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Items: 1 to 50 of 237

1.

Impaired expression of innate immunity-related genes in IgG4-related disease: A possible mechanism in the pathogenesis of IgG4-RD.

Nakamura T, Satoh-Nakamura T, Nakajima A, Kawanami T, Sakai T, Fujita Y, Iwao H, Miki M, Masaki Y, Okazaki T, Ishigaki Y, Kawano M, Yamada K, Matsui S, Saeki T, Kamisawa T, Yamamoto M, Hamano H, Origuchi T, Hirata S, Tanaka Y, Tsuboi H, Sumida T, Okazaki K, Tanaka M, Chiba T, Mimori T, Umehara H.

Mod Rheumatol. 2019 Jul 11:1-7. doi: 10.1080/14397595.2019.1621475. [Epub ahead of print]

PMID:
31116057
2.

Negative and positive self-thoughts predict subjective quality of life in people with schizophrenia.

Takeda T, Nakataki M, Ohta M, Hamatani S, Matsuura K, Yoshida R, Kameoka N, Tominaga T, Umehara H, Kinoshita M, Watanabe S, Numata S, Sumitani S, Ohmori T.

Neuropsychiatr Dis Treat. 2019 Jan 21;15:293-301. doi: 10.2147/NDT.S190381. eCollection 2019.

3.

The front line of research into immunoglobin G4-related disease - Do autoantibodies cause immunoglobin G4-related disease?

Umehara H, Okazaki K, Kawano M, Tanaka Y.

Mod Rheumatol. 2019 Mar;29(2):214-218. doi: 10.1080/14397595.2018.1558519. Epub 2019 Jan 17. Review.

PMID:
30557067
4.

Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis.

Numata S, Umehara H, Ohmori T, Hashimoto R.

Front Pharmacol. 2018 Sep 26;9:1049. doi: 10.3389/fphar.2018.01049. eCollection 2018. Review.

5.

Preclinical and phase I clinical studies of KW-2450, a dual IGF-1R/IR tyrosine kinase inhibitor, in combination with lapatinib and letrozole.

Umehara H, Maekawa Y, Koizumi F, Shimizu M, Ota T, Fouad TM, Willey J, Kaito H, Shiraishi N, Nakashima D, Akinaga S, Ueno NT.

Ther Adv Med Oncol. 2018 Jul 30;10:1758835918786858. doi: 10.1177/1758835918786858. eCollection 2018.

6.

Response to: 'Serum complement factor C5a in IgG4-related disease' by Fukui et al.

Umehara H, Kawano M.

Ann Rheum Dis. 2019 Jul;78(7):e66. doi: 10.1136/annrheumdis-2018-213729. Epub 2018 Jun 6. No abstract available.

PMID:
29875098
7.

Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis.

Tomioka Y, Numata S, Kinoshita M, Umehara H, Watanabe SY, Nakataki M, Iwayama Y, Toyota T, Ikeda M, Yamamori H, Shimodera S, Tajima A, Hashimoto R, Iwata N, Yoshikawa T, Ohmori T.

J Psychiatry Neurosci. 2018 May;43(3):194-200.

8.

Elevated peripheral blood glutamate levels in major depressive disorder.

Inoshita M, Umehara H, Watanabe SY, Nakataki M, Kinoshita M, Tomioka Y, Tajima A, Numata S, Ohmori T.

Neuropsychiatr Dis Treat. 2018 Apr 6;14:945-953. doi: 10.2147/NDT.S159855. eCollection 2018.

9.

Retraction: A significant causal association between C-reactive protein levels and schizophrenia.

Inoshita M, Numata S, Tajima A, Kinoshita M, Umehara H, Nakataki M, Ikeda M, Maruyama S, Yamamori H, Kanazawa T, Shimodera S, Hashimoto R, Imoto I, Yoneda H, Iwata N, Ohmori T.

Sci Rep. 2018 Feb 21;8:46947. doi: 10.1038/srep46947.

10.

