid conophylline inhibits matrix formation of fibroblasts.

Tezuka T, Ota A, Karnan S, Matsuura K, Yokoo K, Hosokawa Y, Vigetti D, Passi A, Hatano S, Umezawa K, Watanabe H.

J Biol Chem. 2018 Dec 28;293(52):20214-20226. doi: 10.1074/jbc.RA118.005783. Epub 2018 Oct 30.

32.

Conophylline suppresses pancreatic cancer desmoplasia and cancer-promoting cytokines produced by cancer-associated fibroblasts.

Ishii N, Araki K, Yokobori T, Hagiwara K, Gantumur D, Yamanaka T, Handa T, Tsukagoshi M, Igarashi T, Watanabe A, Kubo N, Harimoto N, Masamune A, Umezawa K, Kuwano H, Shirabe K.

Cancer Sci. 2019 Jan;110(1):334-344. doi: 10.1111/cas.13847. Epub 2018 Dec 13.

33.

NF‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2.5‑induced inflammation model.

Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K.

Mol Med Rep. 2018 Dec;18(6):5279-5285. doi: 10.3892/mmr.2018.9533. Epub 2018 Oct 3.

PMID:
30320338
34.

The Pro-Oxidant Activity of Pheomelanin is Significantly Enhanced by UVA Irradiation: Benzothiazole Moieties Are More Reactive than Benzothiazine Moieties.

Tanaka H, Yamashita Y, Umezawa K, Hirobe T, Ito S, Wakamatsu K.

Int J Mol Sci. 2018 Sep 23;19(10). pii: E2889. doi: 10.3390/ijms19102889.

35.

Carbapenem-resistant Klebsiella pneumoniae in a Febrile Neutropenia Patient With Acute Myelogenous Leukemia After Hematopoietic Stem Cell Transplantation.

Asai S, Ohshima T, Iwashita H, Ishii Y, Aoki K, Minakawa Y, Machida S, Umezawa K, Tateda K, Miyachi H.

Infect Dis Clin Pract (Baltim Md). 2018 Sep;26(5):e38-e39. doi: 10.1097/IPC.0000000000000633. Epub 2018 Apr 21. No abstract available.

36.

Role of S1P/S1PR3 axis in release of CCL20 from human bronchial epithelial cells.

Kawa Y, Nagano T, Yoshizaki A, Dokuni R, Katsurada M, Terashita T, Yasuda Y, Umezawa K, Yamamoto M, Kamiryo H, Kobayashi K, Nishimura Y.

PLoS One. 2018 Sep 7;13(9):e0203211. doi: 10.1371/journal.pone.0203211. eCollection 2018.

37.

A Reversible Fluorescent Probe for Real-Time Live-Cell Imaging and Quantification of Endogenous Hydropolysulfides.

Umezawa K, Kamiya M, Urano Y.

Angew Chem Int Ed Engl. 2018 Jul 20;57(30):9346-9350. doi: 10.1002/anie.201804309. Epub 2018 Jun 20.

PMID:
29797471
38.

Characterization of an aryl-alcohol oxidase from the plant saprophytic basidiomycete Coprinopsis cinerea with broad substrate specificity against aromatic alcohols.

Tamaru Y, Umezawa K, Yoshida M.

Biotechnol Lett. 2018 Jul;40(7):1077-1086. doi: 10.1007/s10529-018-2534-3. Epub 2018 May 22.

PMID:
29785669
39.

Development of a sensitive immunochromatographic kit using fluorescent silica nanoparticles for rapid serodiagnosis of amebiasis.

Tachibana H, Kakino A, Kazama M, Feng M, Asai S, Umezawa K, Nozaki T, Makiuchi T, Kamada T, Watanabe H, Horiki N, Cheng X, Masuda G.

Parasitology. 2018 Dec;145(14):1890-1895. doi: 10.1017/S0031182018000690. Epub 2018 May 9.

PMID:
29739480
40.

Corrigendum to "poly (ADP-ribose) polymerase inhibition synergizes with the NF-κB inhibitor DHMEQ to kill hepatocellular carcinoma cells" [Biochim. Biophys. Acta 1853(12)(2015) 3224-3234].

Lampiasi N, Umezawa K, Montalto G, Cervello M.

Biochim Biophys Acta Mol Cell Res. 2018 Jul;1865(7):1023. doi: 10.1016/j.bbamcr.2018.04.004. Epub 2018 Apr 21. No abstract available.

