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Incidence of postoperative shivering decreased with the use of acetaminophen: a propensity score matching analysis.
Shirozu K, Umehara K, Ikeda M, Kammura Y, Yamaura K.
J Anesth. 2020 Mar 21. doi: 10.1007/s00540-020-02763-1. [Epub ahead of print]
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Tantipongpiradet A, Monthakantirat O, Vipatpakpaiboon O, Khampukdee C, Umehara K, Noguchi H, Fujiwara H, Matsumoto K, Sekeroglu N, Kijjoa A, Chulikhit Y.
Molecules. 2019 Dec 13;24(24). pii: E4569. doi: 10.3390/molecules24244569.
Physiologically-Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug-Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations.
Taskar KS, Pilla Reddy V, Burt H, Posada MM, Varma M, Zheng M, Ullah M, Emami Riedmaier A, Umehara KI, Snoeys J, Nakakariya M, Chu X, Beneton M, Chen Y, Huth F, Narayanan R, Mukherjee D, Dixit V, Sugiyama Y, Neuhoff S.
Clin Pharmacol Ther. 2019 Oct 19. doi: 10.1002/cpt.1693. [Epub ahead of print] Review.
A Human Immortalized Cell-Based Blood-Brain Barrier Triculture Model: Development and Characterization as a Promising Tool for Drug-Brain Permeability Studies.
Ito R, Umehara K, Suzuki S, Kitamura K, Nunoya KI, Yamaura Y, Imawaka H, Izumi S, Wakayama N, Komori T, Anzai N, Akita H, Furihata T.
Mol Pharm. 2019 Nov 4;16(11):4461-4471. doi: 10.1021/acs.molpharmaceut.9b00519. Epub 2019 Oct 15.
Multiple administrations of fluconazole increase plasma exposure to ruxolitinib in healthy adult subjects.
Aslanis V, Umehara K, Huth F, Ouatas T, Bharathy S, Butler AA, Zhou W, Gadbaw B.
Cancer Chemother Pharmacol. 2019 Oct;84(4):749-757. doi: 10.1007/s00280-019-03907-1. Epub 2019 Jul 19.
Prediction of the Impact of Cytochrome P450 2C9 Genotypes on the Drug-Drug Interaction Potential of Siponimod With Physiologically-Based Pharmacokinetic Modeling: A Comprehensive Approach for Drug Label Recommendations.
Huth F, Gardin A, Umehara K, He H.
Clin Pharmacol Ther. 2019 Nov;106(5):1113-1124. doi: 10.1002/cpt.1547. Epub 2019 Aug 11.
Drug-drug interaction (DDI) assessments of ruxolitinib, a dual substrate of CYP3A4 and CYP2C9, using a verified physiologically based pharmacokinetic (PBPK) model to support regulatory submissions.
Umehara K, Huth F, Jin Y, Schiller H, Aslanis V, Heimbach T, He H.
Drug Metab Pers Ther. 2019 May 30;34(2). pii: /j/dmdi.2019.34.issue-2/dmpt-2018-0042/dmpt-2018-0042.xml. doi: 10.1515/dmpt-2018-0042.
Identification of Novel Metabolites of Vildagliptin in Rats: Thiazoline-Containing Thiol Adducts Formed via Cysteine or Glutathione Conjugation.
Mizuno K, Takeuchi K, Umehara K, Nakajima M.
Drug Metab Dispos. 2019 Aug;47(8):809-817. doi: 10.1124/dmd.119.086546. Epub 2019 May 16.
Examining P-gp efflux kinetics guided by the BDDCS - Rational selection of in vitro assay designs and mathematical models.
Riede J, Umehara KI, Schweigler P, Huth F, Schiller H, Camenisch G, Poller B.
Eur J Pharm Sci. 2019 Apr 30;132:132-141. doi: 10.1016/j.ejps.2019.03.005. Epub 2019 Mar 9.
Dysphagia following C1 laminectomy and posterior atlantoaxial fixation for retro-odontoid pseudotumor: a case report.
Tanioka S, Kuraishi K, Mizuno M, Ishida F, Fuse I, Umehara K, Suzuki H.
Br J Neurosurg. 2018 Nov 19:1-4. doi: 10.1080/02688697.2018.1538485. [Epub ahead of print]
Alleviation of fatty liver in a rat model by enhancing N1-methylnicotinamide bioavailability through aldehyde oxidase inhibition.
Takeuchi K, Yokouchi C, Goto H, Umehara K, Yamada H, Ishii Y.
Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):203-210. doi: 10.1016/j.bbrc.2018.11.008. Epub 2018 Nov 13.
Identification of a novel metabolite of vildagliptin in humans: Cysteine targets the nitrile moiety to form a thiazoline ring.