An International Multispecialty Validation Study of the IgG4-Related Disease Responder Index.

Wallace ZS, Khosroshahi A, Carruthers MD, Perugino CA, Choi H, Campochiaro C, Culver EL, Cortazar F, Della-Torre E, Ebbo M, Fernandes A, Frulloni L, Hart PA, Karadag O, Kawa S, Kawano M, Kim MH, Lanzillotta M, Matsui S, Okazaki K, Ryu JH, Saeki T, Schleinitz N, Tanasa P, Umehara H, Webster G, Zhang W, Stone JH.

Arthritis Care Res (Hoboken). 2018 Nov;70(11):1671-1678. doi: 10.1002/acr.23543.

11.

Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis.

Tomioka Y, Numata S, Kinoshita M, Umehara H, Watanabe SY, Nakataki M, Iwayama Y, Toyota T, Ikeda M, Yamamori H, Shimodera S, Tajima A, Hashimoto R, Iwata N, Yoshikawa T, Ohmori T.

J Psychiatry Neurosci. 2018 Feb 2;43(2):170053. doi: 10.1503/jpn.170053. [Epub ahead of print]

12.

Splicing variant of WDFY4 augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis.

Kochi Y, Kamatani Y, Kondo Y, Suzuki A, Kawakami E, Hiwa R, Momozawa Y, Fujimoto M, Jinnin M, Tanaka Y, Kanda T, Cooper RG, Chinoy H, Rothwell S, Lamb JA, Vencovský J, Mann H, Ohmura K, Myouzen K, Ishigaki K, Nakashima R, Hosono Y, Tsuboi H, Kawasumi H, Iwasaki Y, Kajiyama H, Horita T, Ogawa-Momohara M, Takamura A, Tsunoda S, Shimizu J, Fujio K, Amano H, Mimori A, Kawakami A, Umehara H, Takeuchi T, Sano H, Muro Y, Atsumi T, Mimura T, Kawaguchi Y, Mimori T, Takahashi A, Kubo M, Kohsaka H, Sumida T, Yamamoto K.

Ann Rheum Dis. 2018 Apr;77(4):602-611. doi: 10.1136/annrheumdis-2017-212149. Epub 2018 Jan 13.

PMID:
29331962
13.

Tissue inhibitor of metalloproteinase-1 promotes cell proliferation through YAP/TAZ activation in cancer.

Ando T, Charindra D, Shrestha M, Umehara H, Ogawa I, Miyauchi M, Takata T.

Oncogene. 2018 Jan 11;37(2):263-270. doi: 10.1038/onc.2017.321. Epub 2017 Sep 18.

PMID:
28925394
14.

Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder.

Umehara H, Numata S, Watanabe SY, Hatakeyama Y, Kinoshita M, Tomioka Y, Nakahara K, Nikawa T, Ohmori T.

Sci Rep. 2017 Jul 7;7(1):4855. doi: 10.1038/s41598-017-05121-6.

15.

Safety, pharmacokinetics, and efficacy of E6011, an antifractalkine monoclonal antibody, in a first-in-patient phase 1/2 study on rheumatoid arthritis.

Tanaka Y, Takeuchi T, Umehara H, Nanki T, Yasuda N, Tago F, Kawakubo M, Kitahara Y, Hojo S, Kawano T, Imai T.

Mod Rheumatol. 2018 Jan;28(1):58-65. doi: 10.1080/14397595.2017.1337056. Epub 2017 Jul 6.

PMID:
28681650
16.

Natural History and Predictors of Progression to Sjögren's Syndrome Among Participants of the Sjögren's International Collaborative Clinical Alliance Registry.

Shiboski CH, Baer AN, Shiboski SC, Lam M, Challacombe S, Lanfranchi HE, Schiødt M, Shirlaw P, Srinivasan M, Umehara H, Vivino FB, Akpek E, Bunya V, Vollenweider CF, Greenspan JS, Daniels TE, Criswell LA; Sjögren's International Collaborative Clinical Alliance Research Groups.

