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Structure of UBE2Z Enzyme Provides Functional Insight into Specificity in the FAT10 Protein Conjugation Machinery.
Schelpe J, Monté D, Dewitte F, Sixma TK, Rucktooa P. Schelpe J, et al. J Biol Chem. 2016 Jan 8;291(2):630-9. doi: 10.1074/jbc.M115.671545. Epub 2015 Nov 10. J Biol Chem. 2016. PMID: 26555268 Free PMC article.
We have determined the crystal structure of UBE2Z and report how the different domains of this E2 enzyme are organized. We further combine our structural data with mutational analyses to understand how specificity is achieved in the FAT10 conjugation pathway. We show that …
We have determined the crystal structure of UBE2Z and report how the different domains of this E2 enzyme are organized. We further co …
Upregulation of ubiquitin-conjugating enzyme E2Z is associated with human hepatocellular carcinoma.
Shi X, Wang B, Chen X, Zheng Y, Ding Y, Wang C. Shi X, et al. Biochem Biophys Res Commun. 2020 Feb 26;523(1):25-32. doi: 10.1016/j.bbrc.2019.11.170. Epub 2019 Dec 9. Biochem Biophys Res Commun. 2020. PMID: 31831168
However, its roles in hepatocellular carcinoma (HCC) remain undiscovered. This study aimed at investigating the functions of UBE2Z in HCC. Firstly, we evaluated UBE2Z expression in HCC and identified associations among UBE2Z expression, clinicopathological fe …
However, its roles in hepatocellular carcinoma (HCC) remain undiscovered. This study aimed at investigating the functions of UBE2Z in …
Association between the UBE2Z rs46522 and TCF7L2 rs7903146 polymorphisms with type 2 diabetes in south western Iran.
Foroughmand AM, Shafidelpour S, Zakerkish M, Borujeni MP. Foroughmand AM, et al. Afr Health Sci. 2019 Sep;19(3):2484-2490. doi: 10.4314/ahs.v19i3.24. Afr Health Sci. 2019. PMID: 32127821 Free PMC article.
Association between rs7903146 and T2D risk reported in some of populations. Also many loci such as UBE2Z rs46522 are affecting by TCF7L2 transcription factor have been found associated with T2D. ...
Association between rs7903146 and T2D risk reported in some of populations. Also many loci such as UBE2Z rs46522 are affecting by TCF …
Cloning and characterization of a gene encoding the human putative ubiquitin conjugating enzyme E2Z (UBE2Z).
Gu X, Zhao F, Zheng M, Fei X, Chen X, Huang S, Xie Y, Mao Y. Gu X, et al. Mol Biol Rep. 2007 Sep;34(3):183-8. doi: 10.1007/s11033-006-9033-7. Epub 2006 Dec 12. Mol Biol Rep. 2007. PMID: 17160626
Here we report the research about a human putative ubiquitin conjugating enzyme gene, UBE2Z. The length of UBE2Z cDNA is 3054 base pairs and contains an open reading frame encoding 246 amino acids. The UBE2Z gene was mapped to human chromosome 17q21.32 and co …
Here we report the research about a human putative ubiquitin conjugating enzyme gene, UBE2Z. The length of UBE2Z cDNA is 3054 …
IL-13 Impairs Tight Junctions in Airway Epithelia.
Schmidt H, Braubach P, Schilpp C, Lochbaum R, Neuland K, Thompson K, Jonigk D, Frick M, Dietl P, Wittekindt OH. Schmidt H, et al. Int J Mol Sci. 2019 Jun 30;20(13):3222. doi: 10.3390/ijms20133222. Int J Mol Sci. 2019. PMID: 31262043 Free PMC article.
UBE2Z upregulation occurs within the first day after IL-13 exposure. ...Our data suggest that that IL-13 induces ubiquitination and proteasomal aggregation of TJ proteins via JAK/STAT dependent expression of UBE2Z, resulting in opening of TJs. This may contribute to …
UBE2Z upregulation occurs within the first day after IL-13 exposure. ...Our data suggest that that IL-13 induces ubiquitination and p …
Evaluating the association of common UBE2Z variants with coronary artery disease in an Iranian population.
