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Items: 23

1.

The microRNA-29/PGC1α regulatory axis is critical for metabolic control of cardiac function.

Caravia XM, Fanjul V, Oliver E, Roiz-Valle D, Morán-Álvarez A, Desdín-Micó G, Mittelbrunn M, Cabo R, Vega JA, Rodríguez F, Fueyo A, Gómez M, Lobo-González M, Bueno H, Velasco G, Freije JMP, Andrés V, Ibáñez B, Ugalde AP, López-Otín C.

PLoS Biol. 2018 Oct 22;16(10):e2006247. doi: 10.1371/journal.pbio.2006247. eCollection 2018 Oct.

2.

Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence.

Han R, Li L, Ugalde AP, Tal A, Manber Z, Barbera EP, Chiara VD, Elkon R, Agami R.

Genome Biol. 2018 Aug 17;19(1):118. doi: 10.1186/s13059-018-1494-1.

3.

LncRNA-OIS1 regulates DPP4 activation to modulate senescence induced by RAS.

Li L, van Breugel PC, Loayza-Puch F, Ugalde AP, Korkmaz G, Messika-Gold N, Han R, Lopes R, Barbera EP, Teunissen H, de Wit E, Soares RJ, Nielsen BS, Holmstrøm K, Martínez-Herrera DJ, Huarte M, Louloupi A, Drost J, Elkon R, Agami R.

Nucleic Acids Res. 2018 May 4;46(8):4213-4227. doi: 10.1093/nar/gky087.

4.

Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair.

Gavish-Izakson M, Velpula BB, Elkon R, Prados-Carvajal R, Barnabas GD, Ugalde AP, Agami R, Geiger T, Huertas P, Ziv Y, Shiloh Y.

Nucleic Acids Res. 2018 Jan 25;46(2):730-747. doi: 10.1093/nar/gkx1240.

5.

TGFβ1-induced leucine limitation uncovered by differential ribosome codon reading.

Loayza-Puch F, Rooijers K, Zijlstra J, Moumbeini B, Zaal EA, Oude Vrielink JF, Lopes R, Ugalde AP, Berkers CR, Agami R.

EMBO Rep. 2017 Apr;18(4):549-557. doi: 10.15252/embr.201744000. Epub 2017 Mar 8.

6.

3'UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells.

Hoffman Y, Bublik DR, Ugalde AP, Elkon R, Biniashvili T, Agami R, Oren M, Pilpel Y.

PLoS Genet. 2016 Feb 23;12(2):e1005879. doi: 10.1371/journal.pgen.1005879. eCollection 2016 Feb. Erratum in: PLoS Genet. 2016 Aug;12(8):e1006254.

7.

Tumour-specific proline vulnerability uncovered by differential ribosome codon reading.

Loayza-Puch F, Rooijers K, Buil LC, Zijlstra J, Oude Vrielink JF, Lopes R, Ugalde AP, van Breugel P, Hofland I, Wesseling J, van Tellingen O, Bex A, Agami R.

Nature. 2016 Feb 25;530(7591):490-4. doi: 10.1038/nature16982. Epub 2016 Feb 15.

PMID:
26878238
8.

Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9.

Korkmaz G, Lopes R, Ugalde AP, Nevedomskaya E, Han R, Myacheva K, Zwart W, Elkon R, Agami R.

Nat Biotechnol. 2016 Feb;34(2):192-8. doi: 10.1038/nbt.3450. Epub 2016 Jan 11.

PMID:
26751173
9.

Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3'-End Formation in the Failing Human Heart.

Creemers EE, Bawazeer A, Ugalde AP, van Deutekom HW, van der Made I, de Groot NE, Adriaens ME, Cook SA, Bezzina CR, Hubner N, van der Velden J, Elkon R, Agami R, Pinto YM.

Circ Res. 2016 Feb 5;118(3):433-8. doi: 10.1161/CIRCRESAHA.115.307082. Epub 2015 Dec 15. Erratum in: Circ Res. 2016 Oct 14;119(9):e139.

PMID:
26671978
10.

The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland.

Llobet-Navas D, Rodríguez-Barrueco R, Castro V, Ugalde AP, Sumazin P, Jacob-Sendler D, Demircan B, Castillo-Martín M, Putcha P, Marshall N, Villagrasa P, Chan J, Sanchez-Garcia F, Pe'er D, Rabadán R, Iavarone A, Cordón-Cardó C, Califano A, López-Otín C, Ezhkova E, Silva JM.

