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Items: 1 to 50 of 239

1.

Generation of three induced pluripotent stem cell lines from postmortem tissue derived following sudden death of a young patient with STXBP1 mutation.

Yamamoto T, Otsu M, Okumura T, Horie Y, Ueno Y, Taniguchi H, Ohtaka M, Nakanishi M, Abe Y, Murase T, Umehara T, Ikematsu K.

Stem Cell Res. 2019 Jun 18;39:101485. doi: 10.1016/j.scr.2019.101485. [Epub ahead of print]

2.

Distribution differences in prognostic copy number alteration profiles in IDH-wild-type glioblastoma cause survival discrepancies across cohorts.

Umehara T, Arita H, Yoshioka E, Shofuda T, Kanematsu D, Kinoshita M, Kodama Y, Mano M, Kagawa N, Fujimoto Y, Okita Y, Nonaka M, Nakajo K, Uda T, Tsuyuguchi N, Fukai J, Fujita K, Sakamoto D, Mori K, Kishima H, Kanemura Y.

Acta Neuropathol Commun. 2019 Jun 18;7(1):99. doi: 10.1186/s40478-019-0749-8.

3.

Negative effects of ROS generated during linear sperm motility on gene expression and ATP generation in boar sperm mitochondria.

Zhu Z, Kawai T, Umehara T, Hoque SAM, Zeng W, Shimada M.

Free Radic Biol Med. 2019 Jun 15;141:159-171. doi: 10.1016/j.freeradbiomed.2019.06.018. [Epub ahead of print]

PMID:
31212063
4.

Expression of Bone Morphogenetic Protein-7 Significantly Correlates With Non-small Cell Lung Cancer Progression and Prognosis: A Retrospective Cohort Study.

Aoki M, Umehara T, Kamimura G, Imamura N, Morizono S, Nonaka Y, Tokunaga T, Takeda AH, Maeda K, Watanabe Y, Nagata T, Otsuka T, Yokomakura N, Kariatsumari K, Yanagi M, Sato M.

Clin Med Insights Oncol. 2019 May 28;13:1179554919852087. doi: 10.1177/1179554919852087. eCollection 2019.

5.

Tumor enucleation for Castleman's disease in the pulmonary hilum: a case report.

Aoki M, Kamimura G, Umehara T, Takeda AH, Watanabe Y, Maeda K, Nagata T, Otsuka T, Sato M.

Surg Case Rep. 2019 Jun 10;5(1):95. doi: 10.1186/s40792-019-0652-3.

6.

Effect of an intensive functional rehabilitation program on the recovery of activities of daily living after total knee arthroplasty: A multicenter, randomized, controlled trial.

Tanaka R, Hayashizaki T, Taniguchi R, Kobayashi J, Umehara T.

J Orthop Sci. 2019 Jun 7. pii: S0949-2658(19)30130-7. doi: 10.1016/j.jos.2019.04.009. [Epub ahead of print]

PMID:
31182258
7.

Risk Factors and Prognostic Factors of Hearing Impairment in Neonatal Intensive Care Unit-Treated Infants.

Umehara T, Hosokawa S, Kita JY, Takahashi G, Okamura J, Nakanishi H, Hosokawa K, Kyou K, Hayashi Y, Mineta H.

Audiol Neurootol. 2019 May 27:1-6. doi: 10.1159/000500316. [Epub ahead of print]

PMID:
31132759
8.

Hooks at the Upper Instrumented Vertebra Can Adjust Postoperative Shoulder Balance in Patients with Adolescent Idiopathic Scoliosis: 5 Years or More of Follow-up.

Kuroya S, Akazawa T, Kotani T, Sakuma T, Minami S, Torii Y, Umehara T, Iinuma M, Murakami K, Orita S, Inage K, Eguchi Y, Fujimoto K, Shiga Y, Nakamura J, Inoue G, Miyagi M, Saito W, Ohtori S, Niki H.

Asian Spine J. 2019 May 14. doi: 10.31616/asj.2018.0206. [Epub ahead of print]

9.

MicroRNA-130b functions as an oncomiRNA in non-small cell lung cancer by targeting tissue inhibitor of metalloproteinase-2.

