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Items: 1 to 50 of 65

1.

Transcriptional regulation of neutrophil differentiation and function during inflammation.

Ai Z, Udalova IA.

J Leukoc Biol. 2020 Mar;107(3):419-430. doi: 10.1002/JLB.1RU1219-504RR. Epub 2020 Jan 17. Review.

PMID:
31951039
2.

Caspase-8 promotes c-Rel-dependent inflammatory cytokine expression and resistance against Toxoplasma gondii.

DeLaney AA, Berry CT, Christian DA, Hart A, Bjanes E, Wynosky-Dolfi MA, Li X, Tummers B, Udalova IA, Chen YH, Hershberg U, Freedman BD, Hunter CA, Brodsky IE.

Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11926-11935. doi: 10.1073/pnas.1820529116. Epub 2019 May 30.

3.

Advances and challenges in targeting IRF5, a key regulator of inflammation.

Almuttaqi H, Udalova IA.

FEBS J. 2019 May;286(9):1624-1637. doi: 10.1111/febs.14654. Epub 2018 Sep 21. Review.

4.

Diverse mechanisms of IRF5 action in inflammatory responses.

Khoyratty TE, Udalova IA.

Int J Biochem Cell Biol. 2018 Jun;99:38-42. doi: 10.1016/j.biocel.2018.03.012. Epub 2018 Mar 22. Review.

PMID:
29578052
5.

Multiparametric Analysis of Myeloid Populations by Flow Cytometry.

Mathie SA, Corbin AL, Eames HL, Udalova IA.

Methods Mol Biol. 2018;1745:113-124. doi: 10.1007/978-1-4939-7680-5_7.

PMID:
29476466
6.

Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction.

Akbar N, Digby JE, Cahill TJ, Tavare AN, Corbin AL, Saluja S, Dawkins S, Edgar L, Rawlings N, Ziberna K, McNeill E; Oxford Acute Myocardial Infarction (OxAMI) Study, Johnson E, Aljabali AA, Dragovic RA, Rohling M, Belgard TG, Udalova IA, Greaves DR, Channon KM, Riley PR, Anthony DC, Choudhury RP.

JCI Insight. 2017 Sep 7;2(17). pii: 93344. doi: 10.1172/jci.insight.93344. eCollection 2017 Sep 7.

7.

Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis.

Seneviratne AN, Edsfeldt A, Cole JE, Kassiteridi C, Swart M, Park I, Green P, Khoyratty T, Saliba D, Goddard ME, Sansom SN, Goncalves I, Krams R, Udalova IA, Monaco C.

Circulation. 2017 Sep 19;136(12):1140-1154. doi: 10.1161/CIRCULATIONAHA.117.027844. Epub 2017 Jul 11.

8.

IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans.

Alzaid F, Lagadec F, Albuquerque M, Ballaire R, Orliaguet L, Hainault I, Blugeon C, Lemoine S, Lehuen A, Saliba DG, Udalova IA, Paradis V, Foufelle F, Venteclef N.

JCI Insight. 2016 Dec 8;1(20):e88689. doi: 10.1172/jci.insight.88689.

9.

A critical role for IRF5 in regulating allergic airway inflammation.

Byrne AJ, Weiss M, Mathie SA, Walker SA, Eames HL, Saliba D, Lloyd CM, Udalova IA.

Mucosal Immunol. 2017 May;10(3):716-726. doi: 10.1038/mi.2016.92. Epub 2016 Oct 19.

10.

Macrophage heterogeneity in the context of rheumatoid arthritis.

Udalova IA, Mantovani A, Feldmann M.

Nat Rev Rheumatol. 2016 Aug;12(8):472-85. doi: 10.1038/nrrheum.2016.91. Epub 2016 Jul 7. Review.

PMID:
27383913
11.

IRF5 controls both acute and chronic inflammation.

Weiss M, Byrne AJ, Blazek K, Saliba DG, Pease JE, Perocheau D, Feldmann M, Udalova IA.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11001-6. doi: 10.1073/pnas.1506254112. Epub 2015 Aug 17.

