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Items: 1 to 50 of 53

1.

7'-substituted benzothiazolothio- and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors.

Zhang L, Fan J, Vu K, Hong K, Le Brazidec JY, Shi J, Biamonte M, Busch DJ, Lough RE, Grecko R, Ran Y, Sensintaffar JL, Kamal A, Lundgren K, Burrows FJ, Mansfield R, Timony GA, Ulm EH, Kasibhatla SR, Boehm MF.

J Med Chem. 2006 Aug 24;49(17):5352-62.

PMID:
16913725
2.

Bexarotene metabolism in rat, dog, and human, synthesis of oxidative metabolites, and in vitro activity at retinoid receptors.

Howell SR, Shirley MA, Grese TA, Neel DA, Wells KE, Ulm EH.

Drug Metab Dispos. 2001 Jul;29(7):990-8.

PMID:
11408365
3.

A Phase I study of LGD1069 in adults with advanced cancer.

Rizvi NA, Marshall JL, Dahut W, Ness E, Truglia JA, Loewen G, Gill GM, Ulm EH, Geiser R, Jaunakais D, Hawkins MJ.

Clin Cancer Res. 1999 Jul;5(7):1658-64.

4.

Phase I study of 9-cis-retinoic acid (ALRT1057 capsules) in adults with advanced cancer.

Rizvi NA, Marshall JL, Ness E, Yoe J, Gill GM, Truglia JA, Loewen GR, Jaunakais D, Ulm EH, Hawkins MJ.

Clin Cancer Res. 1998 Jun;4(6):1437-42.

6.

Initial clinical trial of the retinoid receptor pan agonist 9-cis retinoic acid.

Miller VA, Rigas JR, Benedetti FM, Verret AL, Tong WP, Kris MG, Gill GM, Loewen GR, Truglia JA, Ulm EH, Warrell RP Jr.

Clin Cancer Res. 1996 Mar;2(3):471-5.

7.

Oxidative and reductive metabolism of 9-cis-retinoic acid in the rat. Identification of 13,14-dihydro-9-cis-retinoic acid and its taurine conjugate.

Shirley MA, Bennani YL, Boehm MF, Breau AP, Pathirana C, Ulm EH.

Drug Metab Dispos. 1996 Mar;24(3):293-302.

PMID:
8820419
8.

Pharmacokinetics of 9-cis-retinoic acid in the rhesus monkey.

Adamson PC, Murphy RF, Godwin KA, Ulm EH, Balis FM.

Cancer Res. 1995 Feb 1;55(3):482-5.

9.

Biotransformation of lovastatin. V. Species differences in in vivo metabolite profiles of mouse, rat, dog, and human.

Halpin RA, Ulm EH, Till AE, Kari PH, Vyas KP, Hunninghake DB, Duggan DE.

Drug Metab Dispos. 1993 Nov-Dec;21(6):1003-11.

PMID:
7905377
11.

Dose-dependent pharmacokinetics of MK-417, a potent carbonic anhydrase inhibitor, in rabbits following single and multiple doses.

Lin JH, Chen IW, Ulm EH, Gehret JR, Duggan DE.

Drug Metab Dispos. 1990 Nov-Dec;18(6):836-41.

PMID:
1981525
12.

Species-dependent enantioselective plasma protein binding of MK-571, a potent leukotriene D4 antagonist.

Lin JH, deLuna FA, Ulm EH, Tocco DJ.

Drug Metab Dispos. 1990 Jul-Aug;18(4):484-7.

PMID:
1976072
13.

Biotransformation of lovastatin. I. Structure elucidation of in vitro and in vivo metabolites in the rat and mouse.

Vyas KP, Kari PH, Pitzenberger SM, Halpin RA, Ramjit HG, Arison B, Murphy JS, Hoffman WF, Schwartz MS, Ulm EH, et al.

Drug Metab Dispos. 1990 Mar-Apr;18(2):203-11.

PMID:
1971574
14.

Dose-dependent kinetics of cilastatin in laboratory animals.

Lin JH, Chen IW, Ulm EH.

Drug Metab Dispos. 1989 Jul-Aug;17(4):426-32.

PMID:
2571484
15.

Effect of experimental diabetes on elimination kinetics of diflunisal in rats.

Lin JH, DeLuna FA, Tocco DJ, Ulm EH.

Drug Metab Dispos. 1989 Mar-Apr;17(2):147-52.

PMID:
2565203
16.

Renin inhibitors containing hydrophilic groups. Tetrapeptides with enhanced aqueous solubility and nanomolar potency.

Bock MG, DiPardo RM, Evans BE, Freidinger RM, Rittle KE, Payne LS, Boger J, Whitter WL, LaMont BI, Ulm EH, et al.

