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Items: 1 to 50 of 221

1.

Augmentation of EPR Effect and Efficacy of Anticancer Nanomedicine by Carbon Monoxide Generating Agents.

Fang J, Islam R, Islam W, Yin H, Subr V, Etrych T, Ulbrich K, Maeda H.

Pharmaceutics. 2019 Jul 16;11(7). pii: E343. doi: 10.3390/pharmaceutics11070343.

2.

Impact of Polymer-TLR-7/8 Agonist (Adjuvant) Morphology on the Potency and Mechanism of CD8 T Cell Induction.

Lynn GM, Chytil P, Francica JR, Lagová A, Kueberuwa G, Ishizuka AS, Zaidi N, Ramirez-Valdez RA, Blobel NJ, Baharom F, Leal J, Wang AQ, Gerner MY, Etrych T, Ulbrich K, Seymour LW, Seder RA, Laga R.

Biomacromolecules. 2019 Feb 11;20(2):854-870. doi: 10.1021/acs.biomac.8b01473. Epub 2019 Jan 22.

PMID:
30608149
3.

Augmentation of the Enhanced Permeability and Retention Effect with Nitric Oxide-Generating Agents Improves the Therapeutic Effects of Nanomedicines.

Islam W, Fang J, Imamura T, Etrych T, Subr V, Ulbrich K, Maeda H.

Mol Cancer Ther. 2018 Dec;17(12):2643-2653. doi: 10.1158/1535-7163.MCT-18-0696. Epub 2018 Sep 19.

PMID:
30232144
4.

N-(2-hydroxypropyl)methacrylamide polymer conjugated pyropheophorbide-a, a promising tumor-targeted theranostic probe for photodynamic therapy and imaging.

Fang J, Šubr V, Islam W, Hackbarth S, Islam R, Etrych T, Ulbrich K, Maeda H.

Eur J Pharm Biopharm. 2018 Sep;130:165-176. doi: 10.1016/j.ejpb.2018.06.005. Epub 2018 Jun 8.

PMID:
29885851
5.

Bloodstream Stability Predetermines the Antitumor Efficacy of Micellar Polymer-Doxorubicin Drug Conjugates with pH-Triggered Drug Release.

Chytil P, Šírová M, Kudláčová J, Říhová B, Ulbrich K, Etrych T.

Mol Pharm. 2018 Sep 4;15(9):3654-3663. doi: 10.1021/acs.molpharmaceut.8b00156. Epub 2018 Mar 21.

PMID:
29543465
6.

HPMA copolymer conjugate with pirarubicin: In vitro and ex vivo stability and drug release study.

Islam W, Fang J, Etrych T, Chytil P, Ulbrich K, Sakoguchi A, Kusakabe K, Maeda H.

Int J Pharm. 2018 Jan 30;536(1):108-115. doi: 10.1016/j.ijpharm.2017.11.011. Epub 2017 Nov 10.

PMID:
29133205
7.

HPMA Copolymer-Drug Conjugates with Controlled Tumor-Specific Drug Release.

Chytil P, Koziolová E, Etrych T, Ulbrich K.

Macromol Biosci. 2018 Jan;18(1). doi: 10.1002/mabi.201700209. Epub 2017 Aug 14. Review.

PMID:
28805040
8.

Overcoming multidrug resistance using folate receptor-targeted and pH-responsive polymeric nanogels containing covalently entrapped doxorubicin.

Chen Y, Tezcan O, Li D, Beztsinna N, Lou B, Etrych T, Ulbrich K, Metselaar JM, Lammers T, Hennink WE.

Nanoscale. 2017 Jul 27;9(29):10404-10419. doi: 10.1039/c7nr03592f.

PMID:
28702658
9.

Comparison of the pharmacological and biological properties of HPMA copolymer-pirarubicin conjugates: A single-chain copolymer conjugate and its biodegradable tandem-diblock copolymer conjugate.

Etrych T, Tsukigawa K, Nakamura H, Chytil P, Fang J, Ulbrich K, Otagiri M, Maeda H.

Eur J Pharm Sci. 2017 Aug 30;106:10-19. doi: 10.1016/j.ejps.2017.05.031. Epub 2017 May 18.