Arthritis Care Res (Hoboken). 2018 Feb;70(2):284-294. doi: 10.1002/acr.23264. Epub 2018 Jan 3.

17.

Effect of Clozapine on DNA Methylation in Peripheral Leukocytes from Patients with Treatment-Resistant Schizophrenia.

Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Watanabe S, Umehara H, Shimodera S, Nakazawa T, Kikuchi M, Nakaya A, Hashimoto H, Imoto I, Hashimoto R, Ohmori T.

Int J Mol Sci. 2017 Mar 14;18(3). pii: E632. doi: 10.3390/ijms18030632.

18.

Comparison of performance of the 2016 ACR-EULAR classification criteria for primary Sjögren's syndrome with other sets of criteria in Japanese patients.

Tsuboi H, Hagiwara S, Asashima H, Takahashi H, Hirota T, Noma H, Umehara H, Kawakami A, Nakamura H, Sano H, Tsubota K, Ogawa Y, Takamura E, Saito I, Inoue H, Nakamura S, Moriyama M, Takeuchi T, Tanaka Y, Hirata S, Mimori T, Matsumoto I, Sumida T.

Ann Rheum Dis. 2017 Dec;76(12):1980-1985. doi: 10.1136/annrheumdis-2016-210758. Epub 2017 Mar 22.

19.

How to diagnose IgG4-related disease.

Umehara H, Okazaki K, Kawano M, Mimori T, Chiba T.

Ann Rheum Dis. 2017 Nov;76(11):e46. doi: 10.1136/annrheumdis-2017-211330. Epub 2017 Mar 10. No abstract available.

PMID:
28283514
20.

Gene expression-based biological test for major depressive disorder: an advanced study.

Watanabe SY, Numata S, Iga JI, Kinoshita M, Umehara H, Ishii K, Ohmori T.

Neuropsychiatr Dis Treat. 2017 Feb 21;13:535-541. doi: 10.2147/NDT.S120038. eCollection 2017.

21.

Macroscopic neural mass model constructed from a current-based network model of spiking neurons.

Umehara H, Okada M, Teramae JN, Naruse Y.

Biol Cybern. 2017 Feb;111(1):91-103. doi: 10.1007/s00422-017-0710-5. Epub 2017 Feb 6.

PMID:
28168402
22.

Current approach to the diagnosis of IgG4-related disease - Combination of comprehensive diagnostic and organ-specific criteria.

Umehara H, Okazaki K, Nakamura T, Satoh-Nakamura T, Nakajima A, Kawano M, Mimori T, Chiba T.

Mod Rheumatol. 2017 May;27(3):381-391. doi: 10.1080/14397595.2017.1290911. Review.

PMID:
28165852
23.

Current Concept of IgG4-Related Disease.

Okazaki K, Umehara H.

Curr Top Microbiol Immunol. 2017;401:1-17. doi: 10.1007/82_2016_47. Review.

PMID:
28091932
24.

Genome-Wide Association Analysis Reveals Genetic Heterogeneity of Sjögren's Syndrome According to Ancestry.

Taylor KE, Wong Q, Levine DM, McHugh C, Laurie C, Doheny K, Lam MY, Baer AN, Challacombe S, Lanfranchi H, Schiødt M, Srinivasan M, Umehara H, Vivino FB, Zhao Y, Shiboski SC, Daniels TE, Greenspan JS, Shiboski CH, Criswell LA.

Arthritis Rheumatol. 2017 Jun;69(6):1294-1305. doi: 10.1002/art.40040. Epub 2017 May 9.

25.

Ameloblastin induces tumor suppressive phenotype and enhances chemosensitivity to doxorubicin via Src-Stat3 inactivation in osteosarcoma.

Ando T, Kudo Y, Iizuka S, Tsunematsu T, Umehara H, Shrestha M, Matsuo T, Kubo T, Shimose S, Arihiro K, Ogawa I, Ochi M, Takata T.