Genes Dev. 2014 Apr 1;28(7):765-82. doi: 10.1101/gad.237404.114. Epub 2014 Mar 17.

11.

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.

de la Rosa J, Freije JM, Cabanillas R, Osorio FG, Fraga MF, Fernández-García MS, Rad R, Fanjul V, Ugalde AP, Liang Q, Prosser HM, Bradley A, Cadiñanos J, López-Otín C.

Nat Commun. 2013;4:2268. doi: 10.1038/ncomms3268.

12.

Alternative cleavage and polyadenylation: extent, regulation and function.

Elkon R, Ugalde AP, Agami R.

Nat Rev Genet. 2013 Jul;14(7):496-506. doi: 10.1038/nrg3482. Review.

PMID:
23774734
13.

Cell autonomous and systemic factors in progeria development.

Osorio FG, Ugalde AP, Mariño G, Puente XS, Freije JM, López-Otín C.

Biochem Soc Trans. 2011 Dec;39(6):1710-4. doi: 10.1042/BST20110677. Review.

PMID:
22103512
14.

Micromanaging aging with miRNAs: new messages from the nuclear envelope.

Ugalde AP, Español Y, López-Otín C.

Nucleus. 2011 Nov-Dec;2(6):549-55. doi: 10.4161/nucl.2.6.17986. Epub 2011 Nov 1. Review.

PMID:
22064465
15.

Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53.

Ugalde AP, Ramsay AJ, de la Rosa J, Varela I, Mariño G, Cadiñanos J, Lu J, Freije JM, López-Otín C.

EMBO J. 2011 Jun 1;30(11):2219-32. doi: 10.1038/emboj.2011.124. Epub 2011 Apr 26.

16.

Rejuvenating somatotropic signaling: a therapeutical opportunity for premature aging?

Ugalde AP, Mariño G, López-Otín C.

Aging (Albany NY). 2010 Dec;2(12):1017-22.

17.

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function.

Mariño G, Ugalde AP, Fernández AF, Osorio FG, Fueyo A, Freije JM, López-Otín C.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16268-73. doi: 10.1073/pnas.1002696107. Epub 2010 Aug 30.

18.

Metalloproteases and the degradome.

Ugalde AP, Ordóñez GR, Quirós PM, Puente XS, López-Otín C.

Methods Mol Biol. 2010;622:3-29. doi: 10.1007/978-1-60327-299-5_1.

PMID:
20135273
19.

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

Varela I, Pereira S, Ugalde AP, Navarro CL, Suárez MF, Cau P, Cadiñanos J, Osorio FG, Foray N, Cobo J, de Carlos F, Lévy N, Freije JM, López-Otín C.

Nat Med. 2008 Jul;14(7):767-72. doi: 10.1038/nm1786. Epub 2008 Jun 29.

PMID:
18587406
20.

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

Mariño G, Ugalde AP, Salvador-Montoliu N, Varela I, Quirós PM, Cadiñanos J, van der Pluijm I, Freije JM, López-Otín C.

Hum Mol Genet. 2008 Jul 15;17(14):2196-211. doi: 10.1093/hmg/ddn120. Epub 2008 Apr 28.

PMID:
18443001
21.

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice.

Espada J, Varela I, Flores I, Ugalde AP, Cadiñanos J, Pendás AM, Stewart CL, Tryggvason K, Blasco MA, Freije JM, López-Otín C.

J Cell Biol. 2008 Apr 7;181(1):27-35. doi: 10.1083/jcb.200801096. Epub 2008 Mar 31.

22.

Identification and characterization of human archaemetzincin-1 and -2, two novel members of a family of metalloproteases widely distributed in Archaea.

Díaz-Perales A, Quesada V, Peinado JR, Ugalde AP, Alvarez J, Suárez MF, Gomis-Rüth FX, López-Otín C.

J Biol Chem. 2005 Aug 26;280(34):30367-75. Epub 2005 Jun 22.

23.

Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase.

Díaz-Perales A, Quesada V, Sánchez LM, Ugalde AP, Suárez MF, Fueyo A, López-Otín C.

J Biol Chem. 2005 Apr 8;280(14):14310-7. Epub 2005 Feb 1.

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