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Items: 1 to 50 of 218

1.

Identification of potential markers of fatal hypothermia by a body temperature-dependent gene expression assay.

Umehara T, Murase T, Abe Y, Yamashita H, Shibaike Y, Kagawa S, Yamamoto T, Ikematsu K.

Int J Legal Med. 2018 Jun 29. doi: 10.1007/s00414-018-1888-3. [Epub ahead of print]

PMID:
29959558
2.

Crystal Structure of LSD1 in Complex with 4-[5-(Piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile.

Niwa H, Sato S, Hashimoto T, Matsuno K, Umehara T.

Molecules. 2018 Jun 26;23(7). pii: E1538. doi: 10.3390/molecules23071538.

3.
4.

Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine.

Hirano T, Fujiwara T, Niwa H, Hirano M, Ohira K, Okazaki Y, Sato S, Umehara T, Maemoto Y, Ito A, Yoshida M, Kagechika H.

ChemMedChem. 2018 Jun 7. doi: 10.1002/cmdc.201800233. [Epub ahead of print]

PMID:
29882380
5.

High norepinephrinergic orthostatic hypotension in early Parkinson's disease.

Umehara T, Oka H, Nakahara A, Matsuno H, Toyoda C.

Parkinsonism Relat Disord. 2018 May 28. pii: S1353-8020(18)30257-8. doi: 10.1016/j.parkreldis.2018.05.025. [Epub ahead of print]

PMID:
29880316
6.

The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis.

Kobayashi M, Ohsugi M, Sasako T, Awazawa M, Umehara T, Iwane A, Kobayashi N, Okazaki Y, Kubota N, Suzuki R, Waki H, Horiuchi K, Hamakubo T, Kodama T, Aoe S, Tobe K, Kadowaki T, Ueki K.

Mol Cell Biol. 2018 Jun 4. pii: MCB.00116-18. doi: 10.1128/MCB.00116-18. [Epub ahead of print]

7.

Can the Amount of Interventions during the Convalescent Phase Predict the Achievement of Independence in Activities of Daily Living in Patients with Stroke? A Retrospective Cohort Study.

Umehara T, Tanaka R, Tsunematsu M, Sugihara K, Moriuchi Y, Yata K, Muranaka K, Inoue J, Kohriyama T, Kakehashi M.

J Stroke Cerebrovasc Dis. 2018 May 29. pii: S1052-3057(18)30216-7. doi: 10.1016/j.jstrokecerebrovasdis.2018.04.038. [Epub ahead of print]

PMID:
29857930
8.

Rotigotine Improves Abnormal Circadian Rhythm of Blood Pressure in Parkinson's Disease.

Oka H, Nakahara A, Umehara T.

Eur Neurol. 2018 May 15;79(5-6):281-286. doi: 10.1159/000489574. [Epub ahead of print]

PMID:
29763930
9.

Effect of Continuous Compression Stimulation on Pressure-Pain Threshold and Muscle Spasms in Older Adults With Knee Osteoarthritis: A Randomized Trial.

Tanaka R, Umehara T, Kawabata Y, Sakuda T.

J Manipulative Physiol Ther. 2018 May;41(4):315-322. doi: 10.1016/j.jmpt.2017.09.011.

PMID:
29751849
10.

No association between cardiac ion channel variants and sudden infant death.

Yamamoto T, Matsusue A, Umehara T, Kubo SI, Ikematsu K.

Pediatr Int. 2018 May;60(5):483-484. doi: 10.1111/ped.13532. Epub 2018 Apr 26. No abstract available.

PMID:
29700890
11.

IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling.

Yoneyama Y, Lanzerstorfer P, Niwa H, Umehara T, Shibano T, Yokoyama S, Chida K, Weghuber J, Hakuno F, Takahashi SI.

Elife. 2018 Apr 11;7. pii: e32893. doi: 10.7554/eLife.32893.

