Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 27

1.

Unraveling the Interaction between Carboxylesterase 1c and the Antibody-Drug Conjugate SYD985: Improved Translational PK/PD by Using Ces1c Knockout Mice.

Ubink R, Dirksen EHC, Rouwette M, Bos ES, Janssen I, Egging DF, Loosveld EM, van Achterberg TA, Berentsen K, van der Lee MMC, Bichat F, Raguin O, van der Vleuten MAJ, Groothuis PG, Dokter WHA.

Mol Cancer Ther. 2018 Nov;17(11):2389-2398. doi: 10.1158/1535-7163.MCT-18-0329. Epub 2018 Aug 9.

2.

Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting.

Meyer S, Nederend M, Jansen JH, Reiding KR, Jacobino SR, Meeldijk J, Bovenschen N, Wuhrer M, Valerius T, Ubink R, Boross P, Rouwendal G, Leusen JH.

MAbs. 2016;8(1):87-98. doi: 10.1080/19420862.2015.1106658. Epub 2015 Oct 14. Erratum in: MAbs. 2017 Jan;9(1):165.

3.

A comparison of anti-HER2 IgA and IgG1 in vivo efficacy is facilitated by high N-glycan sialylation of the IgA.

Rouwendal GJ, van der Lee MM, Meyer S, Reiding KR, Schouten J, de Roo G, Egging DF, Leusen JH, Boross P, Wuhrer M, Verheijden GF, Dokter WH, Timmers M, Ubink R.

MAbs. 2016;8(1):74-86. doi: 10.1080/19420862.2015.1102812. Epub 2015 Oct 6.

4.

Simultaneous Targeting of FcγRs and FcαRI Enhances Tumor Cell Killing.

Brandsma AM, Ten Broeke T, Nederend M, Meulenbroek LA, van Tetering G, Meyer S, Jansen JH, Beltrán Buitrago MA, Nagelkerke SQ, Németh I, Ubink R, Rouwendal G, Lohse S, Valerius T, Leusen JH, Boross P.

Cancer Immunol Res. 2015 Dec;3(12):1316-24. doi: 10.1158/2326-6066.CIR-15-0099-T. Epub 2015 Sep 25.

5.

Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody-Drug Conjugate SYD985.

Elgersma RC, Coumans RG, Huijbregts T, Menge WM, Joosten JA, Spijker HJ, de Groot FM, van der Lee MM, Ubink R, van den Dobbelsteen DJ, Egging DF, Dokter WH, Verheijden GF, Lemmens JM, Timmers CM, Beusker PH.

Mol Pharm. 2015 Jun 1;12(6):1813-35. doi: 10.1021/mp500781a. Epub 2015 Feb 18.

PMID:
25635711
6.

The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers.

van der Lee MM, Groothuis PG, Ubink R, van der Vleuten MA, van Achterberg TA, Loosveld EM, Damming D, Jacobs DC, Rouwette M, Egging DF, van den Dobbelsteen D, Beusker PH, Goedings P, Verheijden GF, Lemmens JM, Timmers M, Dokter WH.

Mol Cancer Ther. 2015 Mar;14(3):692-703. doi: 10.1158/1535-7163.MCT-14-0881-T. Epub 2015 Jan 14.

7.

Preclinical profile of the HER2-targeting ADC SYD983/SYD985: introduction of a new duocarmycin-based linker-drug platform.

Dokter W, Ubink R, van der Lee M, van der Vleuten M, van Achterberg T, Jacobs D, Loosveld E, van den Dobbelsteen D, Egging D, Mattaar E, Groothuis P, Beusker P, Coumans R, Elgersma R, Menge W, Joosten J, Spijker H, Huijbregts T, de Groot V, Eppink M, de Roo G, Verheijden G, Timmers M.

Mol Cancer Ther. 2014 Nov;13(11):2618-29. doi: 10.1158/1535-7163.MCT-14-0040-T. Epub 2014 Sep 4.

8.

NPY and its involvement in axon guidance, neurogenesis, and feeding.

Hökfelt T, Stanic D, Sanford SD, Gatlin JC, Nilsson I, Paratcha G, Ledda F, Fetissov S, Lindfors C, Herzog H, Johansen JE, Ubink R, Pfenninger KH.

Nutrition. 2008 Sep;24(9):860-8. doi: 10.1016/j.nut.2008.06.010. Review.

PMID:
18725084
9.

'Neuro'-peptides in glia: focus on NPY and galanin.