Hirono T, Jingushi K, Nagata T, Sato M, Minami K, Aoki M, Takeda AH, Umehara T, Egawa H, Nakatsuji Y, Kitae K, Ueda Y, Hase H, Yamamoto M, Shinsato Y, Kawahara K, Furukawa T, Tsujikawa K.

Sci Rep. 2019 May 6;9(1):6956. doi: 10.1038/s41598-019-43355-8.

10.

Gene Expression and Protein Synthesis in Mitochondria Enhance the Duration of High-Speed Linear Motility in Boar Sperm.

Zhu Z, Umehara T, Okazaki T, Goto M, Fujita Y, Hoque SAM, Kawai T, Zeng W, Shimada M.

Front Physiol. 2019 Mar 12;10:252. doi: 10.3389/fphys.2019.00252. eCollection 2019.

11.

Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.

Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Okue M, Kano Y, Watanabe T, Kitamura K, Shitara E, Muramatsu Y, Yoshida H, Mizutani A, Seimiya H, Yoshida M, Koyama H.

J Med Chem. 2019 Apr 11;62(7):3407-3427. doi: 10.1021/acs.jmedchem.8b01888. Epub 2019 Apr 1.

PMID:
30883102
12.

Glycyl-tRNA synthetase from Nanoarchaeum equitans: The first crystal structure of archaeal GlyRS and analysis of its tRNA glycylation.

Fujisawa A, Toki R, Miyake H, Shoji T, Doi H, Hayashi H, Hanabusa R, Mutsuro-Aoki H, Umehara T, Ando T, Noguchi H, Voet A, Park SY, Tamura K.

Biochem Biophys Res Commun. 2019 Apr 2;511(2):228-233. doi: 10.1016/j.bbrc.2019.01.142. Epub 2019 Feb 13.

PMID:
30771900
13.

Chronic Inflammation in Response to Injury: Retention of Myeloid Cells in Injured Tissue Is Driven by Myeloid Cell Intrinsic Factors.

Torbica T, Wicks K, Umehara T, Gungordu L, Alrdahe S, Wemyss K, Grainger JR, Mace KA.

J Invest Dermatol. 2019 Jul;139(7):1583-1592. doi: 10.1016/j.jid.2018.12.030. Epub 2019 Jan 28.

PMID:
30703358
14.

Effects of complementary loop composition in truncated R3C ligase ribozymes on kiss switch activation.

Hamachi K, Mutsuro-Aoki H, Tanizawa K, Hirasawa I, Umehara T, Tamura K.

Biosystems. 2019 Mar;177:9-15. doi: 10.1016/j.biosystems.2019.01.004. Epub 2019 Jan 11.

PMID:
30639771
15.

Identification of Specific miRNAs in Neutrophils of Type 2 Diabetic Mice: Overexpression of miRNA-129-2-3p Accelerates Diabetic Wound Healing.

Umehara T, Mori R, Mace KA, Murase T, Abe Y, Yamamoto T, Ikematsu K.

Diabetes. 2019 Mar;68(3):617-630. doi: 10.2337/db18-0313. Epub 2018 Dec 6.

PMID:
30523028
16.

Eradication of Central Nervous System Leukemia of T-Cell Origin with a Brain-Permeable LSD1 Inhibitor.

Saito S, Kikuchi J, Koyama D, Sato S, Koyama H, Osada N, Kuroda Y, Akahane K, Inukai T, Umehara T, Furukawa Y.

Clin Cancer Res. 2019 Mar 1;25(5):1601-1611. doi: 10.1158/1078-0432.CCR-18-0919. Epub 2018 Dec 5.

PMID:
30518632
17.

Tri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8.

Tsusaka T, Kikuchi M, Shimazu T, Suzuki T, Sohtome Y, Akakabe M, Sodeoka M, Dohmae N, Umehara T, Shinkai Y.

Epigenetics Chromatin. 2018 Oct 4;11(1):56. doi: 10.1186/s13072-018-0231-z.

18.

Lysine Acetylation Regulates Alanyl-tRNA Synthetase Activity in Escherichia coli.

Umehara T, Kosono S, Söll D, Tamura K.

Genes (Basel). 2018 Sep 28;9(10). pii: E473. doi: 10.3390/genes9100473.

