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[Clinical Utility of Comprehensive Genome Profiling Using FoundationOne CDx in Japanese Population(PROFILE-F Study)].

Kumaki Y, Takahashi K, Mitsumura T, Yokobori J, Takamine E, Ishibashi E, Sakashita H, Ishikawa T, Ono H, Ban D, Kudo A, Oshima N, Nakagawa T, Kimura K, Kubota K, Onishi I, Tanabe M, Uetake H, Miyake S, Ikeda S.

Gan To Kagaku Ryoho. 2019 Nov;46(11):1715-1719. Japanese.


Colorectal cancer risk factors in asymptomatic Chilean population: a survey of international collaboration between Japan and Chile.

Okada T, Odagaki T, López-Köstner F, Zárate AJ, Ponce A, Kronberg U, Karelovic S, Flores S, Estela R, Ito T, Yasuno M, Uetake H, Kojima K, Kitagawa M.

Eur J Cancer Prev. 2019 Aug 20. doi: 10.1097/CEJ.0000000000000531. [Epub ahead of print]


Uncovering Potential Therapeutic Targets in Colorectal Cancer by Deciphering Mutational Status and Expression of Druggable Oncogenes.

Menyhart O, Kakisaka T, Pongor LS, Uetake H, Goel A, Győrffy B.

Cancers (Basel). 2019 Jul 14;11(7). pii: E983. doi: 10.3390/cancers11070983.


Randomised phase II trial of mFOLFOX6 plus bevacizumab versus mFOLFOX6 plus cetuximab as first-line treatment for colorectal liver metastasis (ATOM trial).

Oki E, Emi Y, Yamanaka T, Uetake H, Muro K, Takahashi T, Nagasaka T, Hatano E, Ojima H, Manaka D, Kusumoto T, Katayose Y, Fujiwara T, Yoshida K, Unno M, Hyodo I, Tomita N, Sugihara K, Maehara Y.

Br J Cancer. 2019 Jul;121(3):222-229. doi: 10.1038/s41416-019-0518-2. Epub 2019 Jul 9.


Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer.

Hashiguchi Y, Muro K, Saito Y, Ito Y, Ajioka Y, Hamaguchi T, Hasegawa K, Hotta K, Ishida H, Ishiguro M, Ishihara S, Kanemitsu Y, Kinugasa Y, Murofushi K, Nakajima TE, Oka S, Tanaka T, Taniguchi H, Tsuji A, Uehara K, Ueno H, Yamanaka T, Yamazaki K, Yoshida M, Yoshino T, Itabashi M, Sakamaki K, Sano K, Shimada Y, Tanaka S, Uetake H, Yamaguchi S, Yamaguchi N, Kobayashi H, Matsuda K, Kotake K, Sugihara K; Japanese Society for Cancer of the Colon and Rectum.

Int J Clin Oncol. 2019 Jun 15. doi: 10.1007/s10147-019-01485-z. [Epub ahead of print]


Prospective Multicenter Study on the Prognostic and Predictive Impact of Tumor Budding in Stage II Colon Cancer: Results From the SACURA Trial.

Ueno H, Ishiguro M, Nakatani E, Ishikawa T, Uetake H, Matsuda C, Nakamoto Y, Kotake M, Kurachi K, Egawa T, Yasumasa K, Murata K, Ikawa O, Shinji S, Murotani K, Matsui S, Teramukai S, Tomita N, Sugihara K; SACURA Study Group.

J Clin Oncol. 2019 Aug 1;37(22):1886-1894. doi: 10.1200/JCO.18.02059. Epub 2019 Jun 10.


Cancer stem cell-associated miRNAs serve as prognostic biomarkers in colorectal cancer.

Toden S, Kunitoshi S, Cardenas J, Gu J, Hutchins E, Van Keuren-Jensen K, Uetake H, Toiyama Y, Goel A.

JCI Insight. 2019 Mar 21;4(6). pii: 125294. doi: 10.1172/jci.insight.125294. eCollection 2019 Mar 21.


Assessment of the Severity of Ischaemia and the Outcomes of Revascularisation in Peripheral Arterial Disease Patients Based on the Skin Microcirculatory Response to a Thermal Load Test.

Yamamoto Y, Inoue Y, Igari K, Toyofuku T, Kudo T, Uetake H.

EJVES Short Rep. 2019 Feb 1;42:21-25. doi: 10.1016/j.ejvssr.2018.12.003. eCollection 2019.


