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Items: 50

1.

Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice.

Wang CY, Core AB, Canali S, Zumbrennen-Bullough KB, Ozer S, Umans L, Zwijsen A, Babitt JL.

Blood. 2017 Jul 6;130(1):73-83. doi: 10.1182/blood-2016-12-759423. Epub 2017 Apr 24.

2.

Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells.

Stryjewska A, Dries R, Pieters T, Verstappen G, Conidi A, Coddens K, Francis A, Umans L, van IJcken WF, Berx G, van Grunsven LA, Grosveld FG, Goossens S, Haigh JJ, Huylebroeck D.

Stem Cells. 2017 Mar;35(3):611-625. doi: 10.1002/stem.2521. Epub 2016 Nov 8.

3.

BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks.

Beets K, Staring MW, Criem N, Maas E, Schellinx N, de Sousa Lopes SM, Umans L, Zwijsen A.

BMC Dev Biol. 2016 Oct 10;16(1):34.

4.

Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.

Villacorte M, Delmarcelle AS, Lernoux M, Bouquet M, Lemoine P, Bolsée J, Umans L, de Sousa Lopes SC, Van Der Smissen P, Sasaki T, Bommer G, Henriet P, Refetoff S, Lemaigre FP, Zwijsen A, Courtoy PJ, Pierreux CE.

Development. 2016 Jun 1;143(11):1958-70. doi: 10.1242/dev.134171. Epub 2016 Apr 11.

5.

BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells.

Gomes Fernandes M, Dries R, Roost MS, Semrau S, de Melo Bernardo A, Davis RP, Ramakrishnan R, Szuhai K, Maas E, Umans L, Abon Escalona V, Salvatori D, Deforce D, Van Criekinge W, Huylebroeck D, Mummery C, Zwijsen A, de Sousa Lopes SM.

Stem Cell Reports. 2016 Jan 12;6(1):85-94. doi: 10.1016/j.stemcr.2015.11.012. Epub 2015 Dec 17.

6.

Smad1/5/8 are myogenic regulators of murine and human mesoangioblasts.

Costamagna D, Quattrocelli M, van Tienen F, Umans L, de Coo IF, Zwijsen A, Huylebroeck D, Sampaolesi M.

J Mol Cell Biol. 2016 Feb;8(1):73-87. doi: 10.1093/jmcb/mjv059. Epub 2015 Oct 8.

7.

Endothelial Msx1 transduces hemodynamic changes into an arteriogenic remodeling response.

Vandersmissen I, Craps S, Depypere M, Coppiello G, van Gastel N, Maes F, Carmeliet G, Schrooten J, Jones EA, Umans L, Devlieger R, Koole M, Gheysens O, Zwijsen A, Aranguren XL, Luttun A.

J Cell Biol. 2015 Sep 28;210(7):1239-56. doi: 10.1083/jcb.201502003. Epub 2015 Sep 21.

8.

Smad1/5 and Smad4 expression are important for osteoclast differentiation.

Tasca A, Stemig M, Broege A, Huang B, Davydova J, Zwijsen A, Umans L, Jensen ED, Gopalakrishnan R, Mansky KC.

J Cell Biochem. 2015 Jul;116(7):1350-60. doi: 10.1002/jcb.25092.

9.

TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.

Gómez-Herreros F, Romero-Granados R, Zeng Z, Alvarez-Quilón A, Quintero C, Ju L, Umans L, Vermeire L, Huylebroeck D, Caldecott KW, Cortés-Ledesma F.

PLoS Genet. 2013;9(3):e1003226. doi: 10.1371/journal.pgen.1003226. Epub 2013 Mar 7.

10.

Robustness in angiogenesis: notch and BMP shaping waves.

Beets K, Huylebroeck D, Moya IM, Umans L, Zwijsen A.

Trends Genet. 2013 Mar;29(3):140-9. doi: 10.1016/j.tig.2012.11.008. Epub 2012 Dec 30. Review.

PMID:
23279848
11.