12.

Creatine enhances the duration of sperm capacitation: a novel factor for improving in vitro fertilization with small numbers of sperm.

Umehara T, Kawai T, Goto M, Richards JS, Shimada M.

Hum Reprod. 2018 Jun 1;33(6):1117-1129. doi: 10.1093/humrep/dey081.

PMID:
29635630
13.

Relative adrenal insufficiency in adult-onset cerebral X-linked adrenoleukodystrophy.

Sato T, Umehara T, Nakahara A, Oka H.

Neurol Clin Pract. 2017 Oct;7(5):398-400. doi: 10.1212/CPJ.0000000000000310. No abstract available.

PMID:
29620081
14.

Lysine-specific demethylase 1 inhibitors prevent teratoma development from human induced pluripotent stem cells.

Osada N, Kikuchi J, Umehara T, Sato S, Urabe M, Abe T, Hayashi N, Sugitani M, Hanazono Y, Furukawa Y.

Oncotarget. 2018 Jan 8;9(5):6450-6462. doi: 10.18632/oncotarget.24030. eCollection 2018 Jan 19.

15.

Inductions of granulosa cell luteinization and cumulus expansion are dependent on the fibronectin-integrin pathway during ovulation process in mice.

Kitasaka H, Kawai T, Hoque SAM, Umehara T, Fujita Y, Shimada M.

PLoS One. 2018 Feb 8;13(2):e0192458. doi: 10.1371/journal.pone.0192458. eCollection 2018.

16.

Detection of alternative subpleural lymph flow pathways using indocyanine green fluorescence.

Takeda AH, Watanabe Y, Nagata T, Aoki M, Umehara T, Suzuki S, Kamimura G, Wakida K, Otsuka T, Yokomakura N, Kariatsumari K, Sakasegawa K, Nakamura Y, Sato M.

Surg Today. 2018 Jun;48(6):640-648. doi: 10.1007/s00595-018-1631-1. Epub 2018 Jan 30.

PMID:
29383594
17.

The stromal fibrosis in aging ovary.

Umehara T, Richards JS, Shimada M.

Aging (Albany NY). 2018 Jan 19;10(1):9-10. doi: 10.18632/aging.101370. No abstract available.

18.

The Kiss Switch Brings Inactive R3C Ligase Ribozyme Back to Life.

Tanizawa K, Uchida S, Kurihara E, Umehara T, Tamura K.

Biology (Basel). 2018 Jan 9;7(1). pii: E7. doi: 10.3390/biology7010007.

19.

Early diagnosis using canonical discriminant analysis of innate immune receptor gene expression profiles in a murine infectious or sterile systemic inflammation model.

Tajima G, Tokunaga A, Umehara T, Ikematsu K, Miyamoto J, Sato S, Tasaki O.

J Trauma Acute Care Surg. 2018 Apr;84(4):583-589. doi: 10.1097/TA.0000000000001789.

PMID:
29287057
20.

Effective exercise intervention period for improving body function or activity in patients with knee osteoarthritis undergoing total knee arthroplasty: a systematic review and meta-analysis.

Umehara T, Tanaka R.

Braz J Phys Ther. 2017 Nov 8. pii: S1413-3555(17)30063-1. doi: 10.1016/j.bjpt.2017.10.005. [Epub ahead of print] Review.

PMID:
29174345
21.

A step into the RNA world: Conditional analysis of hydrogel formation of adenosine 5'-monophosphate induced by cyanuric acid.

Yokosawa T, Enomoto R, Uchino S, Hirasawa I, Umehara T, Tamura K.

Biosystems. 2017 Dec;162:53-58. doi: 10.1016/j.biosystems.2017.09.004. Epub 2017 Sep 5.

PMID:
28887177
22.

Pulmonary function and thoracic deformities in adolescent idiopathic scoliosis 27 years or longer after spinal fusion with Harrington instrument.