Transcriptomic expression profiling identifies ITGBL1, an epithelial to mesenchymal transition (EMT)-associated gene, is a promising recurrence prediction biomarker in colorectal cancer.

Matsuyama T, Ishikawa T, Takahashi N, Yamada Y, Yasuno M, Kawano T, Uetake H, Goel A.

Mol Cancer. 2019 Feb 4;18(1):19. doi: 10.1186/s12943-019-0945-y.


[Two Cases of Rectal Cancer with Pelvic Local Recurrence Complicated with Sepsis after Rectal Cancer Surgery Successfully Treated with Radiation Therapy].

Takaoka A, Ishikawa T, Sasaki M, Orita F, Miura T, Kikuchi A, Yamauchi S, Matsuyama T, Ishiguro M, Yasuno M, Nakajima Y, Kojima K, Uetake H, Kinugasa Y.

Gan To Kagaku Ryoho. 2018 Dec;45(13):2078-2080. Japanese.


Need and demand for nutritional counselling and their association with quality of life, nutritional status and eating-related distress among patients with cancer receiving outpatient chemotherapy: a cross-sectional study.

Koshimoto S, Arimoto M, Saitou K, Uchibori M, Hashizume A, Honda A, Amano K, Nakajima Y, Uetake H, Matsushima E.

Support Care Cancer. 2019 Sep;27(9):3385-3394. doi: 10.1007/s00520-018-4628-9. Epub 2019 Jan 14.


mFOLFOX6 plus bevacizumab to treat liver-only metastases of colorectal cancer that are unsuitable for upfront resection (TRICC0808): a multicenter phase II trial comprising the final analysis for survival.

Yasuno M, Uetake H, Ishiguro M, Mizunuma N, Komori T, Miyata G, Shiomi A, Kagimura T, Sugihara K.

Int J Clin Oncol. 2019 May;24(5):516-525. doi: 10.1007/s10147-018-01393-8. Epub 2019 Jan 5.


Large-Scale, Prospective Observational Study of Regorafenib in Japanese Patients with Metastatic Colorectal Cancer in a Real-World Clinical Setting.

Yamaguchi K, Komatsu Y, Satoh T, Uetake H, Yoshino T, Nishida T, Yamazaki N, Takikawa H, Morimoto T, Chosa M, Sunaya T, Hamada Y, Muro K, Sugihara K.

Oncologist. 2019 Jul;24(7):e450-e457. doi: 10.1634/theoncologist.2018-0377. Epub 2019 Jan 3.


Improvement in Neuropathy Outcomes With Normalizing HbA1c in Patients With Type 2 Diabetes.

Ishibashi F, Taniguchi M, Kosaka A, Uetake H, Tavakoli M.

Diabetes Care. 2019 Jan;42(1):110-118. doi: 10.2337/dc18-1560. Epub 2018 Nov 19.


A phase II study of NK012, a polymeric micelle formulation of SN-38, in unresectable, metastatic or recurrent colorectal cancer patients.

Hamaguchi T, Tsuji A, Yamaguchi K, Takeda K, Uetake H, Esaki T, Amagai K, Sakai D, Baba H, Kimura M, Matsumura Y, Tsukamoto T.

Cancer Chemother Pharmacol. 2018 Dec;82(6):1021-1029. doi: 10.1007/s00280-018-3693-6. Epub 2018 Oct 4.


Effect of a patient-support program on once-daily teriparatide adherence and persistence in the Japan Fracture Observational Study (JFOS).

Sato M, Tsujimoto M, Kajimoto K, Uetake H, Shimoda H, Fujiwara S.

Arch Osteoporos. 2018 Jul 5;13(1):74. doi: 10.1007/s11657-018-0487-8.


Frequencies and expression levels of programmed death ligand 1 (PD-L1) in circulating tumor RNA (ctRNA) in various cancer types.

Ishiba T, Hoffmann AC, Usher J, Elshimali Y, Sturdevant T, Dang M, Jaimes Y, Tyagi R, Gonzales R, Grino M, Pinski JK, Barzi A, Raez LE, Eberhardt WE, Theegarten D, Lenz HJ, Uetake H, Danenberg PV, Danenberg K.

Biochem Biophys Res Commun. 2018 Jun 7;500(3):621-625. doi: 10.1016/j.bbrc.2018.04.120. Epub 2018 Apr 30.


Colorectal carcinoma: Ex vivo evaluation using q-space imaging; Correlation with histopathologic findings.