Sci Rep. 2017 Jan 5;7:40187. doi: 10.1038/srep40187.

26.

Cumulative effect of the plasma total homocysteine-related genetic variants on schizophrenia risk.

Kinoshita M, Numata S, Tajima A, Nishi A, Muraki S, Tsuchiya A, Umehara H, Watanabe SY, Imoto I, Ohmori T.

Psychiatry Res. 2016 Dec 30;246:833-837. doi: 10.1016/j.psychres.2016.10.017. Epub 2016 Oct 17.

PMID:
27810229
27.

1H-magnetic resonance spectroscopy study of glutamate-related abnormality in bipolar disorder.

Kubo H, Nakataki M, Sumitani S, Iga JI, Numata S, Kameoka N, Watanabe SY, Umehara H, Kinoshita M, Inoshita M, Tamaru M, Ohta M, Nakayama-Yamauchi C, Funakoshi Y, Harada M, Ohmori T.

J Affect Disord. 2017 Jan 15;208:139-144. doi: 10.1016/j.jad.2016.08.046. Epub 2016 Oct 8.

PMID:
27770643
28.

The hypophagic factor oleoylethanolamide differentially increases c-fos expression in appetite regulating centres in the brain of wild type and histamine deficient mice.

Umehara H, Fabbri R, Provensi G, Passani MB.

Pharmacol Res. 2016 Nov;113(Pt A):100-107. doi: 10.1016/j.phrs.2016.08.020. Epub 2016 Aug 16.

PMID:
27543461
29.

Epirubicin, Identified Using a Novel Luciferase Reporter Assay for Foxp3 Inhibitors, Inhibits Regulatory T Cell Activity.

Kashima H, Momose F, Umehara H, Miyoshi N, Ogo N, Muraoka D, Shiku H, Harada N, Asai A.

PLoS One. 2016 Jun 10;11(6):e0156643. doi: 10.1371/journal.pone.0156643. eCollection 2016.

30.

Calcium Signaling Pathway Is Associated with the Long-Term Clinical Response to Selective Serotonin Reuptake Inhibitors (SSRI) and SSRI with Antipsychotics in Patients with Obsessive-Compulsive Disorder.

Umehara H, Numata S, Tajima A, Nishi A, Nakataki M, Imoto I, Sumitani S, Ohmori T.

PLoS One. 2016 Jun 9;11(6):e0157232. doi: 10.1371/journal.pone.0157232. eCollection 2016.

31.

A significant causal association between C-reactive protein levels and schizophrenia.

Inoshita M, Numata S, Tajima A, Kinoshita M, Umehara H, Nakataki M, Ikeda M, Maruyama S, Yamamori H, Kanazawa T, Shimodera S, Hashimoto R, Imoto I, Yoneda H, Iwata N, Ohmori T.

Sci Rep. 2016 May 19;6:26105. doi: 10.1038/srep26105. Retraction in: Sci Rep. 2018 Feb 21;8:46947.

32.

No association between BDNF Val66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population.

Umehara H, Numata S, Kinoshita M, Watanabe S, Nakaaki S, Sumitani S, Ohmori T.

Neuropsychiatr Dis Treat. 2016 Mar 11;12:611-5. doi: 10.2147/NDT.S102100. eCollection 2016.

33.

Isolation of vascular smooth muscle antigen-reactive CD4(+)αβTh1 clones that induce pulmonary vasculitis in MRL/Mp-Fas(+/+) mice.

Fujita Y, Fujii T, Shimizu H, Sato T, Nakamura T, Iwao H, Nakajima A, Miki M, Sakai T, Kawanami T, Tanaka M, Masaki Y, Fukushima T, Okazaki T, Umehara H, Mimori T.

Cell Immunol. 2016 May;303:50-4. doi: 10.1016/j.cellimm.2016.03.004. Epub 2016 Mar 21.

PMID:
27019130
34.

Association study of polymorphism in the serotonin transporter gene promoter, methylation profiles, and expression in patients with major depressive disorder.

