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Items: 17


UBTD1 is a mechano-regulator controlling cancer aggressiveness.

Torrino S, Roustan FR, Kaminski L, Bertero T, Pisano S, Ambrosetti D, Dufies M, Uhler JP, Lemichez E, Mettouchi A, Gesson M, Laurent K, Gaggioli C, Michiels JF, Lamaze C, Bost F, Clavel S.

EMBO Rep. 2019 Apr;20(4). pii: e46570. doi: 10.15252/embr.201846570. Epub 2019 Feb 25.


Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions.

Persson Ö, Muthukumar Y, Basu S, Jenninger L, Uhler JP, Berglund AK, McFarland R, Taylor RW, Gustafsson CM, Larsson E, Falkenberg M.

Nat Commun. 2019 Feb 15;10(1):759. doi: 10.1038/s41467-019-08673-5.


RNase H1 directs origin-specific initiation of DNA replication in human mitochondria.

Posse V, Al-Behadili A, Uhler JP, Clausen AR, Reyes A, Zeviani M, Falkenberg M, Gustafsson CM.

PLoS Genet. 2019 Jan 3;15(1):e1007781. doi: 10.1371/journal.pgen.1007781. eCollection 2019 Jan.


A two-nuclease pathway involving RNase H1 is required for primer removal at human mitochondrial OriL.

Al-Behadili A, Uhler JP, Berglund AK, Peter B, Doimo M, Reyes A, Wanrooij S, Zeviani M, Falkenberg M.

Nucleic Acids Res. 2018 Oct 12;46(18):9471-9483. doi: 10.1093/nar/gky708.


Identification of a G-quadruplex forming sequence in the promoter of UCP1.

Zhao Y, Uhler JP.

Acta Biochim Biophys Sin (Shanghai). 2018 Jul 1;50(7):718-722. doi: 10.1093/abbs/gmy059.


Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.

Matic S, Jiang M, Nicholls TJ, Uhler JP, Dirksen-Schwanenland C, Polosa PL, Simard ML, Li X, Atanassov I, Rackham O, Filipovska A, Stewart JB, Falkenberg M, Larsson NG, Milenkovic D.

Nat Commun. 2018 Mar 23;9(1):1202. doi: 10.1038/s41467-018-03552-x.


MGME1 processes flaps into ligatable nicks in concert with DNA polymerase γ during mtDNA replication.

Uhler JP, Thörn C, Nicholls TJ, Matic S, Milenkovic D, Gustafsson CM, Falkenberg M.

Nucleic Acids Res. 2016 Jul 8;44(12):5861-71. doi: 10.1093/nar/gkw468. Epub 2016 May 24.


Primer removal during mammalian mitochondrial DNA replication.

Uhler JP, Falkenberg M.

DNA Repair (Amst). 2015 Oct;34:28-38. doi: 10.1016/j.dnarep.2015.07.003. Epub 2015 Aug 12. Review.


Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element.

Jemt E, Persson Ö, Shi Y, Mehmedovic M, Uhler JP, Dávila López M, Freyer C, Gustafsson CM, Samuelsson T, Falkenberg M.

Nucleic Acids Res. 2015 Oct 30;43(19):9262-75. doi: 10.1093/nar/gkv804. Epub 2015 Aug 7.


The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication.

Macao B, Uhler JP, Siibak T, Zhu X, Shi Y, Sheng W, Olsson M, Stewart JB, Gustafsson CM, Falkenberg M.

Nat Commun. 2015 Jun 22;6:7303. doi: 10.1038/ncomms8303.


The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes.

Uhler JP, Spåhr H, Farge G, Clavel S, Larsson NG, Falkenberg M, Samuelsson T, Gustafsson CM.

Biochem Biophys Res Commun. 2014 Jan 3;443(1):7-12. doi: 10.1016/j.bbrc.2013.10.137. Epub 2013 Nov 6.


A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop.

Wanrooij PH, Uhler JP, Shi Y, Westerlund F, Falkenberg M, Gustafsson CM.

Nucleic Acids Res. 2012 Nov 1;40(20):10334-44. doi: 10.1093/nar/gks802. Epub 2012 Sep 10.


G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer formation.

Wanrooij PH, Uhler JP, Simonsson T, Falkenberg M, Gustafsson CM.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16072-7. doi: 10.1073/pnas.1006026107. Epub 2010 Aug 26.


Reversal of RNA polymerase II ubiquitylation by the ubiquitin protease Ubp3.

Kvint K, Uhler JP, Taschner MJ, Sigurdsson S, Erdjument-Bromage H, Tempst P, Svejstrup JQ.

Mol Cell. 2008 May 23;30(4):498-506. doi: 10.1016/j.molcel.2008.04.018.


A role for noncoding transcription in activation of the yeast PHO5 gene.

Uhler JP, Hertel C, Svejstrup JQ.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):8011-6. Epub 2007 Apr 30.


Altered electrical properties in Drosophila neurons developing without synaptic transmission.

Baines RA, Uhler JP, Thompson A, Sweeney ST, Bate M.

J Neurosci. 2001 Mar 1;21(5):1523-31.


Scandinavian studies in the United States.

Uhler JP.

Science. 1887 Jun 17;9(228S):599-600. No abstract available.


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