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Items: 1 to 50 of 59

1.

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.

Luo L, Ambrozkiewicz MC, Benseler F, Chen C, Dumontier E, Falkner S, Furlanis E, Gomez AM, Hoshina N, Huang WH, Hutchison MA, Itoh-Maruoka Y, Lavery LA, Li W, Maruo T, Motohashi J, Pai EL, Pelkey KA, Pereira A, Philips T, Sinclair JL, Stogsdill JA, Traunmüller L, Wang J, Wortel J, You W, Abumaria N, Beier KT, Brose N, Burgess HA, Cepko CL, Cloutier JF, Eroglu C, Goebbels S, Kaeser PS, Kay JN, Lu W, Luo L, Mandai K, McBain CJ, Nave KA, Prado MAM, Prado VF, Rothstein J, Rubenstein JLR, Saher G, Sakimura K, Sanes JR, Scheiffele P, Takai Y, Umemori H, Verhage M, Yuzaki M, Zoghbi HY, Kawabe H, Craig AM.

Neuron. 2020 Feb 5. pii: S0896-6273(20)30008-8. doi: 10.1016/j.neuron.2020.01.008. [Epub ahead of print]

PMID:
32027825
2.

Neuronal fibroblast growth factor 22 signaling during development, but not in adults, is involved in anhedonia.

Terauchi A, Durlacher E, Pitino J, Umemori H.

Neuroreport. 2020 Jan 27;31(2):125-130. doi: 10.1097/WNR.0000000000001399.

PMID:
31895747
3.

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development.

Lehrman EK, Wilton DK, Litvina EY, Welsh CA, Chang ST, Frouin A, Walker AJ, Heller MD, Umemori H, Chen C, Stevens B.

Neuron. 2018 Oct 10;100(1):120-134.e6. doi: 10.1016/j.neuron.2018.09.017.

4.

Tyrosine phosphorylation of the transmembrane protein SIRPα: Sensing synaptic activity and regulating ectodomain cleavage for synapse maturation.

Nagappan-Chettiar S, Johnson-Venkatesh EM, Umemori H.

J Biol Chem. 2018 Aug 3;293(31):12026-12042. doi: 10.1074/jbc.RA117.001488. Epub 2018 Jun 18.

5.

Selective Inactivation of Fibroblast Growth Factor 22 (FGF22) in CA3 Pyramidal Neurons Impairs Local Synaptogenesis and Affective Behavior Without Affecting Dentate Neurogenesis.

Terauchi A, Gavin E, Wilson J, Umemori H.

Front Synaptic Neurosci. 2017 Dec 19;9:17. doi: 10.3389/fnsyn.2017.00017. eCollection 2017.

6.

A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory.

Mathew RS, Tatarakis A, Rudenko A, Johnson-Venkatesh EM, Yang YJ, Murphy EA, Todd TP, Schepers ST, Siuti N, Martorell AJ, Falls WA, Hammack SE, Walsh CA, Tsai LH, Umemori H, Bouton ME, Moazed D.

Elife. 2016 Dec 21;5. pii: e22467. doi: 10.7554/eLife.22467.

7.

Activity-dependent proteolytic cleavage of cell adhesion molecules regulates excitatory synaptic development and function.

Nagappan-Chettiar S, Johnson-Venkatesh EM, Umemori H.

Neurosci Res. 2017 Mar;116:60-69. doi: 10.1016/j.neures.2016.12.003. Epub 2016 Dec 10. Review.

8.

Postsynaptic SDC2 induces transsynaptic signaling via FGF22 for bidirectional synaptic formation.

Hu HT, Umemori H, Hsueh YP.

Sci Rep. 2016 Sep 15;6:33592. doi: 10.1038/srep33592.

9.

Buttressing a balanced brain: Target-derived FGF signaling regulates excitatory/inhibitory tone and adult neurogenesis within the maturating hippocampal network.

Dabrowski A, Umemori H.