Biochem Pharmacol. 2018 Oct;156:312-321. doi: 10.1016/j.bcp.2018.08.043. Epub 2018 Aug 31.
Differentiated HASTR/ci35 cells: A promising in vitro human astrocyte model for facilitating CNS drug development studies.
Kitamura K, Ito R, Umehara K, Morio H, Saito K, Suzuki S, Hashimoto M, Saito Y, Anzai N, Akita H, Chiba K, Furihata T.
J Pharmacol Sci. 2018 Aug;137(4):350-358. doi: 10.1016/j.jphs.2018.06.013. Epub 2018 Aug 9.
Serum 1,25-Dihydroxyvitamin D Level Is Inappropriate for Use in Prospective Studies of Cancer Incidence　- Reply.
Umehara K, Mukai N, Kitazono T, Hoka S, Kiyohara Y, Ninomiya T.
Circ J. 2018 Jul 25;82(8):2216. doi: 10.1253/circj.CJ-17-0909. Epub 2018 Jul 11. No abstract available.
Correlation between the Potency of Flavonoids on Mushroom Tyrosinase Inhibitory Activity and Melanin Synthesis in Melanocytes.
Promden W, Viriyabancha W, Monthakantirat O, Umehara K, Noguchi H, De-Eknamkul W.
Molecules. 2018 Jun 9;23(6). pii: E1403. doi: 10.3390/molecules23061403.
Case of generalized pustular psoriasis that might have progressed from terbinafine-induced acute generalized exanthematous pustulosis.
Yasuno S, Yamaguchi M, Tanaka A, Umehara K, Okita T, Asano N, Kashiwagi K, Shimomura Y.
J Dermatol. 2018 Dec;45(12):e328-e329. doi: 10.1111/1346-8138.14476. Epub 2018 May 15. No abstract available.
Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication.
Umehara K, Hoshikawa M, Tochio N, Tate SI.
Molecules. 2018 Feb 27;23(3). pii: E528. doi: 10.3390/molecules23030528.
Verification of a physiologically based pharmacokinetic model of ritonavir to estimate drug-drug interaction potential of CYP3A4 substrates.
Umehara KI, Huth F, Won CS, Heimbach T, He H.
Biopharm Drug Dispos. 2018 Mar;39(3):152-163. doi: 10.1002/bdd.2122.
Soluble CD40 ligand disrupts the blood-brain barrier and exacerbates inflammation in experimental autoimmune encephalomyelitis.
Masuda H, Mori M, Umehara K, Furihata T, Uchida T, Uzawa A, Kuwabara S.
J Neuroimmunol. 2018 Mar 15;316:117-120. doi: 10.1016/j.jneuroim.2018.01.001. Epub 2018 Jan 3.
Estimation of fractions metabolized by hepatic CYP enzymes using a concept of inter-system extrapolation factors (ISEFs) - a comparison with the chemical inhibition method.
Umehara KI, Huth F, Gu H, Schiller H, Heimbach T, He H.
Drug Metab Pers Ther. 2017 Dec 20;32(4):191-200. doi: 10.1515/dmpt-2017-0024.
α-Keto tetrahydrofuran lignan glucosides from the Bangladeshi medicinal plant Terminalia citrina inhibit estradiol (E2) induced proliferation in cancer cells.
Muhit MA, Umehara K, Noguchi H.
Phytochemistry. 2018 Jan;145:161-167. doi: 10.1016/j.phytochem.2017.10.011. Epub 2017 Nov 14.
Ribociclib Bioavailability Is Not Affected by Gastric pH Changes or Food Intake: In Silico and Clinical Evaluations.
Samant TS, Dhuria S, Lu Y, Laisney M, Yang S, Grandeury A, Mueller-Zsigmondy M, Umehara K, Huth F, Miller M, Germa C, Elmeliegy M.
Clin Pharmacol Ther. 2018 Aug;104(2):374-383. doi: 10.1002/cpt.940. Epub 2017 Dec 8.
A New Conditionally Immortalized Human Fetal Brain Pericyte Cell Line: Establishment and Functional Characterization as a Promising Tool for Human Brain Pericyte Studies.
Umehara K, Sun Y, Hiura S, Hamada K, Itoh M, Kitamura K, Oshima M, Iwama A, Saito K, Anzai N, Chiba K, Akita H, Furihata T.
Mol Neurobiol. 2018 Jul;55(7):5993-6006. doi: 10.1007/s12035-017-0815-9. Epub 2017 Nov 11.
Application of Super-Resolution Convolutional Neural Network for Enhancing Image Resolution in Chest CT.
Umehara K, Ota J, Ishida T.
J Digit Imaging. 2018 Aug;31(4):441-450. doi: 10.1007/s10278-017-0033-z.
Efficacy of the combined use of a mild foaming cleanser and moisturizer for the care of infant skin.
