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Items: 1 to 50 of 54

1.

Investigation of the pathways related to intrinsic miltefosine tolerance in Leishmania (Viannia) braziliensis clinical isolates reveals differences in drug uptake.

Espada CR, Magalhães RM, Cruz MC, Machado PR, Schriefer A, Carvalho EM, Hornillos V, Alves JM, Cruz AK, Coelho AC, Uliana SRB.

Int J Parasitol Drugs Drug Resist. 2019 Feb 25. pii: S2211-3207(18)30168-4. doi: 10.1016/j.ijpddr.2019.02.005. [Epub ahead of print]

2.

Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania.

Trinconi CT, Miguel DC, Silber AM, Brown C, Mina JGM, Denny PW, Heise N, Uliana SRB.

Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):475-487. doi: 10.1016/j.ijpddr.2018.10.007. Epub 2018 Oct 24.

3.

Case Report: Atypical Cutaneous Leishmaniasis in a Patient with Mixed Leishmania guyanensis and Leishmania amazonensis Infection.

Gosch CS, Resende BS, Amorim CB, Marques CP, Pereira LIA, Pinto SA, Uliana SRB, Coelho AC, Ribeiro-Dias F, Dorta ML.

Am J Trop Med Hyg. 2018 Nov;99(5):1165-1169. doi: 10.4269/ajtmh.17-0760.

PMID:
30203744
4.

Promastigote parasites cultured from the lesions of patients with mucosal leishmaniasis are more resistant to oxidative stress than promastigotes from a cutaneous lesion.

Ávila LR, Gomes CM, Oliveira PG, Gomes RS, Vinaud MC, Dorta ML, Uliana SRB, Ribeiro-Dias F, Oliveira MAP.

Free Radic Biol Med. 2018 Dec;129:35-45. doi: 10.1016/j.freeradbiomed.2018.09.005. Epub 2018 Sep 7.

PMID:
30196081
5.

Tamoxifen and meglumine antimoniate combined therapy in cutaneous leishmaniasis patients: a randomised trial.

Machado PRL, Ribeiro CS, França-Costa J, Dourado MEF, Trinconi CT, Yokoyama-Yasunaka JKU, Malta-Santos H, Borges VM, Carvalho EM, Uliana SRB.

Trop Med Int Health. 2018 Sep;23(9):936-942. doi: 10.1111/tmi.13119. Epub 2018 Jul 11.

6.

Identification of Leishmania (Viannia) species and clinical isolates of Leishmania (Leishmania) amazonensis from Brazil using PCR-RFLP of the heat-shock protein 70 gene reveals some unexpected observations.

Espada CR, Ortiz PA, Shaw JJ, Barral AMP, Costa JML, Uliana SRB, Coelho AC.

Diagn Microbiol Infect Dis. 2018 Aug;91(4):312-318. doi: 10.1016/j.diagmicrobio.2018.03.004. Epub 2018 Mar 12.

PMID:
29653798
7.

New iminodibenzyl derivatives with anti-leishmanial activity.

Arndt A, Liria CW, Yokoyama-Yasunaka JKU, Machini MT, Uliana SRB, Espósito BP.

J Inorg Biochem. 2017 Jul;172:9-15. doi: 10.1016/j.jinorgbio.2017.04.004. Epub 2017 Apr 4.

PMID:
28414928
8.

Topical tamoxifen in the therapy of cutaneous leishmaniasis.

Trinconi CT, Reimão JQ, Bonano VI, Espada CR, Miguel DC, Yokoyama-Yasunaka JKU, Uliana SRB.

Parasitology. 2018 Apr;145(4):490-496. doi: 10.1017/S0031182017000130. Epub 2017 Mar 9.

PMID:
28274283
9.

Chemical Composition, Antiprotozoal and Cytotoxic Activities of Indole Alkaloids and Benzofuran Neolignan of Aristolochia cordigera.

Pereira MDP, da Silva T, Aguiar ACC, Oliva G, Guido RVC, Yokoyama-Yasunaka JKU, Uliana SRB, Lopes LMX.