J Med Chem. 1988 Oct;31(10):1918-23.

PMID:
3050088
17.

Differential renal handling of angiotensin-converting enzyme inhibitors enalaprilat and lisinopril in rats.

Lin JH, Chen IW, Ulm EH, Duggan DE.

Drug Metab Dispos. 1988 May-Jun;16(3):392-6.

PMID:
2900730
18.
19.
20.

Renin inhibitors. Statine-containing tetrapeptides with varied hydrophobic carboxy termini.

Bock MG, DiPardo RM, Evans BE, Rittle KE, Boger J, Poe M, LaMont BI, Lynch RJ, Ulm EH, Vlasuk GP, et al.

J Med Chem. 1987 Oct;30(10):1853-7.

PMID:
3309316
21.

Differential effects of phenobarbital on ester and ether glucuronidation of diflunisal in rats.

Lin JH, Chen IW, Ulm EH, Duggan DE.

J Pharmacol Exp Ther. 1987 Sep;242(3):1013-8.

PMID:
3656106
22.

Renal effects of enalapril in dogs.

MacDonald JS, Bagdon WJ, Peter CP, Sina JF, Robertson RT, Ulm EH, Bokelman DL.

Kidney Int Suppl. 1987 May;20:S148-53. No abstract available.

PMID:
3037165
23.

Urinary excretion kinetics of famotidine in rats.

Lin JH, Los LE, Ulm EH, Duggan DE.

Drug Metab Dispos. 1987 Mar-Apr;15(2):212-6.

PMID:
2882981
24.

Possible mechanisms for reduced plasma clearance of diflunisal in rat experimental renal failure.

Lin JH, Ulm EH, Duggan DE.

J Pharmacol Exp Ther. 1986 Sep;238(3):978-84.

PMID:
3746671
25.

Conformationally restricted inhibitors of angiotensin converting enzyme: synthesis and computations.

Thorsett ED, Harris EE, Aster SD, Peterson ER, Snyder JP, Springer JP, Hirshfield J, Tristram EW, Patchett AA, Ulm EH, et al.

J Med Chem. 1986 Feb;29(2):251-60.

PMID:
3005569
26.

Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine.

Boger J, Payne LS, Perlow DS, Lohr NS, Poe M, Blaine EH, Ulm EH, Schorn TW, LaMont BI, Lin TY, et al.

J Med Chem. 1985 Dec;28(12):1779-90.

PMID:
3906131
27.

A uniquely potent renin inhibitor and its unanticipated plasma binding component.

Evans BE, Rittle KE, Bock MG, Bennett CD, DiPardo RM, Boger J, Poe M, Ulm EH, LaMont BI, Blaine EH, et al.

J Med Chem. 1985 Dec;28(12):1755-6. No abstract available.

PMID:
3906130
28.
29.

Angiotensin-converting enzyme inhibitors: synthesis and biological activity of acyl tripeptide analogues of enalapril.

Greenlee WJ, Allibone PL, Perlow DS, Patchett AA, Ulm EH, Vassil TC.

J Med Chem. 1985 Apr;28(4):434-42.

PMID:
2984419
30.

Design of proteolytically-stable, peptidal renin inhibitors and determination of their fate in vivo.

Boger J, Bennett CD, Payne LS, Ulm EH, Blaine EH, Homnick CF, Schorn TW, Lamont BI, Veber DF.

Regul Pept Suppl. 1985;4:8-13. No abstract available.

PMID:
3903877
31.

Renin inhibitors containing 2-substituted statine.

Veber DF, Bock MG, Brady SF, Ulm EH, Cochran DW, Smith GM, LaMont BI, Dipardo RM, Poe M, Freidinger RM, et al.

Biochem Soc Trans. 1984 Dec;12(6):956-9. No abstract available.

PMID:
6442237
32.

Azapeptides: a new class of angiotensin-converting enzyme inhibitors.

Greenlee WJ, Thorsett ED, Springer JP, Patchett AA, Ulm EH, Vassil TC.

Biochem Biophys Res Commun. 1984 Jul 31;122(2):791-7.

PMID:
6087816
34.

Benzolactams. A new class of converting enzyme inhibitors.

Parsons WH, Davidson JL, Taub D, Aster SD, Thorsett ED, Patchett AA, Ulm EH, Lamont BI.

Biochem Biophys Res Commun. 1983 Nov 30;117(1):108-13.

PMID:
6318742
35.

Novel renin inhibitors containing the amino acid statine.

Boger J, Lohr NS, Ulm EH, Poe M, Blaine EH, Fanelli GM, Lin TY, Payne LS, Schorn TW, LaMont BI, Vassil TC, Stabilito II, Veber DF, Rich DH, Bopari AS.

Nature. 1983 May 5-11;303(5912):81-4.