Akazawa T, Kuroya S, Iinuma M, Asano K, Torii Y, Umehara T, Kotani T, Sakuma T, Minami S, Orita S, Inage K, Fujimoto K, Shiga Y, Inoue G, Miyagi M, Saito W, Ohtori S, Niki H.

J Orthop Sci. 2018 Jan;23(1):45-50. doi: 10.1016/j.jos.2017.08.016. Epub 2017 Sep 5.

PMID:
28887065
23.

Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock.

Shinohara Y, Koyama YM, Ukai-Tadenuma M, Hirokawa T, Kikuchi M, Yamada RG, Ukai H, Fujishima H, Umehara T, Tainaka K, Ueda HR.

Mol Cell. 2017 Sep 7;67(5):783-798.e20. doi: 10.1016/j.molcel.2017.08.009.

PMID:
28886336
24.

The acceleration of reproductive aging in Nrg1flox/flox ;Cyp19-Cre female mice.

Umehara T, Kawai T, Kawashima I, Tanaka K, Okuda S, Kitasaka H, Richards JS, Shimada M.

Aging Cell. 2017 Dec;16(6):1288-1299. doi: 10.1111/acel.12662. Epub 2017 Aug 31.

25.

Temporal expression of chitinase-like 3 in wounded murine skin.

Murase T, Yamamoto T, Koide A, Yagi Y, Kagawa S, Tsuruya S, Abe Y, Umehara T, Ikematsu K.

Int J Legal Med. 2017 Nov;131(6):1623-1631. doi: 10.1007/s00414-017-1658-7. Epub 2017 Aug 6.

PMID:
28780759
26.

Modic Changes and Disc Degeneration of Nonfused Segments 27 to 45 Years After Harrington Instrumentation for Adolescent Idiopathic Scoliosis: Comparison to Healthy Controls.

Akazawa T, Kotani T, Sakuma T, Minami S, Orita S, Inage K, Fujimoto K, Shiga Y, Torii Y, Umehara T, Iinuma M, Kuroya S, Niki H, Ohtori S, Takahashi K.

Spine (Phila Pa 1976). 2018 Apr 15;43(8):556-561. doi: 10.1097/BRS.0000000000002362.

PMID:
28767629
27.

Postmortem genetic analysis of sudden unexpected death in infancy: neonatal genetic screening may enable the prevention of sudden infant death.

Oshima Y, Yamamoto T, Ishikawa T, Mishima H, Matsusue A, Umehara T, Murase T, Abe Y, Kubo SI, Yoshiura KI, Makita N, Ikematsu K.

J Hum Genet. 2017 Nov;62(11):989-995. doi: 10.1038/jhg.2017.79. Epub 2017 Jul 27.

PMID:
28747690
28.

Binding Properties of Split tRNA to the C-terminal Domain of Methionyl-tRNA Synthetase of Nanoarchaeum equitans.

Suzuki H, Kaneko A, Yamamoto T, Nambo M, Hirasawa I, Umehara T, Yoshida H, Park SY, Tamura K.

J Mol Evol. 2017 Jun;84(5-6):267-278. doi: 10.1007/s00239-017-9796-6. Epub 2017 Jun 6.

PMID:
28589220
29.

RNA-Dependent Cysteine Biosynthesis in Bacteria and Archaea.

Mukai T, Crnković A, Umehara T, Ivanova NN, Kyrpides NC, Söll D.

MBio. 2017 May 9;8(3). pii: e00561-17. doi: 10.1128/mBio.00561-17.

30.

Coil Intrabronchial Migration in an Arteriovenous Malformation Patient Treated 10 Years Ago.

Umehara T, Aoki M, Kamimura G, Wakida K, Nagata T, Otsuka T, Sato M.

Ann Thorac Cardiovasc Surg. 2017 Aug 20;23(4):200-202. doi: 10.5761/atcs.cr.16-00250. Epub 2017 Apr 28.

