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Items: 1 to 50 of 100

1.

Drug leads derived from Japanese marine organisms.

Uemura D, Kawazoe Y, Inuzuka T, Itakura Y, Kawamata C, Abe T.

Curr Med Chem. 2019 Oct 22. doi: 10.2174/0929867326666191022125851. [Epub ahead of print]

PMID:
31642409
2.

Anti-obesity activities of the yoshinone A and the related marine γ-pyrone compounds.

Koyama T, Kawazoe Y, Iwasaki A, Ohno O, Suenaga K, Uemura D.

J Antibiot (Tokyo). 2016 Apr;69(4):348-51. doi: 10.1038/ja.2016.19. Epub 2016 Mar 2. No abstract available.

3.

Stereodivergent Synthesis and Stereochemical Reassignment of the C79-C104 Fragment of Symbiodinolide.

Takamura H, Fujiwara T, Kawakubo Y, Kadota I, Uemura D.

Chemistry. 2016 Feb;22(6):1984-1996. doi: 10.1002/chem.201503881. Epub 2016 Jan 7.

4.

Stereoselective Synthesis of the Proposed C79-C104 Fragment of Symbiodinolide.

Takamura H, Fujiwara T, Kawakubo Y, Kadota I, Uemura D.

Chemistry. 2016 Feb;22(6):1979-1983. doi: 10.1002/chem.201503880. Epub 2015 Dec 11.

5.

Isolation of Monovalerianester A, an Inhibitor of Fat Accumulation, from Valeriana fauriei.

Yuki K, Ikeda M, Yoshida S, Ohno O, Suenaga K, Yamada K, Uemura D, Miyamoto K.

Nat Prod Commun. 2015 Aug;10(8):1333-4.

PMID:
26434106
6.

Stereodivergent synthesis and relative stereostructure of the C1-C13 fragment of symbiodinolide.

Takamura H, Wada H, Ogino M, Kikuchi T, Kadota I, Uemura D.

J Org Chem. 2015 Mar 20;80(6):3111-23. doi: 10.1021/acs.joc.5b00027. Epub 2015 Mar 9.

7.

Total synthesis of the antibiotic kendomycin: a macrocyclization using the Tsuji-Trost etherification.

Sengoku T, Xu S, Ogura K, Emori Y, Kitada K, Uemura D, Arimoto H.

Angew Chem Int Ed Engl. 2014 Apr 14;53(16):4213-6. doi: 10.1002/anie.201400305. Epub 2014 Mar 12.

PMID:
24623596
8.

Stereoselective synthesis of the C79-C97 fragment of symbiodinolide.

Takamura H, Fujiwara T, Kadota I, Uemura D.

Beilstein J Org Chem. 2013 Sep 25;9:1931-5. doi: 10.3762/bjoc.9.228. eCollection 2013.

9.

Enantioselective total synthesis of pinnaic acid and halichlorine.

Xu S, Unabara D, Uemura D, Arimoto H.

Chem Asian J. 2014 Jan;9(1):367-75. doi: 10.1002/asia.201301248. Epub 2013 Oct 17.

PMID:
24136879
10.

Ternatin, a cyclic peptide isolated from mushroom, and its derivative suppress hyperglycemia and hepatic fatty acid synthesis in spontaneously diabetic KK-A(y) mice.

Kobayashi M, Kawashima H, Takemori K, Ito H, Murai A, Masuda S, Yamada K, Uemura D, Horio F.

Biochem Biophys Res Commun. 2012 Oct 19;427(2):299-304. doi: 10.1016/j.bbrc.2012.09.045. Epub 2012 Sep 18.

PMID:
23000156
11.

Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei.

Yuki K, Ikeda M, Miyamoto K, Ohno O, Yamada K, Uemura D.

Biosci Biotechnol Biochem. 2012;76(6):1233-5. Epub 2012 Jun 7.

12.

Construction of a metagenomic library for the marine sponge Halichondria okadai.

Abe T, Sahin FP, Akiyama K, Naito T, Kishigami M, Miyamoto K, Sakakibara Y, Uemura D.

Biosci Biotechnol Biochem. 2012;76(4):633-9. Epub 2012 Apr 7.