Planta Med. 2017 Jul;83(11):912-920. doi: 10.1055/s-0043-104776. Epub 2017 Mar 6.

PMID:
28264205
10.

Chemotherapy of leishmaniasis: present challenges.

Uliana SRB, Trinconi CT, Coelho AC.

Parasitology. 2018 Apr;145(4):464-480. doi: 10.1017/S0031182016002523. Epub 2017 Jan 20. Review.

PMID:
28103966
11.

Susceptibility to Miltefosine in Brazilian Clinical Isolates of Leishmania (Viannia) braziliensis.

Espada CR, Ribeiro-Dias F, Dorta ML, Pereira LIA, Carvalho EM, Machado PR, Schriefer A, Yokoyama-Yasunaka JKU, Coelho AC, Uliana SRB.

Am J Trop Med Hyg. 2017 Mar;96(3):656-659. doi: 10.4269/ajtmh.16-0811. Epub 2017 Apr 6.

12.

In Vitro and In Vivo Miltefosine Susceptibility of a Leishmania amazonensis Isolate from a Patient with Diffuse Cutaneous Leishmaniasis: Follow-Up.

Coelho AC, Trinconi CT, Costa CH, Uliana SR.

PLoS Negl Trop Dis. 2016 Jul 14;10(7):e0004720. doi: 10.1371/journal.pntd.0004720. eCollection 2016 Jul. No abstract available.

13.

A Luciferase-Expressing Leishmania braziliensis Line That Leads to Sustained Skin Lesions in BALB/c Mice and Allows Monitoring of Miltefosine Treatment Outcome.

Coelho AC, Oliveira JC, Espada CR, Reimão JQ, Trinconi CT, Uliana SR.

PLoS Negl Trop Dis. 2016 May 4;10(5):e0004660. doi: 10.1371/journal.pntd.0004660. eCollection 2016 May.

14.

Distinct courses of infection with Leishmania (L.) amazonensis are observed in BALB/c, BALB/c nude and C57BL/6 mice.

Velasquez LG, Galuppo MK, DE Rezende E, Brandão WN, Peron JP, Uliana SR, Duarte MI, Stolf BS.

Parasitology. 2016 May;143(6):692-703. doi: 10.1017/S003118201600024X. Epub 2016 Feb 19.

PMID:
26892342
15.

Efficacy of tamoxifen and miltefosine combined therapy for cutaneous leishmaniasis in the murine model of infection with Leishmania amazonensis.

Trinconi CT, Reimão JQ, Coelho AC, Uliana SR.

J Antimicrob Chemother. 2016 May;71(5):1314-22. doi: 10.1093/jac/dkv495. Epub 2016 Feb 6.

PMID:
26851606
16.

Identification and Biological Characterization of Leishmania (Viannia) guyanensis Isolated from a Patient with Tegumentary Leishmaniasis in Goiás, a Nonendemic Area for This Species in Brazil.

Pires Ada S, Borges AF, Cappellazzo Coelho A, Dorta ML, Lino Junior Rde S, Pereira LI, Pinto SA, Pelli de Oliveira MA, de Matos GG, Abrahamsohn IA, Uliana SR, Lima GM, Ribeiro-Dias F.

Biomed Res Int. 2015;2015:350764. doi: 10.1155/2015/350764. Epub 2015 Oct 25.

17.

Leishmania is not prone to develop resistance to tamoxifen.

Coelho AC, Trinconi CT, Senra L, Yokoyama-Yasunaka JK, Uliana SR.

Int J Parasitol Drugs Drug Resist. 2015 Jun 17;5(3):77-83. doi: 10.1016/j.ijpddr.2015.05.006. eCollection 2015 Dec.

18.

Generation of luciferase-expressing Leishmania infantum chagasi and assessment of miltefosine efficacy in infected hamsters through bioimaging.

Reimão JQ, Oliveira JC, Trinconi CT, Cotrim PC, Coelho AC, Uliana SR.