Yamada I, Hikishima K, Yoshino N, Sakamoto J, Miyasaka N, Yamauchi S, Uetake H, Yasuno M, Saida Y, Tateishi U, Kobayashi D, Eishi Y.

J Magn Reson Imaging. 2018 Oct;48(4):1059-1068. doi: 10.1002/jmri.26018. Epub 2018 Mar 30.


Genome-wide Discovery and Identification of a Novel miRNA Signature for Recurrence Prediction in Stage II and III Colorectal Cancer.

Kandimalla R, Gao F, Matsuyama T, Ishikawa T, Uetake H, Takahashi N, Yamada Y, Becerra C, Kopetz S, Wang X, Goel A.

Clin Cancer Res. 2018 Aug 15;24(16):3867-3877. doi: 10.1158/1078-0432.CCR-17-3236. Epub 2018 Mar 7.


[A Case of Ipsilateral Breast Tumor Recurrence with Breast Ulcer].

Oda G, Nakagawa T, Fukuda M, Ishiba T, Kubota K, Fujioka T, Onishi I, Uetake H.

Gan To Kagaku Ryoho. 2017 Nov;44(12):1850-1852. Japanese.


[A Case of Metastasis to the Base of the Skull after Rectal Cancer Operation with Symptom Management via Radiotherapy].

Sasaki M, Ishikawa T, Yamauchi S, Orita F, Miura T, Tokura M, Hanaoka M, Kikuchi A, Ishiguro M, Yasuno M, Uetake H.

Gan To Kagaku Ryoho. 2017 Nov;44(12):1335-1337. Japanese.


[Two Cases of Colon Cancer with Severe Liver Dysfunction Due to Multiple Liver Metastases Effectively Treated with Hepatic Arterial Infusion Chemotherapy plus CetuximabFollowed by Systemic Chemotherapy].

Orita F, Ishikawa T, Sasaki M, Miura T, Tokura M, Hanaoka M, Yamauchi S, Kikuchi A, Ishiguro M, Yasuno M, Uetake H.

Gan To Kagaku Ryoho. 2017 Nov;44(12):1245-1247. Japanese.


[Long-Term Survival of a Case with Brain and Lung Metastases from Resected Rectal Cancer by Gamma Knife Radiosurgery].

Miura T, Ishikawa T, Orita F, Sasaki M, Tokura M, Kikuchi A, Yamauchi S, Matsuyama T, Ishiguro M, Uetake H, Yasuno M.

Gan To Kagaku Ryoho. 2017 Nov;44(12):1179-1181. Review. Japanese.


The evaluation of contralateral foot circulation after unilateral revascularization procedures using indocyanine green angiography.

Nakamura M, Igari K, Toyofuku T, Kudo T, Inoue Y, Uetake H.

Sci Rep. 2017 Nov 23;7(1):16171. doi: 10.1038/s41598-017-16527-7.


Clinical Features of Regorafenib-induced Liver Injury in Japanese Patients From Postmarketing Experience.

Uetake H, Sugihara K, Muro K, Sunaya T, Horiuchi-Yamamoto Y, Takikawa H.

Clin Colorectal Cancer. 2018 Mar;17(1):e49-e58. doi: 10.1016/j.clcc.2017.09.004. Epub 2017 Sep 28.


Expression of ATF6 as a marker of pre-cancerous atypical change in ulcerative colitis-associated colorectal cancer: a potential role in the management of dysplasia.

Hanaoka M, Ishikawa T, Ishiguro M, Tokura M, Yamauchi S, Kikuchi A, Uetake H, Yasuno M, Kawano T.

J Gastroenterol. 2018 May;53(5):631-641. doi: 10.1007/s00535-017-1387-1. Epub 2017 Sep 7.


CCAT1 and CCAT2 long noncoding RNAs, located within the 8q.24.21 'gene desert', serve as important prognostic biomarkers in colorectal cancer.

Ozawa T, Matsuyama T, Toiyama Y, Takahashi N, Ishikawa T, Uetake H, Yamada Y, Kusunoki M, Calin G, Goel A.

Ann Oncol. 2017 Aug 1;28(8):1882-1888. doi: 10.1093/annonc/mdx248.


High expression of P21-activated kinase 5 protein is associated with poor survival in gastric cancer.

Aburatani T, Inokuchi M, Takagi Y, Ishikawa T, Okuno K, Gokita K, Tomii C, Tanioka T, Murase H, Otsuki S, Uetake H, Kojima K, Kawano T.