13.

Secondary metabolites with new medicinal functions from marine organisms.

Ohno O, Suenaga K, Uemura D.

Adv Food Nutr Res. 2012;65:185-93. doi: 10.1016/B978-0-12-416003-3.00011-1. Review.

PMID:
22361187
14.

Sea-originated cytotoxic substances.

Maru N, Uemura D.

Adv Food Nutr Res. 2012;65:171-84. doi: 10.1016/B978-0-12-416003-3.00010-X. Review.

PMID:
22361186
15.

Halichonines A, B, and C, novel sesquiterpene alkaloids from the marine sponge Halichondria okadai Kadota.

Ohno O, Chiba T, Todoroki S, Yoshimura H, Maru N, Maekawa K, Imagawa H, Yamada K, Wakamiya A, Suenaga K, Uemura D.

Chem Commun (Camb). 2011 Dec 14;47(46):12453-5. doi: 10.1039/c1cc15557a. Epub 2011 Oct 31.

PMID:
22042320
16.

Melanin biosynthesis inhibitors from Tarragon Artemisia dracunculus.

Yamada M, Nakamura K, Watabe T, Ohno O, Kawagoshi M, Maru N, Uotsu N, Chiba T, Yamaguchi K, Uemura D.

Biosci Biotechnol Biochem. 2011;75(8):1628-30. Epub 2011 Aug 7.

17.

Dramatically improved catalytic activity of an artificial (S)-selective arylmalonate decarboxylase by structure-guided directed evolution.

Miyauchi Y, Kourist R, Uemura D, Miyamoto K.

Chem Commun (Camb). 2011 Jul 14;47(26):7503-5. doi: 10.1039/c1cc11953b. Epub 2011 May 11.

PMID:
21559536
18.

Pinnarine, another member of the halichlorine family. Isolation and preparation from pinnaic acid.

Xu S, Yoshimura H, Maru N, Ohno O, Arimoto H, Uemura D.

J Nat Prod. 2011 May 27;74(5):1323-6. doi: 10.1021/np200031d. Epub 2011 Mar 16.

PMID:
21410164
19.

Engineering the promiscuous racemase activity of an arylmalonate decarboxylase.

Kourist R, Miyauchi Y, Uemura D, Miyamoto K.

Chemistry. 2011 Jan 10;17(2):557-63. doi: 10.1002/chem.201001924. Epub 2010 Nov 9.

PMID:
21207573
20.

Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from Piper longum on melanin production in B16 mouse melanoma cells.

Ohno O, Watabe T, Nakamura K, Kawagoshi M, Uotsu N, Chiba T, Yamada M, Yamaguchi K, Yamada K, Miyamoto K, Uemura D.

Biosci Biotechnol Biochem. 2010;74(7):1504-6. Epub 2010 Jul 7.

21.

Halichlorine reduces monocyte adhesion to endothelium through the suppression of nuclear factor-kappaB activation.

Tsubosaka Y, Murata T, Yamada K, Uemura D, Hori M, Ozaki H.

J Pharmacol Sci. 2010;113(3):208-13. Epub 2010 Jun 16.

22.

Symbiopolyol, a VCAM-1 inhibitor from a symbiotic dinoflagellate of the jellyfish Mastigias papua.

Hanif N, Ohno O, Kitamura M, Yamada K, Uemura D.

J Nat Prod. 2010 Jul 23;73(7):1318-22. doi: 10.1021/np100221k.

PMID:
20557071
23.

Bioactive secondary metabolites from symbiotic marine dinoflagellates: symbiodinolide and durinskiols.

Kita M, Ohno O, Han C, Uemura D.

Chem Rec. 2010 Apr;10(2):57-69. doi: 10.1002/tcr.200900007. Review.

PMID:
20333719
24.
25.

Marine huge molecules: the longest carbon chains in natural products.

Kita M, Uemura D.

Chem Rec. 2010 Mar;10(1):48-52. doi: 10.1002/tcr.200900030. Review.

PMID:
20143381
26.
27.

Neocomplanines A and B, a complanine family isolated from the marine fireworm.

