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Items: 47

1.

BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells.

Čančer M, Drews LF, Bengtsson J, Bolin S, Rosén G, Westermark B, Nelander S, Forsberg-Nilsson K, Uhrbom L, Weishaupt H, Swartling FJ.

Cell Death Dis. 2019 Nov 21;10(12):881. doi: 10.1038/s41419-019-2120-1.

2.

Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors.

Kaffes I, Szulzewsky F, Chen Z, Herting CJ, Gabanic B, Velázquez Vega JE, Shelton J, Switchenko JM, Ross JL, McSwain LF, Huse JT, Westermark B, Nelander S, Forsberg-Nilsson K, Uhrbom L, Maturi NP, Cimino PJ, Holland EC, Kettenmann H, Brennan CW, Brat DJ, Hambardzumyan D.

Oncoimmunology. 2019 Aug 22;8(11):e1655360. doi: 10.1080/2162402X.2019.1655360. eCollection 2019.

3.

Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity.

Wallmann T, Zhang XM, Wallerius M, Bolin S, Joly AL, Sobocki C, Leiss L, Jiang Y, Bergh J, Holland EC, Enger PØ, Andersson J, Swartling FJ, Miletic H, Uhrbom L, Harris RA, Rolny C.

iScience. 2018 Nov 30;9:71-83. doi: 10.1016/j.isci.2018.10.011. Epub 2018 Oct 16.

4.

LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients.

Xie Y, Sundström A, Maturi NP, Tan EJ, Marinescu VD, Jarvius M, Tirfing M, Jin C, Chen L, Essand M, Swartling FJ, Nelander S, Jiang Y, Uhrbom L.

J Pathol. 2019 Feb;247(2):228-240. doi: 10.1002/path.5186. Epub 2019 Jan 10.

PMID:
30357839
5.

Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells.

Caja L, Tzavlaki K, Dadras MS, Tan EJ, Hatem G, Maturi NP, Morén A, Wik L, Watanabe Y, Savary K, Kamali-Moghaddan M, Uhrbom L, Heldin CH, Moustakas A.

Oncogene. 2018 May;37(19):2515-2531. doi: 10.1038/s41388-018-0136-0. Epub 2018 Feb 16.

6.

Retraction Notice to: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule.

Kitambi SS, Toledo EM, Usoskin D, Wee S, Harisankar A, Svensson R, Sigmundsson K, Kalderén C, Niklasson M, Kundu S, Aranda S, Westermark B, Uhrbom L, Andäng M, Damberg P, Nelander S, Arenas E, Artursson P, Walfridsson J, Nilsson KF, Hammarström LGJ, Ernfors P.

Cell. 2017 Jul 13;170(2):407. doi: 10.1016/j.cell.2017.06.044. No abstract available.

7.

Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential.

Roy A, Libard S, Weishaupt H, Gustavsson I, Uhrbom L, Hesselager G, Swartling FJ, Pontén F, Alafuzoff I, Tchougounova E.

Front Oncol. 2017 Jun 2;7:115. doi: 10.3389/fonc.2017.00115. eCollection 2017.

8.

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin.

Jiang Y, Marinescu VD, Xie Y, Jarvius M, Maturi NP, Haglund C, Olofsson S, Lindberg N, Olofsson T, Leijonmarck C, Hesselager G, Alafuzoff I, Fryknäs M, Larsson R, Nelander S, Uhrbom L.

Cell Rep. 2017 May 2;19(5):1080-1081. doi: 10.1016/j.celrep.2017.04.053. No abstract available.

9.

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin.

Jiang Y, Marinescu VD, Xie Y, Jarvius M, Maturi NP, Haglund C, Olofsson S, Lindberg N, Olofsson T, Leijonmarck C, Hesselager G, Alafuzoff I, Fryknäs M, Larsson R, Nelander S, Uhrbom L.

Cell Rep. 2017 Jan 24;18(4):977-990. doi: 10.1016/j.celrep.2017.01.003. Erratum in: Cell Rep. 2017 May 2;19(5):1080-1081.

