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Items: 1 to 50 of 176

1.

The skin as a metabolic and immune-competent organ: implications fordrug-induced skin rash.

Sharma A, Saito Y, Hung SI, Naisbitt D, Uetrecht J, Bussiere J.

J Immunotoxicol. 2018 Oct 14:1-12. doi: 10.1080/1547691X.2018.1514444. [Epub ahead of print]

PMID:
30318948
2.

Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?

Kenna JG, Uetrecht J.

Drug Metab Dispos. 2018 Nov;46(11):1658-1669. doi: 10.1124/dmd.118.082719. Epub 2018 Jul 18.

PMID:
30021844
3.

The Effects of Immune Modulators on Amodiaquine-Induced Liver Injury.

Mak A, Cho TE, Uetrecht J.

Chem Res Toxicol. 2018 Aug 20;31(8):739-744. doi: 10.1021/acs.chemrestox.8b00091. Epub 2018 Jul 10.

PMID:
29938495
4.

Use of an animal model to test whether non-alcoholic fatty liver disease increases the risk of idiosyncratic drug-induced liver injury.

Mak A, Cho T, Uetrecht J.

J Immunotoxicol. 2018 Dec;15(1):90-95. doi: 10.1080/1547691X.2018.1467982.

PMID:
29733743
5.

Nevirapine-induced liver lipid-SER inclusions and other ultrastructural aberrations.

Sastry J, Mohammed H, Campos MM, Uetrecht J, Abu-Asab M.

Ultrastruct Pathol. 2018 Mar-Apr;42(2):108-115. doi: 10.1080/01913123.2017.1422831. Epub 2018 Feb 9.

PMID:
29424579
6.

Editor's Highlight: An Impaired Immune Tolerance Animal Model Distinguishes the Potential of Troglitazone/Pioglitazone and Tolcapone/Entacapone to Cause IDILI.

Mak A, Kato R, Weston K, Hayes A, Uetrecht J.

Toxicol Sci. 2018 Feb 1;161(2):412-420. doi: 10.1093/toxsci/kfx219.

PMID:
29087505
7.

Dose-dependent acute liver injury with hypersensitivity features in humans due to a novel microsomal prostaglandin E synthase 1 inhibitor.

Jin Y, Regev A, Kam J, Phipps K, Smith C, Henck J, Campanale K, Hu L, Hall DG, Yang XY, Nakano M, McNearney TA, Uetrecht J, Landschulz W.

Br J Clin Pharmacol. 2018 Jan;84(1):179-188. doi: 10.1111/bcp.13423. Epub 2017 Oct 8.

PMID:
28865237
8.

Supernatant from Hepatocyte Cultures with Drugs That Cause Idiosyncratic Liver Injury Activates Macrophage Inflammasomes.

Kato R, Uetrecht J.

Chem Res Toxicol. 2017 Jun 19;30(6):1327-1332. doi: 10.1021/acs.chemrestox.7b00065. Epub 2017 Jun 2.

PMID:
28525267
9.

Effects of immunization and checkpoint inhibition on amodiaquine-induced liver injury.

Mak A, Johnston A, Uetrecht J.

J Immunotoxicol. 2017 Dec;14(1):89-94. doi: 10.1080/1547691X.2017.1290716.

PMID:
28279082
10.

How Reactive Metabolites Induce an Immune Response That Sometimes Leads to an Idiosyncratic Drug Reaction.

Cho T, Uetrecht J.

Chem Res Toxicol. 2017 Jan 17;30(1):295-314. doi: 10.1021/acs.chemrestox.6b00357. Epub 2016 Nov 8. Review.

PMID:
27775332
11.

Exploring an animal model of amodiaquine-induced liver injury in rats and mice.

Liu F, Cai P, Metushi I, Li J, Nakayawa T, Vega L, Uetrecht J.

J Immunotoxicol. 2016 Sep;13(5):694-712. doi: 10.3109/1547691X.2016.1166167. Epub 2016 Jul 14.

PMID:
27416278
12.

Deferiprone-induced agranulocytosis: 20 years of clinical observations.

Tricta F, Uetrecht J, Galanello R, Connelly J, Rozova A, Spino M, Palmblad J.