Nakamura K, Tachikawa Y, Ohno O, Kitamura M, Suganuma M, Uemura D.

J Nat Prod. 2010 Mar 26;73(3):303-5. doi: 10.1021/np900694j.

PMID:
20028030
28.

Duck-billed platypus venom peptides induce Ca2+ influx in neuroblastoma cells.

Kita M, Black DS, Ohno O, Yamada K, Kigoshi H, Uemura D.

J Am Chem Soc. 2009 Dec 23;131(50):18038-9. doi: 10.1021/ja908148z.

PMID:
19928958
29.

Total synthesis and cytotoxicity evaluation of all ochratoxin A stereoisomers.

Cramer B, Harrer H, Nakamura K, Uemura D, Humpf HU.

Bioorg Med Chem. 2010 Jan 1;18(1):343-7. doi: 10.1016/j.bmc.2009.10.050. Epub 2009 Oct 30.

PMID:
19919898
30.

Halichlorine is a novel L-type Ca(2+) channel inhibitor isolated from the marine sponge Halichondria okadai Kadota.

Tsubosaka Y, Murata T, Kinoshita K, Yamada K, Uemura D, Hori M, Ozaki H.

Eur J Pharmacol. 2010 Feb 25;628(1-3):128-31. doi: 10.1016/j.ejphar.2009.11.026. Epub 2009 Nov 15.

PMID:
19919831
31.

Stereoselective synthesis and absolute configuration of the C1'-C25' fragment of symbiodinolide.

Takamura H, Murata T, Asai T, Kadota I, Uemura D.

J Org Chem. 2009 Sep 4;74(17):6658-66. doi: 10.1021/jo901162v.

PMID:
19655754
32.

Synthesis and structural revision of symbiodinolide C23-C34 fragment.

Murata T, Sano M, Takamura H, Kadota I, Uemura D.

J Org Chem. 2009 Jul 3;74(13):4797-803. doi: 10.1021/jo900546k.

PMID:
19480417
33.

(-)-Complanine, an inflammatory substance of marine fireworm: a synthetic study.

Nakamura K, Tachikawa Y, Uemura D.

Beilstein J Org Chem. 2009 Apr 16;5:12. doi: 10.3762/bjoc.5.12.

34.

(-)-Ternatin inhibits adipogenesis and lipid metabolism in 3T3-L1 cells.

Ito M, Ito J, Kitazawa H, Shimamura K, Fukami T, Tokita S, Shimokawa K, Yamada K, Kanatani A, Uemura D.

Peptides. 2009 Jun;30(6):1074-81. doi: 10.1016/j.peptides.2009.02.008. Epub 2009 Feb 21.

PMID:
19463739
35.

Symbiospirols: novel long carbon-chain compounds isolated from symbiotic marine dinoflagellate Symbiodinium sp.

Tsunematsu Y, Ohno O, Konishi K, Yamada K, Suganuma M, Uemura D.

Org Lett. 2009 May 21;11(10):2153-6. doi: 10.1021/ol900299x.

PMID:
19361202
36.

Importance of the backbone conformation of (-)-ternatin in its fat-accumulation inhibitory activity against 3T3-L1 adipocytes.

Shimokawa K, Miwa R, Yamada K, Uemura D.

Org Biomol Chem. 2009 Feb 21;7(4):777-84. doi: 10.1039/b818903j. Epub 2009 Jan 7.

PMID:
19194593
37.

Structure-based hybridization of the bioactive natural products rhizonin A and ternatin leading to a selective fat-accumulation inhibitor against 3T3-L1 adipocytes.

Shimokawa K, Yamada K, Uemura D.

Bioorg Med Chem Lett. 2009 Feb 1;19(3):867-9. doi: 10.1016/j.bmcl.2008.11.109. Epub 2008 Dec 6.

PMID:
19097891
38.

Design, synthesis, and biological evaluation of biotin-labeled (-)-ternatin, a potent fat-accumulation inhibitor against 3T3-L1 adipocytes.

Shimokawa K, Yamada K, Ohno O, Oba Y, Uemura D.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):92-5. doi: 10.1016/j.bmcl.2008.11.003. Epub 2008 Nov 6.

