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Elevated Presepsin Is Associated With Perioperative Major Adverse Cardiovascular and Cerebrovascular Complications in Elevated-Risk Patients Undergoing Noncardiac Surgery: The Leukocytes and Cardiovascular Perioperative Events Study.

Handke J, Scholz AS, Gillmann HJ, Janssen H, Dehne S, Arens C, Kummer L, Uhle F, Weigand MA, Motsch J, Larmann J.

Anesth Analg. 2019 Jun;128(6):1344-1353. doi: 10.1213/ANE.0000000000003738.


Trauma-Induced Long-Term Alterations of Human T Cells and Monocytes-Results of an Explorative, Cross-Sectional Study.

Ruhrmann S, Schneck E, Markmann M, Zink J, Zajonz TS, Arens C, Uhle F, Sander M, Koch C.

Shock. 2019 Apr 14. doi: 10.1097/SHK.0000000000001358. [Epub ahead of print]


Monocyte HLA-DR Assessment by a Novel Point-of-Care Device Is Feasible for Early Identification of ICU Patients With Complicated Courses-A Proof-of-Principle Study.

Tamulyte S, Kopplin J, Brenner T, Weigand MA, Uhle F.

Front Immunol. 2019 Mar 12;10:432. doi: 10.3389/fimmu.2019.00432. eCollection 2019.


New approaches for the detection of invasive fungal diseases in patients following liver transplantation-results of an observational clinical pilot study.

Decker SO, Krüger A, Wilk H, Grumaz S, Vainshtein Y, Schmitt FCF, Uhle F, Bruckner T, Zimmermann S, Mehrabi A, Mieth M, Weiss KH, Weigand MA, Hofer S, Sohn K, Brenner T.

Langenbecks Arch Surg. 2019 May;404(3):309-325. doi: 10.1007/s00423-019-01769-y. Epub 2019 Mar 5.


Gut microbiome patterns correlate with higher postoperative complication rates after pancreatic surgery.

Schmitt FCF, Brenner T, Uhle F, Loesch S, Hackert T, Ulrich A, Hofer S, Dalpke AH, Weigand MA, Boutin S.

BMC Microbiol. 2019 Feb 18;19(1):42. doi: 10.1186/s12866-019-1399-5.


Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study.

Schmitt FCF, Manolov V, Morgenstern J, Fleming T, Heitmeier S, Uhle F, Al-Saeedi M, Hackert T, Bruckner T, Schöchl H, Weigand MA, Hofer S, Brenner T.

Ann Intensive Care. 2019 Jan 30;9(1):19. doi: 10.1186/s13613-019-0499-6.


Sepsis Induces a Long-Lasting State of Trained Immunity in Bone Marrow Monocytes.

Bomans K, Schenz J, Sztwiertnia I, Schaack D, Weigand MA, Uhle F.

Front Immunol. 2018 Nov 19;9:2685. doi: 10.3389/fimmu.2018.02685. eCollection 2018.


Sepsis in mechanically ventilated patients with spinal cord injury: a retrospective analysis.

Weiterer S, Frick S, Lichtenstern C, Hug A, Uhle F, Weigand MA, Hundt G, Siegler BH.

Spinal Cord. 2019 Apr;57(4):293-300. doi: 10.1038/s41393-018-0217-5. Epub 2018 Nov 9.


Impact of human sepsis on CCCTC-binding factor associated monocyte transcriptional response of Major Histocompatibility Complex II components.

Siegler BH, Uhle F, Lichtenstern C, Arens C, Bartkuhn M, Weigand MA, Weiterer S.

PLoS One. 2018 Sep 13;13(9):e0204168. doi: 10.1371/journal.pone.0204168. eCollection 2018.


Elevated Presepsin Is Associated With Perioperative Major Adverse Cardiovascular and Cerebrovascular Complications in Elevated-Risk Patients Undergoing Noncardiac Surgery: The Leukocytes and Cardiovascular Perioperative Events Study.

Handke J, Scholz AS, Gillmann HJ, Janssen H, Dehne S, Arens C, Kummer L, Uhle F, Weigand MA, Motsch J, Larmann J.

Anesth Analg. 2018 Sep 5. doi: 10.1213/ANE.0000000000003738. [Epub ahead of print]


Caspofungin Modulates Ryanodine Receptor-Mediated Calcium Release in Human Cardiac Myocytes.

Koch C, Jersch J, Schneck E, Edinger F, Maxeiner H, Uhle F, Weigand MA, Markmann M, Sander M, Henrich M.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01114-18. doi: 10.1128/AAC.01114-18. Print 2018 Nov.


Association of Immune Cell Subtypes and Phenotype With Subsequent Invasive Candidiasis in Patients With Abdominal Sepsis.