PLoS Negl Trop Dis. 2015 Feb 13;9(2):e0003556. doi: 10.1371/journal.pntd.0003556. eCollection 2015 Feb.

19.

In vitro and in vivo miltefosine susceptibility of a Leishmania amazonensis isolate from a patient with diffuse cutaneous leishmaniasis.

Coelho AC, Trinconi CT, Costa CH, Uliana SR.

PLoS Negl Trop Dis. 2014 Jul 17;8(7):e2999. doi: 10.1371/journal.pntd.0002999. eCollection 2014 Jul.

20.

Antileishmanial activity of the estrogen receptor modulator raloxifene.

Reimão JQ, Miguel DC, Taniwaki NN, Trinconi CT, Yokoyama-Yasunaka JK, Uliana SR.

PLoS Negl Trop Dis. 2014 May 8;8(5):e2842. doi: 10.1371/journal.pntd.0002842. eCollection 2014 May.

21.

Combination therapy with tamoxifen and amphotericin B in experimental cutaneous leishmaniasis.

Trinconi CT, Reimão JQ, Yokoyama-Yasunaka JK, Miguel DC, Uliana SR.

Antimicrob Agents Chemother. 2014 May;58(5):2608-13. doi: 10.1128/AAC.01315-13. Epub 2014 Feb 18.

22.

Discovery of synthetic Leishmania inhibitors by screening of a 2-arylbenzothiophene library.

Bonano VI, Yokoyama-Yasunaka JK, Miguel DC, Jones SA, Dodge JA, Uliana SR.

Chem Biol Drug Des. 2014 Mar;83(3):289-96. doi: 10.1111/cbdd.12239. Epub 2013 Dec 26.

PMID:
24119198
23.

Parasite burden in Leishmania (Leishmania) amazonensis-infected mice: validation of luciferase as a quantitative tool.

Reimão JQ, Trinconi CT, Yokoyama-Yasunaka JK, Miguel DC, Kalil SP, Uliana SR.

J Microbiol Methods. 2013 May;93(2):95-101. doi: 10.1016/j.mimet.2013.02.007. Epub 2013 Mar 4.

PMID:
23466934
24.

Leishmania metacyclogenesis is promoted in the absence of purines.

Serafim TD, Figueiredo AB, Costa PA, Marques-da-Silva EA, Gonçalves R, de Moura SA, Gontijo NF, da Silva SM, Michalick MS, Meyer-Fernandes JR, de Carvalho RP, Uliana SR, Fietto JL, Afonso LC.

PLoS Negl Trop Dis. 2012;6(9):e1833. doi: 10.1371/journal.pntd.0001833. Epub 2012 Sep 20.

25.

A dysflagellar mutant of Leishmania (Viannia) braziliensis isolated from a cutaneous leishmaniasis patient.

Zauli RC, Yokoyama-Yasunaka JK, Miguel DC, Moura AS, Pereira LIa, da Silva IA Jr, Lemes LG, Dorta ML, de Oliveira MA, Pitaluga AN, Ishikawa EA, Rodrigues JC, Traub-Cseko YM, Bijovsky AT, Ribeiro-Dias F, Uliana SR.

Parasit Vectors. 2012 Jan 11;5:11. doi: 10.1186/1756-3305-5-11.

26.

Increasing the activity of copper(II) complexes against Leishmania through lipophilicity and pro-oxidant ability.

Portas Ados S, Miguel DC, Yokoyama-Yasunaka JK, Uliana SR, Espósito BP.

J Biol Inorg Chem. 2012 Jan;17(1):107-12. doi: 10.1007/s00775-011-0834-3. Epub 2011 Aug 25.

PMID:
21866394
27.

Clinical isolates of New World Leishmania from cutaneous and visceral leishmaniasis patients are uniformly sensitive to tamoxifen.

Miguel DC, Zauli-Nascimento RC, Yokoyama-Yasunaka JK, Pereira LI, Jerônimo SM, Ribeiro-Dias F, Dorta ML, Uliana SR.

Int J Antimicrob Agents. 2011 Jul;38(1):93-4. doi: 10.1016/j.ijantimicag.2011.03.012. Epub 2011 May 8. No abstract available.