Neurogenesis (Austin). 2016 Apr 12;3(1):e1168504. doi: 10.1080/23262133.2016.1168504. eCollection 2016.

10.

Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain.

Terauchi A, Johnson-Venkatesh EM, Bullock B, Lehtinen MK, Umemori H.

Elife. 2016 Apr 15;5. pii: e12151. doi: 10.7554/eLife.12151.

11.

Deletion of fibroblast growth factor 22 (FGF22) causes a depression-like phenotype in adult mice.

Williams AJ, Yee P, Smith MC, Murphy GG, Umemori H.

Behav Brain Res. 2016 Jul 1;307:11-7. doi: 10.1016/j.bbr.2016.03.047. Epub 2016 Mar 29.

12.

Excitability governs neural development in a hippocampal region-specific manner.

Johnson-Venkatesh EM, Khan MN, Murphy GG, Sutton MA, Umemori H.

Development. 2015 Nov 15;142(22):3879-91. doi: 10.1242/dev.121202. Epub 2015 Sep 28.

13.

Distinct sets of FGF receptors sculpt excitatory and inhibitory synaptogenesis.

Dabrowski A, Terauchi A, Strong C, Umemori H.

Development. 2015 May 15;142(10):1818-30. doi: 10.1242/dev.115568. Epub 2015 Apr 29.

14.

FGF22 signaling regulates synapse formation during post-injury remodeling of the spinal cord.

Jacobi A, Loy K, Schmalz AM, Hellsten M, Umemori H, Kerschensteiner M, Bareyre FM.

EMBO J. 2015 May 5;34(9):1231-43. doi: 10.15252/embj.201490578. Epub 2015 Mar 12.

15.

Selective synaptic targeting of the excitatory and inhibitory presynaptic organizers FGF22 and FGF7.

Terauchi A, Timmons KM, Kikuma K, Pechmann Y, Kneussel M, Umemori H.

J Cell Sci. 2015 Jan 15;128(2):281-92. doi: 10.1242/jcs.158337. Epub 2014 Nov 27.

16.

5-HT1A receptor-mediated phosphorylation of extracellular signal-regulated kinases (ERK1/2) is modulated by regulator of G protein signaling protein 19.

Wang Q, Terauchi A, Yee CH, Umemori H, Traynor JR.

Cell Signal. 2014 Sep;26(9):1846-52. doi: 10.1016/j.cellsig.2014.04.017. Epub 2014 May 2.

PMID:
24793302
17.

The best-laid plans go oft awry: synaptogenic growth factor signaling in neuropsychiatric disease.

Williams AJ, Umemori H.

Front Synaptic Neurosci. 2014 Mar 18;6:4. doi: 10.3389/fnsyn.2014.00004. eCollection 2014. Review.

18.

Synapse maturation by activity-dependent ectodomain shedding of SIRPα.

Toth AB, Terauchi A, Zhang LY, Johnson-Venkatesh EM, Larsen DJ, Sutton MA, Umemori H.

Nat Neurosci. 2013 Oct;16(10):1417-25. doi: 10.1038/nn.3516. Epub 2013 Sep 15.

19.

Suppression of epileptogenesis-associated changes in response to seizures in FGF22-deficient mice.

Lee CH, Umemori H.

Front Cell Neurosci. 2013 Apr 18;7:43. doi: 10.3389/fncel.2013.00043. eCollection 2013.

20.

Neurogenesis is enhanced and mossy fiber sprouting arises in FGF7-deficient mice during development.

Lee CH, Javed D, Althaus AL, Parent JM, Umemori H.

Mol Cell Neurosci. 2012 Nov;51(3-4):61-7. doi: 10.1016/j.mcn.2012.07.010. Epub 2012 Aug 3.

21.

Fibroblast growth factor 22 contributes to the development of retinal nerve terminals in the dorsal lateral geniculate nucleus.

Singh R, Su J, Brooks J, Terauchi A, Umemori H, Fox MA.

