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Items: 12

1.

Liver safety evaluation of endothelin receptor antagonists using HepatoPac® : A single model impact assessment on hepatocellular health, function and bile acid disposition.

Aleo MD, Ukairo O, Moore A, Irrechukwu O, Potter DM, Schneider RP.

J Appl Toxicol. 2019 Aug;39(8):1192-1207. doi: 10.1002/jat.3805. Epub 2019 May 27.

PMID:
31134659
2.

Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans.

Atienzar FA, Blomme EA, Chen M, Hewitt P, Kenna JG, Labbe G, Moulin F, Pognan F, Roth AB, Suter-Dick L, Ukairo O, Weaver RJ, Will Y, Dambach DM.

Biomed Res Int. 2016;2016:9737920. Epub 2016 Sep 5. Review.

3.

Application of a Micropatterned Cocultured Hepatocyte System To Predict Preclinical and Human-Specific Drug Metabolism.

Ballard TE, Wang S, Cox LM, Moen MA, Krzyzewski S, Ukairo O, Obach RS.

Drug Metab Dispos. 2016 Feb;44(2):172-9. doi: 10.1124/dmd.115.066688. Epub 2015 Nov 25.

PMID:
26608083
4.

Establishment of a hepatocyte-kupffer cell coculture model for assessment of proinflammatory cytokine effects on metabolizing enzymes and drug transporters.

Nguyen TV, Ukairo O, Khetani SR, McVay M, Kanchagar C, Seghezzi W, Ayanoglu G, Irrechukwu O, Evers R.

Drug Metab Dispos. 2015 May;43(5):774-85. doi: 10.1124/dmd.114.061317. Epub 2015 Mar 4.

PMID:
25739975
5.

Bioactivation and toxicity of acetaminophen in a rat hepatocyte micropatterned coculture system.

Ukairo O, McVay M, Krzyzewski S, Aoyama S, Rose K, Andersen ME, Khetani SR, Lecluyse EL.

J Biochem Mol Toxicol. 2013 Oct;27(10):471-8. doi: 10.1002/jbt.21512. Epub 2013 Aug 5.

PMID:
23918466
6.

Long-term stability of primary rat hepatocytes in micropatterned cocultures.

Ukairo O, Kanchagar C, Moore A, Shi J, Gaffney J, Aoyama S, Rose K, Krzyzewski S, McGeehan J, Andersen ME, Khetani SR, Lecluyse EL.

J Biochem Mol Toxicol. 2013 Mar;27(3):204-12. doi: 10.1002/jbt.21469. Epub 2013 Jan 11.

PMID:
23315828
7.

Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans.

Khetani SR, Kanchagar C, Ukairo O, Krzyzewski S, Moore A, Shi J, Aoyama S, Aleo M, Will Y.

Toxicol Sci. 2013 Mar;132(1):107-17. doi: 10.1093/toxsci/kfs326. Epub 2012 Nov 14.

PMID:
23152190
8.

Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis.

Mnich SJ, Blanner PM, Hu LG, Shaffer AF, Happa FA, O'Neil S, Ukairo O, Weiss D, Welsh E, Storer C, Mbalaviele G, Ichijo H, Monahan JB, Hardy MM, Eda H.

Int Immunopharmacol. 2010 Oct;10(10):1170-6. doi: 10.1016/j.intimp.2010.06.023. Epub 2010 Jul 6.

PMID:
20609399
9.
11.
12.

Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter.

Wang W, Sonders MS, Ukairo OT, Scott H, Kloetzel MK, Surratt CK.

Mol Pharmacol. 2003 Aug;64(2):430-9.

PMID:
12869648

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