Am J Hematol. 2016 Oct;91(10):1026-31. doi: 10.1002/ajh.24479. Epub 2016 Aug 4.

13.

Protein Targets of Isoniazid-Reactive Metabolites in Mouse Liver in Vivo.

Koen YM, Galeva NA, Metushi IG, Uetrecht J, Hanzlik RP.

Chem Res Toxicol. 2016 Jun 20;29(6):1064-72. doi: 10.1021/acs.chemrestox.6b00098. Epub 2016 May 5.

PMID:
27097313
14.

Mechanism of isoniazid-induced hepatotoxicity: then and now.

Metushi I, Uetrecht J, Phillips E.

Br J Clin Pharmacol. 2016 Jun;81(6):1030-6. doi: 10.1111/bcp.12885. Epub 2016 Feb 25. Review.

15.

The Combination of Anti-CTLA-4 and PD1-/- Mice Unmasks the Potential of Isoniazid and Nevirapine To Cause Liver Injury.

Mak A, Uetrecht J.

Chem Res Toxicol. 2015 Dec 21;28(12):2287-91. doi: 10.1021/acs.chemrestox.5b00305. Epub 2015 Nov 20.

16.

The Role of CD8 T Cells in Amodiaquine-Induced Liver Injury in PD1-/- Mice Cotreated with Anti-CTLA-4.

Mak A, Uetrecht J.

Chem Res Toxicol. 2015 Aug 17;28(8):1567-73. doi: 10.1021/acs.chemrestox.5b00137. Epub 2015 Jul 15.

PMID:
26154582
17.

Inhibition of immune tolerance unmasks drug-induced allergic hepatitis.

Uetrecht J, Kaplowitz N.

Hepatology. 2015 Aug;62(2):346-8. doi: 10.1002/hep.27824. Epub 2015 Apr 22. No abstract available.

PMID:
25833746
18.

Immunization with amodiaquine-modified hepatic proteins prevents amodiaquine-induced liver injury.

Mak A, Uetrecht J.

J Immunotoxicol. 2015;12(4):361-7. doi: 10.3109/1547691X.2014.983660. Epub 2014 Nov 26.

PMID:
25425471
19.

Current understanding of the mechanisms of idiosyncratic drug-induced agranulocytosis.

Johnston A, Uetrecht J.

Expert Opin Drug Metab Toxicol. 2015 Feb;11(2):243-57. doi: 10.1517/17425255.2015.985649. Epub 2014 Nov 26. Review.

PMID:
25424130
20.

Treatment of PD-1(-/-) mice with amodiaquine and anti-CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients.

Metushi IG, Hayes MA, Uetrecht J.

Hepatology. 2015 Apr;61(4):1332-42. doi: 10.1002/hep.27549. Epub 2015 Feb 23.

PMID:
25283142
21.

Development of a novel mouse model of amodiaquine-induced liver injury with a delayed onset.

Metushi IG, Cai P, Dervovic D, Liu F, Lobach A, Nakagawa T, Uetrecht J.

J Immunotoxicol. 2015 Jul-Sep;12(3):247-60. doi: 10.3109/1547691X.2014.934977. Epub 2014 Jul 21.

PMID:
25046026
22.

Clozapine promotes the proliferation of granulocyte progenitors in the bone marrow leading to increased granulopoiesis and neutrophilia in rats.

Lobach AR, Uetrecht J.

Chem Res Toxicol. 2014 Jul 21;27(7):1109-19. doi: 10.1021/tx500184c. Epub 2014 Jul 8.

PMID:
24968143
23.

Effect of clozapine and olanzapine on neutrophil kinetics: implications for drug-induced agranulocytosis.

Ng W, Kennar R, Uetrecht J.

Chem Res Toxicol. 2014 Jul 21;27(7):1104-8. doi: 10.1021/tx500183x. Epub 2014 Jul 8.

PMID:
24968069
24.

Activation of inflammasomes by agents causing idiosyncratic skin reactions: a possible biomarker.

Weston JK, Uetrecht J.

Chem Res Toxicol. 2014 Jun 16;27(6):949-51. doi: 10.1021/tx5001333. Epub 2014 Jun 2.

PMID:
24877608
25.

IgG3 is the dominant subtype of anti-isoniazid antibodies in patients with isoniazid-induced liver failure.

