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Items: 43


Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle.

Fukuda S, Kaneshige A, Kaji T, Noguchi YT, Takemoto Y, Zhang L, Tsujikawa K, Kokubo H, Uezumi A, Maehara K, Harada A, Ohkawa Y, Fukada SI.

Elife. 2019 Sep 23;8. pii: e48284. doi: 10.7554/eLife.48284.


Expression and Functional Analyses of Dlk1 in Muscle Stem Cells and Mesenchymal Progenitors during Muscle Regeneration.

Zhang L, Uezumi A, Kaji T, Tsujikawa K, Andersen DC, Jensen CH, Fukada SI.

Int J Mol Sci. 2019 Jul 3;20(13). pii: E3269. doi: 10.3390/ijms20133269.


Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites.

Noguchi YT, Nakamura M, Hino N, Nogami J, Tsuji S, Sato T, Zhang L, Tsujikawa K, Tanaka T, Izawa K, Okada Y, Doi T, Kokubo H, Harada A, Uezumi A, Gessler M, Ohkawa Y, Fukada SI.

Development. 2019 Feb 20;146(4). pii: dev163618. doi: 10.1242/dev.163618.


Myogenin promoter-associated lncRNA Myoparr is essential for myogenic differentiation.

Hitachi K, Nakatani M, Takasaki A, Ouchi Y, Uezumi A, Ageta H, Inagaki H, Kurahashi H, Tsuchida K.

EMBO Rep. 2019 Mar;20(3). pii: e47468. doi: 10.15252/embr.201847468. Epub 2019 Jan 8.


UBL3 modification influences protein sorting to small extracellular vesicles.

Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K, Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K.

Nat Commun. 2018 Sep 26;9(1):3936. doi: 10.1038/s41467-018-06197-y.


Tbx1 regulates inherited metabolic and myogenic abilities of progenitor cells derived from slow- and fast-type muscle.

Motohashi N, Uezumi A, Asakura A, Ikemoto-Uezumi M, Mori S, Mizunoe Y, Takashima R, Miyagoe-Suzuki Y, Takeda S, Shigemoto K.

Cell Death Differ. 2019 Jun;26(6):1024-1036. doi: 10.1038/s41418-018-0186-4. Epub 2018 Aug 28.


Implication of basal lamina dependency in survival of Nrf2-null muscle stem cells via an antioxidative-independent mechanism.

Takemoto Y, Inaba S, Zhang L, Tsujikawa K, Uezumi A, Fukada SI.

J Cell Physiol. 2019 Feb;234(2):1689-1698. doi: 10.1002/jcp.27040. Epub 2018 Aug 2.


Disuse Atrophy Accompanied by Intramuscular Ectopic Adipogenesis in Vastus Medialis Muscle of Advanced Osteoarthritis Patients.

Ikemoto-Uezumi M, Matsui Y, Hasegawa M, Fujita R, Kanayama Y, Uezumi A, Watanabe T, Harada A, Poole AR, Hashimoto N.

Am J Pathol. 2017 Dec;187(12):2674-2685. doi: 10.1016/j.ajpath.2017.08.009. Epub 2017 Sep 15.


Promethazine Hydrochloride Inhibits Ectopic Fat Cell Formation in Skeletal Muscle.

Kasai T, Nakatani M, Ishiguro N, Ohno K, Yamamoto N, Morita M, Yamada H, Tsuchida K, Uezumi A.

Am J Pathol. 2017 Dec;187(12):2627-2634. doi: 10.1016/j.ajpath.2017.08.008. Epub 2017 Sep 15.


Gm7325 is MyoD-dependently expressed in activated muscle satellite cells.

Takei D, Nishi M, Fukada S, Doi M, Okamura H, Uezumi A, Zhang L, Yoshida M, Miyazato M, Ichimura A, Takeshima H.

Biomed Res. 2017;38(3):215-219. doi: 10.2220/biomedres.38.215.


Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity.

Sakai H, Fukuda S, Nakamura M, Uezumi A, Noguchi YT, Sato T, Morita M, Yamada H, Tsuchida K, Tajbakhsh S, Fukada SI.