PMID:
21555208
28.

The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice.

Miguel DC, Ferraz ML, Alves Rde O, Yokoyama-Yasunaka JK, Torrecilhas AC, Romanha AJ, Uliana SR.

Mem Inst Oswaldo Cruz. 2010 Nov;105(7):945-8.

29.

Leishmania-specific surface antigens show sub-genus sequence variation and immune recognition.

Depledge DP, MacLean LM, Hodgkinson MR, Smith BA, Jackson AP, Ma S, Uliana SR, Smith DF.

PLoS Negl Trop Dis. 2010 Sep 28;4(9):e829. doi: 10.1371/journal.pntd.0000829.

30.

Leishmania amazonensis META2 protein confers protection against heat shock and oxidative stress.

Ramos CS, Yokoyama-Yasunaka JK, Guerra-Giraldez C, Price HP, Mortara RA, Smith DF, Uliana SR.

Exp Parasitol. 2011 Jan;127(1):228-37. doi: 10.1016/j.exppara.2010.08.004. Epub 2010 Aug 14.

PMID:
20713053
31.

Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma.

Graebin CS, Madeira Mde F, Yokoyama-Yasunaka JK, Miguel DC, Uliana SR, Benitez D, Cerecetto H, González M, Rosa RG, Eifler-Lima VL.

Eur J Med Chem. 2010 Apr;45(4):1524-8. doi: 10.1016/j.ejmech.2009.12.061. Epub 2010 Jan 14.

PMID:
20116908
32.

Repurposing for neglected diseases.

Uliana SR, Barcinski MA.

Science. 2009 Nov 13;326(5955):935; author reply 935. doi: 10.1126/science.326.5955.935-a. No abstract available.

PMID:
19965498
33.

In vitro sensitivity of Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis Brazilian isolates to meglumine antimoniate and amphotericin B.

Zauli-Nascimento RC, Miguel DC, Yokoyama-Yasunaka JK, Pereira LI, Pelli de Oliveira MA, Ribeiro-Dias F, Dorta ML, Uliana SR.

Trop Med Int Health. 2010 Jan;15(1):68-76. doi: 10.1111/j.1365-3156.2009.02414.x. Epub 2009 Oct 26.

34.

Synthesis, characterization and evaluation of antileishmanial activity of copper(II) with fluorinated α-hydroxycarboxylate ligands.

da Silva Maffei R, Yokoyama-Yasunaka JK, Miguel DC, Uliana SR, Espósito BP.

Biometals. 2009 Dec;22(6):1095-101. doi: 10.1007/s10534-009-9260-1.

PMID:
19680603
35.

Inhibitory activity of limonene against Leishmania parasites in vitro and in vivo.

Arruda DC, Miguel DC, Yokoyama-Yasunaka JK, Katzin AM, Uliana SR.

Biomed Pharmacother. 2009 Nov;63(9):643-9. doi: 10.1016/j.biopha.2009.02.004. Epub 2009 Mar 10.

PMID:
19321295
36.

Tamoxifen as a potential antileishmanial agent: efficacy in the treatment of Leishmania braziliensis and Leishmania chagasi infections.

Miguel DC, Zauli-Nascimento RC, Yokoyama-Yasunaka JK, Katz S, Barbiéri CL, Uliana SR.

J Antimicrob Chemother. 2009 Feb;63(2):365-8. doi: 10.1093/jac/dkn509. Epub 2008 Dec 17.

PMID:
19095684
37.

Tamoxifen is effective in the treatment of Leishmania amazonensis infections in mice.

Miguel DC, Yokoyama-Yasunaka JK, Uliana SR.

PLoS Negl Trop Dis. 2008 Jun 11;2(6):e249. doi: 10.1371/journal.pntd.0000249.

38.

Leishmania amazonensis: biosynthesis of polyprenols of 9 isoprene units by amastigotes.

Arruda DC, D'Alexandri FL, Katzin AM, Uliana SR.

