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Items: 17

1.

A quantitative affinity-based technique for the identification of potential lead compounds.

Arai T, Uehata M, Akatsuka H, Kamiyama T.

Anal Biochem. 2013 May 15;436(2):109-11. doi: 10.1016/j.ab.2013.01.010. Epub 2013 Jan 25.

PMID:
23357232
2.

A quantitative analysis to unveil specific binding proteins for bioactive compounds.

Arai T, Uehata M, Akatsuka H, Kamiyama T.

Protein Eng Des Sel. 2013 Apr;26(4):249-54. doi: 10.1093/protein/gzs103. Epub 2012 Dec 23.

PMID:
23267120
3.

Direct in vitro and in vivo evidence for interaction between Hsp47 protein and collagen triple helix.

Ono T, Miyazaki T, Ishida Y, Uehata M, Nagata K.

J Biol Chem. 2012 Feb 24;287(9):6810-8. doi: 10.1074/jbc.M111.280248. Epub 2012 Jan 10.

4.

A fluorescence polarization-based assay for the identification and evaluation of calmodulin antagonists.

Arai T, Yatabe M, Furui M, Akatsuka H, Uehata M, Kamiyama T.

Anal Biochem. 2010 Oct 15;405(2):147-52. doi: 10.1016/j.ab.2010.06.025. Epub 2010 Jun 17.

PMID:
20599654
5.

Effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys.

Tokushige H, Inatani M, Nemoto S, Sakaki H, Katayama K, Uehata M, Tanihara H.

Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3216-22.

PMID:
17591891
6.

WF-536 inhibits metastatic invasion by enhancing the host cell barrier and inhibiting tumour cell motility.

Nakajima M, Katayama K, Tamechika I, Hayashi K, Amano Y, Uehata M, Goto N, Kondo T.

Clin Exp Pharmacol Physiol. 2003 Jul;30(7):457-63.

PMID:
12823259
7.

Effect of Wf-536, a novel ROCK inhibitor, against metastasis of B16 melanoma.

Nakajima M, Hayashi K, Egi Y, Katayama K, Amano Y, Uehata M, Ohtsuki M, Fujii A, Oshita K, Kataoka H, Chiba K, Goto N, Kondo T.

Cancer Chemother Pharmacol. 2003 Oct;52(4):319-24. Epub 2003 May 29.

PMID:
12783205
8.

Wf-536 prevents tumor metastasis by inhibiting both tumor motility and angiogenic actions.

Nakajima M, Hayashi K, Katayama K, Amano Y, Egi Y, Uehata M, Goto N, Kondo T.

Eur J Pharmacol. 2003 Jan 17;459(2-3):113-20.

PMID:
12524136
9.

Small guanosine triphospatase RhoA and Rho-associated kinase as regulators of trophoblast migration.

Shiokawa S, Iwashita M, Akimoto Y, Nagamatsu S, Sakai K, Hanashi H, Kabir-Salmani M, Nakamura Y, Uehata M, Yoshimura Y.

J Clin Endocrinol Metab. 2002 Dec;87(12):5808-16.

PMID:
12466390
10.

Use and properties of ROCK-specific inhibitor Y-27632.

Narumiya S, Ishizaki T, Uehata M.

Methods Enzymol. 2000;325:273-84. No abstract available.

PMID:
11036610
11.
12.

Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.

Ishizaki T, Uehata M, Tamechika I, Keel J, Nonomura K, Maekawa M, Narumiya S.

Mol Pharmacol. 2000 May;57(5):976-83.

PMID:
10779382
13.

[Drug development from protein kinase inhibitors].

Miyamoto E, Satoh S, Asano T, Uehata M.

Tanpakushitsu Kakusan Koso. 2000 Apr;45(6 Suppl):845-51. Review. Japanese. No abstract available.

PMID:
10771642
14.

The suppression of small GTPase rho signal transduction pathway inhibits angiogenesis in vitro and in vivo.

Uchida S, Watanabe G, Shimada Y, Maeda M, Kawabe A, Mori A, Arii S, Uehata M, Kishimoto T, Oikawa T, Imamura M.

Biochem Biophys Res Commun. 2000 Mar 16;269(2):633-40.

PMID:
10708606
15.

An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

Itoh K, Yoshioka K, Akedo H, Uehata M, Ishizaki T, Narumiya S.

Nat Med. 1999 Feb;5(2):221-5.

PMID:
9930872
16.

Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells.

Hirose M, Ishizaki T, Watanabe N, Uehata M, Kranenburg O, Moolenaar WH, Matsumura F, Maekawa M, Bito H, Narumiya S.

J Cell Biol. 1998 Jun 29;141(7):1625-36.

17.

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension.

Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Narumiya S.

Nature. 1997 Oct 30;389(6654):990-4.

PMID:
9353125

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