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CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways.

Wein AN, McMaster SR, Takamura S, Dunbar PR, Cartwright EK, Hayward SL, McManus DT, Shimaoka T, Ueha S, Tsukui T, Masumoto T, Kurachi M, Matsushima K, Kohlmeier JE.

J Exp Med. 2019 Sep 26. pii: jem.20181308. doi: 10.1084/jem.20181308. [Epub ahead of print]


Interstitial-resident memory CD8+ T cells sustain frontline epithelial memory in the lung.

Takamura S, Kato S, Motozono C, Shimaoka T, Ueha S, Matsuo K, Miyauchi K, Masumoto T, Katsushima A, Nakayama T, Tomura M, Matsushima K, Kubo M, Miyazawa M.

J Exp Med. 2019 Sep 26. pii: jem.20190557. doi: 10.1084/jem.20190557. [Epub ahead of print]


First-in-human phase 1 study of IT1208, a defucosylated humanized anti-CD4 depleting antibody, in patients with advanced solid tumors.

Shitara K, Ueha S, Shichino S, Aoki H, Ogiwara H, Nakatsura T, Suzuki T, Shimomura M, Yoshikawa T, Shoda K, Kitano S, Yamashita M, Nakayama T, Sato A, Kuroda S, Wakabayashi M, Nomura S, Yokochi S, Ito S, Matsushima K, Doi T.

J Immunother Cancer. 2019 Jul 24;7(1):195. doi: 10.1186/s40425-019-0677-y.


Novel Targeting to XCR1+ Dendritic Cells Using Allogeneic T Cells for Polytopical Antibody Responses in the Lymph Nodes.

Kitazawa Y, Ueta H, Sawanobori Y, Katakai T, Yoneyama H, Ueha S, Matsushima K, Tokuda N, Matsuno K.

Front Immunol. 2019 May 29;10:1195. doi: 10.3389/fimmu.2019.01195. eCollection 2019.


In vitro expansion of endogenous human alveolar epithelial type II cells in fibroblast-free spheroid culture.

Shiraishi K, Nakajima T, Shichino S, Deshimaru S, Matsushima K, Ueha S.

Biochem Biophys Res Commun. 2019 Aug 6;515(4):579-585. doi: 10.1016/j.bbrc.2019.05.187. Epub 2019 Jun 6.


Gli signaling pathway modulates fibroblast activation and facilitates scar formation in pulmonary fibrosis.

Tsukui T, Ueha S, Shichino S, Hashimoto S, Nakajima T, Shiraishi K, Kihara M, Kiyonari H, Inagaki Y, Matsushima K.

Biochem Biophys Res Commun. 2019 Jun 30;514(3):684-690. doi: 10.1016/j.bbrc.2019.05.011. Epub 2019 May 8.


Engraftment and proliferation potential of embryonic lung tissue cells in irradiated mice with emphysema.

Shiraishi K, Shichino S, Tsukui T, Hashimoto S, Ueha S, Matsushima K.

Sci Rep. 2019 Mar 6;9(1):3657. doi: 10.1038/s41598-019-40237-x.


TCR Repertoire Analysis Reveals Mobilization of Novel CD8+ T Cell Clones Into the Cancer-Immunity Cycle Following Anti-CD4 Antibody Administration.

Aoki H, Ueha S, Shichino S, Ogiwara H, Hashimoto SI, Kakimi K, Ito S, Matsushima K.

Front Immunol. 2019 Jan 24;9:3185. doi: 10.3389/fimmu.2018.03185. eCollection 2018.


Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice.

Chen CY, Ueha S, Ishiwata Y, Yokochi S, Yang, Oppenheim JJ, Ogiwara H, Shichino S, Deshimaru S, Shand FHW, Shibayama S, Matsushima K.

J Immunother Cancer. 2019 Jan 29;7(1):21. doi: 10.1186/s40425-019-0503-6.


Mesenchymal-Epithelial Interactome Analysis Reveals Essential Factors Required for Fibroblast-Free Alveolosphere Formation.

Shiraishi K, Shichino S, Ueha S, Nakajima T, Hashimoto S, Yamazaki S, Matsushima K.

iScience. 2019 Jan 25;11:318-333. doi: 10.1016/j.isci.2018.12.022. Epub 2018 Dec 26.