Front Mol Neurosci. 2012;4:61. doi: 10.3389/fnmol.2011.00061. Epub 2012 Jan 10.

22.

Multiple forms of activity-dependent competition refine hippocampal circuits in vivo.

Yasuda M, Johnson-Venkatesh EM, Zhang H, Parent JM, Sutton MA, Umemori H.

Neuron. 2011 Jun 23;70(6):1128-42. doi: 10.1016/j.neuron.2011.04.027.

23.

Specific sets of intrinsic and extrinsic factors drive excitatory and inhibitory circuit formation.

Terauchi A, Umemori H.

Neuroscientist. 2012 Jun;18(3):271-86. doi: 10.1177/1073858411404228. Epub 2011 Jun 7. Review.

24.

Orchestrating the synaptic network by tyrosine phosphorylation signalling.

Dabrowski A, Umemori H.

J Biochem. 2011 Jun;149(6):641-53. doi: 10.1093/jb/mvr047. Epub 2011 Apr 20. Review.

25.

NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala.

Delawary M, Tezuka T, Kiyama Y, Yokoyama K, Inoue T, Hattori S, Hashimoto R, Umemori H, Manabe T, Yamamoto T, Nakazawa T.

Mol Brain. 2010 Nov 30;3:37. doi: 10.1186/1756-6606-3-37.

26.

Secreted factors as synaptic organizers.

Johnson-Venkatesh EM, Umemori H.

Eur J Neurosci. 2010 Jul;32(2):181-90. doi: 10.1111/j.1460-9568.2010.07338.x. Epub 2010 Jul 14. Review.

27.

Distinct FGFs promote differentiation of excitatory and inhibitory synapses.

Terauchi A, Johnson-Venkatesh EM, Toth AB, Javed D, Sutton MA, Umemori H.

Nature. 2010 Jun 10;465(7299):783-7. doi: 10.1038/nature09041. Epub 2010 May 26.

28.

Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour.

Taniguchi S, Nakazawa T, Tanimura A, Kiyama Y, Tezuka T, Watabe AM, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy NP, Hashimoto K, Kano M, Manabe T, Yamamoto T.

EMBO J. 2009 Dec 2;28(23):3717-29. doi: 10.1038/emboj.2009.300. Epub 2009 Oct 15.

29.

Weaving the neuronal net with target-derived fibroblast growth factors.

Umemori H.

Dev Growth Differ. 2009 Apr;51(3):263-70. doi: 10.1111/j.1440-169X.2008.01079.x. Epub 2008 Dec 19. Review.

30.

Signal regulatory proteins (SIRPS) are secreted presynaptic organizing molecules.

Umemori H, Sanes JR.

J Biol Chem. 2008 Dec 5;283(49):34053-61. doi: 10.1074/jbc.M805729200. Epub 2008 Sep 26.

31.

Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein, p250GAP.

Nakazawa T, Kuriu T, Tezuka T, Umemori H, Okabe S, Yamamoto T.

J Neurochem. 2008 May;105(4):1384-93. doi: 10.1111/j.1471-4159.2008.05335.x. Epub 2008 Mar 9.

32.

Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals.

Fox MA, Sanes JR, Borza DB, Eswarakumar VP, Fässler R, Hudson BG, John SW, Ninomiya Y, Pedchenko V, Pfaff SL, Rheault MN, Sado Y, Segal Y, Werle MJ, Umemori H.

Cell. 2007 Apr 6;129(1):179-93.

33.

NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.

Nakazawa T, Komai S, Watabe AM, Kiyama Y, Fukaya M, Arima-Yoshida F, Horai R, Sudo K, Ebine K, Delawary M, Goto J, Umemori H, Tezuka T, Iwakura Y, Watanabe M, Yamamoto T, Manabe T.

EMBO J. 2006 Jun 21;25(12):2867-77. Epub 2006 May 18.

34.

Seeking long-term relationship: axon and target communicate to organize synaptic differentiation.