12.

Interferon regulatory factor 5 in human autoimmunity and murine models of autoimmune disease.

Eames HL, Corbin AL, Udalova IA.

Transl Res. 2016 Jan;167(1):167-82. doi: 10.1016/j.trsl.2015.06.018. Epub 2015 Jul 4. Review.

PMID:
26207886
13.

IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production.

Blazek K, Eames HL, Weiss M, Byrne AJ, Perocheau D, Pease JE, Doyle S, McCann F, Williams RO, Udalova IA.

J Exp Med. 2015 Jun 1;212(6):845-53. doi: 10.1084/jem.20140995. Epub 2015 May 4.

14.

Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity.

Dalmas E, Toubal A, Alzaid F, Blazek K, Eames HL, Lebozec K, Pini M, Hainault I, Montastier E, Denis RG, Ancel P, Lacombe A, Ling Y, Allatif O, Cruciani-Guglielmacci C, André S, Viguerie N, Poitou C, Stich V, Torcivia A, Foufelle F, Luquet S, Aron-Wisnewsky J, Langin D, Clément K, Udalova IA, Venteclef N.

Nat Med. 2015 Jun;21(6):610-8. doi: 10.1038/nm.3829. Epub 2015 May 4.

PMID:
25939064
15.

Activation and function of interferon regulatory factor 5.

Ryzhakov G, Eames HL, Udalova IA.

J Interferon Cytokine Res. 2015 Feb;35(2):71-8. doi: 10.1089/jir.2014.0023. Epub 2014 Sep 26. Review.

PMID:
25259415
16.

IRF5:RelA interaction targets inflammatory genes in macrophages.

Saliba DG, Heger A, Eames HL, Oikonomopoulos S, Teixeira A, Blazek K, Androulidaki A, Wong D, Goh FG, Weiss M, Byrne A, Pasparakis M, Ragoussis J, Udalova IA.

Cell Rep. 2014 Sep 11;8(5):1308-17. doi: 10.1016/j.celrep.2014.07.034. Epub 2014 Aug 21.

17.

IRF5 is a specific marker of inflammatory macrophages in vivo.

Weiss M, Blazek K, Byrne AJ, Perocheau DP, Udalova IA.

Mediators Inflamm. 2013;2013:245804. doi: 10.1155/2013/245804. Epub 2013 Dec 23.

18.

Cross-species analysis reveals evolving and conserved features of the nuclear factor κB (NF-κB) proteins.

Ryzhakov G, Teixeira A, Saliba D, Blazek K, Muta T, Ragoussis J, Udalova IA.

J Biol Chem. 2013 Apr 19;288(16):11546-54. doi: 10.1074/jbc.M113.451153. Epub 2013 Mar 18.

19.

IL-17 receptor adaptor protein Act1/CIKS plays an evolutionarily conserved role in antiviral signaling.

Ryzhakov G, Blazek K, Lai CC, Udalova IA.

J Immunol. 2012 Nov 15;189(10):4852-8. doi: 10.4049/jimmunol.1200428. Epub 2012 Oct 12.

20.

KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophages.

Eames HL, Saliba DG, Krausgruber T, Lanfrancotti A, Ryzhakov G, Udalova IA.

Immunobiology. 2012 Dec;217(12):1315-24. doi: 10.1016/j.imbio.2012.07.026. Epub 2012 Aug 11.

PMID:
22995936
21.

The alarmin IL-33 is a notch target in quiescent endothelial cells.

Sundlisaeter E, Edelmann RJ, Hol J, Sponheim J, Küchler AM, Weiss M, Udalova IA, Midwood KS, Kasprzycka M, Haraldsen G.

Am J Pathol. 2012 Sep;181(3):1099-111. doi: 10.1016/j.ajpath.2012.06.003. Epub 2012 Jul 16.

PMID:
22809957
22.

FOXO3 as a new IKK-ε-controlled check-point of regulation of IFN-β expression.