PMID:
28528285
10.

Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin.

Fang J, Liao L, Yin H, Nakamura H, Subr V, Ulbrich K, Maeda H.

Future Sci OA. 2015 Nov 1;1(3):FSO4. doi: 10.4155/fso.15.2. eCollection 2015 Nov.

11.

Pronounced Cellular Uptake of Pirarubicin versus That of Other Anthracyclines: Comparison of HPMA Copolymer Conjugates of Pirarubicin and Doxorubicin.

Nakamura H, Koziolová E, Chytil P, Tsukigawa K, Fang J, Haratake M, Ulbrich K, Etrych T, Maeda H.

Mol Pharm. 2016 Dec 5;13(12):4106-4115. Epub 2016 Nov 21.

PMID:
27934482
12.

Biodegradable Micellar HPMA-Based Polymer-Drug Conjugates with Betulinic Acid for Passive Tumor Targeting.

Lomkova EA, Chytil P, Janoušková O, Mueller T, Lucas H, Filippov SK, Trhlíková O, Aleshunin PA, Skorik YA, Ulbrich K, Etrych T.

Biomacromolecules. 2016 Nov 14;17(11):3493-3507. Epub 2016 Sep 30.

PMID:
27636143
13.

[Missile-Type Tumor-Targeting Polymer Drug, P-THP, Seeks Tumors via Three Different Steps Based on the EPR Effect].

Maeda H, Fang J, Ulbrich K, Etrych T, Nakamura H.

Gan To Kagaku Ryoho. 2016 May;43(5):549-57. Japanese.

PMID:
27210083
14.

Overcoming multidrug resistance in Dox-resistant neuroblastoma cell lines via treatment with HPMA copolymer conjugates containing anthracyclines and P-gp inhibitors.

Koziolová E, Janoušková O, Cuchalová L, Hvězdová Z, Hraběta J, Eckschlager T, Sivák L, Ulbrich K, Etrych T, Šubr V.

J Control Release. 2016 Jul 10;233:136-46. doi: 10.1016/j.jconrel.2016.05.036. Epub 2016 May 14.

PMID:
27189135
15.

Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies.

Ulbrich K, Holá K, Šubr V, Bakandritsos A, Tuček J, Zbořil R.

Chem Rev. 2016 May 11;116(9):5338-431. doi: 10.1021/acs.chemrev.5b00589. Epub 2016 Apr 25. Review.

PMID:
27109701
16.

Polymer inhibitors of ABC transporter overcoming multidrug resistance: Synthesis, characterization and in vitro evaluation.

Šubr V, Koziolová E, Sivák L, Říhová B, Kovář M, Ulbrich K.

J Control Release. 2015 Sep 10;213:e107-8. doi: 10.1016/j.jconrel.2015.05.180. Epub 2015 Aug 19. No abstract available.

PMID:
27005035
17.

Fluorescent boronate-based polymer nanoparticles with reactive oxygen species (ROS)-triggered cargo release for drug-delivery applications.

Jäger E, Höcherl A, Janoušková O, Jäger A, Hrubý M, Konefał R, Netopilik M, Pánek J, Šlouf M, Ulbrich K, Štěpánek P.

Nanoscale. 2016 Apr 7;8(13):6958-63. doi: 10.1039/c6nr00791k.

PMID:
26961769
18.

iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties.

Šácha P, Knedlík T, Schimer J, Tykvart J, Parolek J, Navrátil V, Dvořáková P, Sedlák F, Ulbrich K, Strohalm J, Majer P, Šubr V, Konvalinka J.

Angew Chem Int Ed Engl. 2016 Feb 12;55(7):2356-60. doi: 10.1002/anie.201508642. Epub 2016 Jan 8.

19.

The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia.

Tomalova B, Sirova M, Rossmann P, Pola R, Strohalm J, Chytil P, Cerny V, Tomala J, Kabesova M, Rihova B, Ulbrich K, Etrych T, Kovar M.

J Control Release. 2016 Feb 10;223:1-10. doi: 10.1016/j.jconrel.2015.12.023. Epub 2015 Dec 18.