Periostin as a biomarker of the amniotic membrane.

Dobreva MP, Lhoest L, Pereira PN, Umans L, Camus A, Chuva de Sousa Lopes SM, Zwijsen A.

Stem Cells Int. 2012;2012:987185. doi: 10.1155/2012/987185. Epub 2012 Jul 1. Erratum in: Stem Cells Int. 2013;2013:509593. Camus, Anne [added].

12.

Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion.

Pereira PN, Dobreva MP, Maas E, Cornelis FM, Moya IM, Umans L, Verfaillie CM, Camus A, de Sousa Lopes SM, Huylebroeck D, Zwijsen A.

Development. 2012 Sep;139(18):3343-54. doi: 10.1242/dev.075465.

13.

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

Zeng Z, Sharma A, Ju L, Murai J, Umans L, Vermeire L, Pommier Y, Takeda S, Huylebroeck D, Caldecott KW, El-Khamisy SF.

Nucleic Acids Res. 2012 Sep 1;40(17):8371-80. Epub 2012 Jun 26.

14.

BMP receptor-activated Smads confer diverse functions during the development of the dorsal spinal cord.

Hazen VM, Andrews MG, Umans L, Crenshaw EB 3rd, Zwijsen A, Butler SJ.

Dev Biol. 2012 Jul 15;367(2):216-27. doi: 10.1016/j.ydbio.2012.05.014. Epub 2012 May 17. Erratum in: Dev Biol. 2012 Sep 15;369(2):386.

15.

Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.

Moya IM, Umans L, Maas E, Pereira PN, Beets K, Francis A, Sents W, Robertson EJ, Mummery CL, Huylebroeck D, Zwijsen A.

Dev Cell. 2012 Mar 13;22(3):501-14. doi: 10.1016/j.devcel.2012.01.007. Epub 2012 Feb 23.

16.

Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo.

Conidi A, Cazzola S, Beets K, Coddens K, Collart C, Cornelis F, Cox L, Joke D, Dobreva MP, Dries R, Esguerra C, Francis A, Ibrahimi A, Kroes R, Lesage F, Maas E, Moya I, Pereira PN, Stappers E, Stryjewska A, van den Berghe V, Vermeire L, Verstappen G, Seuntjens E, Umans L, Zwijsen A, Huylebroeck D.

Cytokine Growth Factor Rev. 2011 Oct-Dec;22(5-6):287-300. doi: 10.1016/j.cytogfr.2011.11.006. Epub 2011 Nov 26. Review.

PMID:
22119658
17.

The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization.

Goossens S, Janzen V, Bartunkova S, Yokomizo T, Drogat B, Crisan M, Haigh K, Seuntjens E, Umans L, Riedt T, Bogaert P, Haenebalcke L, Berx G, Dzierzak E, Huylebroeck D, Haigh JJ.

Blood. 2011 May 26;117(21):5620-30. doi: 10.1182/blood-2010-08-300236. Epub 2011 Feb 25.

PMID:
21355089
18.

Smad1 and its target gene Wif1 coordinate BMP and Wnt signaling activities to regulate fetal lung development.

Xu B, Chen C, Chen H, Zheng SG, Bringas P Jr, Xu M, Zhou X, Chen D, Umans L, Zwijsen A, Shi W.

Development. 2011 Mar;138(5):925-35. doi: 10.1242/dev.062687. Epub 2011 Jan 26.

19.

Loss of Smad5 leads to the disassembly of the apical junctional complex and increased susceptibility to experimental colitis.

Allaire JM, Darsigny M, Marcoux SS, Roy SA, Schmouth JF, Umans L, Zwijsen A, Boudreau F, Perreault N.

Am J Physiol Gastrointest Liver Physiol. 2011 Apr;300(4):G586-97. doi: 10.1152/ajpgi.00041.2010. Epub 2011 Jan 6.

20.

Transforming Growth Factor type beta and Smad family signaling in stem cell function.