Arens C, Kramm T, Decker S, Spannenberger J, Brenner T, Richter DC, Weigand MA, Uhle F, Lichtenstern C.

Shock. 2019 Aug;52(2):191-197. doi: 10.1097/SHK.0000000000001251.


Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.

Jabaudon M, Blondonnet R, Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, Sapin V, Matthay MA, Constantin JM, Calfee CS.

Intensive Care Med. 2018 Sep;44(9):1388-1399. doi: 10.1007/s00134-018-5327-1. Epub 2018 Jul 26.


The Interplay of Notch Signaling and STAT3 in TLR-Activated Human Primary Monocytes.

Hildebrand D, Uhle F, Sahin D, Krauser U, Weigand MA, Heeg K.

Front Cell Infect Microbiol. 2018 Jul 10;8:241. doi: 10.3389/fcimb.2018.00241. eCollection 2018.


Paternal sepsis induces alterations of the sperm methylome and dampens offspring immune responses-an animal study.

Bomans K, Schenz J, Tamulyte S, Schaack D, Weigand MA, Uhle F.

Clin Epigenetics. 2018 Jun 28;10:89. doi: 10.1186/s13148-018-0522-z. eCollection 2018.


Implementation of the Sepsis-3 definition in German university intensive care units : A survey.

Keppler U, Schmoch T, Siegler BH, Weigand MA, Uhle F.

Anaesthesist. 2018 Sep;67(9):647-653. doi: 10.1007/s00101-018-0465-y. Epub 2018 Jun 26.


The immunosuppressive face of sepsis early on intensive care unit-A large-scale microarray meta-analysis.

Schaack D, Siegler BH, Tamulyte S, Weigand MA, Uhle F.

PLoS One. 2018 Jun 19;13(6):e0198555. doi: 10.1371/journal.pone.0198555. eCollection 2018.


From macrophage to osteoclast - How metabolism determines function and activity.

Kubatzky KF, Uhle F, Eigenbrod T.

Cytokine. 2018 Dec;112:102-115. doi: 10.1016/j.cyto.2018.06.013. Epub 2018 Jun 18.


Longitudinal Evaluation of Plasma Concentrations of Presepsin in Patients after Severe Trauma: A Prospective Observational Study.

Koch C, Ruhrmann S, Pöhlmann M, Schneck E, Arneth B, Zajonz T, Sander M, Weigand MA, Uhle F.

Surg Infect (Larchmt). 2018 Jul;19(5):480-487. doi: 10.1089/sur.2017.266. Epub 2018 Apr 23.


Cell cycle arrest and cell death correlate with the extent of ischaemia and reperfusion injury in patients following kidney transplantation - results of an observational pilot study.

Schmitt FCF, Salgado E, Friebe J, Schmoch T, Uhle F, Fleming T, Zemva J, Kihm L, Nusshag C, Morath C, Zeier M, Bruckner T, Mehrabi A, Nawroth PP, Weigand MA, Hofer S, Brenner T.

Transpl Int. 2018 Jul;31(7):751-760. doi: 10.1111/tri.13148. Epub 2018 Mar 30.


Ablation of the Right Cardiac Vagus Nerve Reduces Acetylcholine Content without Changing the Inflammatory Response during Endotoxemia.

Plaschke K, Do TQM, Uhle F, Brenner T, Weigand MA, Kopitz J.

Int J Mol Sci. 2018 Feb 1;19(2). pii: E442. doi: 10.3390/ijms19020442.


Changes in the microarchitecture of the pancreatic cancer stroma are linked to neutrophil-dependent reprogramming of stellate cells and reflected by diffusion-weighted magnetic resonance imaging.

Mayer P, Dinkic C, Jesenofsky R, Klauss M, Schirmacher P, Dapunt U, Hackert T, Uhle F, Hänsch GM, Gaida MM.

Theranostics. 2018 Jan 1;8(1):13-30. doi: 10.7150/thno.21089. eCollection 2018.


Inflammation and Its Consequences After Surgical Versus Transcatheter Aortic Valve Replacement.

Uhle F, Castrup C, Necaev AM, Grieshaber P, Lichtenstern C, Weigand MA, Böning A.

Artif Organs. 2018 Feb;42(2):E1-E12. doi: 10.1111/aor.13051. Epub 2017 Dec 11.


Data on microcirculatory parameters of GTS- 21 treated rats assessed by intravital microscopy.

Schmidt K, Bhakdisongkhram S, Uhle F, Philipsenburg C, Zivkovic AR, Brenner T, Motsch J, Weigand MA, Hofer S.

Data Brief. 2017 Sep 23;15:228-233. doi: 10.1016/j.dib.2017.09.045. eCollection 2017 Dec.


