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Items: 1 to 50 of 187

1.

Serum 1,25-Dihydroxyvitamin D Level Is Inappropriate for Use in Prospective Studies of Cancer Incidence - Reply.

Umehara K, Mukai N, Kitazono T, Hoka S, Kiyohara Y, Ninomiya T.

Circ J. 2018 Jul 11. doi: 10.1253/circj.CJ-17-0909. [Epub ahead of print] No abstract available.

2.

Correlation between the Potency of Flavonoids on Mushroom Tyrosinase Inhibitory Activity and Melanin Synthesis in Melanocytes.

Promden W, Viriyabancha W, Monthakantirat O, Umehara K, Noguchi H, De-Eknamkul W.

Molecules. 2018 Jun 9;23(6). pii: E1403. doi: 10.3390/molecules23061403.

3.

Case of generalized pustular psoriasis that might have progressed from terbinafine-induced acute generalized exanthematous pustulosis.

Yasuno S, Yamaguchi M, Tanaka A, Umehara K, Okita T, Asano N, Kashiwagi K, Shimomura Y.

J Dermatol. 2018 May 15. doi: 10.1111/1346-8138.14476. [Epub ahead of print] No abstract available.

PMID:
29766566
4.

Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication.

Umehara K, Hoshikawa M, Tochio N, Tate SI.

Molecules. 2018 Feb 27;23(3). pii: E528. doi: 10.3390/molecules23030528.

5.

Verification of a physiologically based pharmacokinetic model of ritonavir to estimate drug-drug interaction potential of CYP3A4 substrates.

Umehara KI, Huth F, Won CS, Heimbach T, He H.

Biopharm Drug Dispos. 2018 Mar;39(3):152-163. doi: 10.1002/bdd.2122.

PMID:
29451681
6.

Soluble CD40 ligand disrupts the blood-brain barrier and exacerbates inflammation in experimental autoimmune encephalomyelitis.

Masuda H, Mori M, Umehara K, Furihata T, Uchida T, Uzawa A, Kuwabara S.

J Neuroimmunol. 2018 Mar 15;316:117-120. doi: 10.1016/j.jneuroim.2018.01.001. Epub 2018 Jan 3.

PMID:
29329699
7.

Estimation of fractions metabolized by hepatic CYP enzymes using a concept of inter-system extrapolation factors (ISEFs) - a comparison with the chemical inhibition method.

Umehara KI, Huth F, Gu H, Schiller H, Heimbach T, He H.

Drug Metab Pers Ther. 2017 Dec 20;32(4):191-200. doi: 10.1515/dmpt-2017-0024.

PMID:
29176011
8.

α-Keto tetrahydrofuran lignan glucosides from the Bangladeshi medicinal plant Terminalia citrina inhibit estradiol (E2) induced proliferation in cancer cells.

Muhit MA, Umehara K, Noguchi H.

Phytochemistry. 2018 Jan;145:161-167. doi: 10.1016/j.phytochem.2017.10.011. Epub 2017 Nov 14.

PMID:
29149663
9.

Ribociclib Bioavailability Is Not Affected by Gastric pH Changes or Food Intake: In Silico and Clinical Evaluations.

Samant TS, Dhuria S, Lu Y, Laisney M, Yang S, Grandeury A, Mueller-Zsigmondy M, Umehara K, Huth F, Miller M, Germa C, Elmeliegy M.

Clin Pharmacol Ther. 2017 Nov 14. doi: 10.1002/cpt.940. [Epub ahead of print]

PMID:
29134635
10.

A New Conditionally Immortalized Human Fetal Brain Pericyte Cell Line: Establishment and Functional Characterization as a Promising Tool for Human Brain Pericyte Studies.

Umehara K, Sun Y, Hiura S, Hamada K, Itoh M, Kitamura K, Oshima M, Iwama A, Saito K, Anzai N, Chiba K, Akita H, Furihata T.