10.

Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype.

Sreedharan S, Maturi NP, Xie Y, Sundström A, Jarvius M, Libard S, Alafuzoff I, Weishaupt H, Fryknäs M, Larsson R, Swartling FJ, Uhrbom L.

Cancer Res. 2017 Feb 1;77(3):802-812. doi: 10.1158/0008-5472.CAN-16-2482. Epub 2016 Nov 15.

11.

Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses.

Niklasson M, Maddalo G, Sramkova Z, Mutlu E, Wee S, Sekyrova P, Schmidt L, Fritz N, Dehnisch I, Kyriatzis G, Krafcikova M, Carson BB, Feenstra JM, Marinescu VD, Segerman A, Haraldsson M, Gustavsson AL, Hammarström LG, Jenmalm Jensen A, Uhrbom L, Altelaar AF, Linnarsson S, Uhlén P, Trantirek L, Vincent CT, Nelander S, Enger PØ, Andäng M.

Cancer Res. 2017 Apr 1;77(7):1741-1752. doi: 10.1158/0008-5472.CAN-16-2274. Epub 2017 Jan 13.

12.

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition.

Segerman A, Niklasson M, Haglund C, Bergström T, Jarvius M, Xie Y, Westermark A, Sönmez D, Hermansson A, Kastemar M, Naimaie-Ali Z, Nyberg F, Berglund M, Sundström M, Hesselager G, Uhrbom L, Gustafsson M, Larsson R, Fryknäs M, Segerman B, Westermark B.

Cell Rep. 2016 Dec 13;17(11):2994-3009. doi: 10.1016/j.celrep.2016.11.056.

13.

Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells.

Zhang L, Laaniste L, Jiang Y, Alafuzoff I, Uhrbom L, Dimberg A.

Oncotarget. 2016 Dec 6;7(49):80382-80390. doi: 10.18632/oncotarget.12983.

14.

Case-specific potentiation of glioblastoma drugs by pterostilbene.

Schmidt L, Baskaran S, Johansson P, Padhan N, Matuszewski D, Green LC, Elfineh L, Wee S, Häggblad M, Martens U, Westermark B, Forsberg-Nilsson K, Uhrbom L, Claesson-Welsh L, Andäng M, Sintorn IM, Lundgren B, Lönnstedt I, Krona C, Nelander S.

Oncotarget. 2016 Nov 8;7(45):73200-73215. doi: 10.18632/oncotarget.12298.

15.

ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells.

Wee B, Pietras A, Ozawa T, Bazzoli E, Podlaha O, Antczak C, Westermark B, Nelander S, Uhrbom L, Forsberg-Nilsson K, Djaballah H, Michor F, Holland EC.

Sci Rep. 2016 Jul 26;6:25956. doi: 10.1038/srep25956.

16.

The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes.

Xie Y, Bergström T, Jiang Y, Johansson P, Marinescu VD, Lindberg N, Segerman A, Wicher G, Niklasson M, Baskaran S, Sreedharan S, Everlien I, Kastemar M, Hermansson A, Elfineh L, Libard S, Holland EC, Hesselager G, Alafuzoff I, Westermark B, Nelander S, Forsberg-Nilsson K, Uhrbom L.

EBioMedicine. 2015 Aug 15;2(10):1351-63. doi: 10.1016/j.ebiom.2015.08.026. eCollection 2015 Oct.

17.

Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells.

Roy A, Coum A, Marinescu VD, Põlajeva J, Smits A, Nelander S, Uhrbom L, Westermark B, Forsberg-Nilsson K, Pontén F, Tchougounova E.

Oncotarget. 2015 Sep 15;6(27):23647-61.

18.

Selective calcium sensitivity in immature glioma cancer stem cells.

Wee S, Niklasson M, Marinescu VD, Segerman A, Schmidt L, Hermansson A, Dirks P, Forsberg-Nilsson K, Westermark B, Uhrbom L, Linnarsson S, Nelander S, Andäng M.

