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Author Correction: Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy.

Abdel-Gadir A, Stephen-Victor E, Gerber GK, Noval Rivas M, Wang S, Harb H, Wang L, Li N, Crestani E, Spielman S, Secor W, Biehl H, DiBenedetto N, Dong X, Umetsu DT, Bry L, Rachid R, Chatila TA.

Nat Med. 2019 Sep;25(9):1458. doi: 10.1038/s41591-019-0572-6.


Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy.

Abdel-Gadir A, Stephen-Victor E, Gerber GK, Noval Rivas M, Wang S, Harb H, Wang L, Li N, Crestani E, Spielman S, Secor W, Biehl H, DiBenedetto N, Dong X, Umetsu DT, Bry L, Rachid R, Chatila TA.

Nat Med. 2019 Jul;25(7):1164-1174. doi: 10.1038/s41591-019-0461-z. Epub 2019 Jun 24. Erratum in: Nat Med. 2019 Sep;25(9):1458.


Pregnancy outcomes in the omalizumab pregnancy registry and a disease-matched comparator cohort.

Namazy JA, Blais L, Andrews EB, Scheuerle AE, Cabana MD, Thorp JM, Umetsu DT, Veith JH, Sun D, Kaufman DG, Covington DL, Mukhopadhyay S, Fogel RB, Lopez-Leon S, Spain CV.

J Allergy Clin Immunol. 2019 May 27. pii: S0091-6749(19)30690-6. doi: 10.1016/j.jaci.2019.05.019. [Epub ahead of print]


Blockade of RGMb inhibits allergen-induced airways disease.

Yu S, Leung KM, Kim HY, Umetsu SE, Xiao Y, Albacker LA, Lee HJ, Umetsu DT, Freeman GJ, DeKruyff RH.

J Allergy Clin Immunol. 2019 Jul;144(1):94-108.e11. doi: 10.1016/j.jaci.2018.12.1022. Epub 2019 Jan 29.


Immunoglobulin E blockade during food allergen ingestion enhances the induction of inhibitory immunoglobulin G antibodies.

Stranks AJ, Minnicozzi SC, Miller SJ, Burton OT, Logsdon SL, Spergel JM, Nadeau KC, Pongracic JA, Umetsu DT, Rachid R, MacGinnitie AJ, Schneider LC, Oettgen HC.

Ann Allergy Asthma Immunol. 2019 Feb;122(2):213-215. doi: 10.1016/j.anai.2018.10.024. Epub 2018 Nov 4. No abstract available.


Long-Term Outcome of Peanut Oral Immunotherapy Facilitated Initially by Omalizumab.

Yee CSK, Albuhairi S, Noh E, El-Khoury K, Rezaei S, Abdel-Gadir A, Umetsu DT, Burke-Roberts E, LeBovidge J, Schneider L, Rachid R.

J Allergy Clin Immunol Pract. 2019 Feb;7(2):451-461.e7. doi: 10.1016/j.jaip.2018.09.015. Epub 2018 Sep 26.


A natural killer T-cell subset that protects against airway hyperreactivity.

Chuang YT, Leung K, Chang YJ, DeKruyff RH, Savage PB, Cruse R, Benoit C, Elewaut D, Baumgarth N, Umetsu DT.

J Allergy Clin Immunol. 2019 Feb;143(2):565-576.e7. doi: 10.1016/j.jaci.2018.03.022. Epub 2018 May 29.


Oral immunotherapy with omalizumab reverses the Th2 cell-like programme of regulatory T cells and restores their function.

Abdel-Gadir A, Schneider L, Casini A, Charbonnier LM, Little SV, Harrington T, Umetsu DT, Rachid R, Chatila TA.

Clin Exp Allergy. 2018 Jul;48(7):825-836. doi: 10.1111/cea.13161. Epub 2018 May 29.


Anaphylaxis associated with omalizumab administration: Risk factors and patient characteristics.

Lieberman PL, Jones I, Rajwanshi R, Rosén K, Umetsu DT.

J Allergy Clin Immunol. 2017 Dec;140(6):1734-1736.e4. doi: 10.1016/j.jaci.2017.07.013. Epub 2017 Aug 7. No abstract available.



Lieberman PL, Umetsu DT, Carrigan GJ, Rahmaoui A.

J Allergy Clin Immunol. 2017 May;139(5):1718-1719. doi: 10.1016/j.jaci.2016.12.976. Epub 2017 Mar 3. No abstract available.


Omalizumab facilitates rapid oral desensitization for peanut allergy.