Iga J, Watanabe SY, Numata S, Umehara H, Nishi A, Kinoshita M, Inoshita M, Shimodera S, Fujita H, Ohmori T.

Hum Psychopharmacol. 2016 May;31(3):193-9. doi: 10.1002/hup.2527. Epub 2016 Mar 23.

PMID:
27005686
35.

Intravenous administration of the selective toll-like receptor 7 agonist DSR-29133 leads to anti-tumor efficacy in murine solid tumor models which can be potentiated by combination with fractionated radiotherapy.

Dovedi SJ, Adlard AL, Ota Y, Murata M, Sugaru E, Koga-Yamakawa E, Eguchi K, Hirose Y, Yamamoto S, Umehara H, Honeychurch J, Cheadle EJ, Hughes G, Jewsbury PJ, Wilkinson RW, Stratford IJ, Illidge TM.

Oncotarget. 2016 Mar 29;7(13):17035-46. doi: 10.18632/oncotarget.7928.

36.

Global DNA hypomethylation coupled to cellular transformation and metastatic ability.

Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Okumura M, Oboki K, Matsumoto K, Saito H, Nakano T.

FEBS Lett. 2015 Dec 21;589(24 Pt B):4053-60. doi: 10.1016/j.febslet.2015.11.020. Epub 2015 Nov 19.

37.

Sex differences of leukocytes DNA methylation adjusted for estimated cellular proportions.

Inoshita M, Numata S, Tajima A, Kinoshita M, Umehara H, Yamamori H, Hashimoto R, Imoto I, Ohmori T.

Biol Sex Differ. 2015 Jun 25;6:11. doi: 10.1186/s13293-015-0029-7. eCollection 2015.

38.

TLR7 tolerance is independent of the type I IFN pathway and leads to loss of anti-tumor efficacy in mice.

Koga-Yamakawa E, Murata M, Dovedi SJ, Wilkinson RW, Ota Y, Umehara H, Sugaru E, Hirose Y, Harada H, Jewsbury PJ, Yamamoto S, Robinson DT, Li CJ.

Cancer Immunol Immunother. 2015 Oct;64(10):1229-39. doi: 10.1007/s00262-015-1730-4. Epub 2015 Jun 20.

PMID:
26091797
39.

No association between the COMT Val158Met polymorphism and the long-term clinical response in obsessive-compulsive disorder in the Japanese population.

Umehara H, Numata S, Tajima A, Kinoshita M, Nakaaki S, Imoto I, Sumitani S, Ohmori T.

Hum Psychopharmacol. 2015 Sep;30(5):372-6. doi: 10.1002/hup.2485. Epub 2015 May 26.

PMID:
26010653
40.

Polymorphism in the promoter of the gene for the serotonin transporter affects the age of onset of major depressive disorder in the Japanese population.

Watanabe SY, Iga J, Numata S, Umehara H, Nishi A, Kinoshita M, Inoshita M, Ohmori T.

J Affect Disord. 2015 Sep 1;183:156-8. doi: 10.1016/j.jad.2015.05.009. Epub 2015 May 15.

PMID:
26005777
41.

Decreased Expression of Innate Immunity-Related Genes in Peripheral Blood Mononuclear Cells from Patients with IgG4-Related Disease.

Nakajima A, Masaki Y, Nakamura T, Kawanami T, Ishigaki Y, Takegami T, Kawano M, Yamada K, Tsukamoto N, Matsui S, Saeki T, Okazaki K, Kamisawa T, Miyashita T, Yakushijin Y, Fujikawa K, Yamamoto M, Hamano H, Origuchi T, Hirata S, Tsuboi H, Sumida T, Morimoto H, Sato T, Iwao H, Miki M, Sakai T, Fujita Y, Tanaka M, Fukushima T, Okazaki T, Umehara H.

PLoS One. 2015 May 14;10(5):e0126582. doi: 10.1371/journal.pone.0126582. eCollection 2015.

