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Metformin Prevents Peritoneal Dissemination via Immune-suppressive Cells in the Tumor Microenvironment.

Hirayama T, Nagata Y, Nishida M, Matsuo M, Kobayashi S, Yoneda A, Kanetaka K, Udono H, Eguchi S.

Anticancer Res. 2019 Sep;39(9):4699-4709. doi: 10.21873/anticanres.13652.


An Approach to Optimize the Thermoelectric Properties of III-V Ternary InGaSb Crystals by Defect Engineering via Point Defects and Microscale Compositional Segregations.

Kumar VN, Hayakawa Y, Udono H, Inatomi Y.

Inorg Chem. 2019 Sep 3;58(17):11579-11588. doi: 10.1021/acs.inorgchem.9b01430. Epub 2019 Aug 20.


Berberine improved experimental chronic colitis by regulating interferon-γ- and IL-17A-producing lamina propria CD4+ T cells through AMPK activation.

Takahara M, Takaki A, Hiraoka S, Adachi T, Shimomura Y, Matsushita H, Nguyen TTT, Koike K, Ikeda A, Takashima S, Yamasaki Y, Inokuchi T, Kinugasa H, Sugihara Y, Harada K, Eikawa S, Morita H, Udono H, Okada H.

Sci Rep. 2019 Aug 15;9(1):11934. doi: 10.1038/s41598-019-48331-w.


Metformin Promotes the Protection of Mice Infected With Plasmodium yoelii Independently of γδ T Cell Expansion.

Miyakoda M, Bayarsaikhan G, Kimura D, Akbari M, Udono H, Yui K.

Front Immunol. 2018 Dec 13;9:2942. doi: 10.3389/fimmu.2018.02942. eCollection 2018.


Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects.

Uehara T, Eikawa S, Nishida M, Kunisada Y, Yoshida A, Fujiwara T, Kunisada T, Ozaki T, Udono H.

Int Immunol. 2019 Mar 28;31(4):187-198. doi: 10.1093/intimm/dxy079.


Study Protocol: Phase-Ib Trial of Nivolumab Combined With Metformin for Refractory/Recurrent Solid Tumors.

Kubo T, Ninomiya T, Hotta K, Kozuki T, Toyooka S, Okada H, Fujiwara T, Udono H, Kiura K.

Clin Lung Cancer. 2018 Nov;19(6):e861-e864. doi: 10.1016/j.cllc.2018.07.010. Epub 2018 Aug 9.


Metformin Mediates Protection against Legionella Pneumonia through Activation of AMPK and Mitochondrial Reactive Oxygen Species.

Kajiwara C, Kusaka Y, Kimura S, Yamaguchi T, Nanjo Y, Ishii Y, Udono H, Standiford TJ, Tateda K.

J Immunol. 2018 Jan 15;200(2):623-631. doi: 10.4049/jimmunol.1700474. Epub 2017 Dec 15.


Visualization of the native shape of bodipy-labeled DNA in Escherichia coli by correlative microscopy.

Loukanov A, Mladenova P, Toshev S, Udono H, Nakabayashi S.

Microsc Res Tech. 2018 Mar;81(3):267-274. doi: 10.1002/jemt.22975. Epub 2017 Nov 27.


[Metabolic Competition in Tumor Microenvironment].

Eikawa S, Udono H.

Gan To Kagaku Ryoho. 2017 Nov;44(11):972-976. Japanese.


Attenuation of CD4+CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug.

Kunisada Y, Eikawa S, Tomonobu N, Domae S, Uehara T, Hori S, Furusawa Y, Hase K, Sasaki A, Udono H.

EBioMedicine. 2017 Nov;25:154-164. doi: 10.1016/j.ebiom.2017.10.009. Epub 2017 Oct 16.


Extracellular and Non-Chaperone Function of Heat Shock Protein-90α Is Required for Skin Wound Healing.

Bhatia A, O'Brien K, Guo J, Lincoln V, Kajiwara C, Chen M, Woodley DT, Udono H, Li W.

J Invest Dermatol. 2018 Feb;138(2):423-433. doi: 10.1016/j.jid.2017.08.043. Epub 2017 Sep 20.


Metformin-dependent metabolic reprogramming contributes to efficient anti-tumor immunity.

Tomonobu N, Eikawa S, Udono H.