Metushi IG, Lee WM, Uetrecht J.

Chem Res Toxicol. 2014 May 19;27(5):738-40. doi: 10.1021/tx500108u. Epub 2014 May 2.

PMID:
24786179
26.

D-penicillamine-induced granulomatous hepatitis in brown Norway rats.

Metushi IG, Zhu X, Uetrecht J.

Mol Cell Biochem. 2014 Aug;393(1-2):229-35. doi: 10.1007/s11010-014-2065-8. Epub 2014 Apr 27.

PMID:
24771069
27.

Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing.

Shuhendler AJ, Pu K, Cui L, Uetrecht JP, Rao J.

Nat Biotechnol. 2014 Apr;32(4):373-80. doi: 10.1038/nbt.2838. Epub 2014 Mar 23.

28.

Paradoxical attenuation of autoimmune hepatitis by oral isoniazid in wild-type and N-acetyltransferase-deficient mice.

Metushi IG, Cai P, Vega L, Grant DM, Uetrecht J.

Drug Metab Dispos. 2014 Jun;42(6):963-73. doi: 10.1124/dmd.113.056622. Epub 2014 Mar 12.

29.

Involvement of myeloperoxidase and NADPH oxidase in the covalent binding of amodiaquine and clozapine to neutrophils: implications for drug-induced agranulocytosis.

Lobach AR, Uetrecht J.

Chem Res Toxicol. 2014 Apr 21;27(4):699-709. doi: 10.1021/tx500019u. Epub 2014 Mar 17.

PMID:
24588327
30.

Mild isoniazid-induced liver injury in humans is associated with an increase in Th17 cells and T cells producing IL-10.

Metushi IG, Zhu X, Chen X, Gardam MA, Uetrecht J.

Chem Res Toxicol. 2014 Apr 21;27(4):683-9. doi: 10.1021/tx500013z. Epub 2014 Mar 6.

PMID:
24564876
31.

Hepatic effects of aminoglutethimide: a model aromatic amine.

Ng W, Metushi IG, Uetrecht J.

J Immunotoxicol. 2015 Jan-Mar;12(1):24-32. doi: 10.3109/1547691X.2013.867912. Epub 2013 Dec 19.

PMID:
24350727
32.

Isoniazid-induced liver injury and immune response in mice.

Metushi IG, Uetrecht J.

J Immunotoxicol. 2014 Oct;11(4):383-92. doi: 10.3109/1547691X.2013.860644. Epub 2013 Dec 4.

PMID:
24303880
33.

Bioactivation of drugs in the skin: relationship to cutaneous adverse drug reactions.

Sharma AM, Uetrecht J.

Drug Metab Rev. 2014 Feb;46(1):1-18. doi: 10.3109/03602532.2013.848214. Epub 2013 Oct 29. Review.

PMID:
24164504
34.

Lack of liver injury in Wistar rats treated with the combination of isoniazid and rifampicin.

Metushi IG, Uetrecht J.

Mol Cell Biochem. 2014 Feb;387(1-2):9-17. doi: 10.1007/s11010-013-1864-7. Epub 2013 Oct 23.

PMID:
24150712
35.

Identification of danger signals in nevirapine-induced skin rash.

Zhang X, Sharma AM, Uetrecht J.

Chem Res Toxicol. 2013 Sep 16;26(9):1378-83. doi: 10.1021/tx400232s. Epub 2013 Aug 30.

PMID:
23947594
36.

Effect of aminoglutethimide on neutrophils in rats: implications for idiosyncratic drug-induced blood dyscrasias.

Ng W, Uetrecht J.

Chem Res Toxicol. 2013 Aug 19;26(8):1272-81. doi: 10.1021/tx400224j. Epub 2013 Aug 9.

PMID:
23889370
37.

Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure.

Metushi IG, Sanders C; Acute Liver Study Group, Lee WM, Uetrecht J.

Hepatology. 2014 Mar;59(3):1084-93. doi: 10.1002/hep.26564. Epub 2014 Jan 27.

38.

12-OH-nevirapine sulfate, formed in the skin, is responsible for nevirapine-induced skin rash.

Sharma AM, Novalen M, Tanino T, Uetrecht JP.