MacGinnitie AJ, Rachid R, Gragg H, Little SV, Lakin P, Cianferoni A, Heimall J, Makhija M, Robison R, Chinthrajah RS, Lee J, Lebovidge J, Dominguez T, Rooney C, Lewis MO, Koss J, Burke-Roberts E, Chin K, Logvinenko T, Pongracic JA, Umetsu DT, Spergel J, Nadeau KC, Schneider LC.

J Allergy Clin Immunol. 2017 Mar;139(3):873-881.e8. doi: 10.1016/j.jaci.2016.08.010. Epub 2016 Sep 5.


Mechanisms by which obesity impacts upon asthma.

Umetsu DT.

Thorax. 2017 Feb;72(2):174-177. doi: 10.1136/thoraxjnl-2016-209130. Epub 2016 Sep 26. Review.


Anaphylactic reactions associated with omalizumab administration: Analysis of a case-control study.

Lieberman PL, Umetsu DT, Carrigan GJ, Rahmaoui A.

J Allergy Clin Immunol. 2016 Sep;138(3):913-915.e2. doi: 10.1016/j.jaci.2016.03.030. Epub 2016 Apr 26. No abstract available.


Innate lymphoid cells in asthma: Will they take your breath away?

Kim HY, Umetsu DT, Dekruyff RH.

Eur J Immunol. 2016 Apr;46(4):795-806. doi: 10.1002/eji.201444557. Epub 2016 Mar 16. Review.


Oral immunotherapy and anti-IgE antibody treatment for food allergy.

Umetsu DT, Rachid R, Schneider LC.

World Allergy Organ J. 2015 Jul 6;8(1):20. doi: 10.1186/s40413-015-0070-3. eCollection 2015.


A new player on the psoriasis block: IL-17A- and IL-22-producing innate lymphoid cells.

Ward NL, Umetsu DT.

J Invest Dermatol. 2014 Sep;134(9):2305-2307. doi: 10.1038/jid.2014.216.


Targeting IgE to facilitate oral immunotherapy for food allergy: a potential new role for anti-IgE therapy?

Umetsu DT.

Expert Rev Clin Immunol. 2014 Sep;10(9):1125-8. doi: 10.1586/1744666X.2014.948849.


Oral immunotherapy induces IgG antibodies that act through FcγRIIb to suppress IgE-mediated hypersensitivity.

Burton OT, Logsdon SL, Zhou JS, Medina-Tamayo J, Abdel-Gadir A, Noval Rivas M, Koleoglou KJ, Chatila TA, Schneider LC, Rachid R, Umetsu DT, Oettgen HC.

J Allergy Clin Immunol. 2014 Dec;134(6):1310-1317.e6. doi: 10.1016/j.jaci.2014.05.042. Epub 2014 Jul 16.


Innate immunity in the lung regulates the development of asthma.

DeKruyff RH, Yu S, Kim HY, Umetsu DT.

Immunol Rev. 2014 Jul;260(1):235-48. doi: 10.1111/imr.12187. Review.


RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance.

Xiao Y, Yu S, Zhu B, Bedoret D, Bu X, Francisco LM, Hua P, Duke-Cohan JS, Umetsu DT, Sharpe AH, DeKruyff RH, Freeman GJ.

J Exp Med. 2014 May 5;211(5):943-59. doi: 10.1084/jem.20130790. Epub 2014 Apr 21.


Innate lymphoid cells and asthma.

Yu S, Kim HY, Chang YJ, DeKruyff RH, Umetsu DT.

J Allergy Clin Immunol. 2014 Apr;133(4):943-50; quiz 51. doi: 10.1016/j.jaci.2014.02.015. Review.


Consequences of antibiotics and infections in infancy: bugs, drugs, and wheezing.

Ong MS, Umetsu DT, Mandl KD.

Ann Allergy Asthma Immunol. 2014 May;112(5):441-445.e1. doi: 10.1016/j.anai.2014.01.022. Epub 2014 Mar 13.


Enhanced shedding of extracellular vesicles from amoeboid prostate cancer cells: potential effects on the tumor microenvironment.

Kim J, Morley S, Le M, Bedoret D, Umetsu DT, Di Vizio D, Freeman MR.

Cancer Biol Ther. 2014 Apr;15(4):409-18. doi: 10.4161/cbt.27627. Epub 2014 Jan 14.


Budesonide nebulization added to systemic prednisolone in the treatment of acute asthma in children: a double-blind, randomized, controlled trial.

Alangari AA, Malhis N, Mubasher M, Al-Ghamedi N, Al-Tannir M, Riaz M, Umetsu DT, Al-Tamimi S.

Chest. 2014 Apr;145(4):772-778. doi: 10.1378/chest.13-2298.


Pivotal role of IL-6 in the hyperinflammatory responses to subacute ozone in adiponectin-deficient mice.