Luron L, Saliba D, Blazek K, Lanfrancotti A, Udalova IA.

Eur J Immunol. 2012 Apr;42(4):1030-7. doi: 10.1002/eji.201141969.

23.

Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding.

Siggers T, Chang AB, Teixeira A, Wong D, Williams KJ, Ahmed B, Ragoussis J, Udalova IA, Smale ST, Bulyk ML.

Nat Immunol. 2011 Nov 20;13(1):95-102. doi: 10.1038/ni.2151.

24.

Extensive characterization of NF-κB binding uncovers non-canonical motifs and advances the interpretation of genetic functional traits.

Wong D, Teixeira A, Oikonomopoulos S, Humburg P, Lone IN, Saliba D, Siggers T, Bulyk M, Angelov D, Dimitrov S, Udalova IA, Ragoussis J.

Genome Biol. 2011 Jul 29;12(7):R70. doi: 10.1186/gb-2011-12-7-r70.

25.

Evolution of vertebrate immunity: sequence and functional analysis of the SEFIR domain family member Act1.

Ryzhakov G, Blazek K, Udalova IA.

J Mol Evol. 2011 Jun;72(5-6):521-30. doi: 10.1007/s00239-011-9450-7. Epub 2011 Jun 4.

PMID:
21643828
26.

Expression and immune function of tenascin-C.

Udalova IA, Ruhmann M, Thomson SJ, Midwood KS.

Crit Rev Immunol. 2011;31(2):115-45. Review.

PMID:
21542790
27.

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses.

Krausgruber T, Blazek K, Smallie T, Alzabin S, Lockstone H, Sahgal N, Hussell T, Feldmann M, Udalova IA.

Nat Immunol. 2011 Mar;12(3):231-8. doi: 10.1038/ni.1990. Epub 2011 Jan 16.

PMID:
21240265
28.

Beyond the enhanceosome: cluster of novel κB sites downstream of the human IFN-β gene is essential for lipopolysaccharide-induced gene activation.

Goh FG, Thomson SJ, Krausgruber T, Lanfrancotti A, Copley RR, Udalova IA.

Blood. 2010 Dec 16;116(25):5580-8. doi: 10.1182/blood-2010-05-282285. Epub 2010 Sep 20.

PMID:
20855868
29.

IRF5 is required for late-phase TNF secretion by human dendritic cells.

Krausgruber T, Saliba D, Ryzhakov G, Lanfrancotti A, Blazek K, Udalova IA.

Blood. 2010 Jun 3;115(22):4421-30. doi: 10.1182/blood-2010-01-263020. Epub 2010 Mar 17.

PMID:
20237317
30.

Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation.

Goh FG, Piccinini AM, Krausgruber T, Udalova IA, Midwood KS.

J Immunol. 2010 Mar 1;184(5):2655-62. doi: 10.4049/jimmunol.0903359. Epub 2010 Jan 27.

31.

The role of transposable elements in the regulation of IFN-lambda1 gene expression.

Thomson SJ, Goh FG, Banks H, Krausgruber T, Kotenko SV, Foxwell BM, Udalova IA.

Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11564-9. doi: 10.1073/pnas.0904477106. Epub 2009 Jul 1.

32.

Quantitative measurement of cytokine expression in synoviocytes derived from rheumatoid arthritis patients.

Thomson S, Udalova IA.

Methods Mol Biol. 2009;512:233-48. doi: 10.1007/978-1-60327-530-9_12.

PMID:
19347280
33.

Detecting and modulating the NF-kB activity in human immune cells: generation of human cell lines with altered levels of NF-kappaB.

Goh FG, Banks H, Udalova IA.

Methods Mol Biol. 2009;512:39-54. doi: 10.1007/978-1-60327-530-9_4.

PMID:
19347272
34.

Functional conservation of Rel binding sites in drosophilid genomes.

Copley RR, Totrov M, Linnell J, Field S, Ragoussis J, Udalova IA.