Nihon Rinsho. 2017 Feb;75(2):323-328. Japanese.


Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90.

Hong F, Mohammad Rachidi S, Lundgren D, Han D, Huang X, Zhao H, Kimura Y, Hirano H, Ohara O, Udono H, Meng S, Liu B, Li Z.

PLoS One. 2017 Jan 5;12(1):e0169260. doi: 10.1371/journal.pone.0169260. eCollection 2017.


Radiotherapy using IMRT boosts after hyperbaric oxygen therapy with chemotherapy for glioblastoma.

Yahara K, Ohguri T, Udono H, Yamamoto J, Tomura K, Onoda T, Imada H, Nishizawa S, Korogi Y.

J Radiat Res. 2017 May 1;58(3):351-356. doi: 10.1093/jrr/rrw105.


Study about the Efficacy of Metformin to Immune Function in Cancer Patients.

Watanabe M, Yamamoto H, Eikawa S, Shien K, Shien T, Soh J, Hotta K, Wada J, Hinotsu S, Fujiwara T, Kiura K, Doihara H, Miyoshi S, Udono H, Toyooka S.

Acta Med Okayama. 2016 Aug;70(4):327-30.


The induction of antigen-specific CTL by in situ Ad-REIC gene therapy.

Ariyoshi Y, Watanabe M, Eikawa S, Yamazaki C, Sadahira T, Hirata T, Araki M, Ebara S, Nasu Y, Udono H, Kumon H.

Gene Ther. 2016 May;23(5):408-14. doi: 10.1038/gt.2016.7. Epub 2016 Feb 2.


Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients.

Kurose K, Ohue Y, Wada H, Iida S, Ishida T, Kojima T, Doi T, Suzuki S, Isobe M, Funakoshi T, Kakimi K, Nishikawa H, Udono H, Oka M, Ueda R, Nakayama E.

Clin Cancer Res. 2015 Oct 1;21(19):4327-36. doi: 10.1158/1078-0432.CCR-15-0357.


Detection and Tracking of NY-ESO-1-Specific CD8+ T Cells by High-Throughput T Cell Receptor β (TCRB) Gene Rearrangements Sequencing in a Peptide-Vaccinated Patient.

Miyai M, Eikawa S, Hosoi A, Iino T, Matsushita H, Isobe M, Uenaka A, Udono H, Nakajima J, Nakayama E, Kakimi K.

PLoS One. 2015 Aug 20;10(8):e0136086. doi: 10.1371/journal.pone.0136086. eCollection 2015.


Immunotherapy for Bone and Soft Tissue Sarcomas.

Uehara T, Fujiwara T, Takeda K, Kunisada T, Ozaki T, Udono H.

Biomed Res Int. 2015;2015:820813. doi: 10.1155/2015/820813. Epub 2015 Jun 17. Review.


Immune-mediated antitumor effect by type 2 diabetes drug, metformin.

Eikawa S, Nishida M, Mizukami S, Yamazaki C, Nakayama E, Udono H.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1809-14. doi: 10.1073/pnas.1417636112. Epub 2015 Jan 26.


HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse.

Ichiyanagi T, Ichiyanagi K, Ogawa A, Kuramochi-Miyagawa S, Nakano T, Chuma S, Sasaki H, Udono H.

Nucleic Acids Res. 2014 Oct 29;42(19):11903-11. doi: 10.1093/nar/gku881. Epub 2014 Sep 27.


[Regulation of T-cell immune exhaustion and cancer immunotherapy].

Eikawa S, Udono H.

Gan To Kagaku Ryoho. 2014 Sep;41(9):1066-70. Japanese.


Monitoring multifunctionality of immune-exhausted CD8 T cells in cancer patients.

Eikawa S, Mizukami S, Udono H.

Methods Mol Biol. 2014;1142:11-7. doi: 10.1007/978-1-4939-0404-4_2.


Vaccination with NY-ESO-1 overlapping peptides mixed with Picibanil OK-432 and montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen.

Wada H, Isobe M, Kakimi K, Mizote Y, Eikawa S, Sato E, Takigawa N, Kiura K, Tsuji K, Iwatsuki K, Yamasaki M, Miyata H, Matsushita H, Udono H, Seto Y, Yamada K, Nishikawa H, Pan L, Venhaus R, Oka M, Doki Y, Nakayama E.