19.

Life-Threatening Hemorrhagic Moyamoya Disease: Report of Rare Case of Atraumatic Acute Subdural Hematoma Due to Ruptured Transdural Anastomosis.

Umehara T, Goto Y, Kajikawa R, Wakayama A, Kishima H.

World Neurosurg. 2018 Oct;118:16-20. doi: 10.1016/j.wneu.2018.06.197. Epub 2018 Jul 2.

PMID:
30257290
20.

11C-methionine-18F-FDG dual-PET-tracer-based target delineation of malignant glioma: evaluation of its geometrical and clinical features for planning radiation therapy.

Hirata T, Kinoshita M, Tamari K, Seo Y, Suzuki O, Wakai N, Achiha T, Umehara T, Arita H, Kagawa N, Kanemura Y, Shimosegawa E, Hashimoto N, Hatazawa J, Kishima H, Teshima T, Ogawa K.

J Neurosurg. 2018 Sep 1:1-11. doi: 10.3171/2018.4.JNS1859. [Epub ahead of print]

PMID:
30239314
21.

Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds.

de Kerckhove M, Tanaka K, Umehara T, Okamoto M, Kanematsu S, Hayashi H, Yano H, Nishiura S, Tooyama S, Matsubayashi Y, Komatsu T, Park S, Okada Y, Takahashi R, Kawano Y, Hanawa T, Iwasaki K, Nozaki T, Torigoe H, Ikematsu K, Suzuki Y, Tanaka K, Martin P, Shimokawa I, Mori R.

EMBO Mol Med. 2018 Oct;10(10). pii: e9024. doi: 10.15252/emmm.201809024.

22.

JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states.

Handoko L, Kaczkowski B, Hon CC, Lizio M, Wakamori M, Matsuda T, Ito T, Jeyamohan P, Sato Y, Sakamoto K, Yokoyama S, Kimura H, Minoda A, Umehara T.

Epigenetics. 2018;13(4):410-431. doi: 10.1080/15592294.2018.1469891. Epub 2018 Aug 6.

23.

Identification of potential markers of fatal hypothermia by a body temperature-dependent gene expression assay.

Umehara T, Murase T, Abe Y, Yamashita H, Shibaike Y, Kagawa S, Yamamoto T, Ikematsu K.

Int J Legal Med. 2019 Mar;133(2):335-345. doi: 10.1007/s00414-018-1888-3. Epub 2018 Jun 29.

PMID:
29959558
24.

Crystal Structure of LSD1 in Complex with 4-[5-(Piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile.

Niwa H, Sato S, Hashimoto T, Matsuno K, Umehara T.

Molecules. 2018 Jun 26;23(7). pii: E1538. doi: 10.3390/molecules23071538.

25.
26.

Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine.

Hirano T, Fujiwara T, Niwa H, Hirano M, Ohira K, Okazaki Y, Sato S, Umehara T, Maemoto Y, Ito A, Yoshida M, Kagechika H.

ChemMedChem. 2018 Aug 10;13(15):1530-1540. doi: 10.1002/cmdc.201800233. Epub 2018 Jul 6.

PMID:
29882380
27.

High norepinephrinergic orthostatic hypotension in early Parkinson's disease.

Umehara T, Oka H, Nakahara A, Matsuno H, Toyoda C.

Parkinsonism Relat Disord. 2018 Oct;55:97-102. doi: 10.1016/j.parkreldis.2018.05.025. Epub 2018 May 28.

PMID:
29880316
28.

The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis.

Kobayashi M, Ohsugi M, Sasako T, Awazawa M, Umehara T, Iwane A, Kobayashi N, Okazaki Y, Kubota N, Suzuki R, Waki H, Horiuchi K, Hamakubo T, Kodama T, Aoe S, Tobe K, Kadowaki T, Ueki K.

Mol Cell Biol. 2018 Jul 30;38(16). pii: e00116-18. doi: 10.1128/MCB.00116-18. Print 2018 Aug 15.

29.

Can the Amount of Interventions during the Convalescent Phase Predict the Achievement of Independence in Activities of Daily Living in Patients with Stroke? A Retrospective Cohort Study.