Transcriptome network analysis identifies protective role of the LXR/SREBP-1c axis in murine pulmonary fibrosis.

Shichino S, Ueha S, Hashimoto S, Otsuji M, Abe J, Tsukui T, Deshimaru S, Nakajima T, Kosugi-Kanaya M, Shand FH, Inagaki Y, Shimano H, Matsushima K.

JCI Insight. 2019 Jan 10;4(1). pii: 122163. doi: 10.1172/jci.insight.122163. [Epub ahead of print]


Dose-Dependent Effects of Insulin-Like Growth Factor 1 in the Aged Olfactory Epithelium.

Ueha R, Kondo K, Ueha S, Yamasoba T.

Front Aging Neurosci. 2018 Nov 20;10:385. doi: 10.3389/fnagi.2018.00385. eCollection 2018.


Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-β-associated fibroblast activation in murine pulmonary fibrosis.

Souma K, Shichino S, Hashimoto S, Ueha S, Tsukui T, Nakajima T, Suzuki HI, Shand FHW, Inagaki Y, Nagase T, Matsushima K.

Sci Rep. 2018 Nov 9;8(1):16642. doi: 10.1038/s41598-018-34839-0.


Cigarette Smoke-Induced Cell Death Causes Persistent Olfactory Dysfunction in Aged Mice.

Ueha R, Ueha S, Kondo K, Kikuta S, Yamasoba T.

Front Aging Neurosci. 2018 Jun 13;10:183. doi: 10.3389/fnagi.2018.00183. eCollection 2018.


Reduction of Proliferating Olfactory Cells and Low Expression of Extracellular Matrix Genes Are Hallmarks of the Aged Olfactory Mucosa.

Ueha R, Shichino S, Ueha S, Kondo K, Kikuta S, Nishijima H, Matsushima K, Yamasoba T.

Front Aging Neurosci. 2018 Mar 27;10:86. doi: 10.3389/fnagi.2018.00086. eCollection 2018.


Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen.

Ueta H, Kitazawa Y, Sawanobori Y, Ueno T, Ueha S, Matsushima K, Matsuno K.

Int Immunol. 2018 Mar 8;30(2):53-67. doi: 10.1093/intimm/dxx078.


Increased diversity with reduced "diversity evenness" of tumor infiltrating T-cells for the successful cancer immunotherapy.

Hosoi A, Takeda K, Nagaoka K, Iino T, Matsushita H, Ueha S, Aoki S, Matsushima K, Kubo M, Morikawa T, Kitaura K, Suzuki R, Kakimi K.

Sci Rep. 2018 Jan 18;8(1):1058. doi: 10.1038/s41598-018-19548-y.


Long-Lasting Graft-Derived Donor T Cells Contribute to the Pathogenesis of Chronic Graft-versus-Host Disease in Mice.

Kosugi-Kanaya M, Ueha S, Abe J, Shichino S, Shand FHW, Morikawa T, Kurachi M, Shono Y, Sudo N, Yamashita A, Suenaga F, Yokoyama A, Yong W, Imamura M, Teshima T, Matsushima K.

Front Immunol. 2017 Dec 18;8:1842. doi: 10.3389/fimmu.2017.01842. eCollection 2017.


The HIV co-receptor CCR5 regulates osteoclast function.

Lee JW, Hoshino A, Inoue K, Saitou T, Uehara S, Kobayashi Y, Ueha S, Matsushima K, Yamaguchi A, Imai Y, Iimura T.

Nat Commun. 2017 Dec 20;8(1):2226. doi: 10.1038/s41467-017-02368-5.


Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function.

Kurachi M, Kurachi J, Chen Z, Johnson J, Khan O, Bengsch B, Stelekati E, Attanasio J, McLane LM, Tomura M, Ueha S, Wherry EJ.

Nat Protoc. 2017 Sep;12(9):1980-1998. doi: 10.1038/nprot.2017.083. Epub 2017 Aug 31.


Combination of anti-CD4 antibody treatment and donor lymphocyte infusion ameliorates graft-versus-host disease while preserving graft-versus-tumor effects in murine allogeneic hematopoietic stem cell transplantation.