31.

Crystal structure of RNA polymerase II from Komagataella pastoris.

Ehara H, Umehara T, Sekine SI, Yokoyama S.

Biochem Biophys Res Commun. 2017 May 27;487(2):230-235. doi: 10.1016/j.bbrc.2017.04.039. Epub 2017 Apr 12.

32.

Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1.

Amano Y, Kikuchi M, Sato S, Yokoyama S, Umehara T, Umezawa N, Higuchi T.

Bioorg Med Chem. 2017 May 1;25(9):2617-2624. doi: 10.1016/j.bmc.2017.03.016. Epub 2017 Mar 9.

PMID:
28336409
33.

A genomically modified Escherichia coli strain carrying an orthogonal E. coli histidyl-tRNA synthetase•tRNAHis pair.

Englert M, Vargas-Rodriguez O, Reynolds NM, Wang YS, Söll D, Umehara T.

Biochim Biophys Acta. 2017 Nov;1861(11 Pt B):3009-3015. doi: 10.1016/j.bbagen.2017.03.003. Epub 2017 Mar 10.

PMID:
28288813
34.

Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases.

Niwa H, Umehara T.

Epigenetics. 2017 May 4;12(5):340-352. doi: 10.1080/15592294.2017.1290032. Epub 2017 Feb 10. Review.

35.

Characterization of lysine acetylation of a phosphoenolpyruvate carboxylase involved in glutamate overproduction in Corynebacterium glutamicum.

Nagano-Shoji M, Hamamoto Y, Mizuno Y, Yamada A, Kikuchi M, Shirouzu M, Umehara T, Yoshida M, Nishiyama M, Kosono S.

Mol Microbiol. 2017 May;104(4):677-689. doi: 10.1111/mmi.13658. Epub 2017 Mar 20.

PMID:
28256782
36.

The Measurement of X-ray Fluoroscopy Input-output Characteristics in Angiography System.

Hagihara Y, Umehara T, Matsumoto K, Fujita T, Ikeuchi Y, Fujikawa K, Takahashi Y, Kotoura N.

Nihon Hoshasen Gijutsu Gakkai Zasshi. 2017;73(2):96-103. doi: 10.6009/jjrt.2017_JSRT_73.2.96. Japanese.

37.

Activation of lysine-specific demethylase 1 inhibitor peptide by redox-controlled cleavage of a traceless linker.

Amano Y, Umezawa N, Sato S, Watanabe H, Umehara T, Higuchi T.

Bioorg Med Chem. 2017 Feb 1;25(3):1227-1234. doi: 10.1016/j.bmc.2016.12.033. Epub 2016 Dec 23.

PMID:
28065500
38.

Clinical Prediction Rule for Declines in Activities of Daily Living at 6 Months After Surgery for Hip Fracture Repair.

Tanaka R, Umehara T, Fujimura T, Ozawa J.

Arch Phys Med Rehabil. 2016 Dec;97(12):2076-2084. doi: 10.1016/j.apmr.2016.07.016. Epub 2016 Aug 13.

39.

Neuregulin 1 Regulates Proliferation of Leydig Cells to Support Spermatogenesis and Sexual Behavior in Adult Mice.

Umehara T, Kawashima I, Kawai T, Hoshino Y, Morohashi KI, Shima Y, Zeng W, Richards JS, Shimada M.

Endocrinology. 2016 Dec;157(12):4899-4913. Epub 2016 Oct 12.

40.

The Strip-Hippo Pathway Regulates Synaptic Terminal Formation by Modulating Actin Organization at the Drosophila Neuromuscular Synapses.

Sakuma C, Saito Y, Umehara T, Kamimura K, Maeda N, Mosca TJ, Miura M, Chihara T.

Cell Rep. 2016 Aug 30;16(9):2289-97. doi: 10.1016/j.celrep.2016.07.066. Epub 2016 Aug 18.