PLoS One. 2014 Dec 22;9(12):e115698. doi: 10.1371/journal.pone.0115698. eCollection 2014.

19.

Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from human glioblastoma.

Babateen O, Jin Z, Bhandage A, Korol SV, Westermark B, Forsberg Nilsson K, Uhrbom L, Smits A, Birnir B.

Eur J Pharmacol. 2015 Feb 5;748:101-7. doi: 10.1016/j.ejphar.2014.12.001. Epub 2014 Dec 12.

PMID:
25510230
20.

Oncogenic signaling is dominant to cell of origin and dictates astrocytic or oligodendroglial tumor development from oligodendrocyte precursor cells.

Lindberg N, Jiang Y, Xie Y, Bolouri H, Kastemar M, Olofsson T, Holland EC, Uhrbom L.

J Neurosci. 2014 Oct 29;34(44):14644-51. doi: 10.1523/JNEUROSCI.2977-14.2014.

21.

RETRACTED: Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule.

Kitambi SS, Toledo EM, Usoskin D, Wee S, Harisankar A, Svensson R, Sigmundsson K, Kalderén C, Niklasson M, Kundu S, Aranda S, Westermark B, Uhrbom L, Andäng M, Damberg P, Nelander S, Arenas E, Artursson P, Walfridsson J, Forsberg Nilsson K, Hammarström LGJ, Ernfors P.

Cell. 2014 Apr 10;157(2):313-328. doi: 10.1016/j.cell.2014.02.021. Epub 2014 Mar 20. Retraction in: Cell. 2017 Jul 13;170(2):407.

22.

Comparative drug pair screening across multiple glioblastoma cell lines reveals novel drug-drug interactions.

Schmidt L, Kling T, Monsefi N, Olsson M, Hansson C, Baskaran S, Lundgren B, Martens U, Häggblad M, Westermark B, Forsberg Nilsson K, Uhrbom L, Karlsson-Lindahl L, Gerlee P, Nelander S.

Neuro Oncol. 2013 Nov;15(11):1469-78. doi: 10.1093/neuonc/not111. Epub 2013 Oct 6.

23.

Snail depletes the tumorigenic potential of glioblastoma.

Savary K, Caglayan D, Caja L, Tzavlaki K, Bin Nayeem S, Bergström T, Jiang Y, Uhrbom L, Forsberg-Nilsson K, Westermark B, Heldin CH, Ferletta M, Moustakas A.

Oncogene. 2013 Nov 21;32(47):5409-20. doi: 10.1038/onc.2013.67. Epub 2013 Mar 25.

24.

Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures.

Yu D, Jin C, Ramachandran M, Xu J, Nilsson B, Korsgren O, Le Blanc K, Uhrbom L, Forsberg-Nilsson K, Westermark B, Adamson R, Maitland N, Fan X, Essand M.

PLoS One. 2013;8(1):e54952. doi: 10.1371/journal.pone.0054952. Epub 2013 Jan 25.

25.

miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma.

Põlajeva J, Swartling FJ, Jiang Y, Singh U, Pietras K, Uhrbom L, Westermark B, Roswall P.

BMC Cancer. 2012 Aug 29;12:378. doi: 10.1186/1471-2407-12-378.

26.

On the origin of glioma.

Jiang Y, Uhrbom L.

Ups J Med Sci. 2012 May;117(2):113-21. doi: 10.3109/03009734.2012.658976. Epub 2012 Feb 21.

27.

Mast cell accumulation in glioblastoma with a potential role for stem cell factor and chemokine CXCL12.

Põlajeva J, Sjösten AM, Lager N, Kastemar M, Waern I, Alafuzoff I, Smits A, Westermark B, Pejler G, Uhrbom L, Tchougounova E.

PLoS One. 2011;6(9):e25222. doi: 10.1371/journal.pone.0025222. Epub 2011 Sep 19.

28.

RAD51 can inhibit PDGF-B-induced gliomagenesis and genomic instability.