Ueha S, Yokochi S, Ishiwata Y, Kosugi-Kanaya M, Shono Y, Shibayama S, Ito S, Matsushima K.

Cancer Sci. 2017 Oct;108(10):1967-1973. doi: 10.1111/cas.13346. Epub 2017 Aug 29.


Laryngeal mucus hypersecretion is exacerbated after smoking cessation and ameliorated by glucocorticoid administration.

Ueha R, Ueha S, Kondo K, Nito T, Fujimaki Y, Nishijima H, Tsunoda K, Shand FH, Matsushima K, Yamasoba T.

Toxicol Lett. 2017 Jan 4;265:140-146. doi: 10.1016/j.toxlet.2016.11.023. Epub 2016 Dec 2.


Cigarette Smoke Delays Regeneration of the Olfactory Epithelium in Mice.

Ueha R, Ueha S, Sakamoto T, Kanaya K, Suzukawa K, Nishijima H, Kikuta S, Kondo K, Matsushima K, Yamasoba T.

Neurotox Res. 2016 Aug;30(2):213-24. doi: 10.1007/s12640-016-9617-5. Epub 2016 Mar 22.


Local fibroblast proliferation but not influx is responsible for synovial hyperplasia in a murine model of rheumatoid arthritis.

Matsuo Y, Mizoguchi F, Saito T, Kawahata K, Ueha S, Matsushima K, Inagaki Y, Miyasaka N, Kohsaka H.

Biochem Biophys Res Commun. 2016 Feb 12;470(3):504-509. doi: 10.1016/j.bbrc.2016.01.121. Epub 2016 Jan 22.


Damage to Olfactory Progenitor Cells Is Involved in Cigarette Smoke-Induced Olfactory Dysfunction in Mice.

Ueha R, Ueha S, Kondo K, Sakamoto T, Kikuta S, Kanaya K, Nishijima H, Matsushima K, Yamasoba T.

Am J Pathol. 2016 Mar;186(3):579-86. doi: 10.1016/j.ajpath.2015.11.009. Epub 2016 Jan 22.


A Combination of Mitochondrial Oxidative Stress and Excess Fat/Calorie Intake Accelerates Steatohepatitis by Enhancing Hepatic CC Chemokine Production in Mice.

Moro T, Nakao S, Sumiyoshi H, Ishii T, Miyazawa M, Ishii N, Sato T, Iida Y, Okada Y, Tanaka M, Hayashi H, Ueha S, Matsushima K, Inagaki Y.

PLoS One. 2016 Jan 8;11(1):e0146592. doi: 10.1371/journal.pone.0146592. eCollection 2016.


Reduced supply of monocyte-derived macrophages leads to a transition from nodular to diffuse lesions and tissue cell activation in silica-induced pulmonary fibrosis in mice.

Shichino S, Abe J, Ueha S, Otsuji M, Tsukui T, Kosugi-Kanaya M, Shand FH, Hashimoto S, Suzuki HI, Morikawa T, Inagaki Y, Matsushima K.

Am J Pathol. 2015 Nov;185(11):2923-38. doi: 10.1016/j.ajpath.2015.07.013. Epub 2015 Oct 9.


Intratracheal cell transfer demonstrates the profibrotic potential of resident fibroblasts in pulmonary fibrosis.

Tsukui T, Ueha S, Shichino S, Inagaki Y, Matsushima K.

Am J Pathol. 2015 Nov;185(11):2939-48. doi: 10.1016/j.ajpath.2015.07.022. Epub 2015 Oct 9.


Robust Antitumor Effects of Combined Anti-CD4-Depleting Antibody and Anti-PD-1/PD-L1 Immune Checkpoint Antibody Treatment in Mice.

Ueha S, Yokochi S, Ishiwata Y, Ogiwara H, Chand K, Nakajima T, Hachiga K, Shichino S, Terashima Y, Toda E, Shand FH, Kakimi K, Ito S, Matsushima K.

Cancer Immunol Res. 2015 Jun;3(6):631-40. doi: 10.1158/2326-6066.CIR-14-0190. Epub 2015 Feb 20.


Adventitial CXCL1/G-CSF expression in response to acute aortic dissection triggers local neutrophil recruitment and activation leading to aortic rupture.