Ubink R, Calza L, Hökfelt T.

Trends Neurosci. 2003 Nov;26(11):604-9. Review.

PMID:
14585600
10.

Dynamics and plasticity of peptidergic control centres in the retino-brain-pituitary system of Xenopus laevis.

Kramer BM, Kolk SM, Berghs CA, Tuinhof R, Ubink R, Jenks BG, Roubos EW.

Microsc Res Tech. 2001 Aug 1;54(3):188-99. Review.

PMID:
11458401
11.

Transient prenatal expression of NPY-Y1 receptor in trigeminal axons innervating the mystacial vibrissae.

Ubink R, Kopp J, Wong H, Walsh JH, Pedrazzini T, Hökfelt T.

J Comp Neurol. 2001 Jan 8;429(2):183-91.

PMID:
11116213
12.

Excitatory amino acids, monoamine, and nitric oxide synthase systems in organotypic cultures: biochemical and immunohistochemical analysis.

Herrera-Marschitz M, Kohlhauser C, Gomez-Urquijo S, Ubink R, Goiny M, Hökfelt T.

Amino Acids. 2000;19(1):33-43.

PMID:
11026471
13.

Neuropeptide Y expression in Schwann cell precursors.

Ubink R, Hökfelt T.

Glia. 2000 Oct;32(1):71-83.

PMID:
10975912
14.

Expression of neuropeptide Y in olfactory ensheathing cells during prenatal development.

Ubink R, Hökfelt T.

J Comp Neurol. 2000 Jul 17;423(1):13-25.

PMID:
10861533
15.

Neuropeptides--an overview.

Hökfelt T, Broberger C, Xu ZQ, Sergeyev V, Ubink R, Diez M.

Neuropharmacology. 2000 Jun 8;39(8):1337-56. Review.

PMID:
10818251
16.
17.

Serotonergic innervation of the pituitary pars intermedia of xenopus laevis.

Ubink R, Buzzi M, Cruijsen PM, Tuinhof R, Verhofstad AA, Jenks BG, Roubos EW.

J Neuroendocrinol. 1999 Mar;11(3):211-9.

PMID:
10201817
18.
19.
20.

Role of nitric oxide synthase and nitric oxide in background adaptation in Xenopus laevis.

Allaerts W, Ubink R, Buzzi M, Jenks BG, Roubos EW.

Ann N Y Acad Sci. 1998 May 15;839:564-5. No abstract available.

PMID:
9629218
21.

Distribution of pro-opiomelanocortin and its peptide end products in the brain and hypophysis of the aquatic toad, Xenopus laevis.

Tuinhof R, Ubink R, Tanaka S, Atzori C, van Strien FJ, Roubos EW.

Cell Tissue Res. 1998 May;292(2):251-65.

PMID:
9560468
22.

Nitric oxide synthase and background adaptation in Xenopus laevis.

Allaerts W, Ubink R, de Vente J, Tuinhof R, Jenks BG, Roubos EW.

J Chem Neuroanat. 1997 Dec;14(1):21-31.

PMID:
9498164
23.

Physiologically induced Fos expression in the hypothalamo-hypophyseal system of Xenopus laevis.

Ubink R, Jenks BG, Roubos EW.

Neuroendocrinology. 1997 Jun;65(6):413-22.

PMID:
9208403
24.

Neuropeptide Y and galanin binding sites in rat and monkey lumbar dorsal root ganglia and spinal cord and effect of peripheral axotomy.

Zhang X, Ji RR, Nilsson S, Villar M, Ubink R, Ju G, Wiesenfeld-Hallin Z, Hökfelt T.

Eur J Neurosci. 1995 Mar 1;7(3):367-80.

PMID:
7539691
26.

Immunologically induced sympathectomy of preganglionic nerves by antibodies against acetylcholinesterase: increased levels of peptides and their messenger RNAs in rat adrenal chromaffin cells.

Dagerlind A, Pelto-Huikko M, Lundberg JM, Ubink R, Verhofstad A, Brimijoin S, Hökfelt T.

Neuroscience. 1994 Sep;62(1):217-39. Erratum in: Neuroscience 1994 Nov;63(1):349.

PMID:
7816201
27.

Neuropeptide tyrosine is expressed in ensheathing cells around the olfactory nerves in the rat olfactory bulb.

Ubink R, Halasz N, Zhang X, Dagerlind A, Hökfelt T.

Neuroscience. 1994 Jun;60(3):709-26.

PMID:
7936197

Supplemental Content

Support Center