Umehara T, Tanaka R, Tsunematsu M, Sugihara K, Moriuchi Y, Yata K, Muranaka K, Inoue J, Kohriyama T, Kakehashi M.

J Stroke Cerebrovasc Dis. 2018 Sep;27(9):2436-2444. doi: 10.1016/j.jstrokecerebrovasdis.2018.04.038. Epub 2018 May 29.

PMID:
29857930
30.

Rotigotine Improves Abnormal Circadian Rhythm of Blood Pressure in Parkinson's Disease.

Oka H, Nakahara A, Umehara T.

Eur Neurol. 2018;79(5-6):281-286. doi: 10.1159/000489574. Epub 2018 May 15.

PMID:
29763930
31.

Effect of Continuous Compression Stimulation on Pressure-Pain Threshold and Muscle Spasms in Older Adults With Knee Osteoarthritis: A Randomized Trial.

Tanaka R, Umehara T, Kawabata Y, Sakuda T.

J Manipulative Physiol Ther. 2018 May;41(4):315-322. doi: 10.1016/j.jmpt.2017.09.011.

PMID:
29751849
32.

No association between cardiac ion channel variants and sudden infant death.

Yamamoto T, Matsusue A, Umehara T, Kubo SI, Ikematsu K.

Pediatr Int. 2018 May;60(5):483-484. doi: 10.1111/ped.13532. Epub 2018 Apr 26. No abstract available.

PMID:
29700890
33.

IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling.

Yoneyama Y, Lanzerstorfer P, Niwa H, Umehara T, Shibano T, Yokoyama S, Chida K, Weghuber J, Hakuno F, Takahashi SI.

Elife. 2018 Apr 11;7. pii: e32893. doi: 10.7554/eLife.32893.

34.

Creatine enhances the duration of sperm capacitation: a novel factor for improving in vitro fertilization with small numbers of sperm.

Umehara T, Kawai T, Goto M, Richards JS, Shimada M.

Hum Reprod. 2018 Jun 1;33(6):1117-1129. doi: 10.1093/humrep/dey081.

35.

Relative adrenal insufficiency in adult-onset cerebral X-linked adrenoleukodystrophy.

Sato T, Umehara T, Nakahara A, Oka H.

Neurol Clin Pract. 2017 Oct;7(5):398-400. doi: 10.1212/CPJ.0000000000000310. No abstract available.

36.

Lysine-specific demethylase 1 inhibitors prevent teratoma development from human induced pluripotent stem cells.

Osada N, Kikuchi J, Umehara T, Sato S, Urabe M, Abe T, Hayashi N, Sugitani M, Hanazono Y, Furukawa Y.

Oncotarget. 2018 Jan 8;9(5):6450-6462. doi: 10.18632/oncotarget.24030. eCollection 2018 Jan 19.

37.

Inductions of granulosa cell luteinization and cumulus expansion are dependent on the fibronectin-integrin pathway during ovulation process in mice.

Kitasaka H, Kawai T, Hoque SAM, Umehara T, Fujita Y, Shimada M.

PLoS One. 2018 Feb 8;13(2):e0192458. doi: 10.1371/journal.pone.0192458. eCollection 2018.

38.

Detection of alternative subpleural lymph flow pathways using indocyanine green fluorescence.

Takeda AH, Watanabe Y, Nagata T, Aoki M, Umehara T, Suzuki S, Kamimura G, Wakida K, Otsuka T, Yokomakura N, Kariatsumari K, Sakasegawa K, Nakamura Y, Sato M.

Surg Today. 2018 Jun;48(6):640-648. doi: 10.1007/s00595-018-1631-1. Epub 2018 Jan 30.

PMID:
29383594
39.

The stromal fibrosis in aging ovary.

Umehara T, Richards JS, Shimada M.

Aging (Albany NY). 2018 Jan 19;10(1):9-10. doi: 10.18632/aging.101370. No abstract available.

40.

The Kiss Switch Brings Inactive R3C Ligase Ribozyme Back to Life.

Tanizawa K, Uchida S, Kurihara E, Umehara T, Tamura K.

Biology (Basel). 2018 Jan 9;7(1). pii: E7. doi: 10.3390/biology7010007.