Anzai A, Shimoda M, Endo J, Kohno T, Katsumata Y, Matsuhashi T, Yamamoto T, Ito K, Yan X, Shirakawa K, Shimizu-Hirota R, Yamada Y, Ueha S, Shinmura K, Okada Y, Fukuda K, Sano M.

Circ Res. 2015 Feb 13;116(4):612-23. doi: 10.1161/CIRCRESAHA.116.304918. Epub 2015 Jan 6.


Loss of lymph node fibroblastic reticular cells and high endothelial cells is associated with humoral immunodeficiency in mouse graft-versus-host disease.

Suenaga F, Ueha S, Abe J, Kosugi-Kanaya M, Wang Y, Yokoyama A, Shono Y, Shand FH, Morishita Y, Kunisawa J, Sato S, Kiyono H, Matsushima K.

J Immunol. 2015 Jan 1;194(1):398-406. doi: 10.4049/jimmunol.1401022. Epub 2014 Nov 24.


Cytotoxic T lymphocytes block tumor growth both by lytic activity and IFNγ-dependent cell-cycle arrest.

Matsushita H, Hosoi A, Ueha S, Abe J, Fujieda N, Tomura M, Maekawa R, Matsushima K, Ohara O, Kakimi K.

Cancer Immunol Res. 2015 Jan;3(1):26-36. doi: 10.1158/2326-6066.CIR-14-0098. Epub 2014 Aug 15.


Tracking and quantification of dendritic cell migration and antigen trafficking between the skin and lymph nodes.

Tomura M, Hata A, Matsuoka S, Shand FH, Nakanishi Y, Ikebuchi R, Ueha S, Tsutsui H, Inaba K, Matsushima K, Miyawaki A, Kabashima K, Watanabe T, Kanagawa O.

Sci Rep. 2014 Aug 12;4:6030. doi: 10.1038/srep06030.


Lymph node stromal cells negatively regulate antigen-specific CD4+ T cell responses.

Abe J, Shichino S, Ueha S, Hashimoto S, Tomura M, Inagaki Y, Stein JV, Matsushima K.

J Immunol. 2014 Aug 15;193(4):1636-44. doi: 10.4049/jimmunol.1302946. Epub 2014 Jul 14.


Viral disruption of olfactory progenitors is exacerbated in allergic mice.

Ueha R, Mukherjee S, Ueha S, de Almeida Nagata DE, Sakamoto T, Kondo K, Yamasoba T, Lukacs NW, Kunkel SL.

Int Immunopharmacol. 2014 Sep;22(1):242-7. doi: 10.1016/j.intimp.2014.06.034. Epub 2014 Jul 2.


Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes.

Shand FH, Ueha S, Otsuji M, Koid SS, Shichino S, Tsukui T, Kosugi-Kanaya M, Abe J, Tomura M, Ziogas J, Matsushima K.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7771-6. doi: 10.1073/pnas.1402914111. Epub 2014 May 13.


Bone marrow graft-versus-host disease: evaluation of its clinical impact on disrupted hematopoiesis after allogeneic hematopoietic stem cell transplantation.

Shono Y, Shiratori S, Kosugi-Kanaya M, Ueha S, Sugita J, Shigematsu A, Kondo T, Hashimoto D, Fujimoto K, Endo T, Nishio M, Hashino S, Matsuno Y, Matsushima K, Tanaka J, Imamura M, Teshima T.

Biol Blood Marrow Transplant. 2014 Apr;20(4):495-500. doi: 10.1016/j.bbmt.2013.12.568. Epub 2013 Dec 27.


Adoptive cytotoxic T lymphocyte therapy triggers a counter-regulatory immunosuppressive mechanism via recruitment of myeloid-derived suppressor cells.

Hosoi A, Matsushita H, Shimizu K, Fujii S, Ueha S, Abe J, Kurachi M, Maekawa R, Matsushima K, Kakimi K.

Int J Cancer. 2014 Apr 15;134(8):1810-22. doi: 10.1002/ijc.28506. Epub 2013 Oct 21.


Thickness design, fabrication, and evaluation of 100-MHz polyurea ultrasonic transducer.