J Immunother. 2014 Feb-Mar;37(2):84-92. doi: 10.1097/CJI.0000000000000017.


Frequency, outcome and prognostic factors of carotid blowout syndrome after hypofractionated re-irradiation of head and neck cancer using CyberKnife: a multi-institutional study.

Yamazaki H, Ogita M, Kodani N, Nakamura S, Inoue H, Himei K, Kotsuma T, Yoshida K, Yoshioka Y, Yamashita K, Udono H.

Radiother Oncol. 2013 Jun;107(3):305-9. doi: 10.1016/j.radonc.2013.05.005. Epub 2013 Jun 7.


[Heat shock protein and antigen cross-presentation].

Udono H.

Seikagaku. 2012 Oct;84(10):829-39. Review. Japanese. No abstract available.


Spermatogenesis arrest caused by conditional deletion of Hsp90α in adult mice.

Kajiwara C, Kondo S, Uda S, Dai L, Ichiyanagi T, Chiba T, Ishido S, Koji T, Udono H.

Biol Open. 2012 Oct 15;1(10):977-82. doi: 10.1242/bio.2012646. Epub 2012 Aug 17.


Phenotypic analysis of monocyte-derived dendritic cells loaded with tumor antigen with heat-shock cognate protein-70.

Ito S, Nagata Y, Susumu S, Yoneda A, Matsuo M, Yui K, Udono H, Eguchi S, Kanematsu T.

Anticancer Res. 2012 Nov;32(11):4897-904.


HSP70 and HSP90 Differentially Regulate Translocation of Extracellular Antigen to the Cytosol for Cross-Presentation.

Kato Y, Kajiwara C, Ishige I, Mizukami S, Yamazaki C, Eikawa S, Kakimi K, Udono H.

Autoimmune Dis. 2012;2012:745962. doi: 10.1155/2012/745962. Epub 2012 Sep 25.


HSP90α deficiency does not affect immunoglobulin gene hypermutation and class switch but causes enhanced MHC class II antigen presentation.

Li Y, Li S, Hoshino M, Ishikawa R, Kajiwara C, Gao X, Zhao Y, Ishido S, Udono H, Wang JY.

Int Immunol. 2012 Dec;24(12):751-8. doi: 10.1093/intimm/dxs076. Epub 2012 Aug 1.


Induction of CD8 T-cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20-mer NY-ESO-1f (NY-ESO-1 91-110) peptide.

Eikawa S, Kakimi K, Isobe M, Kuzushima K, Luescher I, Ohue Y, Ikeuchi K, Uenaka A, Nishikawa H, Udono H, Oka M, Nakayama E.

Int J Cancer. 2013 Jan 15;132(2):345-54. doi: 10.1002/ijc.27682. Epub 2012 Jul 11.


Differential MyD88/IRAK4 requirements for cross-priming and tumor rejection induced by heat shock protein 70-model antigen fusion protein.

Mizukami S, Kajiwara C, Tanaka M, Kaisho T, Udono H.

Cancer Sci. 2012 May;103(5):851-9. doi: 10.1111/j.1349-7006.2012.02233.x. Epub 2012 Mar 14.


Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells.

Imai T, Kato Y, Kajiwara C, Mizukami S, Ishige I, Ichiyanagi T, Hikida M, Wang JY, Udono H.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16363-8. doi: 10.1073/pnas.1108372108. Epub 2011 Sep 19.


Photoemission study on the valence band of a β-FeSi2 thin film using synchrotron radiation.

Fujimoto H, Ogawa K, Takarabe K, Udono H, Sugiyama H, Azuma J, Takahashi K, Kamada M.

Dalton Trans. 2011 Jun 14;40(22):6023-7. doi: 10.1039/c0dt01832e. Epub 2011 May 9.


Semiconducting behavior of type-I Si clathrate K8Ga8Si38.

Imai M, Sato A, Udono H, Imai Y, Tajima H.

Dalton Trans. 2011 Apr 28;40(16):4045-7. doi: 10.1039/c1dt10071h. Epub 2011 Mar 8.


Quantitative assessment of inter-observer variability in target volume delineation on stereotactic radiotherapy treatment for pituitary adenoma and meningioma near optic tract.