Mol Neurobiol. 2018 Jul;55(7):5993-6006. doi: 10.1007/s12035-017-0815-9. Epub 2017 Nov 11.

PMID:
29128907
11.

Application of Super-Resolution Convolutional Neural Network for Enhancing Image Resolution in Chest CT.

Umehara K, Ota J, Ishida T.

J Digit Imaging. 2017 Oct 18. doi: 10.1007/s10278-017-0033-z. [Epub ahead of print]

PMID:
29047035
12.

Efficacy of the combined use of a mild foaming cleanser and moisturizer for the care of infant skin.

Okamoto N, Umehara K, Sonoda J, Hotta M, Mizushima H, Takagi Y, Matsuo K, Baba N.

Clin Cosmet Investig Dermatol. 2017 Oct 3;10:393-401. doi: 10.2147/CCID.S140716. eCollection 2017.

13.

Naphthalene glycosides in the Thai medicinal plant Diospyros mollis.

Suwama T, Watanabe K, Monthakantirat O, Luecha P, Noguchi H, Watanabe K, Umehara K.

J Nat Med. 2018 Jan;72(1):220-229. doi: 10.1007/s11418-017-1134-1. Epub 2017 Oct 10.

PMID:
29019024
14.

Design and synthesis of benzoacridines as estrogenic and anti-estrogenic agents.

Torikai K, Koga R, Liu X, Umehara K, Kitano T, Watanabe K, Oishi T, Noguchi H, Shimohigashi Y.

Bioorg Med Chem. 2017 Oct 15;25(20):5216-5237. doi: 10.1016/j.bmc.2017.07.067. Epub 2017 Aug 24.

PMID:
28882502
15.

Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in rat.

Yilmaz Y, Umehara K, Williams G, Faller T, Schiller H, Walles M, Kraehenbuehl S, Camenisch G, Manevski N.

Xenobiotica. 2018 Aug;48(8):793-803. doi: 10.1080/00498254.2017.1373311. Epub 2017 Sep 29.

PMID:
28879796
16.

Association Between Serum Vitamin D and All-Cause and Cause-Specific Death in a General Japanese Population - The Hisayama Study.

Umehara K, Mukai N, Hata J, Hirakawa Y, Ohara T, Yoshida D, Kishimoto H, Kitazono T, Hoka S, Kiyohara Y, Ninomiya T.

Circ J. 2017 Aug 25;81(9):1315-1321. doi: 10.1253/circj.CJ-16-0954. Epub 2017 Apr 20.

17.

Absorption, distribution and excretion of the anti-tuberculosis drug delamanid in rats: Extensive tissue distribution suggests potential therapeutic value for extrapulmonary tuberculosis.

Shibata M, Shimokawa Y, Sasahara K, Yoda N, Sasabe H, Suzuki M, Umehara K.

Biopharm Drug Dispos. 2017 May;38(4):301-312. doi: 10.1002/bdd.2064. Epub 2017 Mar 8.

PMID:
28092695
18.

Non-RVD mutations that enhance the dynamics of the TAL repeat array along the superhelical axis improve TALEN genome editing efficacy.

Tochio N, Umehara K, Uewaki JI, Flechsig H, Kondo M, Dewa T, Sakuma T, Yamamoto T, Saitoh T, Togashi Y, Tate SI.

Sci Rep. 2016 Nov 24;6:37887. doi: 10.1038/srep37887.

19.

Isolation of a new compound, 2-butanone 4-glucopyranoside 6'-O-gallate and other 8 compounds from the anti-inflammatory leave extracts of Memecylon edule Roxb.

Nualkaew S, Thongpraditchote S, Wongkrajang Y, Umehara K, Noguchi H.

Nat Prod Res. 2017 Jun;31(12):1370-1378. doi: 10.1080/14786419.2016.1253074. Epub 2016 Nov 7.

PMID:
27820960
20.

Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction.

Njuguna NM, Umehara KI, Huth F, Schiller H, Chibale K, Camenisch G.