41.

DTCM-glutarimide Delays Growth and Radiosensitizes Glioblastoma.

Roberto GM, Paiva HH, Botelho de Souza LE, Pezuk JA, Vieira GM, de Oliveira HF, Umezawa K, Tone LG, Brassesco MS.

Anticancer Agents Med Chem. 2018;18(9):1323-1329. doi: 10.2174/1871520618666180423105740.

PMID:
29683097
42.

The Pyrroloquinoline-Quinone-Dependent Pyranose Dehydrogenase from Coprinopsis cinerea Drives Lytic Polysaccharide Monooxygenase Action.

Várnai A, Umezawa K, Yoshida M, Eijsink VGH.

Appl Environ Microbiol. 2018 May 17;84(11). pii: e00156-18. doi: 10.1128/AEM.00156-18. Print 2018 Jun 1.

43.

[Two Cases of Difficult-to-Treat Acute Epidural Hematoma and a Review of Decompressive Craniectomy with Hematoma Evacuation].

Okamoto T, Umezawa K, Ogita S, Kurosaki K, Takegami T, Kimura S.

No Shinkei Geka. 2018 Mar;46(3):227-234. doi: 10.11477/mf.1436203709. Japanese.

PMID:
29567873
44.

Inhibition of Late and Early Phases of Cancer Metastasis by the NF-κB Inhibitor DHMEQ Derived from Microbial Bioactive Metabolite Epoxyquinomicin: A Review.

Lin Y, Ukaji T, Koide N, Umezawa K.

Int J Mol Sci. 2018 Mar 3;19(3). pii: E729. doi: 10.3390/ijms19030729. Review.

45.

Structural and dynamical characteristics of tropomyosin epitopes as the major allergens in shrimp.

Ozawa H, Umezawa K, Takano M, Ishizaki S, Watabe S, Ochiai Y.

Biochem Biophys Res Commun. 2018 Mar 25;498(1):119-124. doi: 10.1016/j.bbrc.2018.02.172. Epub 2018 Feb 27.

PMID:
29496452
46.

Silicon Rhodamine-Based Near-Infrared Fluorescent Probe for γ-Glutamyltransferase.

Iwatate RJ, Kamiya M, Umezawa K, Kashima H, Nakadate M, Kojima R, Urano Y.

Bioconjug Chem. 2018 Feb 21;29(2):241-244. doi: 10.1021/acs.bioconjchem.7b00776. Epub 2018 Jan 19.

PMID:
29323873
47.

Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegenerative disease models.

Umezawa K, Kojima I, Simizu S, Lin Y, Fukatsu H, Koide N, Nakade Y, Yoneda M.

Hum Cell. 2018 Apr;31(2):95-101. doi: 10.1007/s13577-017-0196-4. Epub 2017 Dec 16. Review.

PMID:
29249016
48.

The Implementation of a Hospital-wide Practice for the Selective Use of Carbapenems Based on the Monitoring of Susceptibility of Pseudomonas aeruginosa Isolates.

Ohshima T, Asai S, Miyazawa M, Yamamoto Y, Hisada A, Kumazawa C, Hashimoto M, Fukawa K, Iwashita H, Umezawa K, Yamada S, Yamamoto Y, Miyachi H.

Tokai J Exp Clin Med. 2017 Dec 20;42(4):176-181.

49.

Antineoplastic Effects of NF-κB Inhibition by DHMEQ (Dehydroxymethylepoxyquinomicin) Alone and in Co-treatment with Radio-and Chemotherapy in Medulloblastoma Cell Lines.

Ramos PMM, Pezuk JA, Castro-Gamero AM, Oliveira HF, Scrideli CA, Umezawa K, Tone LG.

Anticancer Agents Med Chem. 2018;18(4):541-549. doi: 10.2174/1871520617666171113151335.

PMID:
29141555
50.

Microenvironmental stromal cells abrogate NF-κB inhibitor-induced apoptosis in chronic lymphocytic leukemia.

Simon-Gabriel CP, Foerster K, Saleem S, Bleckmann D, Benkisser-Petersen M, Thornton N, Umezawa K, Decker S, Burger M, Veelken H, Claus R, Dierks C, Duyster J, Zirlik K.

Haematologica. 2018 Jan;103(1):136-147. doi: 10.3324/haematol.2017.165381. Epub 2017 Nov 9.

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