41.

Crystal structure of human nucleosome core particle containing enzymatically introduced CpG methylation.

Fujii Y, Wakamori M, Umehara T, Yokoyama S.

FEBS Open Bio. 2016 May 3;6(6):498-514. doi: 10.1002/2211-5463.12064. eCollection 2016 Jun.

42.

Predictors of postprandial hypotension in elderly patients with de novo Parkinson's disease.

Umehara T, Nakahara A, Matsuno H, Toyoda C, Oka H.

J Neural Transm (Vienna). 2016 Nov;123(11):1331-1339. Epub 2016 Jul 8.

PMID:
27393383
43.

Body weight and dysautonomia in early Parkinson's disease.

Umehara T, Nakahara A, Matsuno H, Toyoda C, Oka H.

Acta Neurol Scand. 2017 May;135(5):560-567. doi: 10.1111/ane.12633. Epub 2016 Jun 30.

PMID:
27357472
44.

Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.

Takemoto Y, Ito A, Niwa H, Okamura M, Fujiwara T, Hirano T, Handa N, Umehara T, Sonoda T, Ogawa K, Tariq M, Nishino N, Dan S, Kagechika H, Yamori T, Yokoyama S, Yoshida M.

J Med Chem. 2016 Apr 28;59(8):3650-60. doi: 10.1021/acs.jmedchem.5b01732. Epub 2016 Apr 18.

PMID:
27088648
45.

A case of pilocytic astrocytoma requiring tumor resection during pregnancy.

Umehara T, Okita Y, Nonaka M, Kanemura Y, Kodama Y, Mano M, Nakajima S, Fujinaka T.

Mol Clin Oncol. 2016 Apr;4(4):567-570. Epub 2016 Feb 9.

46.

Histone H4 lysine 20 acetylation is associated with gene repression in human cells.

Kaimori JY, Maehara K, Hayashi-Takanaka Y, Harada A, Fukuda M, Yamamoto S, Ichimaru N, Umehara T, Yokoyama S, Matsuda R, Ikura T, Nagao K, Obuse C, Nozaki N, Takahara S, Takao T, Ohkawa Y, Kimura H, Isaka Y.

Sci Rep. 2016 Apr 11;6:24318. doi: 10.1038/srep24318.

47.

Immunohistochemical detection of CD14 and combined assessment with CD32B and CD68 for wound age estimation.

Yagi Y, Murase T, Kagawa S, Tsuruya S, Nakahara A, Yamamoto T, Umehara T, Ikematsu K.

Forensic Sci Int. 2016 May;262:113-20. doi: 10.1016/j.forsciint.2016.02.031. Epub 2016 Mar 4.

PMID:
26974714
48.

Successful closure of a tracheocutaneous fistula after tracheostomy using two skin flaps: a case report.

Watanabe Y, Umehara T, Harada A, Aoki M, Tokunaga T, Suzuki S, Kamimura G, Wakida K, Nagata T, Otsuka T, Yokomakura N, Kariatsumari K, Nakamura Y, Watanabe Y, Sato M.

Surg Case Rep. 2015 Dec;1(1):43. doi: 10.1186/s40792-015-0045-1. Epub 2015 May 27.

49.

Crystal structure of eukaryotic translation initiation factor 2B.

Kashiwagi K, Takahashi M, Nishimoto M, Hiyama TB, Higo T, Umehara T, Sakamoto K, Ito T, Yokoyama S.

Nature. 2016 Mar 3;531(7592):122-5. doi: 10.1038/nature16991. Epub 2016 Feb 22.

PMID:
26901872
50.

Roles of epidermal growth factor (EGF)-like factor in the ovulation process.

Shimada M, Umehara T, Hoshino Y.

Reprod Med Biol. 2016 Feb 15;15(4):201-216. doi: 10.1007/s12522-016-0236-x. eCollection 2016 Oct. Review.

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