GTS-21 reduces microvascular permeability during experimental endotoxemia.

Schmidt K, Bhakdisongkhram S, Uhle F, Philipsenburg C, Zivkovic AR, Brenner T, Motsch J, Weigand MA, Hofer S.

Microvasc Res. 2018 Jan;115:75-82. doi: 10.1016/j.mvr.2017.08.002. Epub 2017 Aug 15.


Advanced glycation endproducts induce self- and cross-tolerance in monocytes.

Uhle F, Weiterer S, Siegler BH, Brenner T, Lichtenstern C, Weigand MA.

Inflamm Res. 2017 Nov;66(11):961-968. doi: 10.1007/s00011-017-1076-9. Epub 2017 Jun 28.


[New Sepsis-3 definition : Do we have to treat sepsis before we can diagnose it from now on?]

Schmoch T, Bernhard M, Uhle F, Gründling M, Brenner T, Weigand MA.

Anaesthesist. 2017 Aug;66(8):614-621. doi: 10.1007/s00101-017-0316-2. German.


Plasma DNA and RNA differentially impact coagulation during abdominal sepsis-an explorative study.

Schneck E, Samara O, Koch C, Hecker A, Padberg W, Lichtenstern C, Weigand MA, Uhle F.

J Surg Res. 2017 Apr;210:231-243. doi: 10.1016/j.jss.2016.11.044. Epub 2016 Nov 30.


Reduced future-oriented decision making in individuals with subjective cognitive decline: A functional MRI study.

Hu X, Uhle F, Fliessbach K, Wagner M, Han Y, Weber B, Jessen F.

Alzheimers Dement (Amst). 2017 Mar 14;6:222-231. doi: 10.1016/j.dadm.2017.02.005. eCollection 2017.


The Glyoxalase System and Methylglyoxal-Derived Carbonyl Stress in Sepsis: Glycotoxic Aspects of Sepsis Pathophysiology.

Schmoch T, Uhle F, Siegler BH, Fleming T, Morgenstern J, Nawroth PP, Weigand MA, Brenner T.

Int J Mol Sci. 2017 Mar 17;18(3). pii: E657. doi: 10.3390/ijms18030657. Review.


Pathogenic, immunologic, and clinical aspects of sepsis - update 2016.

Uhle F, Chousterman BG, Grützmann R, Brenner T, Weber GF.

Expert Rev Anti Infect Ther. 2016 Oct;14(10):917-27. doi: 10.1080/14787210.2016.1224971. Epub 2016 Sep 1. Review.


Soluble TREM-1 as a diagnostic and prognostic biomarker in patients with septic shock: an observational clinical study.

Brenner T, Uhle F, Fleming T, Wieland M, Schmoch T, Schmitt F, Schmidt K, Zivkovic AR, Bruckner T, Weigand MA, Hofer S.

Biomarkers. 2017 Feb;22(1):63-69. doi: 10.1080/1354750X.2016.1204005. Epub 2016 Jul 6.


Why a second look might be worth it: immuno-modulatory therapies in the critically ill patient.

Siegler BH, Brenner T, Uhle F, Weiterer S, Weigand MA, Hofer S.

J Thorac Dis. 2016 Jun;8(6):E424-30. doi: 10.21037/jtd.2016.04.37.


RAGE-mediated inflammation in patients with septic shock.

Hofer S, Uhle F, Fleming T, Hell C, Schmoch T, Bruckner T, Weigand MA, Brenner T.

J Surg Res. 2016 May 15;202(2):315-27. doi: 10.1016/j.jss.2016.01.019. Epub 2016 Jan 20.


Sepsis-induced long-term immune paralysis--results of a descriptive, explorative study.

Arens C, Bajwa SA, Koch C, Siegler BH, Schneck E, Hecker A, Weiterer S, Lichtenstern C, Weigand MA, Uhle F.

Crit Care. 2016 Feb 29;20:93. doi: 10.1186/s13054-016-1233-5.


NDRG2 and NDRG4 Expression Is Altered in Glioblastoma and Influences Survival in Patients with MGMT-methylated Tumors.

Kolodziej MA, Weischer C, Reinges MH, Uhl E, Weigand MA, Schwarm FP, Schänzer A, Acker T, Quint K, Uhle F, Stein M.

Anticancer Res. 2016 Mar;36(3):887-97.


High-mobility group AT-hook protein 2 expression and its prognostic significance in MGMT methylated and unmethylated glioblastoma.

Schwarm FP, Uhle F, Schänzer A, Acker T, Stein M, Reinges MH, Weischer C, Weigand MA, Uhl E, Kolodziej MA.