Nakazawa M, Tabaru M, Aoyagi T, Nakamura K, Ueha S.

IEEE Trans Ultrason Ferroelectr Freq Control. 2013 Oct;60(10):2175-88. doi: 10.1109/TUFFC.2013.2808.


Experimental study of underwater transmission characteristics of high-frequency 30 MHz polyurea ultrasonic transducer.

Nakazawa M, Aoyagi T, Tabaru M, Nakamura K, Ueha S.

Ultrasonics. 2014 Feb;54(2):526-36. doi: 10.1016/j.ultras.2013.08.006. Epub 2013 Sep 4.


Qualitative rather than quantitative changes are hallmarks of fibroblasts in bleomycin-induced pulmonary fibrosis.

Tsukui T, Ueha S, Abe J, Hashimoto S, Shichino S, Shimaoka T, Shand FH, Arakawa Y, Oshima K, Hattori M, Inagaki Y, Tomura M, Matsushima K.

Am J Pathol. 2013 Sep;183(3):758-73. doi: 10.1016/j.ajpath.2013.06.005. Epub 2013 Jul 22.


Specific antibody in IV immunoglobulin for postsplenectomy sepsis.

Nakamura K, Doi K, Okamoto K, Arai S, Ueha S, Matsushima K, Nakajima S, Yahagi N, Noiri E.

Crit Care Med. 2013 Aug;41(8):e163-70. doi: 10.1097/CCM.0b013e318287f1de.


Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota.

Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, Fukuda S, Saito T, Narushima S, Hase K, Kim S, Fritz JV, Wilmes P, Ueha S, Matsushima K, Ohno H, Olle B, Sakaguchi S, Taniguchi T, Morita H, Hattori M, Honda K.

Nature. 2013 Aug 8;500(7461):232-6. doi: 10.1038/nature12331. Epub 2013 Jul 10.


Roles of chemokine receptor CX3CR1 in maintaining murine bone homeostasis through the regulation of both osteoblasts and osteoclasts.

Hoshino A, Ueha S, Hanada S, Imai T, Ito M, Yamamoto K, Matsushima K, Yamaguchi A, Iimura T.

J Cell Sci. 2013 Feb 15;126(Pt 4):1032-45. doi: 10.1242/jcs.113910. Epub 2012 Dec 21.


Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin.

Nagao K, Kobayashi T, Moro K, Ohyama M, Adachi T, Kitashima DY, Ueha S, Horiuchi K, Tanizaki H, Kabashima K, Kubo A, Cho YH, Clausen BE, Matsushima K, Suematsu M, Furtado GC, Lira SA, Farber JM, Udey MC, Amagai M.

Nat Immunol. 2012 Jun 24;13(8):744-52. doi: 10.1038/ni.2353.


Cellular and molecular mechanisms of chronic inflammation-associated organ fibrosis.

Ueha S, Shand FH, Matsushima K.

Front Immunol. 2012 Apr 10;3:71. doi: 10.3389/fimmu.2012.00071. eCollection 2012.


B cells regulate antibody responses through the medullary remodeling of inflamed lymph nodes.

Abe J, Ueha S, Yoneyama H, Shono Y, Kurachi M, Goto A, Fukayama M, Tomura M, Kakimi K, Matsushima K.

Int Immunol. 2012 Jan;24(1):17-27. doi: 10.1093/intimm/dxr089. Epub 2011 Dec 20.


Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration.

Kurachi M, Kurachi J, Suenaga F, Tsukui T, Abe J, Ueha S, Tomura M, Sugihara K, Takamura S, Kakimi K, Matsushima K.

J Exp Med. 2011 Aug 1;208(8):1605-20. doi: 10.1084/jem.20102101. Epub 2011 Jul 25.


Requirement for chemokine receptor 5 in the development of allergen-induced airway hyperresponsiveness and inflammation.

Fuchimoto Y, Kanehiro A, Miyahara N, Koga H, Ikeda G, Waseda K, Tanimoto Y, Ueha S, Kataoka M, Gelfand EW, Tanimoto M.

Am J Respir Cell Mol Biol. 2011 Dec;45(6):1248-55. doi: 10.1165/rcmb.2010-0465OC. Epub 2011 Jul 14.

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