Seuntjens E, Umans L, Zwijsen A, Sampaolesi M, Verfaillie CM, Huylebroeck D.

Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):449-58. doi: 10.1016/j.cytogfr.2009.10.005. Epub 2009 Nov 4. Review.

PMID:
19892581
21.

The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation.

Rajagopal R, Huang J, Dattilo LK, Kaartinen V, Mishina Y, Deng CX, Umans L, Zwijsen A, Roberts AB, Beebe DC.

Dev Biol. 2009 Nov 15;335(2):305-16. doi: 10.1016/j.ydbio.2009.08.027. Epub 2009 Sep 3.

22.

Essential validation of gene trap mouse ES cell lines: a test case with the gene Ttrap.

Vermeire L, Ibrahimi A, Voet T, Umans L, Coddens K, Francis A, Van de Putte T, van Grunsven LA, Zwijsen A, Huylebroeck D, Nelles L.

Int J Dev Biol. 2009;53(7):1045-51. doi: 10.1387/ijdb.092859lv.

23.

FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate.

Huang J, Dattilo LK, Rajagopal R, Liu Y, Kaartinen V, Mishina Y, Deng CX, Umans L, Zwijsen A, Roberts AB, Beebe DC.

Development. 2009 May;136(10):1741-50. doi: 10.1242/dev.034082. Epub 2009 Apr 15.

24.

A broken heart: a stretch too far: an overview of mouse models with mutations in stretch-sensor components.

Cox L, Umans L, Cornelis F, Huylebroeck D, Zwijsen A.

Int J Cardiol. 2008 Dec 17;131(1):33-44. doi: 10.1016/j.ijcard.2008.06.049. Epub 2008 Aug 20. Review.

PMID:
18715658
25.

Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival.

Rajagopal R, Dattilo LK, Kaartinen V, Deng CX, Umans L, Zwijsen A, Roberts AB, Bottinger EP, Beebe DC.

Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4953-60. doi: 10.1167/iovs.08-2217. Epub 2008 Jun 19.

26.

Functional redundancy of TGF-beta family type I receptors and receptor-Smads in mediating anti-Mullerian hormone-induced Mullerian duct regression in the mouse.

Orvis GD, Jamin SP, Kwan KM, Mishina Y, Kaartinen VM, Huang S, Roberts AB, Umans L, Huylebroeck D, Zwijsen A, Wang D, Martin JF, Behringer RR.

Biol Reprod. 2008 Jun;78(6):994-1001. doi: 10.1095/biolreprod.107.066605. Epub 2008 Mar 5.

27.

Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice.

Pangas SA, Li X, Umans L, Zwijsen A, Huylebroeck D, Gutierrez C, Wang D, Martin JF, Jamin SP, Behringer RR, Robertson EJ, Matzuk MM.

Mol Cell Biol. 2008 Jan;28(1):248-57. Epub 2007 Oct 29.

28.

Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis.

Umans L, Cox L, Tjwa M, Bito V, Vermeire L, Laperre K, Sipido K, Moons L, Huylebroeck D, Zwijsen A.

Am J Pathol. 2007 May;170(5):1460-72.

29.

Smad5 is dispensable for adult murine hematopoiesis.

Singbrant S, Moody JL, Blank U, Karlsson G, Umans L, Zwijsen A, Karlsson S.

Blood. 2006 Dec 1;108(12):3707-12. Epub 2006 Aug 8.

PMID:
16896158
30.

Mice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cells.

Van Laer L, Pfister M, Thys S, Vrijens K, Mueller M, Umans L, Serneels L, Van Nassauw L, Kooy F, Smith RJ, Timmermans JP, Van Leuven F, Van Camp G.

Neurobiol Dis. 2005 Aug;19(3):386-99.

PMID:
16023581
31.

Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse.

Umans L, Vermeire L, Francis A, Chang H, Huylebroeck D, Zwijsen A.

Genesis. 2003 Sep;37(1):5-11.

PMID:
14502571
32.

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.

Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, Umans L, Lübke T, Lena Illert A, von Figura K, Saftig P.

Hum Mol Genet. 2002 Oct 1;11(21):2615-24.

PMID:
12354787
33.

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

Dewachter I, Reversé D, Caluwaerts N, Ris L, Kuipéri C, Van den Haute C, Spittaels K, Umans L, Serneels L, Thiry E, Moechars D, Mercken M, Godaux E, Van Leuven F.

J Neurosci. 2002 May 1;22(9):3445-53.

34.

Transforming growth factor beta signalling in vitro and in vivo: activin ligand-receptor interaction, Smad5 in vasculogenesis, and repression of target genes by the deltaEF1/ZEB-related SIP1 in the vertebrate embryo.

Zwijsen A, van Grunsven LA, Bosman EA, Collart C, Nelles L, Umans L, Van de Putte T, Wuytens G, Huylebroeck D, Verschueren K.

Mol Cell Endocrinol. 2001 Jun 30;180(1-2):13-24. Review.

PMID:
11451567
35.
37.

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.

Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, Van Leuven F, De Strooper B.

Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11872-7.

38.

alpha2-macroglobulin- and murinoglobulin-1- deficient mice. A mouse model for acute pancreatitis.

Umans L, Serneels L, Overbergh L, Stas L, Van Leuven F.

Am J Pathol. 1999 Sep;155(3):983-93.

39.

Humanization of mouse 5-hydroxytryptamine1B receptor gene by homologous recombination: in vitro and in vivo characterization.

Bonaventure P, Umans L, Bakker MH, Cras P, Langlois X, Luyten WH, Megens AA, Serneels L, Van Leuven F, Leysen JE.

Mol Pharmacol. 1999 Jul;56(1):54-67.

PMID:
10385684
40.

Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin.

Roebroek AJ, Umans L, Pauli IG, Robertson EJ, van Leuven F, Van de Ven WJ, Constam DB.

Development. 1998 Dec;125(24):4863-76.

42.

Targeted inactivation of the mouse alpha 2-macroglobulin gene.

Umans L, Serneels L, Overbergh L, Lorent K, Van Leuven F, Van den Berghe H.

J Biol Chem. 1995 Aug 25;270(34):19778-85.

44.

Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein.

Van Leuven F, Stas L, Hilliker C, Lorent K, Umans L, Serneels L, Overbergh L, Torrekens S, Moechars D, De Strooper B, et al.

Genomics. 1994 Nov 1;24(1):78-89.

PMID:
7534747
45.

The human and mouse genes coding for the alpha 2MR-associated protein.

Van Leuven F, Serneels L, Raymakers L, Hilliker C, Umans L.

Ann N Y Acad Sci. 1994 Sep 10;737:504-5. No abstract available.

PMID:
7944154
46.

Structure and targeting in ES cells of the gene coding for mouse alpha 2-macroglobulin.

Umans L, Serneels L, Hilliker C, Van Leuven F.

Ann N Y Acad Sci. 1994 Sep 10;737:500-1. No abstract available.

PMID:
7524431
47.

Molecular analysis of the human and mouse alpha 2M family.

Van Leuven F, Umans L, Lorent K, Hilliker C, Serneels L, Overbergh L, Stas L, Raymakers L.

Ann N Y Acad Sci. 1994 Sep 10;737:163-71. Review. No abstract available.

PMID:
7524394
48.

Molecular cloning of the mouse gene coding for alpha 2-macroglobulin and targeting of the gene in embryonic stem cells.

Umans L, Serneels L, Hilliker C, Stas L, Overbergh L, De Strooper B, Van Leuven F, Van den Berghe H.

Genomics. 1994 Aug;22(3):519-29.

PMID:
7528166
49.

Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA.

Van Leuven F, Stas L, Raymakers L, Overbergh L, De Strooper B, Hilliker C, Lorent K, Fias E, Umans L, Torrekens S, et al.

Biochim Biophys Acta. 1993 Apr 29;1173(1):71-4.

PMID:
8485155

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