Int J Oncol. 2016 Apr;48(4):1485-92. doi: 10.3892/ijo.2016.3397. Epub 2016 Feb 17.


Role of the RAGE Axis during the Immune Response after Severe Trauma: A Prospective Pilot Study.

Uhle F, Lichtenstern C, Brenner T, Fleming T, Koch C, Hecker A, Heiss C, Nawroth PP, Hofer S, Weigand MA, Weismüller K.

Mediators Inflamm. 2015;2015:691491. doi: 10.1155/2015/691491. Epub 2015 Dec 31.


Galactomannan and Zymosan Block the Epinephrine-Induced Particle Transport in Tracheal Epithelium.

Weiterer S, Kohlen T, Veit F, Sachs L, Uhle F, Lichtenstern C, Weigand MA, Henrich M.

PLoS One. 2015 Nov 16;10(11):e0143163. doi: 10.1371/journal.pone.0143163. eCollection 2015.


Cardiac Effects of Echinocandins in Endotoxemic Rats.

Koch C, Wolff M, Henrich M, Weigand MA, Lichtenstern C, Uhle F.

Antimicrob Agents Chemother. 2015 Oct 26;60(1):301-6. doi: 10.1128/AAC.01766-15. Print 2016 Jan.


Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?

Kojic D, Siegler BH, Uhle F, Lichtenstern C, Nawroth PP, Weigand MA, Hofer S, Brenner T.

World J Exp Med. 2015 May 20;5(2):50-63. doi: 10.5493/wjem.v5.i2.50. eCollection 2015 May 20. Review.


Sepsis induces specific changes in histone modification patterns in human monocytes.

Weiterer S, Uhle F, Lichtenstern C, Siegler BH, Bhuju S, Jarek M, Bartkuhn M, Weigand MA.

PLoS One. 2015 Mar 20;10(3):e0121748. doi: 10.1371/journal.pone.0121748. eCollection 2015.


Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis.

Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, Zönnchen T, Rahbari NN, Schölch S, Klotzsche-von Ameln A, Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, Weissleder R, Swirski FK.

Science. 2015 Mar 13;347(6227):1260-5. doi: 10.1126/science.aaa4268.


Prospective evaluation of regional oxygen saturation to estimate central venous saturation in sepsis.

Koch C, Röhrig R, Monz T, Hecker A, Uhle F, Schneck E, Weigand MA, Lichtenstern C.

J Clin Monit Comput. 2015 Aug;29(4):443-53. doi: 10.1007/s10877-015-9683-x. Epub 2015 Mar 11.


[Pathophysiology of sepsis].

Uhle F, Lichtenstern C, Brenner T, Weigand MA.

Anasthesiol Intensivmed Notfallmed Schmerzther. 2015 Feb;50(2):114-22. doi: 10.1055/s-0041-100391. Epub 2015 Feb 27. Review. German.


Cardiac effects of echinocandins after central venous administration in adult rats.

Koch C, Uhle F, Wolff M, Arens C, Schulte A, Li L, Niemann B, Henrich M, Rohrbach S, Weigand MA, Lichtenstern C.

Antimicrob Agents Chemother. 2015 Mar;59(3):1612-9. doi: 10.1128/AAC.04446-14. Epub 2014 Dec 29.


Methylglyoxal as a new biomarker in patients with septic shock: an observational clinical study.

Brenner T, Fleming T, Uhle F, Silaff S, Schmitt F, Salgado E, Ulrich A, Zimmermann S, Bruckner T, Martin E, Bierhaus A, Nawroth PP, Weigand MA, Hofer S.

Crit Care. 2014 Dec 12;18(6):683. doi: 10.1186/s13054-014-0683-x.


[Epigenetic regulation in sepsis : current state of knowledge].

Weiterer S, Uhle F, Siegler BH, Lichtenstern C, Bartkuhn M, Weigand MA.

Anaesthesist. 2015 Jan;64(1):42-55. doi: 10.1007/s00101-014-2402-z. Review. German.


Sepsis varies arterial two-pore-domain potassium channel messenger RNA in mice.

Bieling F, Uhle F, Weissmüller K, Weigand MA, Henrich M.

J Surg Res. 2015 Feb;193(2):816-24. doi: 10.1016/j.jss.2014.08.020. Epub 2014 Aug 21.


Plasmatic isoforms of cytokeratin 18 and RAGE after severe trauma: a longitudinal cohort study.

Uhle F, Nouland Dv, Little S, Menges T, Weiterer S, Szalay G, Franke J, Schnettler R, Weigand MA, Lichtenstern C.

J Trauma Acute Care Surg. 2014 Oct;77(4):577-84. doi: 10.1097/TA.0000000000000376.


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