Okamoto N, Umehara K, Sonoda J, Hotta M, Mizushima H, Takagi Y, Matsuo K, Baba N.
Clin Cosmet Investig Dermatol. 2017 Oct 3;10:393-401. doi: 10.2147/CCID.S140716. eCollection 2017.
Naphthalene glycosides in the Thai medicinal plant Diospyros mollis.
Suwama T, Watanabe K, Monthakantirat O, Luecha P, Noguchi H, Watanabe K, Umehara K.
J Nat Med. 2018 Jan;72(1):220-229. doi: 10.1007/s11418-017-1134-1. Epub 2017 Oct 10.
Design and synthesis of benzoacridines as estrogenic and anti-estrogenic agents.
Torikai K, Koga R, Liu X, Umehara K, Kitano T, Watanabe K, Oishi T, Noguchi H, Shimohigashi Y.
Bioorg Med Chem. 2017 Oct 15;25(20):5216-5237. doi: 10.1016/j.bmc.2017.07.067. Epub 2017 Aug 24.
Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in rat.
Yilmaz Y, Umehara K, Williams G, Faller T, Schiller H, Walles M, Kraehenbuehl S, Camenisch G, Manevski N.
Xenobiotica. 2018 Aug;48(8):793-803. doi: 10.1080/00498254.2017.1373311. Epub 2017 Sep 29.
Association Between Serum Vitamin D and All-Cause and Cause-Specific Death in a General Japanese Population　- The Hisayama Study.
Umehara K, Mukai N, Hata J, Hirakawa Y, Ohara T, Yoshida D, Kishimoto H, Kitazono T, Hoka S, Kiyohara Y, Ninomiya T.
Circ J. 2017 Aug 25;81(9):1315-1321. doi: 10.1253/circj.CJ-16-0954. Epub 2017 Apr 20.
Absorption, distribution and excretion of the anti-tuberculosis drug delamanid in rats: Extensive tissue distribution suggests potential therapeutic value for extrapulmonary tuberculosis.
Shibata M, Shimokawa Y, Sasahara K, Yoda N, Sasabe H, Suzuki M, Umehara K.
Biopharm Drug Dispos. 2017 May;38(4):301-312. doi: 10.1002/bdd.2064. Epub 2017 Mar 8.
Non-RVD mutations that enhance the dynamics of the TAL repeat array along the superhelical axis improve TALEN genome editing efficacy.
Tochio N, Umehara K, Uewaki JI, Flechsig H, Kondo M, Dewa T, Sakuma T, Yamamoto T, Saitoh T, Togashi Y, Tate SI.
Sci Rep. 2016 Nov 24;6:37887. doi: 10.1038/srep37887.
Isolation of a new compound, 2-butanone 4-glucopyranoside 6'-O-gallate and other 8 compounds from the anti-inflammatory leave extracts of Memecylon edule Roxb.
Nualkaew S, Thongpraditchote S, Wongkrajang Y, Umehara K, Noguchi H.
Nat Prod Res. 2017 Jun;31(12):1370-1378. doi: 10.1080/14786419.2016.1253074. Epub 2016 Nov 7.
Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction.
Njuguna NM, Umehara KI, Huth F, Schiller H, Chibale K, Camenisch G.
Drug Metab Pers Ther. 2016 Dec 1;31(4):221-228. doi: 10.1515/dmpt-2016-0028.
A novel steroid and cytotoxic constituents from Dioscorea membranacea Pierre against hepatocellular carcinoma and cholangiocarcinoma cells.
Thongdeeying P, Itharat A, Umehara K, Ruangnoo S.
J Ethnopharmacol. 2016 Dec 24;194:91-97. doi: 10.1016/j.jep.2016.08.037. Epub 2016 Aug 24.
[Comparative Study of the Antiemetic Palonosetron for Lung Cancer Patients Treated with a Divided Dose of Cisplatin].
Umehara K, Wakamoto A, Hatsuyama T, Sato H, Kobayashi M, Fujita A, Sekine K.
Gan To Kagaku Ryoho. 2016 Aug;43(8):967-72. Japanese.
Five furofuranone lignan glucosides from Terminalia citrina inhibit in vitro E2-enhanced breast cancer cell proliferation.
Fitoterapia. 2016 Sep;113:74-9. doi: 10.1016/j.fitote.2016.07.004. Epub 2016 Jul 15.
Erratum for Sasabe et al., Antitubercular Agent Delamanid and Metabolites as Substrates and Inhibitors of ABC and Solute Carrier Transporters.
Sasabe H, Shimokawa Y, Shibata M, Hashizume K, Hamasako Y, Ohzone Y, Kashiyama E, Umehara K.
Antimicrob Agents Chemother. 2016 Jun 20;60(7):4431. doi: 10.1128/AAC.01094-16. Print 2016 Jul. No abstract available.