PLoS One. 2017 May 12;12(5):e0177516. doi: 10.1371/journal.pone.0177516. eCollection 2017.


Aging and sarcopenia.

Tsuchida K, Uezumi A.

Nihon Rinsho. 2016 Sep;74(9):1554-1559. Japanese.


Cell-Surface Protein Profiling Identifies Distinctive Markers of Progenitor Cells in Human Skeletal Muscle.

Uezumi A, Nakatani M, Ikemoto-Uezumi M, Yamamoto N, Morita M, Yamaguchi A, Yamada H, Kasai T, Masuda S, Narita A, Miyagoe-Suzuki Y, Takeda S, Fukada S, Nishino I, Tsuchida K.

Stem Cell Reports. 2016 Aug 9;7(2):263-78. doi: 10.1016/j.stemcr.2016.07.004.


Identification, Isolation, and Characterization of Mesenchymal Progenitors in Mouse and Human Skeletal Muscle.

Uezumi A, Kasai T, Tsuchida K.

Methods Mol Biol. 2016;1460:241-53. doi: 10.1007/978-1-4939-3810-0_17.


Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche.

Yamaguchi M, Watanabe Y, Ohtani T, Uezumi A, Mikami N, Nakamura M, Sato T, Ikawa M, Hoshino M, Tsuchida K, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H, Fukada S.

Cell Rep. 2015 Oct 13;13(2):302-14. doi: 10.1016/j.celrep.2015.08.083. Epub 2015 Oct 1.


Evidence of Notch-Hesr-Nrf2 Axis in Muscle Stem Cells, but Absence of Nrf2 Has No Effect on Their Quiescent and Undifferentiated State.

Yamaguchi M, Murakami S, Yoneda T, Nakamura M, Zhang L, Uezumi A, Fukuda S, Kokubo H, Tsujikawa K, Fukada S.

PLoS One. 2015 Sep 29;10(9):e0138517. doi: 10.1371/journal.pone.0138517. eCollection 2015.


Pro-Insulin-Like Growth Factor-II Ameliorates Age-Related Inefficient Regenerative Response by Orchestrating Self-Reinforcement Mechanism of Muscle Regeneration.

Ikemoto-Uezumi M, Uezumi A, Tsuchida K, Fukada S, Yamamoto H, Yamamoto N, Shiomi K, Hashimoto N.

Stem Cells. 2015 Aug;33(8):2456-68. doi: 10.1002/stem.2045. Epub 2015 May 26.


Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration.

Ogawa R, Ma Y, Yamaguchi M, Ito T, Watanabe Y, Ohtani T, Murakami S, Uchida S, De Gaspari P, Uezumi A, Nakamura M, Miyagoe-Suzuki Y, Tsujikawa K, Hashimoto N, Braun T, Tanaka T, Takeda S, Yamamoto H, Fukada S.

Development. 2015 Feb 15;142(4):810. doi: 10.1242/dev.122317. No abstract available.


Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration.

Ogawa R, Ma Y, Yamaguchi M, Ito T, Watanabe Y, Ohtani T, Murakami S, Uchida S, De Gaspari P, Uezumi A, Nakamura M, Miyagoe-Suzuki Y, Tsujikawa K, Hashimoto N, Braun T, Tanaka T, Takeda S, Yamamoto H, Fukada S.

Development. 2015 Jan 1;142(1):51-61. doi: 10.1242/dev.112557. Epub 2014 Dec 5. Erratum in: Development. 2015 Feb 15;142(4):810.


Adult stem cell and mesenchymal progenitor theories of aging.

Fukada S, Ma Y, Uezumi A.

Front Cell Dev Biol. 2014 Mar 28;2:10. doi: 10.3389/fcell.2014.00010. eCollection 2014. Review.


Identification and characterization of PDGFRĪ±+ mesenchymal progenitors in human skeletal muscle.