42.
43.

International Consensus Guidance Statement on the Management and Treatment of IgG4-Related Disease.

Khosroshahi A, Wallace ZS, Crowe JL, Akamizu T, Azumi A, Carruthers MN, Chari ST, Della-Torre E, Frulloni L, Goto H, Hart PA, Kamisawa T, Kawa S, Kawano M, Kim MH, Kodama Y, Kubota K, Lerch MM, Löhr M, Masaki Y, Matsui S, Mimori T, Nakamura S, Nakazawa T, Ohara H, Okazaki K, Ryu JH, Saeki T, Schleinitz N, Shimatsu A, Shimosegawa T, Takahashi H, Takahira M, Tanaka A, Topazian M, Umehara H, Webster GJ, Witzig TE, Yamamoto M, Zhang W, Chiba T, Stone JH; Second International Symposium on IgG4-Related Disease.

Arthritis Rheumatol. 2015 Jul;67(7):1688-99. doi: 10.1002/art.39132. Review. No abstract available.

44.

IgG4-Related Disease.

Umehara H, Kawano M.

JOP. 2015 Mar 20;16(2):217. doi: 10.6092/1590-8577/2945. No abstract available.

45.

The SSB-positive/SSA-negative antibody profile is not associated with key phenotypic features of Sjögren's syndrome.

Baer AN, McAdams DeMarco M, Shiboski SC, Lam MY, Challacombe S, Daniels TE, Dong Y, Greenspan JS, Kirkham BW, Lanfranchi HE, Schiødt M, Srinivasan M, Umehara H, Vivino FB, Vollenweider CF, Zhao Y, Criswell LA, Shiboski CH; Sjögren's International Collaborative Clinical Alliance (SICCA) Research Groups.

Ann Rheum Dis. 2015 Aug;74(8):1557-61. doi: 10.1136/annrheumdis-2014-206683. Epub 2015 Mar 3.

46.

Blood diagnostic biomarkers for major depressive disorder using multiplex DNA methylation profiles: discovery and validation.

Numata S, Ishii K, Tajima A, Iga J, Kinoshita M, Watanabe S, Umehara H, Fuchikami M, Okada S, Boku S, Hishimoto A, Shimodera S, Imoto I, Morinobu S, Ohmori T.

Epigenetics. 2015;10(2):135-41. doi: 10.1080/15592294.2014.1003743. Epub 2015 Jan 14.

47.

Inhibition of maintenance DNA methylation by Stella.

Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Nakano T.

Biochem Biophys Res Commun. 2014 Oct 24;453(3):455-60. doi: 10.1016/j.bbrc.2014.09.101. Epub 2014 Oct 1.

PMID:
25280994
48.

Facilitated lexical ambiguity processing by transcranial direct current stimulation over the left inferior frontal cortex.

Ihara AS, Mimura T, Soshi T, Yorifuji S, Hirata M, Goto T, Yoshinime T, Umehara H, Fujimaki N.

J Cogn Neurosci. 2015 Jan;27(1):26-34. doi: 10.1162/jocn_a_00703. Epub 2014 Sep 11.

PMID:
25208744
49.

Phase shifts in alpha-frequency rhythm detected in electroencephalograms influence reaction time.

Naruse Y, Takiyama K, Okada M, Umehara H, Sakaguchi Y.

Neural Netw. 2015 Feb;62:47-51. doi: 10.1016/j.neunet.2014.07.012. Epub 2014 Aug 1.

PMID:
25150125
50.

Clinical course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis: a retrospective multicenter study.

Mizushima I, Inoue D, Yamamoto M, Yamada K, Saeki T, Ubara Y, Matsui S, Masaki Y, Wada T, Kasashima S, Harada K, Takahashi H, Notohara K, Nakanuma Y, Umehara H, Yamagishi M, Kawano M.

Arthritis Res Ther. 2014 Jul 23;16(4):R156. doi: 10.1186/ar4671.

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