Exp Parasitol. 2008 Apr;118(4):624-8. Epub 2007 Nov 22.

PMID:
18155196
39.

The first records of Leishmania (Leishmania) amazonensis in dogs (Canis familiaris) diagnosed clinically as having canine visceral leishmaniasis from Araçatuba County, São Paulo State, Brazil.

Tolezano JE, Uliana SR, Taniguchi HH, Araújo MF, Barbosa JA, Barbosa JE, Floeter-Winter LM, Shaw JJ.

Vet Parasitol. 2007 Nov 10;149(3-4):280-4. Epub 2007 Aug 27.

PMID:
17720321
40.

Tamoxifen is effective against Leishmania and induces a rapid alkalinization of parasitophorous vacuoles harbouring Leishmania (Leishmania) amazonensis amastigotes.

Miguel DC, Yokoyama-Yasunaka JK, Andreoli WK, Mortara RA, Uliana SR.

J Antimicrob Chemother. 2007 Sep;60(3):526-34. Epub 2007 Jun 21.

PMID:
17584801
41.

Leishmanicidal activity of primary S-nitrosothiols against Leishmania major and Leishmania amazonensis: implications for the treatment of cutaneous leishmaniasis.

de Souza GF, Yokoyama-Yasunaka JK, Seabra AB, Miguel DC, de Oliveira MG, Uliana SR.

Nitric Oxide. 2006 Nov;15(3):209-16. Epub 2006 Mar 9.

PMID:
16527502
42.

Antileishmanial activity of the terpene nerolidol.

Arruda DC, D'Alexandri FL, Katzin AM, Uliana SR.

Antimicrob Agents Chemother. 2005 May;49(5):1679-87.

43.

Characterisation of a developmentally regulated amino acid transporter gene from Leishmania amazonensis.

Geraldo MV, Silber AM, Pereira CA, Uliana SR.

FEMS Microbiol Lett. 2005 Jan 15;242(2):275-80.

44.

Characterisation of a new Leishmania META gene and genomic analysis of the META cluster.

Ramos CS, Franco FA, Smith DF, Uliana SR.

FEMS Microbiol Lett. 2004 Sep 1;238(1):213-9.

45.

Evaluation of the murine immune response to Leishmania meta 1 antigen delivered as recombinant protein or DNA vaccine.

Serezani CH, Franco AR, Wajc M, Umada Yokoyama-Yasunaka JK, Wunderlich G, Borges MM, Uliana SR.

Vaccine. 2002 Nov 1;20(31-32):3755-63.

PMID:
12399206
46.

Geographical distribution of neotropical Leishmania of the subgenus Leishmania analysed by ribosomal oligonucleotide probes.

Uliana SR, Ishikawa E, Stempliuk VA, de Souza A, Shaw JJ, Floeter-Winter LM.

Trans R Soc Trop Med Hyg. 2000 May-Jun;94(3):261-4. No abstract available.

PMID:
10974994
47.

Leishmania: overexpression and comparative structural analysis of the stage-regulated meta 1 gene.

Uliana SR, Goyal N, Freymüller E, Smith DF.

Exp Parasitol. 1999 Jul;92(3):183-91.

PMID:
10403759
48.

Structural and functional characterization of the Leishmania amazonensis ribosomal RNA promoter.

Uliana SR, Fischer W, Stempliuk VA, Floeter-Winter LM.

Mol Biochem Parasitol. 1996 Feb-Mar;76(1-2):245-55.

PMID:
8920010
49.

Characterisation and expression of a stage-regulated gene of Leishmania major.

Nourbakhsh F, Uliana SR, Smith DF.

Mol Biochem Parasitol. 1996 Feb-Mar;76(1-2):201-13.

PMID:
8920007
50.

Discrimination amongst Leishmania by polymerase chain reaction and hybridization with small subunit ribosomal DNA derived oligonucleotides.

Uliana SR, Nelson K, Beverley SM, Camargo EP, Floeter-Winter LM.

J Eukaryot Microbiol. 1994 Jul-Aug;41(4):324-30.

PMID:
8087103

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