Uezumi A, Fukada S, Yamamoto N, Ikemoto-Uezumi M, Nakatani M, Morita M, Yamaguchi A, Yamada H, Nishino I, Hamada Y, Tsuchida K.

Cell Death Dis. 2014 Apr 17;5:e1186. doi: 10.1038/cddis.2014.161.


Roles of nonmyogenic mesenchymal progenitors in pathogenesis and regeneration of skeletal muscle.

Uezumi A, Ikemoto-Uezumi M, Tsuchida K.

Front Physiol. 2014 Feb 24;5:68. doi: 10.3389/fphys.2014.00068. eCollection 2014. Review.


Osteogenic differentiation capacity of human skeletal muscle-derived progenitor cells.

Oishi T, Uezumi A, Kanaji A, Yamamoto N, Yamaguchi A, Yamada H, Tsuchida K.

PLoS One. 2013;8(2):e56641. doi: 10.1371/journal.pone.0056641. Epub 2013 Feb 14.


Imatinib attenuates severe mouse dystrophy and inhibits proliferation and fibrosis-marker expression in muscle mesenchymal progenitors.

Ito T, Ogawa R, Uezumi A, Ohtani T, Watanabe Y, Tsujikawa K, Miyagoe-Suzuki Y, Takeda S, Yamamoto H, Fukada S.

Neuromuscul Disord. 2013 Apr;23(4):349-56. doi: 10.1016/j.nmd.2012.10.025. Epub 2013 Jan 10.


Calcitonin receptor and Odz4 are differently expressed in Pax7-positive cells during skeletal muscle regeneration.

Yamaguchi M, Ogawa R, Watanabe Y, Uezumi A, Miyagoe-Suzuki Y, Tsujikawa K, Yamamoto H, Takeda S, Fukada S.

J Mol Histol. 2012 Oct;43(5):581-7. doi: 10.1007/s10735-012-9421-3. Epub 2012 May 5.


Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle.

Uezumi A, Ito T, Morikawa D, Shimizu N, Yoneda T, Segawa M, Yamaguchi M, Ogawa R, Matev MM, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Tsuchida K, Yamamoto H, Fukada S.

J Cell Sci. 2011 Nov 1;124(Pt 21):3654-64. doi: 10.1242/jcs.086629. Epub 2011 Nov 1.


Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.

Fukada S, Yamaguchi M, Kokubo H, Ogawa R, Uezumi A, Yoneda T, Matev MM, Motohashi N, Ito T, Zolkiewska A, Johnson RL, Saga Y, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H.

Development. 2011 Nov;138(21):4609-19. doi: 10.1242/dev.067165.


Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle.

Uezumi A, Fukada S, Yamamoto N, Takeda S, Tsuchida K.

Nat Cell Biol. 2010 Feb;12(2):143-52. doi: 10.1038/ncb2014. Epub 2010 Jan 17.


Activin signaling as an emerging target for therapeutic interventions.

Tsuchida K, Nakatani M, Hitachi K, Uezumi A, Sunada Y, Ageta H, Inokuchi K.

Cell Commun Signal. 2009 Jun 18;7:15. doi: 10.1186/1478-811X-7-15.


Suppression of macrophage functions impairs skeletal muscle regeneration with severe fibrosis.

Segawa M, Fukada S, Yamamoto Y, Yahagi H, Kanematsu M, Sato M, Ito T, Uezumi A, Hayashi S, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Yamamoto H.

Exp Cell Res. 2008 Oct 15;314(17):3232-44. doi: 10.1016/j.yexcr.2008.08.008. Epub 2008 Aug 22.


Muscle CD31(-) CD45(-) side population cells promote muscle regeneration by stimulating proliferation and migration of myoblasts.

Motohashi N, Uezumi A, Yada E, Fukada S, Fukushima K, Imaizumi K, Miyagoe-Suzuki Y, Takeda S.

Am J Pathol. 2008 Sep;173(3):781-91. doi: 10.2353/ajpath.2008.070902. Epub 2008 Jul 31.


CD90-positive cells, an additional cell population, produce laminin alpha2 upon transplantation to dy(3k)/dy(3k) mice.