Oncol Lett. 2017 Jul;14(1):404-410. doi: 10.3892/ol.2017.6115. Epub 2017 May 3.


Management of patients with asymptomatic colorectal cancer and synchronous irresectable metastases.

Ishikawa T, Yasuno M, Uetake H.

Nihon Shokakibyo Gakkai Zasshi. 2017;114(7):1201-1208. doi: 10.11405/nisshoshi.114.1201. Review. Japanese. No abstract available.


High expression of EphA3 (erythropoietin-producing hepatocellular A3) in gastric cancer is associated with metastasis and poor survival.

Nasri B, Inokuchi M, Ishikawa T, Uetake H, Takagi Y, Otsuki S, Kojima K, Kawano T.

BMC Clin Pathol. 2017 Apr 27;17:8. doi: 10.1186/s12907-017-0047-y. eCollection 2017.


The Preferential Impairment of Pupil Constriction Stimulated by Blue Light in Patients with Type 2 Diabetes without Autonomic Neuropathy.

Ishibashi F, Kojima R, Taniguchi M, Kosaka A, Uetake H, Tavakoli M.

J Diabetes Res. 2017;2017:6069730. doi: 10.1155/2017/6069730. Epub 2017 Mar 22.


Novel assessment tool based on laser speckle contrast imaging to diagnose severe ischemia in the lower limb for patients with peripheral arterial disease.

Katsui S, Inoue Y, Igari K, Toyofuku T, Kudo T, Uetake H.

Lasers Surg Med. 2017 Sep;49(7):645-651. doi: 10.1002/lsm.22669. Epub 2017 Apr 2.


Rationale for and Design of the PARADIGM Study: Randomized Phase III Study of mFOLFOX6 Plus Bevacizumab or Panitumumab in Chemotherapy-naïve Patients With RAS (KRAS/NRAS) Wild-type, Metastatic Colorectal Cancer.

Yoshino T, Uetake H, Tsuchihara K, Shitara K, Yamazaki K, Oki E, Sato T, Naitoh T, Komatsu Y, Kato T, Yamanaka K, Iwasaki K, Soeda J, Hihara M, Yamanaka T, Ochiai A, Muro K.

Clin Colorectal Cancer. 2017 Jun;16(2):158-163. doi: 10.1016/j.clcc.2017.01.001. Epub 2017 Jan 24.


Morphologic change of the psoas muscle as a surrogate marker of sarcopenia and predictor of complications after colorectal cancer surgery.

Hanaoka M, Yasuno M, Ishiguro M, Yamauchi S, Kikuchi A, Tokura M, Ishikawa T, Nakatani E, Uetake H.

Int J Colorectal Dis. 2017 Jun;32(6):847-856. doi: 10.1007/s00384-017-2773-0. Epub 2017 Feb 11.


Clinical Significance of Methylation and Reduced Expression of the Quaking Gene in Colorectal Cancer.

Iwata N, Ishikawa T, Okazaki S, Mogushi K, Baba H, Ishiguro M, Kobayashi H, Tanaka H, Kawano T, Sugihara K, Uetake H.

Anticancer Res. 2017 Feb;37(2):489-498.


[A Rare Case of Retroperitoneal Metastasis from Ascending Colon Cancer That Required Multimodal Treatment].

Hanaoka M, Yamauchi S, Kikuchi A, Tokura M, Ishiguro M, Ishikawa T, Yasuno M, Uetake H.

Gan To Kagaku Ryoho. 2016 Nov;43(12):2169-2171. Japanese.


TPX2 expression is associated with poor survival in gastric cancer.

Tomii C, Inokuchi M, Takagi Y, Ishikawa T, Otsuki S, Uetake H, Kojima K, Kawano T.

World J Surg Oncol. 2017 Jan 9;15(1):14. doi: 10.1186/s12957-016-1095-y.


Colorectal carcinoma: Ex vivo evaluation using 3-T high-spatial-resolution quantitative T2 mapping and its correlation with histopathologic findings.

Yamada I, Yoshino N, Hikishima K, Miyasaka N, Yamauchi S, Uetake H, Yasuno M, Saida Y, Tateishi U, Kobayashi D, Eishi Y.

Magn Reson Imaging. 2017 May;38:174-181. doi: 10.1016/j.mri.2016.12.028. Epub 2017 Jan 5.


Genomic landscape of colorectal cancer in Japan: clinical implications of comprehensive genomic sequencing for precision medicine.