Westermark UK, Lindberg N, Roswall P, Bråsäter D, Helgadottir HR, Hede SM, Zetterberg A, Jasin M, Nistér M, Uhrbom L.

Neuro Oncol. 2011 Dec;13(12):1277-87. doi: 10.1093/neuonc/nor131. Epub 2011 Sep 16.

29.

CGGBP1 regulates cell cycle in cancer cells.

Singh U, Roswall P, Uhrbom L, Westermark B.

BMC Mol Biol. 2011 Jul 7;12:28. doi: 10.1186/1471-2199-12-28.

31.

Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells.

Ferletta M, Caglayan D, Mokvist L, Jiang Y, Kastemar M, Uhrbom L, Westermark B.

Int J Cancer. 2011 Jul 1;129(1):45-60. doi: 10.1002/ijc.25647. Epub 2010 Nov 9.

32.

Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma.

Kärrlander M, Lindberg N, Olofsson T, Kastemar M, Olsson AK, Uhrbom L.

PLoS One. 2009 Dec 31;4(12):e8536. doi: 10.1371/journal.pone.0008536.

33.

IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas.

Moore LM, Holmes KM, Smith SM, Wu Y, Tchougounova E, Uhrbom L, Sawaya R, Bruner JM, Fuller GN, Zhang W.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16675-9. doi: 10.1073/pnas.0900807106. Epub 2009 Sep 16.

34.

Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma.

Lindberg N, Kastemar M, Olofsson T, Smits A, Uhrbom L.

Oncogene. 2009 Jun 11;28(23):2266-75. doi: 10.1038/onc.2009.76. Epub 2009 Apr 27.

PMID:
19421151
35.

Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence.

Tchougounova E, Jiang Y, Bråsäter D, Lindberg N, Kastemar M, Asplund A, Westermark B, Uhrbom L.

Oncogene. 2009 Mar 26;28(12):1537-48. doi: 10.1038/onc.2009.9. Epub 2009 Feb 16.

PMID:
19219070
36.

Sox10 has a broad expression pattern in gliomas and enhances platelet-derived growth factor-B--induced gliomagenesis.

Ferletta M, Uhrbom L, Olofsson T, Pontén F, Westermark B.

Mol Cancer Res. 2007 Sep;5(9):891-7.

37.

Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma.

Tchougounova E, Kastemar M, Bråsäter D, Holland EC, Westermark B, Uhrbom L.

Oncogene. 2007 Sep 20;26(43):6289-96. Epub 2007 Apr 16.

PMID:
17438529
38.

Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis.

Uhrbom L, Kastemar M, Johansson FK, Westermark B, Holland EC.

Cancer Res. 2005 Mar 15;65(6):2065-9.

39.

Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model.

Uhrbom L, Nerio E, Holland EC.

Nat Med. 2004 Nov;10(11):1257-60. Epub 2004 Oct 24.

PMID:
15502845
40.

Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging.

Johansson FK, Brodd J, Eklöf C, Ferletta M, Hesselager G, Tiger CF, Uhrbom L, Westermark B.

Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11334-7. Epub 2004 Jul 23.

41.
42.

p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3.

Wolf RM, Draghi N, Liang X, Dai C, Uhrbom L, Eklöf C, Westermark B, Holland EC, Resh MD.

Genes Dev. 2003 Feb 15;17(4):476-87.

43.
44.

Modeling gliomagenesis with somatic cell gene transfer using retroviral vectors.

Uhrbom L, Holland EC.

J Neurooncol. 2001 Jul;53(3):297-305. Review.

PMID:
11718262
45.

Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells.

Uhrbom L, Hesselager G, Ostman A, Nistér M, Westermark B.

Int J Cancer. 2000 Feb 1;85(3):398-406.

46.

Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus.

Uhrbom L, Hesselager G, Nistér M, Westermark B.

Cancer Res. 1998 Dec 1;58(23):5275-9.

47.

Induction of senescence in human malignant glioma cells by p16INK4A.

Uhrbom L, Nistér M, Westermark B.

Oncogene. 1997 Jul 31;15(5):505-14.

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