Fukada S, Yamamoto Y, Segawa M, Sakamoto K, Nakajima M, Sato M, Morikawa D, Uezumi A, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Yamamoto H.

Exp Cell Res. 2008 Jan 1;314(1):193-203. Epub 2007 Oct 3.


Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice.

Nakatani M, Takehara Y, Sugino H, Matsumoto M, Hashimoto O, Hasegawa Y, Murakami T, Uezumi A, Takeda S, Noji S, Sunada Y, Tsuchida K.

FASEB J. 2008 Feb;22(2):477-87. Epub 2007 Sep 24.


Signal transduction pathway through activin receptors as a therapeutic target of musculoskeletal diseases and cancer.

Tsuchida K, Nakatani M, Uezumi A, Murakami T, Cui X.

Endocr J. 2008 Mar;55(1):11-21. Epub 2007 Sep 14. Review.


NO production results in suspension-induced muscle atrophy through dislocation of neuronal NOS.

Suzuki N, Motohashi N, Uezumi A, Fukada S, Yoshimura T, Itoyama Y, Aoki M, Miyagoe-Suzuki Y, Takeda S.

J Clin Invest. 2007 Sep;117(9):2468-76.


Autologous transplantation of SM/C-2.6(+) satellite cells transduced with micro-dystrophin CS1 cDNA by lentiviral vector into mdx mice.

Ikemoto M, Fukada S, Uezumi A, Masuda S, Miyoshi H, Yamamoto H, Wada MR, Masubuchi N, Miyagoe-Suzuki Y, Takeda S.

Mol Ther. 2007 Dec;15(12):2178-85. Epub 2007 Aug 28.


Molecular signature of quiescent satellite cells in adult skeletal muscle.

Fukada S, Uezumi A, Ikemoto M, Masuda S, Segawa M, Tanimura N, Yamamoto H, Miyagoe-Suzuki Y, Takeda S.

Stem Cells. 2007 Oct;25(10):2448-59. Epub 2007 Jun 28.


Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo.

Oyama T, Nagai T, Wada H, Naito AT, Matsuura K, Iwanaga K, Takahashi T, Goto M, Mikami Y, Yasuda N, Akazawa H, Uezumi A, Takeda S, Komuro I.

J Cell Biol. 2007 Jan 29;176(3):329-41.


Inhibitors of the TGF-beta superfamily and their clinical applications.

Tsuchida K, Sunada Y, Noji S, Murakami T, Uezumi A, Nakatani M.

Mini Rev Med Chem. 2006 Nov;6(11):1255-61. Review.


Functional heterogeneity of side population cells in skeletal muscle.

Uezumi A, Ojima K, Fukada S, Ikemoto M, Masuda S, Miyagoe-Suzuki Y, Takeda S.

Biochem Biophys Res Commun. 2006 Mar 17;341(3):864-73. Epub 2006 Jan 23.


Participation of bone marrow-derived cells in fibrotic changes in denervated skeletal muscle.

Mochizuki Y, Ojima K, Uezumi A, Masuda S, Yoshimura K, Takeda S.

Am J Pathol. 2005 Jun;166(6):1721-32.


Mac-1(low) early myeloid cells in the bone marrow-derived SP fraction migrate into injured skeletal muscle and participate in muscle regeneration.

Ojima K, Uezumi A, Miyoshi H, Masuda S, Morita Y, Fukase A, Hattori A, Nakauchi H, Miyagoe-Suzuki Y, Takeda S.

Biochem Biophys Res Commun. 2004 Sep 3;321(4):1050-61.


Purification and cell-surface marker characterization of quiescent satellite cells from murine skeletal muscle by a novel monoclonal antibody.

Fukada S, Higuchi S, Segawa M, Koda K, Yamamoto Y, Tsujikawa K, Kohama Y, Uezumi A, Imamura M, Miyagoe-Suzuki Y, Takeda S, Yamamoto H.

Exp Cell Res. 2004 Jun 10;296(2):245-55.


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