Nagahashi M, Wakai T, Shimada Y, Ichikawa H, Kameyama H, Kobayashi T, Sakata J, Yagi R, Sato N, Kitagawa Y, Uetake H, Yoshida K, Oki E, Kudo SE, Izutsu H, Kodama K, Nakada M, Tse J, Russell M, Heyer J, Powers W, Sun R, Ring JE, Takabe K, Protopopov A, Ling Y, Okuda S, Lyle S.

Genome Med. 2016 Dec 22;8(1):136. doi: 10.1186/s13073-016-0387-8.


Study protocol of the Asian XELIRI ProjecT (AXEPT): a multinational, randomized, non-inferiority, phase III trial of second-line chemotherapy for metastatic colorectal cancer, comparing the efficacy and safety of XELIRI with or without bevacizumab versus FOLFIRI with or without bevacizumab.

Kotaka M, Xu R, Muro K, Park YS, Morita S, Iwasa S, Uetake H, Nishina T, Nozawa H, Matsumoto H, Yamazaki K, Han SW, Wang W, Ahn JB, Deng Y, Cho SH, Ba Y, Lee KW, Zhang T, Satoh T, Buyse ME, Ryoo BY, Shen L, Sakamoto J, Kim TW.

Chin J Cancer. 2016 Dec 22;35(1):102. doi: 10.1186/s40880-016-0166-3.


Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer.

Kasahara M, Nagahara M, Nakagawa T, Ishikawa T, Sato T, Uetake H, Sugihara K.

Oncol Lett. 2016 Sep;12(3):1909-1914. Epub 2016 Jul 7.


The Expanded Bead Size of Corneal C-Nerve Fibers Visualized by Corneal Confocal Microscopy Is Associated with Slow Conduction Velocity of the Peripheral Nerves in Patients with Type 2 Diabetes Mellitus.

Ishibashi F, Kojima R, Taniguchi M, Kosaka A, Uetake H, Tavakoli M.

J Diabetes Res. 2016;2016:3653459. doi: 10.1155/2016/3653459. Epub 2016 Aug 3.


A Comparison of the Regional Circulation in the Feet between Dialysis and Non-Dialysis Patients using Indocyanine Green Angiography.

Nishizawa M, Igari K, Kudo T, Toyofuku T, Inoue Y, Uetake H.

Scand J Surg. 2017 Sep;106(3):249-254. doi: 10.1177/1457496916666412. Epub 2016 Aug 24.


Identification of SATB1 as a Specific Biomarker for Lymph Node Metastasis in Colorectal Cancer.

Baba H, Ishikawa T, Mogushi K, Ishiguro M, Uetake H, Tanaka H, Sugihara K.

Anticancer Res. 2016 Aug;36(8):4069-76.


Cadherin 5 expression correlates with poor survival in human gastric cancer.

Higuchi K, Inokuchi M, Takagi Y, Ishikawa T, Otsuki S, Uetake H, Kojima K, Kawano T.

J Clin Pathol. 2017 Mar;70(3):217-221. doi: 10.1136/jclinpath-2016-203640. Epub 2016 Jul 26.


Elasticity of the tibial nerve assessed by sonoelastography was reduced before the development of neuropathy and further deterioration associated with the severity of neuropathy in patients with type 2 diabetes.

Ishibashi F, Taniguchi M, Kojima R, Kawasaki A, Kosaka A, Uetake H.

J Diabetes Investig. 2016 May;7(3):404-12. doi: 10.1111/jdi.12408. Epub 2015 Sep 6.


12-Gene Recurrence Score Assay Stratifies the Recurrence Risk in Stage II/III Colon Cancer With Surgery Alone: The SUNRISE Study.

Yamanaka T, Oki E, Yamazaki K, Yamaguchi K, Muro K, Uetake H, Sato T, Nishina T, Ikeda M, Kato T, Kanazawa A, Kusumoto T, Chao C, Lopatin M, Krishnakumar J, Bailey H, Akagi K, Ochiai A, Ohtsu A, Ohashi Y, Yoshino T.

J Clin Oncol. 2016 Aug 20;34(24):2906-13. doi: 10.1200/JCO.2016.67.0414. Epub 2016 Jun 20.


TAS-102 Safety in Metastatic Colorectal Cancer: Results From the First Postmarketing Surveillance Study.

Yoshino T, Uetake H, Fujita N, Furuta T, Katori J, Hara N, Muro K.

Clin Colorectal Cancer. 2016 Dec;15(4):e205-e211. doi: 10.1016/j.clcc.2016.04.004. Epub 2016 May 17.

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