PMID:
6341856
36.

Inhibitors of glycolic acid oxidase. 4-Substituted 3-hydroxy-1H-pyrrole-2,5-dione derivatives.

Rooney CS, Randall WC, Streeter KB, Ziegler C, Cragoe EJ Jr, Schwam H, Michelson SR, Williams HW, Eichler E, Duggan DE, Ulm EH, Noll RM.

J Med Chem. 1983 May;26(5):700-14.

PMID:
6341589
37.

Dipeptide mimics. Conformationally restricted inhibitors of angiotensin-converting enzyme.

Thorsett ED, Harris EE, Aster S, Peterson ER, Taub D, Patchett AA, Ulm EH, Vassil TC.

Biochem Biophys Res Commun. 1983 Feb 28;111(1):166-71. No abstract available.

PMID:
6299286
39.

Enalapril maleate and a lysine analogue (MK-521) in normal volunteers; relationship between plasma drug levels and the renin angiotensin system.

Biollaz J, Schelling JL, Jacot Des Combes B, Brunner DB, Desponds G, Brunner HR, Ulm EH, Hichens M, Gomez HJ.

Br J Clin Pharmacol. 1982 Sep;14(3):363-8.

40.

Enalapril maleate and a lysine analogue (MK-521): disposition in man.

Ulm EH, Hichens M, Gomez HJ, Till AE, Hand E, Vassil TC, Biollaz J, Brunner HR, Schelling JL.

Br J Clin Pharmacol. 1982 Sep;14(3):357-62.

41.
42.

Phosphorus-containing inhibitors of angiotensin-converting enzyme.

Thorsett ED, Harris EE, Peterson ER, Greenlee WJ, Patchett AA, Ulm EH, Vassil TC.

Proc Natl Acad Sci U S A. 1982 Apr;79(7):2176-80.

43.

The physiological disposition and metabolism of enalapril maleate in laboratory animals.

Tocco DJ, deLuna FA, Duncan AE, Vassil TC, Ulm EH.

Drug Metab Dispos. 1982 Jan-Feb;10(1):15-9.

PMID:
6124377
44.

Effect of N-[(S)-1-carboxy-3-phenylpropyl]-L-Ala-L-Pro and its ethyl ester (MK-421) on angiotensin converting enzyme in vitro and angiotensin I pressor responses in vivo.

Gross DM, Sweet CS, Ulm EH, Backlund EP, Morris AA, Weitz D, Bohn DL, Wenger HC, Vassil TC, Stone CA.

J Pharmacol Exp Ther. 1981 Mar;216(3):552-7.

PMID:
6259322
45.

A new class of angiotensin-converting enzyme inhibitors.

Patchett AA, Harris E, Tristram EW, Wyvratt MJ, Wu MT, Taub D, Peterson ER, Ikeler TJ, ten Broeke J, Payne LG, Ondeyka DL, Thorsett ED, Greenlee WJ, Lohr NS, Hoffsommer RD, Joshua H, Ruyle WV, Rothrock JW, Aster SD, Maycock AL, Robinson FM, Hirschmann R, Sweet CS, Ulm EH, Gross DM, Vassil TC, Stone CA.

Nature. 1980 Nov 20;288(5788):280-3.

PMID:
6253826
46.

Antihypertensive activity of some novel pyridinylidene arylurea derivatives in spontaneously hypertensive rats.

Ludden CT, Scriabine A, Ulm EH, Morgan G, Fisher MH, Ruyle WV.

Experientia. 1979 Jun 15;35(6):799-801.

PMID:
467597
47.

Antihypertensive activity of metyrosine in spontaneously hypertensive rats and its enhancement by carbidopa.

Scriabine A, Ludden CT, Sweet CS, Porter CC, Ulm EH, Stone CA, Watkins CJ, Wurtman RJ, Cronin BL.

Clin Sci Mol Med Suppl. 1978 Dec;4:255s-257s. No abstract available.

PMID:
282064
48.

A 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin A in rabbit kidney.

Oien HG, Ham EA, Zanetti ME, Ulm EH, Kuehl FA Jr.

Proc Natl Acad Sci U S A. 1976 Apr;73(4):1107-11.

49.

The reaction of PGA1 with sulfhydryl groups; a component in the binding of A-type prostaglandins to proteins.

Ham EA, Oien HG, Ulm EH, Kuehl FA Jr.

Prostaglandins. 1975 Aug;10(2):217-29.

PMID:
1178903
50.

Involvement of cytosol proteins in oleate activation of rabbit liver fructose-1,6-diphosphatase.

Carlson CW, Tejwani GA, Baxter RC, Ulm EH, Pogell BM.

J Biol Chem. 1975 Jul 10;250(13):4996-5002.

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