PMID:
26708020
20.

Novel IL-2-Poly(HPMA)Nanoconjugate Based Immunotherapy.

Votavova P, Tomala J, Subr V, Strohalm J, Ulbrich K, Rihova B, Kovar M.

J Biomed Nanotechnol. 2015 Sep;11(9):1662-73.

PMID:
26485935
21.
22.

Nanotherapeutics shielded with a pH responsive polymeric layer.

Kostka L, Šubr V, Laga R, Chytil P, Ulbrich K, Seymour LW, Etrych T.

Physiol Res. 2015;64 Suppl 1:S29-40.

23.

Myocardial deformation by strain echocardiography identifies patients with acute coronary syndrome and non-diagnostic ECG presenting in a chest pain unit: a prospective study of diagnostic accuracy.

Schroeder J, Hamada S, Gründlinger N, Rubeau T, Altiok E, Ulbrich K, Keszei A, Marx N, Becker M.

Clin Res Cardiol. 2016 Mar;105(3):248-56. doi: 10.1007/s00392-015-0916-2. Epub 2015 Sep 8.

PMID:
26349786
24.

HPMA Copolymer-Conjugated Pirarubicin in Multimodal Treatment of a Patient with Stage IV Prostate Cancer and Extensive Lung and Bone Metastases.

Dozono H, Yanazume S, Nakamura H, Etrych T, Chytil P, Ulbrich K, Fang J, Arimura T, Douchi T, Kobayashi H, Ikoma M, Maeda H.

Target Oncol. 2016 Feb;11(1):101-6. doi: 10.1007/s11523-015-0379-4.

PMID:
26194363
25.

Thermoresponsive Polymer Micelles as Potential Nanosized Cancerostatics.

Laga R, Janoušková O, Ulbrich K, Pola R, Blažková J, Filippov SK, Etrych T, Pechar M.

Biomacromolecules. 2015 Aug 10;16(8):2493-505. doi: 10.1021/acs.biomac.5b00764. Epub 2015 Jul 16.

PMID:
26153904
26.

Increasing the density of nanomedicines improves their ultrasound-mediated delivery to tumours.

Mo S, Carlisle R, Laga R, Myers R, Graham S, Cawood R, Ulbrich K, Seymour L, Coussios CC.

J Control Release. 2015 Jul 28;210:10-8. doi: 10.1016/j.jconrel.2015.05.265. Epub 2015 May 12.

27.

Synthesis and Properties of Star HPMA Copolymer Nanocarriers Synthesised by RAFT Polymerisation Designed for Selective Anticancer Drug Delivery and Imaging.

Chytil P, Koziolová E, Janoušková O, Kostka L, Ulbrich K, Etrych T.

Macromol Biosci. 2015 Jun;15(6):839-50. doi: 10.1002/mabi.201400510. Epub 2015 Mar 2.

PMID:
25731143
28.

Multi-responsive polymer micelles as ellipticine delivery carriers for cancer therapy.

Studenovský M, Sedláček O, Hrubý M, Pánek J, Ulbrich K.

Anticancer Res. 2015 Feb;35(2):753-7.

PMID:
25667454
29.

Thermal stability, antioxidant, and anti-inflammatory activity of curcumin and its degradation product 4-vinyl guaiacol.

Esatbeyoglu T, Ulbrich K, Rehberg C, Rohn S, Rimbach G.

Food Funct. 2015 Mar;6(3):887-93. doi: 10.1039/c4fo00790e.

PMID:
25619943
30.

Comparison between linear and star-like HPMA conjugated pirarubicin (THP) in pharmacokinetics and antitumor activity in tumor bearing mice.

Nakamura H, Koziolová E, Etrych T, Chytil P, Fang J, Ulbrich K, Maeda H.

Eur J Pharm Biopharm. 2015 Feb;90:90-6. doi: 10.1016/j.ejpb.2014.10.007. Epub 2014 Nov 8.

PMID:
25460144
31.

Synthesis of poly[N-(2-hydroxypropyl)methacrylamide] conjugates of inhibitors of the ABC transporter that overcome multidrug resistance in doxorubicin-resistant P388 cells in vitro.

