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Lack of Both Nucleotide-Binding Oligomerization Domain-Containing Proteins 1 and 2 Primes T Cells for Activation-Induced Cell Death.

Kasimsetty SG, Shigeoka AA, Scheinok AA, Gavin AL, Ulevitch RJ, McKay DB.

J Immunol. 2017 Aug 1;199(3):1196-1205. doi: 10.4049/jimmunol.1600667. Epub 2017 Jun 26.


NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.

Shi H, Wang Y, Li X, Zhan X, Tang M, Fina M, Su L, Pratt D, Bu CH, Hildebrand S, Lyon S, Scott L, Quan J, Sun Q, Russell J, Arnett S, Jurek P, Chen D, Kravchenko VV, Mathison JC, Moresco EM, Monson NL, Ulevitch RJ, Beutler B.

Nat Immunol. 2016 Mar;17(3):250-8. doi: 10.1038/ni.3333. Epub 2015 Dec 7.


The costimulatory immunogen LPS induces the B-Cell clones that infiltrate transplanted human kidneys.

Grover RK, Cheng J, Peng Y, Jones TM, Ruiz DI, Ulevitch RJ, Glass JI, Dennis EA, Salomon DR, Lerner RA.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6036-41. doi: 10.1073/pnas.1202214109. Epub 2012 Apr 6. Erratum in: Proc Natl Acad Sci U S A. 2016 Oct 17;:.


The use of small molecule probes to study spatially separated stimulus-induced signaling pathways.

Kravchenko VV, Gloeckner C, Stowe GN, Kang YJ, Tobias PS, Mathison JC, Ulevitch RJ, Kaufmann GF, Janda KD.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):2043-5. doi: 10.1016/j.bmcl.2012.01.024. Epub 2012 Jan 14.


Modulation of mammalian cell processes by bacterial quorum sensing molecules.

Kravchenko VV, Ulevitch RJ, Kaufmann GF.

Methods Mol Biol. 2011;692:133-45. doi: 10.1007/978-1-60761-971-0_10.


An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury.

Shigeoka AA, Mueller JL, Kambo A, Mathison JC, King AJ, Hall WF, Correia Jda S, Ulevitch RJ, Hoffman HM, McKay DB.

J Immunol. 2010 Nov 15;185(10):6277-85. doi: 10.4049/jimmunol.1002330. Epub 2010 Oct 20. Erratum in: J Immunol. 2011 Feb 1;186(3):1880.


Nod1 and nod2 are expressed in human and murine renal tubular epithelial cells and participate in renal ischemia reperfusion injury.

Shigeoka AA, Kambo A, Mathison JC, King AJ, Hall WF, da Silva Correia J, Ulevitch RJ, McKay DB.

J Immunol. 2010 Mar 1;184(5):2297-304. doi: 10.4049/jimmunol.0903065. Epub 2010 Feb 1.


Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule.

Kravchenko VV, Kaufmann GF, Mathison JC, Scott DA, Katz AZ, Grauer DC, Lehmann M, Meijler MM, Janda KD, Ulevitch RJ.

Science. 2008 Jul 11;321(5886):259-63. doi: 10.1126/science.1156499. Epub 2008 Jun 19.


The quorum quenching antibody RS2-1G9 protects macrophages from the cytotoxic effects of the Pseudomonas aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactone.

Kaufmann GF, Park J, Mee JM, Ulevitch RJ, Janda KD.

Mol Immunol. 2008 May;45(9):2710-4. doi: 10.1016/j.molimm.2008.01.010. Epub 2008 Mar 4.


Infection control by antibody disruption of bacterial quorum sensing signaling.

Park J, Jagasia R, Kaufmann GF, Mathison JC, Ruiz DI, Moss JA, Meijler MM, Ulevitch RJ, Janda KD.

Chem Biol. 2007 Oct;14(10):1119-27.


Genetic analysis of host responses in sepsis.

Beutler B, Ulevitch RJ.

Curr Infect Dis Rep. 2007 Oct;3(5):419-26. doi: 10.1007/s11908-007-1009-9.


MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3.

Pan Q, Mathison J, Fearns C, Kravchenko VV, Da Silva Correia J, Hoffman HM, Kobayashi KS, Bertin J, Grant EP, Coyle AJ, Sutterwala FS, Ogura Y, Flavell RA, Ulevitch RJ.