Drug Metab Pers Ther. 2016 Dec 1;31(4):221-228. doi: 10.1515/dmpt-2016-0028.

PMID:
27718490
21.

A novel steroid and cytotoxic constituents from Dioscorea membranacea Pierre against hepatocellular carcinoma and cholangiocarcinoma cells.

Thongdeeying P, Itharat A, Umehara K, Ruangnoo S.

J Ethnopharmacol. 2016 Dec 24;194:91-97. doi: 10.1016/j.jep.2016.08.037. Epub 2016 Aug 24.

PMID:
27566208
22.

[Comparative Study of the Antiemetic Palonosetron for Lung Cancer Patients Treated with a Divided Dose of Cisplatin].

Umehara K, Wakamoto A, Hatsuyama T, Sato H, Kobayashi M, Fujita A, Sekine K.

Gan To Kagaku Ryoho. 2016 Aug;43(8):967-72. Japanese.

PMID:
27539038
23.

Five furofuranone lignan glucosides from Terminalia citrina inhibit in vitro E2-enhanced breast cancer cell proliferation.

Muhit MA, Umehara K, Noguchi H.

Fitoterapia. 2016 Sep;113:74-9. doi: 10.1016/j.fitote.2016.07.004. Epub 2016 Jul 15.

PMID:
27425446
24.

Erratum for Sasabe et al., Antitubercular Agent Delamanid and Metabolites as Substrates and Inhibitors of ABC and Solute Carrier Transporters.

Sasabe H, Shimokawa Y, Shibata M, Hashizume K, Hamasako Y, Ohzone Y, Kashiyama E, Umehara K.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):4431. doi: 10.1128/AAC.01094-16. Print 2016 Jul. No abstract available.

25.

Abietane-type diterpenoids from the roots of Caryopteris mongolica and their cholinesterase inhibitory activities.

Murata T, Ishikawa Y, Saruul E, Selenge E, Sasaki K, Umehara K, Yoshizaki F, Batkhuu J.

Phytochemistry. 2016 Oct;130:152-8. doi: 10.1016/j.phytochem.2016.05.011. Epub 2016 Jun 10.

PMID:
27298275
26.

Furofuran Lignan Glucosides with Estrogen-Inhibitory Properties from the Bangladeshi Medicinal Plant Terminalia citrina.

Muhit MA, Umehara K, Mori-Yasumoto K, Noguchi H.

J Nat Prod. 2016 May 27;79(5):1298-307. doi: 10.1021/acs.jnatprod.5b01042. Epub 2016 Apr 25.

PMID:
27110635
27.

Antitubercular Agent Delamanid and Metabolites as Substrates and Inhibitors of ABC and Solute Carrier Transporters.

Sasabe H, Shimokawa Y, Shibata M, Hashizume K, Hamasako Y, Ohzone Y, Kashiyama E, Umehara K.

Antimicrob Agents Chemother. 2016 May 23;60(6):3497-508. doi: 10.1128/AAC.03049-15. Print 2016 Jun. Erratum in: Antimicrob Agents Chemother. 2016 Jul;60(7):4431.

28.

New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data.

Riede J, Poller B, Umehara K, Huwyler J, Camenisch G.

Eur J Pharm Sci. 2016 Apr 30;86:96-102. doi: 10.1016/j.ejps.2016.02.022. Epub 2016 Mar 3.

PMID:
26948853
29.

Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors.

Umehara K, Zollinger M, Kigondu E, Witschi M, Juif C, Huth F, Schiller H, Chibale K, Camenisch G.

Xenobiotica. 2016 Oct;46(10):862-7. doi: 10.3109/00498254.2015.1133867. Epub 2016 Feb 18.

PMID:
26887925
30.

Phenolic constituents of the Bangladeshi medicinal plant Pothos scandens and their anti-estrogenic, hyaluronidase inhibition, and histamine release inhibitory activities.

Muhit MA, Izumikawa M, Umehara K, Noguchi H.