PMID:
19022665
39.

Reinvestigation of the bitter compounds in carrots (Daucus carota L.) by using a molecular sensory science approach.

Schmiech L, Uemura D, Hofmann T.

J Agric Food Chem. 2008 Nov 12;56(21):10252-60. doi: 10.1021/jf8023358. Epub 2008 Oct 16.

PMID:
18922011
40.

Whole structure-activity relationships of the fat-accumulation inhibitor (-)-ternatin: recognition of the importance of each amino acid residue.

Shimokawa K, Iwase Y, Miwa R, Yamada K, Uemura D.

J Med Chem. 2008 Oct 9;51(19):5912-4. doi: 10.1021/jm800741n. Epub 2008 Sep 18.

PMID:
18798610
41.

Inhibitory effects of benzyl benzoate and its derivatives on angiotensin II-induced hypertension.

Ohno O, Ye M, Koyama T, Yazawa K, Mura E, Matsumoto H, Ichino T, Yamada K, Nakamura K, Ohno T, Yamaguchi K, Ishida J, Fukamizu A, Uemura D.

Bioorg Med Chem. 2008 Aug 15;16(16):7843-52. doi: 10.1016/j.bmc.2008.03.056. Epub 2008 Mar 27.

PMID:
18672373
42.

Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata.

Nakamura K, Tachikawa Y, Kitamura M, Ohno O, Suganuma M, Uemura D.

Org Biomol Chem. 2008 Jun 21;6(12):2058-60. doi: 10.1039/b803107j. Epub 2008 Apr 24.

PMID:
18528565
43.

Biological activity, structural features, and synthetic studies of (-)-ternatin, a potent fat-accumulation inhibitor of 3T3-L1 adipocytes.

Shimokawa K, Mashima I, Asai A, Ohno T, Yamada K, Kita M, Uemura D.

Chem Asian J. 2008 Feb 1;3(2):438-46. doi: 10.1002/asia.200700243.

PMID:
18181124
44.

Synthesis and inhibitory effect on fat accumulation of (-)-ternatin derivatives modified in the beta-OH-D-Leu(7) moiety.

Shimokawa K, Iwase Y, Yamada K, Uemura D.

Org Biomol Chem. 2008 Jan 7;6(1):58-60. Epub 2007 Nov 22.

PMID:
18075648
45.

[Unelucidated biological phenomena].

Nakamura K, Uemura D.

Tanpakushitsu Kakusan Koso. 2007 Oct;52(13 Suppl):1661-6. Review. Japanese. No abstract available.

PMID:
18051396
46.

Asymmetric total synthesis of pinnaic acid.

Xu S, Arimoto H, Uemura D.

Angew Chem Int Ed Engl. 2007;46(30):5746-9. No abstract available.

PMID:
17592606
47.

Convergent synthesis and in vivo inhibitory effect on fat accumulation of (-)-ternatin, a highly N-methylated cyclic peptide.

Shimokawa K, Yamada K, Kita M, Uemura D.

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4447-9. Epub 2007 Jun 8.

PMID:
17590333
48.

Preparation of quinoline hexose analogs as novel chloroquine-resistant malaria treatments (1). Synthesis of 4-hydroxyquinoline-beta-glucosides.

Suzuki H, Aly NS, Wataya Y, Kim HS, Tamai I, Kita M, Uemura D.

Chem Pharm Bull (Tokyo). 2007 May;55(5):821-4.

49.

Molecular shape of palytoxin in aqueous solution.

Inuzuka T, Fujisawa T, Arimoto H, Uemura D.

Org Biomol Chem. 2007 Mar 21;5(6):897-9. Epub 2007 Feb 8.

PMID:
17340004
50.

Identification of proteins from venom of the paralytic spider wasp, Cyphononyx dorsalis.

Yamamoto T, Arimoto H, Kinumi T, Oba Y, Uemura D.

Insect Biochem Mol Biol. 2007 Mar;37(3):278-86. Epub 2007 Feb 5. Erratum in: Insect Biochem Mol Biol. 2007 May;37(5):520-1.

PMID:
17296502

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