Fox MA, Umemori H.

J Neurochem. 2006 Jun;97(5):1215-31. Epub 2006 Apr 21. Review.

35.

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM.

J Biol Chem. 2006 Jun 9;281(23):15694-700. Epub 2006 Apr 4.

36.

FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain.

Umemori H, Linhoff MW, Ornitz DM, Sanes JR.

Cell. 2004 Jul 23;118(2):257-70.

37.

p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling.

Nakazawa T, Watabe AM, Tezuka T, Yoshida Y, Yokoyama K, Umemori H, Inoue A, Okabe S, Manabe T, Yamamoto T.

Mol Biol Cell. 2003 Jul;14(7):2921-34. Epub 2003 Apr 4.

38.

Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling.

Yoshida Y, von Bubnoff A, Ikematsu N, Blitz IL, Tsuzuku JK, Yoshida EH, Umemori H, Miyazono K, Yamamoto T, Cho KW.

Mech Dev. 2003 May;120(5):629-37.

39.

Mice lacking a transcriptional corepressor Tob are predisposed to cancer.

Yoshida Y, Nakamura T, Komoda M, Satoh H, Suzuki T, Tsuzuku JK, Miyasaka T, Yoshida EH, Umemori H, Kunisaki RK, Tani K, Ishii S, Mori S, Suganuma M, Noda T, Yamamoto T.

Genes Dev. 2003 May 15;17(10):1201-6.

40.

Impairment of N-methyl-D-aspartate receptor-controlled motor activity in LYN-deficient mice.

Umemori H, Ogura H, Tozawa N, Mikoshiba K, Nishizumi H, Yamamoto T.

Neuroscience. 2003;118(3):709-13.

PMID:
12710978
41.

Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors.

Kohda K, Kamiya Y, Matsuda S, Kato K, Umemori H, Yuzaki M.

Brain Res Mol Brain Res. 2003 Jan 31;110(1):27-37.

PMID:
12573530
42.

Negative regulation of BMP/Smad signaling by Tob in osteoblasts.

Yoshida Y, Tanaka S, Umemori H, Minowa O, Usui M, Ikematsu N, Hosoda E, Imamura T, Kuno J, Yamashita T, Miyazono K, Noda M, Noda T, Yamamoto T.

Cell. 2000 Dec 22;103(7):1085-97.

43.

Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor.

Nakazawa T, Komai S, Tezuka T, Hisatsune C, Umemori H, Semba K, Mishina M, Manabe T, Yamamoto T.

J Biol Chem. 2001 Jan 5;276(1):693-9.

44.

The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits.

Hironaka K, Umemori H, Tezuka T, Mishina M, Yamamoto T.

J Biol Chem. 2000 May 26;275(21):16167-73.

45.
46.

Involvement of protein tyrosine phosphatases in activation of the trimeric G protein Gq/11.

Umemori H, Hayashi T, Inoue T, Nakanishi S, Mikoshiba K, Yamamoto T.

Oncogene. 1999 Dec 2;18(51):7399-402.

47.

Distinctive roles of Fyn and Lyn in IgD- and IgM-mediated signaling.

Horikawa K, Nishizumi H, Umemori H, Aizawa S, Takatsu K, Yamamoto T.

Int Immunol. 1999 Sep;11(9):1441-9.

PMID:
10464165
48.

Stimulation of myelin basic protein gene transcription by Fyn tyrosine kinase for myelination.

Umemori H, Kadowaki Y, Hirosawa K, Yoshida Y, Hironaka K, Okano H, Yamamoto T.

J Neurosci. 1999 Feb 15;19(4):1393-7.

49.

PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A.

Tezuka T, Umemori H, Akiyama T, Nakanishi S, Yamamoto T.

Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):435-40.

50.

The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn.

Hayashi T, Umemori H, Mishina M, Yamamoto T.

Nature. 1999 Jan 7;397(6714):72-6.

PMID:
9892356

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