Phytochemistry. 2016 Jan;121:30-7. doi: 10.1016/j.phytochem.2015.10.009. Epub 2015 Nov 2.

PMID:
26542239
31.

Rebamipide does not interfere with the antitumor effect of radiotherapy or chemotherapy in human oral tumor-bearing nude mice.

Shibamori M, Sato M, Uematsu N, Nakashima T, Sato A, Yamamura Y, Sasabe H, Umehara K, Sakurai K.

J Pharmacol Sci. 2015 Sep;129(1):18-25. doi: 10.1016/j.jphs.2015.07.022. Epub 2015 Aug 4.

32.

An Increased Serum N-Terminal Telopeptide of Type I Collagen, a Biochemical Marker of Increased Bone Resorption, Is Associated with Infliximab Therapy in Patients with Crohn's Disease.

Sugimoto K, Ikeya K, Iida T, Kawasaki S, Arai O, Umehara K, Watanabe F, Tani S, Oishi S, Osawa S, Yamamoto T, Hanai H.

Dig Dis Sci. 2016 Jan;61(1):99-106. doi: 10.1007/s10620-015-3838-y. Epub 2015 Aug 8.

PMID:
26254083
33.

[Study on the Antiemetic Effects of Aprepitant in Patients with Lung Cancer Receiving Chemotherapy with Carboplatin].

Hatsuyama T, Umehara K, Wakamoto A, Sato H.

Gan To Kagaku Ryoho. 2015 Jun;42(6):725-9. Japanese.

PMID:
26199245
34.

Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes.

Shimokawa Y, Yoda N, Kondo S, Yamamura Y, Takiguchi Y, Umehara K.

Biol Pharm Bull. 2015;38(9):1425-9. doi: 10.1248/bpb.b15-00313. Epub 2015 Jun 20.

35.

Metabolic Mechanism of Delamanid, a New Anti-Tuberculosis Drug, in Human Plasma.

Shimokawa Y, Sasahara K, Koyama N, Kitano K, Shibata M, Yoda N, Umehara K.

Drug Metab Dispos. 2015 Aug;43(8):1277-83. doi: 10.1124/dmd.115.064550. Epub 2015 Jun 8.

36.

Pharmacokinetics and Metabolism of Delamanid, a Novel Anti-Tuberculosis Drug, in Animals and Humans: Importance of Albumin Metabolism In Vivo.

Sasahara K, Shimokawa Y, Hirao Y, Koyama N, Kitano K, Shibata M, Umehara K.

Drug Metab Dispos. 2015 Aug;43(8):1267-76. doi: 10.1124/dmd.115.064527. Epub 2015 Jun 8.

37.

Comprehensive kinetic analysis and influence of reaction components for chlorzoxazone 6-hydroxylation in human liver microsomes with CYP antibodies.

Yamamura Y, Koyama N, Umehara K.

Xenobiotica. 2015 Apr;45(4):353-60. doi: 10.3109/00498254.2014.985760. Epub 2014 Nov 19.

PMID:
25815637
38.

Flavonoids: separation and quantitation.

De-Eknamkul W, Umehara K, Stevens JF.

ScientificWorldJournal. 2015;2015:874148. doi: 10.1155/2015/874148. Epub 2015 Mar 1. No abstract available.

39.

Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet.

Takeuchi K, Goto H, Ito Y, Sato M, Matsumoto S, Senba T, Yamada H, Umehara K.

J Toxicol Sci. 2015 Apr;40(2):181-91. doi: 10.2131/jts.40.181.

40.

Periodontal therapy for severe chronic periodontitis with periodontal regeneration and different types of prosthesis.

Kinumatsu T, Umehara K, Nagano K, Saito A.

Bull Tokyo Dent Coll. 2014;55(4):217-24.

41.

Delamanid does not inhibit or induce cytochrome p450 enzymes in vitro.

Shimokawa Y, Sasahara K, Yoda N, Mizuno K, Umehara K.