Bastami M, Ghaderian SM, Omrani MD, Mirfakhraie R, Nariman-Saleh-Fam Z, Mansoori Y, Masotti A. Bastami M, et al. Cell Mol Biol (Noisy-le-grand). 2015 Nov 20;61(7):50-4. Cell Mol Biol (Noisy-le-grand). 2015. PMID: 26602883
Genome-wide association studies have discovered several variants associated with CAD. Notably, a recent study has identified UBE2Z rs46522 at 17q21.32 as a CAD-susceptibility variant in Europeans. ...Herein, we evaluated the contribution of rs46522 and a variant in high li …
Genome-wide association studies have discovered several variants associated with CAD. Notably, a recent study has identified UBE2Z rs …
Association of genetic variants with dyslipidemia.
Abe S, Tokoro F, Matsuoka R, Arai M, Noda T, Watanabe S, Horibe H, Fujimaki T, Oguri M, Kato K, Minatoguchi S, Yamada Y. Abe S, et al. Mol Med Rep. 2015 Oct;12(4):5429-36. doi: 10.3892/mmr.2015.4081. Epub 2015 Jul 16. Mol Med Rep. 2015. PMID: 26238946
Comparisons of allele frequencies using the chi2 test revealed that rs964184 of zinc finger gene (ZPR1; FDR=2.1x10-7), rs4845625 of interleukin 6 receptor (IL6R; FDR=0.032), rs46522 of ubiquitin-conjugating enzyme E2Z gene (UBE2Z; FDR=0.032) and rs17514846 of furin (FDR=0. …
Comparisons of allele frequencies using the chi2 test revealed that rs964184 of zinc finger gene (ZPR1; FDR=2.1x10-7), rs4845625 of interleu …
New Clues to Prognostic Biomarkers of Four Hematological Malignancies.
Salifu SP, Doughan A. Salifu SP, et al. J Cancer. 2022 May 9;13(8):2490-2503. doi: 10.7150/jca.69274. eCollection 2022. J Cancer. 2022. PMID: 35711821 Free PMC article.
Survival analyses with clinical data from TCGA showed that high expression of SRSF1, SRSF6, UBE2Z and PCF11, and low expression of HECW2 were correlated with poor prognosis in HMs. ...
Survival analyses with clinical data from TCGA showed that high expression of SRSF1, SRSF6, UBE2Z and PCF11, and low expression of HE …
The rs46522 Polymorphism of the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with Abnormal Metabolic Parameters in Patients with Myocardial Infarction: The Genetics of Atherosclerosis Disease Mexican Study.
Rodríguez-Pérez JM, Posadas-Sánchez R, Vargas-Alarcón G, Blachman-Braun R, García-Flores E, Cazarín-Santos BG, Castillo-Avila RG, Borgonio-Cuadra VM, Tovilla-Zárate CA, González-Castro TB, López-Bautista F, Pérez-Hernández N. Rodríguez-Pérez JM, et al. DNA Cell Biol. 2020 Jul;39(7):1155-1161. doi: 10.1089/dna.2020.5477. Epub 2020 May 11. DNA Cell Biol. 2020. PMID: 32392439
The participation of ubiquitin-conjugating enzyme E2Z (UBE2Z) in atherosclerosis has been reported. We aimed to evaluate the association of the rs46522 polymorphism of the UBE2Z gene with myocardial infarction (MI) and other clinical and metabolic components in the …
The participation of ubiquitin-conjugating enzyme E2Z (UBE2Z) in atherosclerosis has been reported. We aimed to evaluate the associat …
Association Study of Coronary Artery Disease-Associated Genome-Wide Significant SNPs with Coronary Stenosis in Pakistani Population.
Cheema AN, Pirim D, Wang X, Ali J, Bhatti A, John P, Feingold E, Demirci FY, Kamboh MI. Cheema AN, et al. Dis Markers. 2020 Jun 27;2020:9738567. doi: 10.1155/2020/9738567. eCollection 2020. Dis Markers. 2020. PMID: 32685059 Free PMC article.
Five SNPs demonstrated significant associations: three with additive genetic models PLG/rs4252120 (p = 0.0078), KIAA1462/rs2505083 (p = 0.005), and SLC22A3/rs2048327 (p = 0.045) and two with recessive models SORT1/rs602633 (p = 0.005) and UBE2Z/rs46522 (p = 0.03). PLG/rs42 …
Five SNPs demonstrated significant associations: three with additive genetic models PLG/rs4252120 (p = 0.0078), KIAA1462/rs2505083 (p = 0.00 …
21 results