J Leukoc Biol. 2007 Jul;82(1):177-83. Epub 2007 Apr 2.


The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis.

da Silva Correia J, Miranda Y, Leonard N, Ulevitch RJ.

J Biol Chem. 2007 Apr 27;282(17):12557-65. Epub 2007 Mar 2.


Cleavage of p65/RelA of the NF-kappaB pathway by Chlamydia.

Lad SP, Li J, da Silva Correia J, Pan Q, Gadwal S, Ulevitch RJ, Li E.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2933-8. Epub 2007 Feb 14.


Regulation of Nod1-mediated signaling pathways.

da Silva Correia J, Miranda Y, Leonard N, Hsu J, Ulevitch RJ.

Cell Death Differ. 2007 Apr;14(4):830-9. Epub 2006 Dec 22.


N-(3-oxo-acyl)homoserine lactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways.

Kravchenko VV, Kaufmann GF, Mathison JC, Scott DA, Katz AZ, Wood MR, Brogan AP, Lehmann M, Mee JM, Iwata K, Pan Q, Fearns C, Knaus UG, Meijler MM, Janda KD, Ulevitch RJ.

J Biol Chem. 2006 Sep 29;281(39):28822-30. Epub 2006 Aug 7.


Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice.

Saleh M, Mathison JC, Wolinski MK, Bensinger SJ, Fitzgerald P, Droin N, Ulevitch RJ, Green DR, Nicholson DW.

Nature. 2006 Apr 20;440(7087):1064-8. Erratum in: Nature. 2014 Apr 10;508(7495):274.


NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway.

Pan Q, Kravchenko V, Katz A, Huang S, Ii M, Mathison JC, Kobayashi K, Flavell RA, Schreiber RD, Goeddel D, Ulevitch RJ.

Infect Immun. 2006 Apr;74(4):2121-7.


TLR2 is required for the altered transcription of p75NGF receptors in gram positive infection.

Wirz SA, Tobias PS, Ulevitch RJ, Aribibe L, Bartfai T.

Neurochem Res. 2006 Feb;31(2):297-301. Epub 2006 Mar 3.


Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4.

Raetz CR, Garrett TA, Reynolds CM, Shaw WA, Moore JD, Smith DC Jr, Ribeiro AA, Murphy RC, Ulevitch RJ, Fearns C, Reichart D, Glass CK, Benner C, Subramaniam S, Harkewicz R, Bowers-Gentry RC, Buczynski MW, Cooper JA, Deems RA, Dennis EA.

J Lipid Res. 2006 May;47(5):1097-111. Epub 2006 Feb 14.


Nod1-dependent control of tumor growth.

da Silva Correia J, Miranda Y, Austin-Brown N, Hsu J, Mathison J, Xiang R, Zhou H, Li Q, Han J, Ulevitch RJ.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1840-5. Epub 2006 Jan 30.


Limiting inflammatory responses during activation of innate immunity.

Han J, Ulevitch RJ.

Nat Immunol. 2005 Dec;6(12):1198-205. Review.


A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease.

Fort MM, Mozaffarian A, Stöver AG, Correia Jda S, Johnson DA, Crane RT, Ulevitch RJ, Persing DH, Bielefeldt-Ohmann H, Probst P, Jeffery E, Fling SP, Hershberg RM.

J Immunol. 2005 May 15;174(10):6416-23.


Innate immune responses during infection.

Ulevitch RJ, Mathison JC, da Silva Correia J.

Vaccine. 2004 Dec 6;22 Suppl 1:S25-30. Review.


Therapeutics targeting the innate immune system.

Ulevitch RJ.

Nat Rev Immunol. 2004 Jul;4(7):512-20. Review. No abstract available.


Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.

Chuang TH, Ulevitch RJ.

Nat Immunol. 2004 May;5(5):495-502. Epub 2004 Apr 25. Erratum in: Nat Immunol. 2004 Sep;5(9):968.


Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure.

Hayashi M, Kim SW, Imanaka-Yoshida K, Yoshida T, Abel ED, Eliceiri B, Yang Y, Ulevitch RJ, Lee JD.

J Clin Invest. 2004 Apr;113(8):1138-48.


MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury.

Otterbein LE, Otterbein SL, Ifedigbo E, Liu F, Morse DE, Fearns C, Ulevitch RJ, Knickelbein R, Flavell RA, Choi AM.