Biol Pharm Bull. 2014;37(11):1727-35.

42.

Effect of miroestrol on ovariectomy-induced cognitive impairment and lipid peroxidation in mouse brain.

Monthakantirat O, Sukano W, Umehara K, Noguchi H, Chulikhit Y, Matsumoto K.

Phytomedicine. 2014 Sep 25;21(11):1249-55. doi: 10.1016/j.phymed.2014.06.012. Epub 2014 Jul 25.

PMID:
25172786
43.

Identification of a new angiotensin-converting enzyme (ACE) inhibitor from Thai edible plants.

Simaratanamongkol A, Umehara K, Noguchi H, Panichayupakaranant P.

Food Chem. 2014 Dec 15;165:92-7. doi: 10.1016/j.foodchem.2014.05.080. Epub 2014 May 22.

PMID:
25038653
44.

Enantioselective analysis of tolvaptan in rat and dog sera by high-performance liquid chromatography and application to pharmacokinetic study.

Furukawa M, Yamasaki Y, Hirao Y, Umehara K.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 15;965:112-8. doi: 10.1016/j.jchromb.2014.06.007. Epub 2014 Jun 18.

PMID:
25016163
45.

Liquid chromatography-tandem mass spectrometry method for determining tolvaptan and its nine metabolites in rat serum: application to a pharmacokinetic study.

Furukawa M, Miyata K, Kawasome C, Himeda Y, Takeuchi K, Koga T, Hirao Y, Umehara K.

Arch Pharm Res. 2014 Dec;37(12):1578-87. doi: 10.1007/s12272-014-0352-2. Epub 2014 Mar 24.

PMID:
24988986
46.

Risk factors affecting third molar autotransplantation during 5 and 10 years.

Yoshino K, Ishizuka Y, Sugihara N, Kariya N, Namura D, Noji I, Mitsuhashi K, Kimura H, Fukuda A, Kikukawa I, Hayashi T, Yamazaki N, Kimura M, Tsukiyama K, Yamamoto K, Fukuyama A, Hidaka D, Shinoda J, Mibu H, Shimakura Y, Saito A, Ikumi S, Umehara K, Kamei F, Fukuda H, Toake T, Takahashi Y, Miyata Y, Shioji S, Toyoda M, Hattori N, Nishihara H, Matsushima R, Nishibori M, Hokkedo O, Nojima M, Kimura T, Fujiseki M, Okudaira S, Tanabe K, Nakano M, Ito K, Kuroda M, Takiguchi T, Fukai K, Matsukubo T.

Bull Tokyo Dent Coll. 2014;55(2):111-22.

47.

Structure and antioxidant activity relationships of isoflavonoids from Dalbergia parviflora.

Promden W, Monthakantirat O, Umehara K, Noguchi H, De-Eknamkul W.

Molecules. 2014 Feb 20;19(2):2226-37. doi: 10.3390/molecules19022226.

48.

Hemodialysis clearance of iosimenol, a novel iso-osmolar radiographic contrast medium.

Hirao Y, Kashiyama E, Umehara K, Kohno M, Ikei N, Hogstrom B.

Acta Radiol. 2014 Oct;55(8):938-44. doi: 10.1177/0284185113508113. Epub 2013 Oct 12.

PMID:
24123996
49.

Collagen expression in various degenerative meniscal changes: an immunohistological study.

Mine T, Ihara K, Kawamura H, Date R, Umehara K.

J Orthop Surg (Hong Kong). 2013 Aug;21(2):216-20.

PMID:
24014788
50.

Diastereomers of lithospermic acid and lithospermic acid B from Monarda fistulosa and Lithospermum erythrorhizon.

Murata T, Oyama K, Fujiyama M, Oobayashi B, Umehara K, Miyase T, Yoshizaki F.

Fitoterapia. 2013 Dec;91:51-59. doi: 10.1016/j.fitote.2013.08.009. Epub 2013 Aug 23.

PMID:
23978578

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