Chem Res Toxicol. 2013 May 20;26(5):817-27. doi: 10.1021/tx400098z. Epub 2013 May 3.

PMID:
23590230
39.

Idiosyncratic adverse drug reactions: current concepts.

Uetrecht J, Naisbitt DJ.

Pharmacol Rev. 2013 Mar 8;65(2):779-808. doi: 10.1124/pr.113.007450. Print 2013 Apr. Review.

40.

Nevirapine bioactivation and covalent binding in the skin.

Sharma AM, Klarskov K, Uetrecht J.

Chem Res Toxicol. 2013 Mar 18;26(3):410-21. doi: 10.1021/tx3004938. Epub 2013 Feb 25.

PMID:
23387501
41.

A novel T(H)17-type cell is rapidly increased in the liver in response to acetaminophen-induced liver injury: T(H)17 cells and the innate immune response.

Zhu X, Uetrecht J.

J Immunotoxicol. 2013 Jul-Sep;10(3):287-91. doi: 10.3109/1547691X.2012.724730. Epub 2012 Oct 8.

PMID:
23039944
42.

Direct oxidation and covalent binding of isoniazid to rodent liver and human hepatic microsomes: humans are more like mice than rats.

Metushi IG, Nakagawa T, Uetrecht J.

Chem Res Toxicol. 2012 Nov 19;25(11):2567-76. doi: 10.1021/tx300341r. Epub 2012 Oct 16.

43.

Changes in gene expression induced by aromatic amine drugs: testing the danger hypothesis.

Ng W, Uetrecht J.

J Immunotoxicol. 2013 Apr-Jun;10(2):178-91. doi: 10.3109/1547691X.2012.707699. Epub 2012 Sep 12.

PMID:
22970684
44.

Bioactivation of nevirapine to a reactive quinone methide: implications for liver injury.

Sharma AM, Li Y, Novalen M, Hayes MA, Uetrecht J.

Chem Res Toxicol. 2012 Aug 20;25(8):1708-19. doi: 10.1021/tx300172s. Epub 2012 Jul 26.

45.

Animal models of idiosyncratic drug reactions.

Ng W, Lobach AR, Zhu X, Chen X, Liu F, Metushi IG, Sharma A, Li J, Cai P, Ip J, Novalen M, Popovic M, Zhang X, Tanino T, Nakagawa T, Li Y, Uetrecht J.

Adv Pharmacol. 2012;63:81-135. doi: 10.1016/B978-0-12-398339-8.00003-3. Review.

PMID:
22776640
46.

A fresh look at the mechanism of isoniazid-induced hepatotoxicity.

Metushi IG, Cai P, Zhu X, Nakagawa T, Uetrecht JP.

Clin Pharmacol Ther. 2011 Jun;89(6):911-4. doi: 10.1038/clpt.2010.355. Epub 2011 Mar 16. Review. No abstract available.

PMID:
21412230
47.

Involvement of T helper 17 cells in D-penicillamine-induced autoimmune disease in Brown Norway rats.

Zhu X, Li J, Liu F, Uetrecht JP.

Toxicol Sci. 2011 Apr;120(2):331-8. doi: 10.1093/toxsci/kfq392. Epub 2011 Jan 12.

PMID:
21227906
48.

Involvement of the immune system in idiosyncratic drug reactions.

Zhang X, Liu F, Chen X, Zhu X, Uetrecht J.

Drug Metab Pharmacokinet. 2011;26(1):47-59. Epub 2010 Nov 12. Review. Erratum in: Drug Metab Pharmacokinet. 2011 Sep;26(4):440. Zhang, Xiachu [corrected to Zhang, Xiaochu].

49.

Effect of clozapine on neutrophil kinetics in rabbits.

Iverson S, Kautiainen A, Ip J, Uetrecht JP.

Chem Res Toxicol. 2010 Jul 19;23(7):1184-91. doi: 10.1021/tx100035k.

PMID:
20553052
50.

Mechanisms of immune-mediated liver injury.

Adams DH, Ju C, Ramaiah SK, Uetrecht J, Jaeschke H.

Toxicol Sci. 2010 Jun;115(2):307-21. doi: 10.1093/toxsci/kfq009. Epub 2010 Jan 13. Review.

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