Genome Res. 2007 Sep;17(9):1327-35.

35.

Localization of a long-range cis-regulatory element of IL13 by allelic transcript ratio mapping.

Forton JT, Udalova IA, Campino S, Rockett KA, Hull J, Kwiatkowski DP.

Genome Res. 2007 Jan;17(1):82-7. Epub 2006 Nov 29.

36.

Factor H, a regulator of complement activity, is a major determinant of meningococcal disease susceptibility in UK Caucasian patients.

Haralambous E, Dolly SO, Hibberd ML, Litt DJ, Udalova IA, O'dwyer C, Langford PR, Simon Kroll J, Levin M.

Scand J Infect Dis. 2006;38(9):764-71.

PMID:
16938729
37.

Quantitative profiling of protein-DNA binding on microarrays.

Ragoussis J, Field S, Udalova IA.

Methods Mol Biol. 2006;338:261-80.

PMID:
16888364
38.

Context-specific functional effects of IFNGR1 promoter polymorphism.

Koch O, Kwiatkowski DP, Udalova IA.

Hum Mol Genet. 2006 May 1;15(9):1475-81. Epub 2006 Apr 6.

PMID:
16600993
39.

Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility.

Hacking D, Knight JC, Rockett K, Brown H, Frampton J, Kwiatkowski DP, Hull J, Udalova IA.

Genes Immun. 2004 Jun;5(4):274-82.

PMID:
15085176
40.

Quantitative high-throughput analysis of transcription factor binding specificities.

Linnell J, Mott R, Field S, Kwiatkowski DP, Ragoussis J, Udalova IA.

Nucleic Acids Res. 2004 Feb 27;32(4):e44.

41.

Comparing the fine specificity of DNA binding by NF-kappaB p50 and p52 using principal coordinates analysis.

Nijnik A, Mott R, Kwiatkowski DP, Udalova IA.

Nucleic Acids Res. 2003 Mar 1;31(5):1497-501.

42.

Association of accelerated erosive rheumatoid arthritis with a polymorphism that alters NF-kappaB binding to the TNF promoter region.

Udalova IA, Richardson A, Ackerman H, Wordsworth P, Kwiatkowski D.

Rheumatology (Oxford). 2002 Jul;41(7):830-1. No abstract available.

PMID:
12096240
43.

Quantitative prediction of NF-kappa B DNA-protein interactions.

Udalova IA, Mott R, Field D, Kwiatkowski D.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8167-72. Epub 2002 Jun 4.

44.

Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors.

van Heel DA, Udalova IA, De Silva AP, McGovern DP, Kinouchi Y, Hull J, Lench NJ, Cardon LR, Carey AH, Jewell DP, Kwiatkowski D.

Hum Mol Genet. 2002 May 15;11(11):1281-9.

PMID:
12019209
45.

Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa B in primary human macrophages.

Denys A, Udalova IA, Smith C, Williams LM, Ciesielski CJ, Campbell J, Andrews C, Kwaitkowski D, Foxwell BM.

J Immunol. 2002 May 15;168(10):4837-45.

46.

Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region.

Udalova IA, Kwiatkowski D.

Biochem Biophys Res Commun. 2001 Nov 23;289(1):25-33.

PMID:
11708771
47.

Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.

Udalova IA, Richardson A, Denys A, Smith C, Ackerman H, Foxwell B, Kwiatkowski D.

Mol Cell Biol. 2000 Dec;20(24):9113-9.

48.
49.

Similarities and differences between human and murine TNF promoters in their response to lipopolysaccharide.

Kuprash DV, Udalova IA, Turetskaya RL, Kwiatkowski D, Rice NR, Nedospasov SA.

J Immunol. 1999 Apr 1;162(7):4045-52.

50.

Complex NF-kappaB interactions at the distal tumor necrosis factor promoter region in human monocytes.

Udalova IA, Knight JC, Vidal V, Nedospasov SA, Kwiatkowski D.

J Biol Chem. 1998 Aug 14;273(33):21178-86.

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