Subr V, Sivák L, Koziolová E, Braunová A, Pechar M, Strohalm J, Kabešová M, Ríhová B, Ulbrich K, Kovář M.

Biomacromolecules. 2014 Aug 11;15(8):3030-43. doi: 10.1021/bm500649q. Epub 2014 Jul 10.

PMID:
24978588
32.

Coiled coil peptides and polymer-peptide conjugates: synthesis, self-assembly, characterization and potential in drug delivery systems.

Pechar M, Pola R, Laga R, Braunová A, Filippov SK, Bogomolova A, Bednárová L, Vaněk O, Ulbrich K.

Biomacromolecules. 2014 Jul 14;15(7):2590-9. doi: 10.1021/bm500436p. Epub 2014 Jun 3.

PMID:
24857680
33.

Polymer conjugates of doxorubicin bound through an amide and hydrazone bond: Impact of the carrier structure onto synergistic action in the treatment of solid tumours.

Etrych T, Subr V, Laga R, Ríhová B, Ulbrich K.

Eur J Pharm Sci. 2014 Jul 16;58:1-12. doi: 10.1016/j.ejps.2014.02.016. Epub 2014 Mar 13.

PMID:
24632485
34.

Traceless bioresponsive shielding of adenovirus hexon with HPMA copolymers maintains transduction capacity in vitro and in vivo.

Prill JM, Subr V, Pasquarelli N, Engler T, Hoffmeister A, Kochanek S, Ulbrich K, Kreppel F.

PLoS One. 2014 Jan 27;9(1):e82716. doi: 10.1371/journal.pone.0082716. eCollection 2014.

35.

Passive versus active tumor targeting using RGD- and NGR-modified polymeric nanomedicines.

Kunjachan S, Pola R, Gremse F, Theek B, Ehling J, Moeckel D, Hermanns-Sachweh B, Pechar M, Ulbrich K, Hennink WE, Storm G, Lederle W, Kiessling F, Lammers T.

Nano Lett. 2014 Feb 12;14(2):972-81. doi: 10.1021/nl404391r. Epub 2014 Jan 17.

36.

Nanomedicines for inflammatory arthritis: head-to-head comparison of glucocorticoid-containing polymers, micelles, and liposomes.

Quan L, Zhang Y, Crielaard BJ, Dusad A, Lele SM, Rijcken CJF, Metselaar JM, Kostková H, Etrych T, Ulbrich K, Kiessling F, Mikuls TR, Hennink WE, Storm G, Lammers T, Wang D.

ACS Nano. 2014 Jan 28;8(1):458-466. doi: 10.1021/nn4048205. Epub 2013 Dec 27.

37.

Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage.

Nakamura H, Etrych T, Chytil P, Ohkubo M, Fang J, Ulbrich K, Maeda H.

J Control Release. 2014 Jan 28;174:81-7. doi: 10.1016/j.jconrel.2013.11.011. Epub 2013 Nov 21. Erratum in: J Control Release. 2014 May 28;182:97-8.

PMID:
24269967
38.

Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound.

Carlisle R, Choi J, Bazan-Peregrino M, Laga R, Subr V, Kostka L, Ulbrich K, Coussios CC, Seymour LW.

J Natl Cancer Inst. 2013 Nov 20;105(22):1701-10. doi: 10.1093/jnci/djt305. Epub 2013 Oct 29.

39.

HPMA copolymer-bound doxorubicin induces immunogenic tumor cell death.

Sirova M, Kabesova M, Kovar L, Etrych T, Strohalm J, Ulbrich K, Rihova B.

Curr Med Chem. 2013;20(38):4815-26.

PMID:
24083609
40.

Hydrolytically degradable polymer micelles for drug delivery: a SAXS/SANS kinetic study.

Filippov SK, Franklin JM, Konarev PV, Chytil P, Etrych T, Bogomolova A, Dyakonova M, Papadakis CM, Radulescu A, Ulbrich K, Stepanek P, Svergun DI.

Biomacromolecules. 2013 Nov 11;14(11):4061-70. doi: 10.1021/bm401186z. Epub 2013 Oct 25.