Kasahara DI, Kim HY, Mathews JA, Verbout NG, Williams AS, Wurmbrand AP, Ninin FM, Neto FL, Benedito LA, Hug C, Umetsu DT, Shore SA.

Am J Physiol Lung Cell Mol Physiol. 2014 Mar 15;306(6):L508-20. doi: 10.1152/ajplung.00235.2013. Epub 2013 Dec 31.


Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity.

Kim HY, Lee HJ, Chang YJ, Pichavant M, Shore SA, Fitzgerald KA, Iwakura Y, Israel E, Bolger K, Faul J, DeKruyff RH, Umetsu DT.

Nat Med. 2014 Jan;20(1):54-61. doi: 10.1038/nm.3423. Epub 2013 Dec 15.


A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients.

Schneider LC, Rachid R, LeBovidge J, Blood E, Mittal M, Umetsu DT.

J Allergy Clin Immunol. 2013 Dec;132(6):1368-74. doi: 10.1016/j.jaci.2013.09.046. Epub 2013 Oct 28.


Synthesis of fungal glycolipid asperamide B and investigation of its ability to stimulate natural killer T cells.

Chaudhary V, Albacker LA, Deng S, Chuang YT, Li Y, Umetsu DT, Savage PB.

Org Lett. 2013 Oct 18;15(20):5242-5. doi: 10.1021/ol4024375. Epub 2013 Oct 10.


Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity.

Albacker LA, Chaudhary V, Chang YJ, Kim HY, Chuang YT, Pichavant M, DeKruyff RH, Savage PB, Umetsu DT.

Nat Med. 2013 Oct;19(10):1297-304. doi: 10.1038/nm.3321. Epub 2013 Sep 1.


Immunologic effects of omalizumab in children with severe refractory atopic dermatitis: a randomized, placebo-controlled clinical trial.

Iyengar SR, Hoyte EG, Loza A, Bonaccorso S, Chiang D, Umetsu DT, Nadeau KC.

Int Arch Allergy Immunol. 2013;162(1):89-93. doi: 10.1159/000350486. Epub 2013 Jun 27.


The role of type 2 innate lymphoid cells in asthma.

Chang YJ, DeKruyff RH, Umetsu DT.

J Leukoc Biol. 2013 Nov;94(5):933-40. doi: 10.1189/jlb.0313127. Epub 2013 Jun 25. Review.


T-cell immunoglobulin and mucin domain 1 deficiency eliminates airway hyperreactivity triggered by the recognition of airway cell death.

Kim HY, Chang YJ, Chuang YT, Lee HH, Kasahara DI, Martin T, Hsu JT, Savage PB, Shore SA, Freeman GJ, Dekruyff RH, Umetsu DT.

J Allergy Clin Immunol. 2013 Aug;132(2):414-25.e6. doi: 10.1016/j.jaci.2013.03.025. Epub 2013 May 11.


TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine.

Jemielity S, Wang JJ, Chan YK, Ahmed AA, Li W, Monahan S, Bu X, Farzan M, Freeman GJ, Umetsu DT, Dekruyff RH, Choe H.

PLoS Pathog. 2013 Mar;9(3):e1003232. doi: 10.1371/journal.ppat.1003232. Epub 2013 Mar 28.


Intronic SH2D1A mutation with impaired SAP expression and agammaglobulinemia.

Recher M, Fried AJ, Massaad MJ, Kim HY, Rizzini M, Frugoni F, Walter JE, Mathew D, Eibel H, Hess C, Giliani S, Umetsu DT, Notarangelo LD, Geha RS.

Clin Immunol. 2013 Feb;146(2):84-9. doi: 10.1016/j.clim.2012.11.007. Epub 2012 Dec 7.


Oral immunotherapy for food allergy: towards a new horizon.

Khoriaty E, Umetsu DT.

Allergy Asthma Immunol Res. 2013 Jan;5(1):3-15. doi: 10.4168/aair.2013.5.1.3. Epub 2012 Nov 28.


TIM-4, expressed by medullary macrophages, regulates respiratory tolerance by mediating phagocytosis of antigen-specific T cells.

Albacker LA, Yu S, Bedoret D, Lee WL, Umetsu SE, Monahan S, Freeman GJ, Umetsu DT, DeKruyff RH.

Mucosal Immunol. 2013 May;6(3):580-90. doi: 10.1038/mi.2012.100. Epub 2012 Nov 14.


Immunological mechanisms for desensitization and tolerance in food allergy.

Rachid R, Umetsu DT.

Semin Immunopathol. 2012 Sep;34(5):689-702. doi: 10.1007/s00281-012-0333-9. Epub 2012 Jul 21. Review.


Early exposure to germs and the Hygiene Hypothesis.

Umetsu DT.