Abietane-type diterpenoids from the roots of Caryopteris mongolica and their cholinesterase inhibitory activities.
Murata T, Ishikawa Y, Saruul E, Selenge E, Sasaki K, Umehara K, Yoshizaki F, Batkhuu J.
Phytochemistry. 2016 Oct;130:152-8. doi: 10.1016/j.phytochem.2016.05.011. Epub 2016 Jun 10.
Furofuran Lignan Glucosides with Estrogen-Inhibitory Properties from the Bangladeshi Medicinal Plant Terminalia citrina.
Muhit MA, Umehara K, Mori-Yasumoto K, Noguchi H.
J Nat Prod. 2016 May 27;79(5):1298-307. doi: 10.1021/acs.jnatprod.5b01042. Epub 2016 Apr 25.
Antitubercular Agent Delamanid and Metabolites as Substrates and Inhibitors of ABC and Solute Carrier Transporters.
Antimicrob Agents Chemother. 2016 May 23;60(6):3497-508. doi: 10.1128/AAC.03049-15. Print 2016 Jun. Erratum in: Antimicrob Agents Chemother. 2016 Jul;60(7):4431.
New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data.
Riede J, Poller B, Umehara K, Huwyler J, Camenisch G.
Eur J Pharm Sci. 2016 Apr 30;86:96-102. doi: 10.1016/j.ejps.2016.02.022. Epub 2016 Mar 3.
Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors.
Umehara K, Zollinger M, Kigondu E, Witschi M, Juif C, Huth F, Schiller H, Chibale K, Camenisch G.
Xenobiotica. 2016 Oct;46(10):862-7. doi: 10.3109/00498254.2015.1133867. Epub 2016 Feb 18.
Phenolic constituents of the Bangladeshi medicinal plant Pothos scandens and their anti-estrogenic, hyaluronidase inhibition, and histamine release inhibitory activities.
Muhit MA, Izumikawa M, Umehara K, Noguchi H.
Phytochemistry. 2016 Jan;121:30-7. doi: 10.1016/j.phytochem.2015.10.009. Epub 2015 Nov 2.
Rebamipide does not interfere with the antitumor effect of radiotherapy or chemotherapy in human oral tumor-bearing nude mice.
Shibamori M, Sato M, Uematsu N, Nakashima T, Sato A, Yamamura Y, Sasabe H, Umehara K, Sakurai K.
J Pharmacol Sci. 2015 Sep;129(1):18-25. doi: 10.1016/j.jphs.2015.07.022. Epub 2015 Aug 4.
An Increased Serum N-Terminal Telopeptide of Type I Collagen, a Biochemical Marker of Increased Bone Resorption, Is Associated with Infliximab Therapy in Patients with Crohn's Disease.
Sugimoto K, Ikeya K, Iida T, Kawasaki S, Arai O, Umehara K, Watanabe F, Tani S, Oishi S, Osawa S, Yamamoto T, Hanai H.
Dig Dis Sci. 2016 Jan;61(1):99-106. doi: 10.1007/s10620-015-3838-y. Epub 2015 Aug 8.
[Study on the Antiemetic Effects of Aprepitant in Patients with Lung Cancer Receiving Chemotherapy with Carboplatin].
Hatsuyama T, Umehara K, Wakamoto A, Sato H.
Gan To Kagaku Ryoho. 2015 Jun;42(6):725-9. Japanese.
Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes.
Shimokawa Y, Yoda N, Kondo S, Yamamura Y, Takiguchi Y, Umehara K.
Biol Pharm Bull. 2015;38(9):1425-9. doi: 10.1248/bpb.b15-00313. Epub 2015 Jun 20.
Metabolic Mechanism of Delamanid, a New Anti-Tuberculosis Drug, in Human Plasma.
Shimokawa Y, Sasahara K, Koyama N, Kitano K, Shibata M, Yoda N, Umehara K.
Drug Metab Dispos. 2015 Aug;43(8):1277-83. doi: 10.1124/dmd.115.064550. Epub 2015 Jun 8.
Pharmacokinetics and Metabolism of Delamanid, a Novel Anti-Tuberculosis Drug, in Animals and Humans: Importance of Albumin Metabolism In Vivo.
Sasahara K, Shimokawa Y, Hirao Y, Koyama N, Kitano K, Shibata M, Umehara K.
Drug Metab Dispos. 2015 Aug;43(8):1267-76. doi: 10.1124/dmd.115.064527. Epub 2015 Jun 8.
Comprehensive kinetic analysis and influence of reaction components for chlorzoxazone 6-hydroxylation in human liver microsomes with CYP antibodies.
Yamamura Y, Koyama N, Umehara K.
Xenobiotica. 2015 Apr;45(4):353-60. doi: 10.3109/00498254.2014.985760. Epub 2014 Nov 19.
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