PMID:
24083567
41.

HPMA copolymer conjugates of DOX and mitomycin C for combination therapy: physicochemical characterization, cytotoxic effects, combination index analysis, and anti-tumor efficacy.

Kostková H, Etrych T, Ríhová B, Kostka L, Starovoytová L, Kovář M, Ulbrich K.

Macromol Biosci. 2013 Dec;13(12):1648-60. doi: 10.1002/mabi.201300288. Epub 2013 Sep 12.

PMID:
24031022
42.

Fine tuning of the pH-dependent drug release rate from polyHPMA-ellipticinium conjugates.

Sedláček O, Studenovský M, Větvička D, Ulbrich K, Hrubý M.

Bioorg Med Chem. 2013 Sep 15;21(18):5669-72. doi: 10.1016/j.bmc.2013.07.038. Epub 2013 Jul 27.

PMID:
23941688
43.

Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release II: impact of release rate on biodistribution.

Chytil P, Hoffmann S, Schindler L, Kostka L, Ulbrich K, Caysa H, Mueller T, Mäder K, Etrych T.

J Control Release. 2013 Dec 10;172(2):504-12. doi: 10.1016/j.jconrel.2013.05.008. Epub 2013 May 19.

PMID:
23697767
44.

Fine needle aspiration biopsy proves increased T-lymphocyte proliferation in tumor and decreased metastatic infiltration after treatment with doxorubicin bound to PHPMA copolymer carrier.

Betka J, Hovorka O, Boucek J, Ulbrich K, Etrych T, Rihova B.

J Drug Target. 2013 Aug;21(7):648-61. doi: 10.3109/1061186X.2013.792345. Epub 2013 Apr 26.

PMID:
23621109
45.

Enantioselective synthesis of 4-heterosubstituted cyclopentenones.

Ulbrich K, Kreitmeier P, Vilaivan T, Reiser O.

J Org Chem. 2013 Apr 19;78(8):4202-6. doi: 10.1021/jo400409f. Epub 2013 Apr 1.

PMID:
23544701
46.

Polymer therapeutics with a coiled coil motif targeted against murine bcl1 leukemia.

Pola R, Laga R, Ulbrich K, Sieglová I, Král V, Fábry M, Kabešová M, Kovář M, Pechar M.

Biomacromolecules. 2013 Mar 11;14(3):881-9. doi: 10.1021/bm3019592. Epub 2013 Feb 14.

PMID:
23373696
47.

Micelles of zinc protoporphyrin conjugated to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer for imaging and light-induced antitumor effects in vivo.

Nakamura H, Liao L, Hitaka Y, Tsukigawa K, Subr V, Fang J, Ulbrich K, Maeda H.

J Control Release. 2013 Feb 10;165(3):191-8. doi: 10.1016/j.jconrel.2012.11.017. Epub 2012 Dec 3.

PMID:
23220104
48.

Combination chemotherapy using core-shell nanoparticles through the self-assembly of HPMA-based copolymers and degradable polyester.

Jäger E, Jäger A, Chytil P, Etrych T, Ríhová B, Giacomelli FC, Stěpánek P, Ulbrich K.

J Control Release. 2013 Jan 28;165(2):153-61. doi: 10.1016/j.jconrel.2012.11.009. Epub 2012 Nov 23.

PMID:
23178950
49.

Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy.

Talelli M, Oliveira S, Rijcken CJ, Pieters EH, Etrych T, Ulbrich K, van Nostrum RC, Storm G, Hennink WE, Lammers T.

Biomaterials. 2013 Jan;34(4):1255-60. doi: 10.1016/j.biomaterials.2012.09.064. Epub 2012 Nov 2.

PMID:
23122804
50.

Polymer carriers for anticancer drugs targeted to EGF receptor.

Studenovsky M, Pola R, Pechar M, Etrych T, Ulbrich K, Kovar L, Kabesova M, Rihova B.

Macromol Biosci. 2012 Dec;12(12):1714-20. doi: 10.1002/mabi.201200270. Epub 2012 Oct 17.

PMID:
23077133

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