Cell Res. 2012 Aug;22(8):1210-1. doi: 10.1038/cr.2012.65. Epub 2012 Apr 24.


Pulmonary inflammation induced by subacute ozone is augmented in adiponectin-deficient mice: role of IL-17A.

Kasahara DI, Kim HY, Williams AS, Verbout NG, Tran J, Si H, Wurmbrand AP, Jastrab J, Hug C, Umetsu DT, Shore SA.

J Immunol. 2012 May 1;188(9):4558-67. doi: 10.4049/jimmunol.1102363. Epub 2012 Apr 2.


Binding of hepatitis A virus to its cellular receptor 1 inhibits T-regulatory cell functions in humans.

Manangeeswaran M, Jacques J, Tami C, Konduru K, Amharref N, Perrella O, Casasnovas JM, Umetsu DT, Dekruyff RH, Freeman GJ, Perrella A, Kaplan GG.

Gastroenterology. 2012 Jun;142(7):1516-25.e3. doi: 10.1053/j.gastro.2012.02.039. Epub 2012 Mar 16.


Extrathymically generated regulatory T cells control mucosal TH2 inflammation.

Josefowicz SZ, Niec RE, Kim HY, Treuting P, Chinen T, Zheng Y, Umetsu DT, Rudensky AY.

Nature. 2012 Feb 8;482(7385):395-9. doi: 10.1038/nature10772.


Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab.

Bedoret D, Singh AK, Shaw V, Hoyte EG, Hamilton R, DeKruyff RH, Schneider LC, Nadeau KC, Umetsu DT.

Mucosal Immunol. 2012 May;5(3):267-76. doi: 10.1038/mi.2012.5. Epub 2012 Feb 8.


Oral immunotherapy and anti-IgE antibody-adjunctive treatment for food allergy.

Nadeau KC, Kohli A, Iyengar S, DeKruyff RH, Umetsu DT.

Immunol Allergy Clin North Am. 2012 Feb;32(1):111-33. doi: 10.1016/j.iac.2011.11.004. Review.


Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity.

Kim HY, Chang YJ, Subramanian S, Lee HH, Albacker LA, Matangkasombut P, Savage PB, McKenzie AN, Smith DE, Rottman JB, DeKruyff RH, Umetsu DT.

J Allergy Clin Immunol. 2012 Jan;129(1):216-27.e1-6. doi: 10.1016/j.jaci.2011.10.036. Epub 2011 Nov 25.


Genotype, phenotype, and outcomes of nine patients with T-B+NK+ SCID.

Yu GP, Nadeau KC, Berk DR, de Saint Basile G, Lambert N, Knapnougel P, Roberts J, Kavanau K, Dunn E, Stiehm ER, Lewis DB, Umetsu DT, Puck JM, Cowan MJ.

Pediatr Transplant. 2011 Nov;15(7):733-41. doi: 10.1111/j.1399-3046.2011.01563.x. Epub 2011 Aug 23.


Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity.

Chang YJ, Kim HY, Albacker LA, Baumgarth N, McKenzie AN, Smith DE, Dekruyff RH, Umetsu DT.

Nat Immunol. 2011 May 29;12(7):631-8. doi: 10.1038/ni.2045.


Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy.

Nadeau KC, Schneider LC, Hoyte L, Borras I, Umetsu DT.

J Allergy Clin Immunol. 2011 Jun;127(6):1622-4. doi: 10.1016/j.jaci.2011.04.009. Epub 2011 May 4. No abstract available.


Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells.

Xiao S, Zhu B, Jin H, Zhu C, Umetsu DT, DeKruyff RH, Kuchroo VK.

Eur J Immunol. 2011 Jun;41(6):1539-49. doi: 10.1002/eji.201040993. Epub 2011 May 25.


A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans.

Kim HY, Eyheramonho MB, Pichavant M, Gonzalez Cambaceres C, Matangkasombut P, Cervio G, Kuperman S, Moreiro R, Konduru K, Manangeeswaran M, Freeman GJ, Kaplan GG, DeKruyff RH, Umetsu DT, Rosenzweig SD.

J Clin Invest. 2011 Mar;121(3):1111-8. doi: 10.1172/JCI44182. Epub 2011 Feb 21.


Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity.

Chang YJ, Kim HY, Albacker LA, Lee HH, Baumgarth N, Akira S, Savage PB, Endo S, Yamamura T, Maaskant J, Kitano N, Singh A, Bhatt A, Besra GS, van den Elzen P, Appelmelk B, Franck RW, Chen G, DeKruyff RH, Shimamura M, Illarionov P, Umetsu DT.

J Clin Invest. 2011 Jan;121(1):57-69. doi: 10.1172/JCI44845. Epub 2010 Dec 13.

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