41.

Early diagnosis using canonical discriminant analysis of innate immune receptor gene expression profiles in a murine infectious or sterile systemic inflammation model.

Tajima G, Tokunaga A, Umehara T, Ikematsu K, Miyamoto J, Sato S, Tasaki O.

J Trauma Acute Care Surg. 2018 Apr;84(4):583-589. doi: 10.1097/TA.0000000000001789.

PMID:
29287057
42.
43.

A step into the RNA world: Conditional analysis of hydrogel formation of adenosine 5'-monophosphate induced by cyanuric acid.

Yokosawa T, Enomoto R, Uchino S, Hirasawa I, Umehara T, Tamura K.

Biosystems. 2017 Dec;162:53-58. doi: 10.1016/j.biosystems.2017.09.004. Epub 2017 Sep 5.

PMID:
28887177
44.

Pulmonary function and thoracic deformities in adolescent idiopathic scoliosis 27 years or longer after spinal fusion with Harrington instrument.

Akazawa T, Kuroya S, Iinuma M, Asano K, Torii Y, Umehara T, Kotani T, Sakuma T, Minami S, Orita S, Inage K, Fujimoto K, Shiga Y, Inoue G, Miyagi M, Saito W, Ohtori S, Niki H.

J Orthop Sci. 2018 Jan;23(1):45-50. doi: 10.1016/j.jos.2017.08.016. Epub 2017 Sep 5.

PMID:
28887065
45.

Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock.

Shinohara Y, Koyama YM, Ukai-Tadenuma M, Hirokawa T, Kikuchi M, Yamada RG, Ukai H, Fujishima H, Umehara T, Tainaka K, Ueda HR.

Mol Cell. 2017 Sep 7;67(5):783-798.e20. doi: 10.1016/j.molcel.2017.08.009.

46.

The acceleration of reproductive aging in Nrg1flox/flox ;Cyp19-Cre female mice.

Umehara T, Kawai T, Kawashima I, Tanaka K, Okuda S, Kitasaka H, Richards JS, Shimada M.

Aging Cell. 2017 Dec;16(6):1288-1299. doi: 10.1111/acel.12662. Epub 2017 Aug 31.

47.

Temporal expression of chitinase-like 3 in wounded murine skin.

Murase T, Yamamoto T, Koide A, Yagi Y, Kagawa S, Tsuruya S, Abe Y, Umehara T, Ikematsu K.

Int J Legal Med. 2017 Nov;131(6):1623-1631. doi: 10.1007/s00414-017-1658-7. Epub 2017 Aug 6.

PMID:
28780759
48.

Modic Changes and Disc Degeneration of Nonfused Segments 27 to 45 Years After Harrington Instrumentation for Adolescent Idiopathic Scoliosis: Comparison to Healthy Controls.

Akazawa T, Kotani T, Sakuma T, Minami S, Orita S, Inage K, Fujimoto K, Shiga Y, Torii Y, Umehara T, Iinuma M, Kuroya S, Niki H, Ohtori S, Takahashi K.

Spine (Phila Pa 1976). 2018 Apr 15;43(8):556-561. doi: 10.1097/BRS.0000000000002362.

PMID:
28767629
49.

Postmortem genetic analysis of sudden unexpected death in infancy: neonatal genetic screening may enable the prevention of sudden infant death.

Oshima Y, Yamamoto T, Ishikawa T, Mishima H, Matsusue A, Umehara T, Murase T, Abe Y, Kubo SI, Yoshiura KI, Makita N, Ikematsu K.

J Hum Genet. 2017 Nov;62(11):989-995. doi: 10.1038/jhg.2017.79. Epub 2017 Jul 27.

PMID:
28747690
50.

Binding Properties of Split tRNA to the C-terminal Domain of Methionyl-tRNA Synthetase of Nanoarchaeum equitans.

Suzuki H, Kaneko A, Yamamoto T, Nambo M, Hirasawa I, Umehara T, Yoshida H, Park SY, Tamura K.

J Mol Evol. 2017 Jun;84(5-6):267-278. doi: 10.1007/s00239-017-9796-6. Epub 2017 Jun 6.

PMID:
28589220

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