Am J Pathol. 2003 Dec;163(6):2555-63.


Structure-activity relationship of synthetic toll-like receptor 4 agonists.

Stöver AG, Da Silva Correia J, Evans JT, Cluff CW, Elliott MW, Jeffery EW, Johnson DA, Lacy MJ, Baldridge JR, Probst P, Ulevitch RJ, Persing DH, Hershberg RM.

J Biol Chem. 2004 Feb 6;279(6):4440-9. Epub 2003 Oct 21.


How we detect microbes and respond to them: the Toll-like receptors and their transducers.

Beutler B, Hoebe K, Du X, Ulevitch RJ.

J Leukoc Biol. 2003 Oct;74(4):479-85. Epub 2003 Jul 1. Review.


Regulation of receptor-dependent activation of the innate immune response.

Ulevitch RJ.

J Infect Dis. 2003 Jun 15;187 Suppl 2:S351-5.


IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli.

Kravchenko VV, Mathison JC, Schwamborn K, Mercurio F, Ulevitch RJ.

J Biol Chem. 2003 Jul 18;278(29):26612-9. Epub 2003 May 6.


[The signal transduction of cell activation by LPS: the studies from CD14 to p38 MAPK].

Jiang Y, Ulevitch RJ.

Sheng Li Ke Xue Jin Zhan. 1999 Jan;30(1):29-34. Review. Chinese.


ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis.

Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ.

J Biol Chem. 2002 Aug 23;277(34):30454-62. Epub 2002 Jun 4.


Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium.

D'Hauteville H, Khan S, Maskell DJ, Kussak A, Weintraub A, Mathison J, Ulevitch RJ, Wuscher N, Parsot C, Sansonetti PJ.

J Immunol. 2002 May 15;168(10):5240-51.


Toll-like receptor 9 mediates CpG-DNA signaling.

Chuang TH, Lee J, Kline L, Mathison JC, Ulevitch RJ.

J Leukoc Biol. 2002 Mar;71(3):538-44.


IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition.

Sanna MG, da Silva Correia J, Ducrey O, Lee J, Nomoto K, Schrantz N, Deveraux QL, Ulevitch RJ.

Mol Cell Biol. 2002 Mar;22(6):1754-66.


MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.

Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J.

Science. 2002 Feb 15;295(5558):1291-4.


MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor.

da Silva Correia J, Ulevitch RJ.

J Biol Chem. 2002 Jan 18;277(3):1845-54. Epub 2001 Nov 12.


Genetic Analysis of Host Responses in Sepsis.

Beutler B, Ulevitch RJ.

Curr Infect Dis Rep. 2001 Oct;3(5):419-426.


New therapeutic targets revealed through investigations of innate immunity.

Ulevitch RJ.

Crit Care Med. 2001 Jul;29(7 Suppl):S8-12. Review.


Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1.

Riewald M, Kravchenko VV, Petrovan RJ, O'Brien PJ, Brass LF, Ulevitch RJ, Ruf W.

Blood. 2001 May 15;97(10):3109-16.


Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.

Werts C, Tapping RI, Mathison JC, Chuang TH, Kravchenko V, Saint Girons I, Haake DA, Godowski PJ, Hayashi F, Ozinsky A, Underhill DM, Kirschning CJ, Wagner H, Aderem A, Tobias PS, Ulevitch RJ.

Nat Immunol. 2001 Apr;2(4):346-52.


Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2.

da Silva Correia J, Soldau K, Christen U, Tobias PS, Ulevitch RJ.

J Biol Chem. 2001 Jun 15;276(24):21129-35. Epub 2001 Mar 26.


Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells.

Chuang T, Ulevitch RJ.

Biochim Biophys Acta. 2001 Mar 19;1518(1-2):157-61.


Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.

Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.

Nat Immunol. 2000 Dec;1(6):533-40.


TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide.

Lee J, Mira-Arbibe L, Ulevitch RJ.

J Leukoc Biol. 2000 Dec;68(6):909-15.


Toll-like receptors in the induction of the innate immune response.

Aderem A, Ulevitch RJ.

Nature. 2000 Aug 17;406(6797):782-7. Review.


Molecular mechanisms of innate immunity.

Ulevitch RJ.

Immunol Res. 2000;21(2-3):49-54. Review.


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