Yamazaki H, Shiomi H, Tsubokura T, Kodani N, Nishimura T, Aibe N, Udono H, Nishikata M, Baba Y, Ogita M, Yamashita K, Kotsuma T.

Radiat Oncol. 2011 Jan 27;6:10. doi: 10.1186/1748-717X-6-10.


Essential role of endogenous heat shock protein 90 of dendritic cells in antigen cross-presentation.

Ichiyanagi T, Imai T, Kajiwara C, Mizukami S, Nakai A, Nakayama T, Udono H.

J Immunol. 2010 Sep 1;185(5):2693-700. doi: 10.4049/jimmunol.1000821. Epub 2010 Jul 28.


Targeted inhibition of IL-10-secreting CD25- Treg via p38 MAPK suppression in cancer immunotherapy.

Ohkusu-Tsukada K, Toda M, Udono H, Kawakami Y, Takahashi K.

Eur J Immunol. 2010 Apr;40(4):1011-21. doi: 10.1002/eji.200939513.


Heat shock proteins in antigen trafficking--implications on antigen presentation to T cells.

Udono H, Ichiyanagi T, Mizukami S, Imai T.

Int J Hyperthermia. 2009 Dec;25(8):617-25. doi: 10.3109/02656730902902183. Review.


Hsp90-mediated assembly of the 26 S proteasome is involved in major histocompatibility complex class I antigen processing.

Yamano T, Mizukami S, Murata S, Chiba T, Tanaka K, Udono H.

J Biol Chem. 2008 Oct 17;283(42):28060-5. doi: 10.1074/jbc.M803077200. Epub 2008 Aug 14.


Allele-selective effect of PA28 in MHC class I antigen processing.

Yamano T, Sugahara H, Mizukami S, Murata S, Chiba T, Tanaka K, Yui K, Udono H.

J Immunol. 2008 Aug 1;181(3):1655-64.


Both CD4+ and CD8+ T cell epitopes fused to heat shock cognate protein 70 (hsc70) can function to eradicate tumors.

Mizukami S, Kajiwara C, Ishikawa H, Katayama I, Yui K, Udono H.

Cancer Sci. 2008 May;99(5):1008-15. doi: 10.1111/j.1349-7006.2008.00788.x. Epub 2008 Mar 12.


Cross-presentation of NY-ESO-1 cytotoxic T lymphocyte epitope fused to human heat shock cognate protein 70 by dendritic cells.

Susumu S, Nagata Y, Ito S, Matsuo M, Valmori D, Yui K, Udono H, Kanematsu T.

Cancer Sci. 2008 Jan;99(1):107-12. Epub 2007 Nov 7.


Interferon regulatory factor 4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS.

Honma K, Udono H, Kohno T, Yamamoto K, Ogawa A, Takemori T, Kumatori A, Suzuki S, Matsuyama T, Yui K.

Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16001-6. Epub 2005 Oct 21.


Regulation of the maintenance of peripheral T-cell anergy by TAB1-1 mediated p38alpha activation.

Ohkusu-Tsukada K, Tominaga N, Udono H, Yui K.

Mol Cell Biol. 2005 Oct;25(19):8763. No abstract available.


Regulation of the maintenance of peripheral T-cell anergy by TAB1-mediated p38 alpha activation.

Ohkusu-Tsukada K, Tominaga N, Udono H, Yui K.

Mol Cell Biol. 2004 Aug;24(16):6957-66. Erratum in: Mol Cell Biol. 2005 Oct;25(19):8763.


A pitfall in diagnosis of human prion diseases using detection of protease-resistant prion protein in urine. Contamination with bacterial outer membrane proteins.

Furukawa H, Doh-ura K, Okuwaki R, Shirabe S, Yamamoto K, Udono H, Ito T, Katamine S, Niwa M.

J Biol Chem. 2004 May 28;279(22):23661-7. Epub 2004 Mar 18.


Hsp-antigen fusion and their use for immunization.

Udono H, Saito T, Ogawa M, Yui Y.

Methods. 2004 Jan;32(1):21-4.


Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer.

Isomoto H, Oka M, Yano Y, Kanazawa Y, Soda H, Terada R, Yasutake T, Nakayama T, Shikuwa S, Takeshima F, Udono H, Murata I, Ohtsuka K, Kohno S.

Cancer Lett. 2003 Aug 20;198(2):219-28.


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